Intracellular organelles in the saga of Ca 2+ homeostasis: Different molecules for different purposes?

Cellular and Molecular Life Sciences

Volumn 69, Issue 7, 2012, Pages 1077-1104

  Zampese, Enrico ^a   Pizzo, Paola ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Ca 2+ Microdomains; Ca 2+ pumps; Ca 2+ releasing channels; Ca 2+ stores; Mitochondria; Sub cellular signaling

Indexed keywords

CALCIUM BINDING PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL FUNCTION; CELL NUCLEUS; CYTOARCHITECTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GOLGI COMPLEX; HUMAN; MITOCHONDRION; NONHUMAN; PEROXISOME; REVIEW;

ANIMALS; CALCIUM; CALCIUM SIGNALING; HOMEOSTASIS; HUMANS; INTRACELLULAR SPACE;

EID: 84859158543     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0845-9     Document Type: Review

References (365)

1. Catterall WA, Hulme JT, Jiang X, Few WP (2006) Regulation of sodium and calcium channels by signaling complexes. J Recept Signal Transduct Res 26(5-6):577-598
2. Lewis RS (2007) The molecular choreography of a store-operated calcium channel. Nature 446(7133):284-287
3. Wang Y, Deng X, Gill DL (2010) Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal 3(148):pe42
4. Brini M, Carafoli E (2009) Calcium pumps in health and disease. Physiol Rev 89(4):1341-1378
5. Zhu MX, Ma J, Parrington J, Calcraft PJ, Galione A, Evans AM (2010) Calcium signaling via two-pore channels: local or global, that is the question. Am J Physiol Cell Physiol 298(3):C430-C441
6. Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M (2009) Emerging roles of NAD+ and its metabolites in cell signaling. Sci Signal 2(57):mr1
7. Gorlach A, Klappa P, Kietzmann T (2006) The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal 8(9-10):1391-1418
8. Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66(2 Suppl 1):S102-S109
9. Carafoli E (1987) Intracellular calcium homeostasis. Annu Rev Biochem 56:395-433
10. Lynes EM, Simmen T (2011) Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER. Biochim Biophys Acta
11. 2+ delivery system in muscle cells. Appl Physiol Nutr Metab Physiologie appliquee nutrition et metabolisme 34(3):323-327
12. Wray S, Burdyga T (2010) Sarcoplasmic reticulum function in smooth muscle. Physiol Rev 90(1):113-178
13. Borgese N, Francolini M, Snapp E (2006) Endoplasmic reticulum architecture: structures in flux. Curr Opin Cell Biol 18(4):358-364
14. Pendin D, McNew JA, Daga A (2011) Balancing ER dynamics: shaping, bending, severing, and mending membranes. Curr Opin Cell Biol 23(4):435-442
15. Palade GE (1956) The endoplasmic reticulum. J Biophys Biochem Cytol 2(4 Suppl):85-98
16. 2+ stores has a key role in nonmuscle cell signaling and function. J Cell Biol 142(6):1395-1398
17. Aulestia FJ, Redondo PC, Rodriguez-Garcia A, Rosado JA, Salido GM, Alonso MT, Garcia-Sancho J (2011) Two distinct calcium pools in the endoplasmic reticulum of HEK-293T cells. Biochem J 435(1):227-235
18. 2+ stores in vascular smooth muscle: functional implications. Novartis Found Symp 246:125-137 (discussion 137-141, 221-227)
19. 2+ stores in sarcoplasmic and endoplasmic reticulum. Science 275(5306):1643-1648
20. 2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores. Biochem J 301(Pt 3): 879-883
21. 2+ releasing action of cyclic adenosine diphosphateribose in guinea-pig adrenal chromaffin cells. Neurosci Lett 326(3):167-170
22. Pezzati R, Bossi M, Podini P, Meldolesi J, Grohovaz F (1997) High-resolution calcium mapping of the endoplasmic reticulum-Golgi-exocytic membrane system. Electron energy loss imaging analysis of quick frozen-freeze dried PC12 cells. Mol Biol Cell 8:1501-1512
23. 2+] subcompartments in intact HeLa cells. J Cell Biol 139:601-611
24. Lippincott-Schwartz J, Patterson GH (2003) Development and use of fluorescent protein markers in living cells. Science 300(5616):87-91
25. Jones VC, McKeown L, Verkhratsky A, Jones OT (2008) LVpIN-KDEL: a novel lentiviral vector demonstrates the morphology, dynamics and continuity of the endoplasmic reticulum in live neurones. BMC Neurosci 9:10
26. Jones VC, Rodríguez JJ, Verkhratsky A, Jones OT (2009) A lentivirally delivered photoactivatable GFP to assess continuity in the endoplasmic reticulum of neurones and glia. Pflugers Arch 458(4):809-818
27. 2+ entry through basal membrane patch. Cell 88(1):49-55
28. Verkhratsky A (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85(1):201-279
29. 2+ movements and equilibration. EMBO J 19(21):5729-5739
30. 2+] recordings in single rat sensory neurones. Pflugers Arch 446(4):447-454
31. Petersen OH, Verkhratsky A (2007) Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells. Cell Calcium 42(4-5):373-378
32. 2+ store: a view from the lumen. Trends Biochem Sci 23:10-14
33. 2+ analyzed with an improved genetically encoded fluorescent sensor. Proc Natl Acad Sci USA 101(50):17404-17409
34. Hofer AM, Machen TE (1993) Technique for in situ measurement of calcium in intracellular inositol 1, 4, 5-trisphosphatesensitive stores using the fluorescent indicator mag-fura-2. Proc Natl Acad Sci USA 90:2598-2602
35. 2+ based on green fluorescent proteins and calmodulin. Nature 388:882-887
36. 2+ and cytosolic cAMP dynamics in mouse skeletal muscle. J Cell Biol 173(2):187-193
37. 2+ influx in Bcl-2-overexpressing cells. J Cell Biol 148:857-862
38. 2+ release in chromaffin cells seen from inside the ER with targeted aequorin. J Cell Biol 144(2):241-254
39. Burdakov D, Petersen OH, Verkhratsky A (2005) Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38(3-4):303-310
40. Putney JW Jr, Broad LM, Braun FJ, Lievremont JP, Bird GS (2001) Mechanisms of capacitative calcium entry. J Cell Sci 114(Pt 12):2223-2229
