Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 1869-1877

  Hang, Brian I ^a   Thorne, Curtis A ^b   Robbins, David J ^c   Huppert, Stacey S ^a,d,e   Lee, Laura A ^a,d   Lee, Ethan ^a,d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Egg extract; Hedgehog signaling; High throughput screening; Notch signaling; Small molecule; Wnt signaling; Xenopus

Indexed keywords

ACTIN; APC PROTEIN; ATM PROTEIN; ATR PROTEIN; AXIN; BETA CATENIN; CASEIN KINASE IALPHA; COFILIN; DIMINUTOL; DRUG; FCPT; GAMMA SECRETASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; JAGGED1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MONASTRAL; NOTCH RECEPTOR; PROTEIN CDC42; PYRVINIUM EMBONATE; RNA POLYMERASE II; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; T CELL FACTOR PROTEIN; UBISTATIN A; UBISTATIN B; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISMODEGIB; WISKOSTATIN; WISKOTT ALDRICH SYNDROME PROTEIN; WNT PROTEIN;

APOPTOSIS; BASAL CELL CARCINOMA; CELL FREE SYSTEM; CELL NUCLEUS; COLORECTAL CANCER; DIARRHEA; DNA REPAIR; DNA REPLICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; EMBRYO DEVELOPMENT; HIGH THROUGHPUT SCREENING; HUMAN; MICROTUBULE ASSEMBLY; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; XENOPUS;

ERINACEIDAE;

EID: 84857910505     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.044     Document Type: Article

References (114)

