Citrin and aralar1 are Ca2+-stimulated aspartate/glutamate transporters in mitochondria

EMBO Journal

Volumn 20, Issue 18, 2001, Pages 5060-5069

  Palmieri, L ^a   Pardo, B ^b   Lasorsa, F M ^a   Del Arco, A ^b,c   Kobayashi, K ^d   Iijima, M ^d   Runswick, M J ^e   Walker, J E ^e   Saheki, T ^d   Satrustegui J ^b   Palmieri, F ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^d KAGOSHIMA UNIVERSITY   (Japan)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Aralar1; Aspartate; Calcium; Citrin; Glutamate carrier; Mitochondria

Indexed keywords

ARALAR 1; ASPARTIC ACID; ERIODICTYOL 7 O GLUCOSIDE; GLUTAMIC ACID; LIPOSOME; PROTEIN; PROTON; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL MEMBRANE TRANSPORT; CITRULLINEMIA; ESCHERICHIA COLI; GENE MUTATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; UREA CYCLE;

AMINO ACID TRANSPORT SYSTEMS, ACIDIC; ANTIPORTERS; CALCIUM; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL LINE; CITRULLINEMIA; ESCHERICHIA COLI; HUMANS; KINETICS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, CHEMICAL; ORGANIC ANION TRANSPORTERS; PROTEOLIPIDS; TRANSFECTION;

EID: 17944378173     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.18.5060     Document Type: Article

References (46)

1. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
2. Identification and purification of the aspartate/glutamate carrier from bovine heart mitochondria
3. Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA
4. Mitochondrial pyruvate transport in working guinea-pig heart. Work-related vs. carrier-mediated control of pyruvate oxidation
5. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
6. Molecular cloning of aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain
7. Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues
8. Asymmetric orientation of the reconstituted aspartate/glutamate carrier from mitochondria
9. Reaction mechanism of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria
10. Probing the active site of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria: Carbodiimide-catalyzed acylation of a functional lysine residue
11. The human mitochondrial deoxynucleotide carrier and its role in toxicity of nucleoside antivirals
12. Abundant bacterial expression and reconstitution of an intrinsic membrane transport protein from bovine mitochondria
13. The sequence, bacterial expression and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans
14. Identification of the human mitochondrial oxodicarboxylate carrier: Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location
15. Properties of γ-aminobutyric acid synthesis by rat renal mitochondria
16. Pathogenesis of adult-onset type II citrullinemia caused by deficiency of citrin, a mitochondrial solute carrier protein: Tissue and subcellular localization of citrin
17. Messenger RNA coding for argininosuccinate synthetase in citrullinemia
18. A search for the primary abnormality in adult-onset type II citrullinemia
19. Nature and frequency of mutations in the argininosuccinate synthetase gene that cause classical citrullinemia
20. The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein
21. Type II citrullinemia (citrin deficiency): A mysterious disease caused by a defect of calcium-binding mitochondrial carrier protein
22. Isolation and functional reconstitution of the aspartate/glutamate carrier from mitochondria
23. Metabolite transport in mitochondria
24. Evidence for electrogenic aspartate transport in rat liver mitochondria
25. The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine
26. Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria
27. Interrelationships between gluconeogenesis and ureogenesis in isolated hepatocytes
28. 2+ transients that modulate secretion
29. Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions
30. Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria in intact hearts
31. Mitochondrial carrier proteins
32. The transport of L-cysteinesulfinate in rat liver mitochondria
33. Mitochondrial metabolite carrier proteins: Purification, reconstitution and transport studies
34. Perinuclear, perigranular and subplasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport
35. The inhibition of mitochondrial calcium transport by lanthanides and ruthenium red
36. 3-sensitive channels that are sensed by neighboring mitochondria
37. 2+ within electopermeabilized insulin-secreting cells (INS-1)
38. Hereditary disorders of the urea cycle in man: Biochemical and molecular approaches
39. Ruthenium red inhibits the binding of calcium to calmodulin required for enzyme activation
40. Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria
41. The role of micro-compartmentation in the regulation of glutamate metabolism by rat kidney mitochondria
42. Glutamate dehydrogenase activation and ammonia formation by rat kidney mitochondria
43. 2+-related control of gluconeogenesis in perfused liver
44. 2+-dependent activation of the malate-aspartate shuttle by norepinephrine and vasopressin in perfused rat liver
45. Role of anion transport in the regulation of metabolism
46. Identification of two novel mutations in the SLC25A13 gene and detection of seven mutations in 102 patients with adult-onset type II citrullinemia