41. Camello C, Lomax R, Petersen OH, Tepikin AV (2002) Calcium leak from intracellular stores-the enigma of calcium signalling. Cell Calcium 32(5-6):355-361
42. Putney JW (2011) The physiological function of store-operated calcium entry. Neurochem Res 36(7):1157-1165
43. 2+ store to the plasma membrane. Nature 437(7060):902-905
44. 2+ influx. Curr Biol 15(13):1235-1241
45. 2+ store depletion. Proc Natl Acad Sci USA 104(22):9301-9306
46. Prakriya M, Lewis RS (2006) Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode. J Gen Physiol 128(3):373-386
47. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (2006) A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441(7090):179-185
48. 2+) channel activity. Proc Natl Acad Sci USA 103(24):9357-9362
49. Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD (2006) Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443(7108):226-229
50. Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R (2006) CRACM1 multimers form the ion-selective pore of the CRAC channel. Current biology CB 16(20):2073-2079
51. 2+ entry. Nat Cell Biol 11(6):669-677
52. 2+ levels. Cell 131(7):1327-1339
53. 2+ storage in health and disease: a dynamic equilibrium. Cell Calcium 47(4):297-314
54. Roy A, Wonderlin WF (2003) The permeability of the endoplasmic reticulum is dynamically coupled to protein synthesis. J Biol Chem 278(7):4397-4403
55. Flourakis M, Van Coppenolle F, Lehenkyi V, Beck B, Skryma R, Prevarskaya N (2006) Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation. FASEB J 20(8):1215-1217
56. 2+) release via the ER translocon activates store-operated calcium entry. Pflugers Arch 453(6):797-808
57. Anyatonwu GI, Ehrlich BE (2005) Organic cation permeation through the channel formed by polycystin-2. J Biol Chem 280(33):29488-29493
58. 2+ leak channels, a function disrupted by familial Alzheimers disease-linked mutations. Cell 126(5):981-993
59. 2+ channel activity in the endoplasmic reticulum. J Biol Chem 283(23): 15946-15955
60. DHondt C, Ponsaerts R, De Smedt H, Vinken M, De Vuyst E, De Bock M, Wang N, Rogiers V, Leybaert L, Himpens B, Bultynck G (2011) Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum. Cell Signal 23(2):305-316
61. Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 102(1):105-110
62. 2+ homeostasis and accelerates apoptosis. J Biol Chem 281(24):16649-16655
63. 2+ disruption in Alzheimers disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58(6): 871-883
64. Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK (2010) Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimers disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal 3(114):ra22
65. Rybalchenko V, Hwang SY, Rybalchenko N, Koulen P (2008) The cytosolic N terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity. Int J Biochem Cell Biol 40(1):84-97
66. Hayrapetyan V, Rybalchenko V, Rybalchenko N, Koulen P (2008) The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct proteinprotein interaction. Cell Calcium 44(5):507-518
67. 2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J 17(18):5298-5308
68. MacLennan DH, Kranias EG (2003) Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4(7):566-577
69. 2+ uptake. J Cell Mol Med 13:3358-3369
70. John LM, Lechleiter JD, Camacho P (1998) Differential modulation of SERCA2 isoforms by calreticulin. J Cell Biol 142(4):963-973
71. 2+ release channels. Physiol Rev 87(2):593-658
72. 2+ signals into mitochondria. J Biol Chem 280(49):40892-40900
73. 2+ signaling. J Biol Chem 279(12):11967-11975
74. Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH (2001) A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat Cell Biol 3(11):1020-1024
75. 2+ channel and its cellular function. Biochem Soc Symp 74:9-22
76. Yule DI, Betzenhauser MJ, Joseph SK (2010) Linking structure to function: recent lessons from inositol 1, 4, 5-trisphosphate receptor mutagenesis. Cell Calcium 47(6):469-479
77. Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, Mikoshiba K (2005) Subtype-specific and ER lumenal environment-dependent regulation of inositol 1, 4, 5-trisphosphate receptor type 1 by ERp44. Cell 120(1):85-98
78. Berridge MJ (2009) Inositol trisphosphate and calcium signalling mechanisms. Biochim Biophys Acta 1793(6):933-940
79. 2+ signals. Chaos (Woodbury NY) 19(3):037102
80. Wilson BS, Pfeiffer JR, Smith AJ, Oliver JM, Oberdorf JA, Wojcikiewicz RJ (1998) Calcium-dependent clustering of inositol 1, 4, 5-trisphosphate receptors. Mol Biol Cell 9(6):1465-1478
81. Tateishi Y, Hattori M, Nakayama T, Iwai M, Bannai H, Nakamura T, Michikawa T, Inoue T, Mikoshiba K (2005) Cluster formation of inositol 1, 4, 5-trisphosphate receptor requires its transition to open state. J Biol Chem 280(8):6816-6822
82. 2+. Nature 458(7238):655-659
83. Chalmers M, Schell MJ, Thorn P (2006) Agonist-evoked inositol trisphosphate receptor (IP3R) clustering is not dependent on changes in the structure of the endoplasmic reticulum. Biochem J 394(Pt 1):57-66
84. Rios E, Brum G (1987) Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature 325:717-720
85. Fabiato A (1983) Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. J Physiol 245:C1-C4
86. Chavis P, Fagni L, Lansman JB, Bockaert J (1996) Functional coupling between ryanodine receptors and L-type calcium channels in neurons. Nature 382(6593):719-722
87. Schwab Y, Mouton J, Chasserot-Golaz S, Marty I, Maulet Y, Jover E (2001) Calcium-dependent translocation of synaptotagmin to the plasma membrane in the dendrites of developing neurones. Brain Res Mol Brain Res 96(1-2):1-13