1. T. Mitchison J. Chem. Biol. 1 1994 3
2. J.P. Overington, B. Al-Lazikani, and A.L. Hopkins Nat. Rev. Drug Discov. 5 2006 993
3. M.A. Lindsay Nat. Rev. Drug Discov. 2 2003 831
4. J.R. Yeh, and C.M. Crews Dev. Cell 5 2003 11
5. D.C. Swinney, and J. Anthony Nat. Rev. Drug Discov. 10 2011 507
6. T.C. Kwok, N. Ricker, R. Fraser, A.W. Chan, A. Burns, E.F. Stanley, P. McCourt, S.R. Cutler, and P.J. Roy Nature 441 2006 91
7. R.T. Peterson, and M.C. Fishman Methods Cell Biol. 76 2004 569
8. J.H. DeMoe, S. Santaguida, J.R. Daum, A. Musacchio, and G.J. Gorbsky Cancer Res. 69 2009 1509
9. R.W. King, J.M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner Cell 81 1995 279
10. R. Verma, N.R. Peters, M. D'Onofrio, G.P. Tochtrop, K.M. Sakamoto, R. Varadan, M. Zhang, P. Coffino, D. Fushman, R.J. Deshaies, and R.W. King Science 306 2004 117
11. T. Mitchison, and M. Kirschner Nature 312 1984 237
12. J.A. Theriot, J. Rosenblatt, D.A. Portnoy, P.J. Goldschmidt-Clermont, and T.J. Mitchison Cell 76 1994 505
13. R.C. Chan, and D.I. Forbes Methods Mol. Biol. 322 2006 289
14. Kornbluth, S., Yang, J., and Powers, M. (2006). Curr. Protoc. Cell Biol. Chapter 11, Unit 11 11.
15. T.J. Maresca, and R. Heald Methods Mol. Biol. 322 2006 459
16. M.C. Dabauvalle, and U. Scheer Biol. Cell 72 1991 25
17. A.V. Tutter, and J.C. Walter Methods Mol. Biol. 322 2006 121
18. K.I. Shennan Methods Mol. Biol. 322 2006 199
19. M. Glotzer, A.W. Murray, and M.W. Kirschner Nature 349 1991 132
20. A.W. Murray Methods Cell Biol. 36 1991 581
21. A. Salic, E. Lee, L. Mayer, and M.W. Kirschner Mol. Cell 5 2000 523
22. A.W. Murray, M.J. Solomon, and M.W. Kirschner Nature 339 1989 280
23. A.W. Murray, and M.W. Kirschner Nature 339 1989 275
24. M.J. Lohka, M.K. Hayes, and J.L. Maller Proc. Natl. Acad. Sci. U.S.A. 85 1988 3009
25. J.R. Pomerening, S.Y. Kim, and J.E. Ferrell Jr. Cell 122 2005 565
26. M.J. Lohka, and Y. Masui Science 220 1983 719
27. M.J. Lohka, and Y. Masui J. Cell Biol. 98 1984 1222
28. D.R. Finlay, D.D. Newmeyer, T.M. Price, and D.J. Forbes J. Cell Biol. 104 1987 189
29. D.D. Newmeyer, D.R. Finlay, and D.J. Forbes J. Cell Biol. 103 1986 2091
30. J. Newport Cell 48 1987 205
31. J. Newport, and T. Spann Cell 48 1987 219
32. J.J. Blow, and R.A. Laskey Cell 47 1986 577
33. J.J. Blow, and A.M. Sleeman J. Cell Sci. 95 1990 383
34. J.W. Newport, K.L. Wilson, and W.G. Dunphy J. Cell Biol. 111 1990 2247
35. J. Meier, K.H. Campbell, C.C. Ford, R. Stick, and C.J. Hutchison J. Cell Sci. 98 Pt 3 1991 271
36. J. Walter, L. Sun, and J. Newport Mol. Cell 1 1998 519
37. E.E. Arias, and J.C. Walter Front. Biosci. 9 2004 3029
38. E. Garner, and V. Costanzo DNA Repair (Amst.) 8 2009 1025
39. J. Walter, and J. Newport Mol. Cell 5 2000 617
40. M. Shirasu, A. Yonetani, and C.E. Walczak Microsc. Res. Tech. 44 1999 435
41. A. Desai, and T.J. Mitchison Annu. Rev. Cell Dev. Biol. 13 1997 83
42. A. Desai, A. Murray, T.J. Mitchison, and C.E. Walczak Methods Cell Biol. 61 1999 385
43. E. Hannak, and R. Heald Nat. Protoc. 1 2006 2305