88. Zalk R, Lehnart SE, Marks AR (2007) Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem 76:367-385
89. Lanner JT, Georgiou DK, Joshi AD, Hamilton SL (2010) Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harbor Perspect Biol 2(11):a003996
90. Fill M, Copello JA (2002) Ryanodine receptor calcium release channels. Physiol Rev 82(4):893-922
91. 2+ trigger. Sci Signal 1(44):re10
92. 2+ channel. Nature 364(6432):76-79
93. Clapper DL, Walseth TF, Dargie PJ, Lee HC (1987) Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. J Biol Chem 262(20):9561-9568
94. 2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science (New York NY) 253(5024):1143-1146
95. Guse AH (2005) Second messenger function and the structureactivity relationship of cyclic adenosine diphosphoribose (cADPR). FEBS J 272(18):4590-4597
96. Ogunbayo OA, Zhu Y, Rossi D, Sorrentino V, Ma J, Zhu MX, Evans AM (2011) Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. J Biol Chem 286(11):9136-9140
97. 2+ stores: a perspective from cyclic ADP-ribose and NAADP. Curr Mol Med 4(3):227-237
98. Galione A, Churchill GC (2000) Cyclic ADP ribose as a calcium-mobilizing messenger. Sci STKE 2000(41):pe1
99. Walseth TF, Aarhus R, Kerr JA, Lee HC (1993) Identification of cyclic ADP-ribose-binding proteins by photoaffinity labeling. J Biol Chem 268(35):26686-26691
100. 2+ from islet microsomes. J Biol Chem 272(6):3133-3136
101. 2+) release induced by cADPribose is mediated by FKBP12.6 proteins in mouse bladder smooth muscle. Cell Calcium 47(5):449-457
102. BaiN, Lee HC, Laher I (2005) Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle. Pharmacol Ther 105(2):189-207
103. 2+ oscillations in pancreatic acinar cells. EMBO J 13(9):2038-2043
104. Higashida H, Salmina AB, Olovyannikova RY, Hashii M, Yokoyama S, Koizumi K, Jin D, Liu HX, Lopatina O, Amina S, Islam MS, Huang JJ, Noda M (2007) Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. Neurochem Int 51(2-4):192-199
105. 2+ buffers in the heart. BMB Rep 43(3):151-157
106. Coe H, Michalak M (2009) Calcium binding chaperones of the endoplasmic reticulum. Gen Physiol Biophys 28 Spec No Focus: F96-F103
107. Michalak M, Groenendyk J, Szabo E, Gold LI, Opas M (2009) Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417(3):651-666
108. Fliegel L, Burns K, MacLennan DH, Reithmeier RA, Michalak M (1989) Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum. J Biol Chem 264(36):21522-21528
109. 2+ stores and reveals aspects of their lumenal microenvironment and function. J Cell Biol 130:847-855
110. 2+ influx. J Biol Chem 271:9332-9339
111. Mesaeli N, Nakamura K, Zvaritch E, Dickie P, Dziak E, Krause KH, Opas M, MacLennan DH, Michalak M (1999) Calreticulin is essential for cardiac development. J Cell Biol 144(5):857-868
112. Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M (2001) COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development. J Biol Chem 276(4):2797-2801
113. Wada I, Rindress D, Cameron PH, Ou WJ, Doherty JJ 2nd, Louvard D, Bell AW, Dignard D, Thomas DY, Bergeron JJ (1991) SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem 266(29):19599-19610
114. 2+. J Biol Chem 272(49):30873-30879
115. Koch G, Smith M, Macer D, Webster P, Mortara R (1986) Endoplasmic reticulum contains a common, abundant calciumbinding glycoprotein, endoplasmin. J Cell Sci 86:217-232
116. 2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem 269(3):1744-1749
117. Lebeche D, Lucero HA, Kaminer B (1994) Calcium binding properties of rabbit liver protein disulfide isomerase. Biochem Biophys Res Commun 202(1):556-561
118. Lucero HA, Lebeche D, Kaminer B (1994) ERcalcistorin/protein disulfide isomerase (PDI). Sequence determination and expression of a cDNA clone encoding a calcium storage protein with PDI activity from endoplasmic reticulum of the sea urchin egg. J Biol Chem 269(37):23112-23119
119. MacLennan DH, Wong TS (1971) Isolation of a calcium sequestering protein from sarcoplasmic reticulum. Proc Natl Acad Sci USA 68:1231-1235
120. Royer L, Rios E (2009) Deconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle. J Physiol 587(Pt 13):3101-3111
121. Volpe P, Martini A, Furlan S, Meldolesi J (1994) Calsequestrin is a component of smooth muscles: the skeletal-and cardiacmuscle isoforms are both present, although in highly variable amounts and ratios. Biochem J 301(Pt 2):465-469
122. 2+ stores in cerebellum Purkinje neurons. Comp Biochem Physiol Comp Physiol 105(2):205-211
123. Leberer E, Timms BG, Campbell KP, MacLennan DH (1990) Purification, calcium binding properties, and ultrastructural localization of the 53,000-and 160,000 (sarcalumenin)-dalton glycoproteins of the sarcoplasmic reticulum. J Biol Chem 265(17):10118-10124
124. 2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements. J Biol Chem 264(30):18083-18090
125. 2+ entry. EMBO J 21:622-630
126. 2+ response and cell viability in Darier disease. J Cell Sci 119(Pt 4):671-679
127. 2+ ATPase, are associated with Brody disease. Nat Genet 14(2):191-194
128. Kranias EG, Bers DM (2007) Calcium and cardiomyopathies. Subcell Biochem 45:523-537
129. 2+ transport. Nat Rev Cancer 7(7):519-530
130. 2+)- transport ATPase 3 gene (SERCA3) in Caucasian type II diabetic patients (UK Prospective Diabetes Study 48). Diabetologia 42(10):1240-1243
131. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM (2008) SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol 181(7):1107-1116
132. van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (2007) Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet 3(6):e108
133. Hara K, Shiga A, Nozaki H, Mitsui J, Takahashi Y, Ishiguro H, Yomono H, Kurisaki H, Goto J, Ikeuchi T, Tsuji S, Nishizawa M, Onodera O (2008) Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families. Neurology 71(8):547-551
134. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (2008) Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16. J Med Genet 45(1):32-35
135. Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1. Neuron 39(2):227-239
136. Boehning D, Patterson RL, Sedaghat L, Glebova NO, Kurosaki T, Snyder SH (2003) Cytochrome c binds to inositol (1, 4, 5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5(12):1051-1061
137. 2+) signals in apoptotic cells. Biochem Soc Trans 35(Pt 5):1038-1039
138. Rong YP, Barr P, Yee VC, Distelhorst CW (2009) Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1, 4, 5-trisphosphate receptor. Biochim Biophys Acta 1793(6):971-978
139. Vance JE (1990) Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265(13):7248-7256
140. Rusinol AE, Cui Z, Chen MH, Vance JE (1994) A unique mitochondria- associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem 269(44):27494-27502
141. Pizzo P, Pozzan T (2007) Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol 17(10):511-517
142. Betzenhauser MJ, Marks AR (2010) Ryanodine receptor channelopathies. Pflugers Archiv Eur J Physiol 460(2):467-480
143. Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR (2008) Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci USA 105(6):2198-2202
144. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, DArmiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR (2003) FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 113(7):829-840
145. Chakroborty S, Goussakov I, Miller MB, Stutzmann GE (2009) Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. J Neurosci 29(30):9458-9470
146. 2+ disruptions in young, adult, and aged Alzheimers disease mice. J Neurosci 26(19):5180-5189
147. Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F (2007) Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimers mouse models. Ann NY Acad Sci 1097:265-277
148. Supnet C, Noonan C, Richard K, Bradley J, Mayne M (2010) Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimers disease. J Neurochem 112(2):356-365
149. De Matteis MA, Luini A (2008) Exiting the Golgi complex. Nat Rev Mol Cell Biol 9(4):273-284
150. Breton C, Mucha J, Jeanneau C (2001) Structural and functional features of glycosyltransferases. Biochimie 83(8):713-718
151. Chandra S, Kable EP, Morrison GH, Webb WW (1991) Calcium sequestration in the Golgi apparatus of cultured mammalian cells revealed by laser scanning confocal microscopy and ion microscopy. J Cell Sci 100(Pt 4):747-752
152. Carnell L, Moore HP (1994) Transport via the regulated secretory pathway in semi-intact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II. J Cell Biol 127:693-705
153. 2+)-dependent Golgi endoproteases. J Biol Chem 267(24):17465-17471
154. Chanat E, Huttner WB (1991) Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J Cell Biol 115(6):1505-1519
155. Ivessa NE, De Lemos-Chiarandini C, Gravotta D, Sabatini DD, Kreibich G (1995) The Brefeldin A-induced retrograde transport from the Golgi apparatus to the endoplasmic reticulum depends on calcium sequestered to intracellular stores. J Biol Chem 270(43):25960-25967
156. Missiaen L, Dode L, Vanoevelen J, Raeymaekers L, Wuytack F (2007) Calcium in the Golgi apparatus. Cell Calcium 41(5):405-416
157. 2+ storage in the Golgi. J Cell Biol 145(2):279-289
158. Surroca A, Wolff D (2000) Inositol 1, 4, 5-trisphosphate but not ryanodine-receptor agonists induces calcium release from rat liver Golgi apparatus membrane vesicles. J Membr Biol 177(3):243-249
159. 2+)-ATPase SPCA1. Cell Calcium 34(2):157-162
160. Missiaen L, Van Acker K, Van Baelen K, Raeymaekers L, Wuytack F, Parys JB, De Smedt H, Vanoevelen J, Dode L, Rizzuto R, Callewaert G (2004) Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments. Cell Calcium 36(6):479-487
161. 2+ store. Cell Calcium 35(2):115-121
162. 2+ store. J Biol Chem 276(42):39161-39170
163. 2+ signals depending on the functional state of the Golgi in HeLa cells. Cell Calcium 38(5):489-495
164. 2+ store in A7r5 and 16HBE14o-cells. J Biol Chem 277(9):6898-6902
165. Taylor RS, Jones SM, Dahl RH, Nordeen MH, Howell KE (1997) Characterization of the Golgi complex cleared of proteins in transit and examination of calcium uptake activities. Mol Biol Cell 8(10):1911-1931
166. 2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference. Biochem Biophys Res Commun 306(2):430-436
167. 2+-transport ATPases. Chem Rev 109(10):4733-4759
168. 2+-ATPase, hSPCA2, has unusual properties and is expressed in the brain. J Biol Chem 280(12):11608-11614
169. 2+ ions. J Biol Chem 280(24):22800-22808
170. 2+ stores. J Invest Dermatol 121(4):688-694
171. 2+ homeostasis revealed by RNA silencing. Diabetes 53(2):393-400
172. Yoshimoto A, Nakanishi K, Anzai T, Komine S (1990) Effects of inositol 1, 4, 5-trisphosphate on calcium release from the endoplasmic reticulum and Golgi apparatus in mouse mammary epithelial cells: a comparison during pregnancy and lactation. Cell Biochem Funct 8(4):191-198
173. 2+ signaling. Cell Signal 13(5):353-362
174. 2+ homeostasis of the trans-Golgi compartment. Proc Natl Acad Sci USA 107(20):9198-9203
175. 2+) signalling in the Golgi apparatus. Cell Calcium
176. Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG (1998) The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J Cell Biol 141(7):1515-1527
177. 2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J Cell Biol 155(1):41-51
178. 2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol 13(5):521-530