44. K.E. Sawin, and T.J. Mitchison J. Cell Biol. 112 1991 941
45. K.E. Sawin, and T.J. Mitchison J. Cell Biol. 112 1991 925
46. R. Heald, R. Tournebize, T. Blank, R. Sandaltzopoulos, P. Becker, A. Hyman, and E. Karsenti Nature 382 1996 420
47. S.M. Wignall, N.S. Gray, Y.-T. Chang, L. Juarez, R. Jacob, B. Al, P.G. Schultz, and R. Heald Chem Biol. 11 2004 135
48. L.A. Cameron, P.A. Giardini, F.S. Soo, and J.A. Theriot Nat. Rev. Mol. Cell Biol. 1 2000 110
49. L. Ma, L.C. Cantley, P.A. Janmey, and M.W. Kirschner J. Cell Biol. 140 1998 1125
50. R. Rohatgi, H.Y. Ho, and M.W. Kirschner J. Cell Biol. 150 2000 1299
51. J. Rosenblatt, B.J. Agnew, H. Abe, J.R. Bamburg, and T.J. Mitchison J. Cell Biol. 136 1997 1323
52. H.Y. Ho, R. Rohatgi, A.M. Lebensohn, M. Le, J. Li, S.P. Gygi, and M.W. Kirschner Cell 118 2004 203
53. J.R. Peterson, R.S. Lokey, T.J. Mitchison, and M.W. Kirschner Proc. Natl. Acad. Sci. U.S.A. 98 2001 10624
54. P. Deming, and S. Kornbluth Methods Mol. Biol. 322 2006 379
55. S.L. Spencer, and P.K. Sorger Cell 144 2011 926
56. D.D. Newmeyer, D.M. Farschon, and J.C. Reed Cell 79 1994 353
57. L.K. Nutt, S.S. Margolis, M. Jensen, C.E. Herman, W.G. Dunphy, J.C. Rathmell, and S. Kornbluth Cell 123 2005 89
58. C.Y. Logan, and R. Nusse Annu. Rev. Cell Dev. Biol. 20 2004 781
59. H. Clevers Cell 127 2006 469
60. B.T. MacDonald, K. Tamai, and X. He Dev. Cell 17 2009 9
61. D.L. Daniels, and W.I. Weis Nat. Struct. Mol. Biol. 12 2005 364
62. K.W. Kinzler, and B. Vogelstein Cell 87 1996 159
63. K.W. Kinzler, M.C. Nilbert, L.K. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, P. Hedge, and D. McKechnie Science 253 1991 661
64. I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, and P. Hedge Science 253 1991 665
65. L.K. Su, K.W. Kinzler, B. Vogelstein, A.C. Preisinger, A.R. Moser, C. Luongo, K.A. Gould, and W.F. Dove Science 256 1992 668
66. K. Kinzler, M. Nilbert, L. Su, B. Vogelstein, T. Bryan, D. Levy, K. Smith, A. Preisinger, P. Hedge, and D. McKechnie Science 253 1991 661
67. D. Pinto, and H. Clevers Exp. Cell Res. 306 2005 357
68. S. Hoppler Methods Mol. Biol. 469 2008 319
69. J. Newport, and M. Kirschner Cell 30 1982 687
70. J. Newport, and M. Kirschner Cell 30 1982 675
71. M.C. Barton, N. Madani, and B.M. Emerson Genes Dev. 7 1993 1796
72. T. Toyoda, and A.P. Wolffe Dev. Biol. 153 1992 150
73. J. Minshull, J.J. Blow, and T. Hunt Cell 56 1989 947
74. G. Matthews, and A. Colman Nucleic Acids Res. 19 1991 6405
75. C.S. Cselenyi, K.K. Jernigan, E. Tahinci, C.A. Thorne, L.A. Lee, and E. Lee Proc. Natl. Acad. Sci. U.S.A. 105 2008 8032
76. E. Lee, A. Salic, R. Kruger, R. Heinrich, and M.W. Kirschner PLoS Biol. 1 2003 E10
77. J. Mao, J. Wang, B. Liu, W. Pan, G.H. Farr 3rd, C. Flynn, H. Yuan, S. Takada, D. Kimelman, L. Li, and D. Wu Mol. Cell 7 2001 801
78. N.S. Tolwinski, M. Wehrli, A. Rives, N. Erdeniz, S. DiNardo, and E. Wieschaus Dev. Cell 4 2003 407
79. M. Kofron, B. Birsoy, D. Houston, Q. Tao, C. Wylie, and J. Heasman Development 134 2007 503