179. Zerfaoui M, Fukuda M, Langlet C, Mathieu S, Suzuki M, Lombardo D, El-Battari A (2002) The cytosolic and transmembrane domains of the beta 1, 6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant. Glycobiology 12(1):15-24
180. Austin CD, Shields D (1996) Prosomatostatin processing in permeabilized cells. Calcium is required for prohormone cleavage but not formation of nascent secretory vesicles. J Biol Chem 271:1194-1199
181. 2+ depletion on the synthesis, phosphorylation and secretion of caseins in lactating mammary epithelial cells. Biochem J 317:487-493
182. Ramos-Castaneda J, Park YN, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P (2005) Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. J Biol Chem 280(10):9467-9473
183. Foggia L, Hovnanian A (2004) Calcium pump disorders of the skin. Am J Med Genet C Semin Med Genet 131C(1):20-31. doi:10.1002/ajmg.c.30031
184. Missiaen L, Raeymaekers L, Dode L, Vanoevelen J, Van Baelen K, Parys JB, Callewaert G, De Smedt H, Segaert S, Wuytack F (2004) SPCA1 pumps and Hailey-Hailey disease. Biochem Biophys Res Commun 322(4):1204-1213
185. Holst VA, Fair KP, Wilson BB, Patterson JW (2000) Squamous cell carcinoma arising in Hailey-Hailey disease. J Am Acad Dermatol 43(2 Pt 2):368-371
186. Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, Monteith GR (2010) Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem 285(48): 37458-37466
187. Rippe K (2007) Dynamic organization of the cell nucleus. Curr Opin Genet Dev 17(5):373-380
188. Hardingham GE, Arnold FJL, Bading H (2001) A calcium microdomain near NMDA receptors: on switch for ERKdependent synapse-to-nucleus communication. Nat Neurosci 4:565-566
189. Hardingham GE, Chawla S, Johnson CM, Bading H (1997) Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 385:260-265
190. Dolmetsch RE, Xu K, Lewis RS (1998) Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392:933-936
191. Bootman MD, Fearnley C, Smyrnias I, MacDonald F, Roderick HL (2009) An update on nuclear calcium signalling. J Cell Sci 122(Pt 14):2337-2350
192. Hetzer MW (2010) The nuclear envelope. Cold Spring Harbor Perspect Biol 2(3):a000539
193. Ross CA, Meldolesi J, Milner TA, Satoh T, Supattapone S, Snyder SH (1989) Inositol 1, 4, 5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature 339(6224):468-470
194. Gerasimenko J, Maruyama Y, Tepikin A, Petersen OH, Gerasimenko O (2003) Calcium signalling in and around the nuclear envelope. Biochem Soc Trans 31(Pt 1):76-78
195. 2+ concentration in isolated rat liver nuclei. Proc Natl Acad Sci USA 86(2):453-457
196. Malviya AN, Rogue P, Vincendon G (1990) Stereospecific inositol 1, 4, 5-[32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus. Proc Natl Acad Sci USA 87(23):9270-9274
197. Walton PD, Airey JA, Sutko JL, Beck CF, Mignery GA, Sudhof TC, Deerinck TJ, Ellisman MH (1991) Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons. J Cell Biol 113(5):1145-1157
198. Lanini L, Bachs O, Carafoli E (1992) The calcium pump of the liver nuclear membrane is identical to that of endoplasmic reticulum. J Biol Chem 267(16):11548-11552
199. Stehno-Bittel L, Luckhoff A, Clapham DE (1995) Calcium release from the nucleus by InsP3 receptor channels. Neuron 14(1):163-167
200. 2+ from the nuclear envelope. Cell 80(3):439-444
201. Humbert JP, Matter N, Artault JC, Koppler P, Malviya AN (1996) Inositol 1, 4, 5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1, 4, 5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear membranes. J Biol Chem 271(1):478-485
202. 2+). Cell Calcium 28(2):127-136
203. Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF (2006) Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium 39(1):65-73
204. 2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization. J Biol Chem 283(41):27859-27870
205. Bezin S, Fossier P, Cancela JM (2008) Nucleoplasmic reticulum is not essential in nuclear calcium signalling mediated by cyclic ADPribose in primary neurons. Pflugers Archiv Eur J Physiol 456(3):581-586
206. Hoelz A, Debler EW, Blobel G (2011) The structure of the nuclear pore complex. Annu Rev Biochem 80:613-643
207. Peters R (1984) Nucleo-cytoplasmic flux and intracellular mobility in single hepatocytes measured by fluorescence microphotolysis. EMBO J 3(8):1831-1836
208. OMalley DM (1994) Calcium permeability of the neuronal nuclear envelope: evaluation using confocal volumes and intracellular perfusion. J Neurosci 14(10):5741-5758
209. Kapon R, Naim B, Zbaida D, Nevo R, Tsabari O, Reich Z (2010) Permeating the nuclear pore complex. Nucleus (Austin Tex) 1(6):475-480
210. Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH (2003) Nuclear and cytosolic calcium are regulated independently. Proc Natl Acad Sci USA 100(5):2975-2980
211. 2+ can be uncoupled in HeLa cells. Pflugers Archiv Eur J Physiol 436(3):371-376
212. Alonso MT, Villalobos C, Chamero P, Alvarez J, Garcia-Sancho J (2006) Calcium microdomains in mitochondria and nucleus. Cell Calcium 40(5-6):513-525
213. 2+ concentration measured with specifically targeted recombinant aequorin. EMBO J 12(12):4813-4819
214. 2+. Proc Natl Acad Sci USA 98(6):3197-3202
215. 2+ channels. Mol Cell 38(2): 280-290
216. 2+ signals from two different organelles. Pflugers Archiv Eur J Physiol 455(5):961-970
217. Allbritton NL, Oancea E, Kuhn MA, Meyer T (1994) Source of nuclear calcium signals. Proc Natl Acad Sci USA 91(26): 12458-12462
218. Hernandez-Cruz A, Sala F, Adams PR (1990) Subcellular calcium transients visualized by confocal microscopy in a voltageclamped vertebrate neuron. Science 247:858-862
219. Lin C, Hajnoczky G, Thomas AP (1994) Propagation of cytosolic calcium waves into the nuclei of hepatocytes. Cell Calcium 16(4):247-258
220. Shirakawa H, Miyazaki S (1996) Spatiotemporal analysis of calcium dynamics in the nucleus of hamster oocytes. J Physiol 494(Pt 1):29-40
221. Nakazawa H, Murphy TH (1999) Activation of nuclear calcium dynamics by synaptic stimulation in cultured cortical neurons. J Neurochem 73(3):1075-1083
222. Zhao L, Brinton RD (2002) Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Res 943(1):117-131
223. Power JM, Sah P (2002) Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons. J Neurosci 22(9):3454-3462
224. Power JM, Sah P (2007) Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons. J Physiol 580(Pt.3):835-857
225. Williams DA, Fogarty KE, Tsien RY, Fay FS (1985) Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature 318(6046):558-561
226. al-Mohanna FA, Caddy KW, Bolsover SR (1994) The nucleus is insulated from large cytosolic calcium ion changes. Nature 367(6465):745-750
227. Badminton MN, Kendall JM, Sala-Newby G, Campbell AK (1995) Nucleoplasmin-targeted aequorin provides evidence for a nuclear calcium barrier. Exp Cell Res 216(1):236-243
228. 2+ diffusion from cytosol to nucleus in contracting adult rat cardiac myocytes with an ultra-fast confocal imaging system. Cell Calcium 25(3):199-208
229. 2+ oscillations on propagation to nucleus. J Biol Chem 277(52):50226-50229
230. 2+. J Membr Biol 157(3):301-309
231. Greber UF, Gerace L (1995) Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus. J Cell Biol 128(1-2):5-14
232. 2+ stores. Science (New York NY) 273(5283):1875-1877
233. Bustamante JO, Michelette ER, Geibel JP, Dean DA, Hanover JA, McDonnell TJ (2000) Calcium, ATP and nuclear pore channel gating. Pflugers Archiv Eur J Physiol 439(4):433-444
234. 2+ stores in intact mammalian cells. J Gen Physiol 113(2):239-248
235. Fricker M, Hollinshead M, White N, Vaux D (1997) The convoluted nucleus. Trends Cell Biol 7(5):181
236. 2+ signalling. Biochem Biophys Res Commun 247(1):88-93
237. 2+ is released from the nuclear tubular structure into nucleoplasm in C6 glioma cells after stimulation with phorbol ester. FEBS Lett 432(1-2):82-87
238. Echevarria W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH (2003) Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol 5(5):440-446
239. 2+ regulates cardiomyocyte function. Cell Calcium 44(2):230-242
240. Cardenas C, Liberona JL, Molgo J, Colasante C, Mignery GA, Jaimovich E (2005) Nuclear inositol 1, 4, 5-trisphosphate receptors regulate local Ca2 + transients and modulate cAMP response element binding protein phosphorylation. J Cell Sci 118(Pt 14):3131-3140
241. 2+ store. Biochemistry 45(5):1362-1373
242. Huh YH, Yoo SH (2003) Presence of the inositol 1, 4, 5-triphosphate receptor isoforms in the nucleoplasm. FEBS Lett 555(2):411-418
243. Katagiri S, Takamatsu T, Minamikawa T, Fujita S (1993) Secretagogue-induced calcium wave shows higher and prolonged transients of nuclear calcium concentration in mast cells. FEBS Lett 334(3):343-346
244. 2+ signalling in the nucleus of isolated rat hepatocytes. Biochem J 326(Pt 2):491-495
245. Lipp P, Thomas D, Berridge MJ, Bootman MD (1997) Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J 16(23):7166-7173
246. Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P (2009) Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol 41(10):1817-1827
247. Heath-Engel HM, Shore GC (2006) Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim Biophys Acta 1763(5-6):549-560
248. Contreras L, Drago I, Zampese E, Pozzan T (2010) Mitochondria: the calcium connection. Biochim Biophys Acta 1797(6-7): 607-618
249. 2+ as a key regulator of cell life and death. Cell Death Differ 14(7):1267-1274
250. Campello S, Scorrano L (2010) Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep 11(9):678-684
251. Sheridan C, Martin SJ (2010) Mitochondrial fission/fusion dynamics and apoptosis. Mitochondrion 10(6):640-648
252. 2+-mediated apoptosis. Mol Cell 16(1):59-68
253. Jeyaraju DV, Cisbani G, Pellegrini L (2009) Calcium regulation of mitochondria motility and morphology. Biochim Biophys Acta 1787(11):1363-1373
254. Frederick RL, Shaw JM (2007) Moving mitochondria: establishing distribution of an essential organelle. Traffic (Copenhagen Denmark) 8(12):1668-1675
255. Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N (1994) KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79(7):1209-1220
256. Glater EE, Megeath LJ, Stowers RS, Schwarz TL (2006) Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol 173(4):545-557
257. 2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 136(1):163-174
258. 2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci USA 105(52):20728-20733
259. Macaskill AF, Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT (2009) Miro1 is a calcium sensor for glutamate receptordependent localization of mitochondria at synapses. Neuron 61(4):541-555
260. MacAskill AF, Kittler JT (2010) Control of mitochondrial transport and localization in neurons. Trends Cell Biol 20(2):102-112
261. Denton RM (2009) Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta 1787(11):1309-1316
262. 2+ responses. Science 280(5370):1763-1766
263. 2+-stimulated aspartate/glutamate transporters in mitochondria. EMBO J 20(18):5060-5069
264. 2+-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J Biol Chem 278(40):38686-38692
265. 2+ transfer in the control of apoptosis. Oncogene 27(50):6407-6418
266. 2+)-dependent apoptosis and necrosis. Cell Calcium
267. Szalai G, Krishnamurthy R, Hajnoczky G (1999) Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J 18(22):6349-6361
268. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 20(11):2690-2701
269. Deluca HF, Engstrom GW (1961) Calcium uptake by rat kidney mitochondria. Proc Natl Acad Sci USA 47:1744-1750
270. 2+ uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation. J Biol Chem 237:2670-2677
271. Colombini M (1980) Structure and mode of action of a voltage dependent anion-selective channel (VDAC) located in the outer mitochondrial membrane. Ann NY Acad Sci 341:552-563
272. 2+ revealed by specifically targeted recombinant aequorin. Nature 358(6384):325-327
273. 2+ concentration in living single rat cardiac myocytes. Am J Physiol Heart Circ Physiol 261:H1123-H1134
274. Filippin L, Magalhaes PJ, Di Benedetto G, Colella M, Pozzan T (2003) Stable interactions between mitochondria and endoplasmic reticulum allow rapid accumulation of calcium in a subpopulation of mitochondria. J Biol Chem 278:39224-39234
275. Pozzan T, Rizzuto R (2000) The renaissance of mitochondrial calcium transport. Eur J Biochem 267:5269-5273
276. 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262(5134):744-747
277. 2+: molecular determinants and functional consequences. Physiol Rev 86(1):369-408
278. Rizzuto R, Pinton P, Brini M, Chiesa A, Filippin L, Pozzan T (1999) Mitochondria as biosensors of calcium microdomains. Cell Calcium 26(5):193-199
279. Csordas G, Varnai P, Golenar T, Roy S, Purkins G, Schneider TG, Balla T, Hajnoczky G (2010) Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol Cell 39(1):121-132
280. Hoppe UC (2010) Mitochondrial calcium channels. FEBS Lett 584(10):1975-1981
281. Kirichok Y, Krapivinsky G, Clapham DE (2004) The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427(6972):360-364
282. 2+ carrier in rat liver mitochondria. Biochemistry 18(26):5972-5978
283. 2+) uptake. Nature 467(7313): 291-296
284. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK (2011) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature PMID:21685886
285. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R (2011) A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature PMID:21685888
286. 2+ transfer to mitochondria. Cell 142(2):270-283
287. Csordas G, Renken C, Varnai P, Walter L, Weaver D, Buttle KF, Balla T, Mannella CA, Hajnoczky G (2006) Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol 174(7):915-921
288. Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S (2011) Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 124(Pt 13):2143-2152
289. 2+ channels. J Cell Biol 175(6):901-911
290. de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456(7222):605-610
291. Iwasawa R, Mahul-Mellier AL, Datler C, Pazarentzos E, Grimm S (2011) Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J 30(3):556-568
292. Cerqua C, Anesti V, Pyakurel A, Liu D, Naon D, Wiche G, Baffa R, Dimmer KS, Scorrano L (2010) Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO Rep 11(11):854-860
293. Simmen T, Aslan JE, BlagoveshchenskayaAD, Thomas L,Wan L, XiangY, Feliciangeli SF, HungCH, CrumpCM, ThomasG(2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J 24(4):717-729
294. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-481
295. 2+ cross-talk. Proc Natl Acad Sci USA 108(7):2777-2782
296. Zampese E, Fasolato C, Pozzan T, Pizzo P (2011) Presenilin-2 modulation of ER-mitochondria interactions. Commun Integr Biol 4(3):357-360
297. Hayashi T, Rizzuto R, Hajnoczky G, Su TP (2009) MAM: more than just a housekeeper. Trends Cell Biol 19(2):81-88
298. Hayashi T, Su TP (2010) Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. Subcell Biochem 51:381-398
299. 2+ exchange. Proc Natl Acad Sci USA 107(1):436-441
300. 2+ transport mechanism in mitochondria. Biochemistry 15(17):3834-3842
301. Walsh C, Barrow S, Voronina S, Chvanov M, Petersen OH, Tepikin A (2009) Modulation of calcium signalling by mitochondria. Biochim Biophys Acta 1787(11):1374-1382
302. 2+ among cytosol and organella during stimulation of bovine chromaffin cells. FASEB J 16(3):343-353
303. 2+ oscillations. EMBO Rep 7(4):390-396
304. 2+ to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions. J Biol Chem 276(31):29430-29439
305. 2+ signals. EMBO J 18(18):4999-5008
306. Seksek O, Biwersi J, Verkman AS (1995) Direct measurement of trans-Golgi pH in living cells and regulation by second messengers. J Biol Chem 270(10):4967-4970
307. Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY (1998) Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci USA 95(12):6803-6808
308. 2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets. Cell Signal 18(3):373-381
309. Mahapatra NR, Mahata M, Hazra PP, McDonough PM, OConnor DT, Mahata SK (2004) A dynamic pool of calcium in catecholamine storage vesicles. Exploration in living cells by a novel vesicle-targeted chromogranin A-aequorin chimeric photoprotein. J Biol Chem 279(49):51107-51121
310. Duman JG, Chen L, Palmer AE, Hille B (2006) Contributions of intracellular compartments to calcium dynamics: implicating an acidic store. Traffic 7(7):859-872
311. Santodomingo J, Vay L, Camacho M, Hernandez-Sanmiguel E, Fonteriz RI, Lobaton CD, Montero M, Moreno A, Alvarez J (2008) Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules. Eur J Neurosci 28(7):1265-1274
312. Klemper MS (1985) An adenosine triphosphate-dependent calcium uptake pump in human neutrophil lysosomes. J Clin Invest 76(1):303-310
313. 2+)-ATPase in rat liver lysosomal membranes. J Biochem 112(1):33-39
314. Salceda R, Sanchez-Chavez G (2000) Calcium uptake, release and ryanodine binding in melanosomes from retinal pigment epithelium. Cell Calcium 27(4):223-229
315. 2+ accumulation, storage and release. J Biol Chem 267:20159-20167
316. 2+ signaling. Trends Cell Biol 20(5):277-286
317. 2+ fluxes across chromaffin secretory membrane vesicles. J Neurochem 41(5):1269-1276
318. Gerasimenko JV, Tepikin AV, Petersen OH, Gerasimenko OV (1998) Calcium uptake via endocytosis with rapid release from acidifying endosomes. Curr Biol 8(24):1335-1338
319. 2+ in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol 149(5):1053-1062
320. Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH, Tepikin AV (2007) Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci USA 104(13):5674-5679
321. Yoo SH (2010) Secretory granules in inositol 1, 4, 5-trisphosphate- dependent Ca2 + signaling in the cytoplasm of neuroendocrine cells. FASEB J 24(3):653-664
322. 2+ in isolated chromaffin vesicles. Biochemistry 24(26):7760-7765
323. 2+. Nature 395(6705):908-912
324. 2+ store vesicles. Biochemistry 46(50):14663-14671
325. 2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem 278(13):11057-11064
326. 2+ from single isolated pancreatic zymogen granules. Cell 84:473-480
327. 2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci 119(Pt 2):226-238
328. 2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate. Cell 74(4):661-668
329. DellAngelica EC, Mullins C, Caplan S, Bonifacino JS (2000) Lysosome-related organelles. FASEB J 14(10):1265-1278
330. Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14(11):1247-1255
331. Holmsen H, Weiss HJ (1979) Secretable storage pools in platelets. Annu Rev Med 30:119-134
332. Docampo R, de Souza W, Miranda K, Rohloff P, Moreno SN (2005) Acidocalcisomes-conserved from bacteria to man. Nat Rev Microbiol 3(3):251-261
333. Lee HC, Aarhus R (1995) A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J Biol Chem 270(5):2152-2157
334. Lee HC (1998) Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration. Cell Biochem Biophys 28(1):1-17
335. 2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell 111(5):703-708
336. 2+) stores and endocytosis by differential coupling to messengers. Curr Biol 16(19):1931-1937
337. 2+ signals in pancreatic acinar and beta cells. J Biol Chem 279(8):7234-7240
338. Palade P (2007) The hunt for an alternate way to generate NAADP. Focus on "NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells". Am J Physiol Cell Physiol 292(1):C4-C7
339. Soares S, Thompson M, White T, Isbell A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN (2007) NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol 292(1):C227-C239
340. De Flora A, Zocchi E, Guida L, Franco L, Bruzzone S (2004) Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system. Ann NY Acad Sci 1028:176-191
341. Guse AH (2009) Second messenger signaling: multiple receptors for NAADP. Current Biol CB 19(13):R521-R523
342. 2+ release channel from liver lysosomes of rats. J Biol Chem 282(35):25259-25269
343. 2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol 163(2):271-282
344. 2+ signaling in T-lymphocytes. J Biol Chem 280(22):21394-21399
345. 2+ mobilization from acidic organelles triggered by NAADP. FEBS Lett 584(10): 1966-1974
346. Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S (2009) Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol 186(2):201-209
347. Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459(7246): 596-600
348. 2+)-release from lysosomal stores. Pflugers Archiv Eur J Physiol 458(5):891-899
349. Platta HW, Erdmann R (2007) Peroxisomal dynamics. Trends Cell Biol 17(10):474-484
350. Wanders RJ (2004) Peroxisomes, lipid metabolism, and peroxisomal disorders. Mol Genet Metab 83(1-2):16-27
351. Wanders RJ, Waterham HR (2006) Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem 75:295-332
352. Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF (2005) Contribution of the endoplasmic reticulum to peroxisome formation. Cell 122(1):85-95
353. Motley AM, Hettema EH (2007) Yeast peroxisomes multiply by growth and division. J Cell Biol 178(3):399-410
354. Nagotu S, Veenhuis M, van der Klei IJ (2010) Divide et impera: the dictum of peroxisomes. Traffic (Copenhagen Denmark) 11(2):175-184
355. Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, McBride HM (2008) Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol CB 18(2):102-108
356. Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M (2005) A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 16(11):5077-5086
357. Schrader M, Yoon Y (2007) Mitochondria and peroxisomes: are the big brother and the little sister closer than assumed? BioEssays : news and reviews in molecular. Cell Dev Biol 29(11):1105-1114
358. Titorenko VI, Rachubinski RA (2004) The peroxisome: orchestrating important developmental decisions from inside the cell. J Cell Biol 164(5):641-645
359. Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002) Selective cooperation between fatty acid binding proteins and peroxisome proliferatoractivated receptors in regulating transcription. Mol Cell Biol 22(14):5114-5127
360. Fidaleo M (2010) Peroxisomes and peroxisomal disorders: the main facts. Exp Toxicol Pathol 62(6):615-625
361. Raychaudhury B, Gupta S, Banerjee S, Datta SC (2006) Peroxisome is a reservoir of intracellular calcium. Biochim Biophys Acta 1760(7):989-992
362. Drago I, Giacomello M, Pizzo P, Pozzan T (2008) Calcium dynamics in the peroxisomal lumen of living cells. J Biol Chem 283(21):14384-14390
363. Lasorsa FM, Pinton P, Palmieri L, Scarcia P, Rottensteiner H, Rizzuto R, Palmieri F (2008) Peroxisomes as novel players in cell calcium homeostasis. J Biol Chem 283(22):15300-15308
364. Yang T, Poovaiah BW (2002) Hydrogen peroxide homeostasis: activation of plant catalase by calcium/calmodulin. Proc Natl Acad Sci USA 99(6):4097-4102
365. 2+)-dependent scavenging system. Plant J 62(5):760-772