80. C.A. Thorne, A.J. Hanson, J. Schneider, E. Tahinci, D. Orton, C.S. Cselenyi, K.K. Jernigan, K.C. Meyers, B.I. Hang, A.G. Waterson, K. Kim, B. Melancon, V.P. Ghidu, G.A. Sulikowski, B. LaFleur, A. Salic, L.A. Lee, D.M. Miller 3rd, and E. Lee Nat. Chem. Biol. 6 2010 829
81. C.A. Thorne, B. Lafleur, M. Lewis, A.J. Hanson, K.K. Jernigan, D.C. Weaver, K.A. Huppert, T.W. Chen, C. Wichaidit, C.S. Cselenyi, E. Tahinci, K.C. Meyers, E. Waskow, D. Orton, A. Salic, L.A. Lee, D.J. Robbins, S.S. Huppert, and E. Lee J. Biomol. Screen. 16 2011 995
82. S. Saraswati, M.P. Alfaro, C.A. Thorne, J. Atkinson, E. Lee, and P.P. Young PLoS One 5 2010 e15521
83. P.W. Ingham, Y. Nakano, and C. Seger Nat. Rev. Genet. 12 2011 393
84. E.R. Andersson, R. Sandberg, and U. Lendahl Development 138 2011 3593
85. P.A. Beachy, S.S. Karhadkar, and D.M. Berman Nature 432 2004 324
86. P. Ranganathan, K.L. Weaver, and A.J. Capobianco Nat. Rev. Cancer 11 2011 338
87. J.E. Dick Nat. Biotechnol. 27 2009 44
88. N.Y. Frank, T. Schatton, and M.H. Frank J. Clin. Invest. 120 2010 41
89. N. Barker, and H. Clevers Nat. Rev. Drug Discov. 5 2006 997
90. Y. Katoh, and M. Katoh Curr. Mol. Med. 9 2009 873
91. D.J. Robbins, and M. Hebrok EMBO Rep. 8 2007 451
92. E.J. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald Genes Dev. 11 1997 3182
93. C. Oberg, J. Li, A. Pauley, E. Wolf, M. Gurney, and U. Lendahl J. Biol. Chem. 276 2001 35847
94. G. Wu, S. Lyapina, I. Das, J. Li, M. Gurney, A. Pauley, I. Chui, R.J. Deshaies, and J. Kitajewski Mol. Cell Biol. 21 2001 7403
95. S.K. Ogden, M. Ascano Jr., M.A. Stegman, and D.J. Robbins Biochem. Pharmacol. 67 2004 805
96. K.W. Kinzler, S.H. Bigner, D.D. Bigner, J.M. Trent, M.L. Law, S.J. O'Brien, A.J. Wong, and B. Vogelstein Science 236 1987 70
97. N. Dahmane, J. Lee, P. Robins, P. Heller, and A. Ruiz i Altaba Nature 389 1997 876
98. J. Green, I.M. Leigh, R. Poulsom, and A.G. Quinn Br. J. Dermatol. 139 1998 911
99. H. Hahn, C. Wicking, P.G. Zaphiropoulous, M.R. Gailani, S. Shanley, A. Chidambaram, I. Vorechovsky, E. Holmberg, A.B. Unden, S. Gillies, K. Negus, I. Smyth, C. Pressman, D.J. Leffell, B. Gerrard, A.M. Goldstein, M. Dean, R. Toftgard, G. Chenevix-Trench, B. Wainwright, and A.E. Bale Cell 85 1996 841
100. R.L. Johnson, A.L. Rothman, J. Xie, L.V. Goodrich, J.W. Bare, J.M. Bonifas, A.G. Quinn, R.M. Myers, D.R. Cox, E.H. Epstein Jr., and M.P. Scott Science 272 1996 1668
101. L.L. Rubin, and F.J. de Sauvage Nat. Rev. Drug Discov. 5 2006 1026
102. R.L. Yauch, G.J. Dijkgraaf, B. Alicke, T. Januario, C.P. Ahn, T. Holcomb, K. Pujara, J. Stinson, C.A. Callahan, T. Tang, J.F. Bazan, Z. Kan, S. Seshagiri, C.L. Hann, S.E. Gould, J.A. Low, C.M. Rudin, and F.J. de Sauvage Science 326 2009 572
103. R. Kopan, and M.X. Ilagan Cell 137 2009 216
104. M.S. Wolfe) Semin. Cell Dev. Biol. 20 2009 219
105. A.P. Weng, A.A. Ferrando, W. Lee, J.P.T. Morris, L.B. Silverman, C. Sanchez-Irizarry, S.C. Blacklow, A.T. Look, and J.C. Aster Science 306 2004 269
106. B. Westhoff, I.N. Colaluca, G. D'Ario, M. Donzelli, D. Tosoni, S. Volorio, G. Pelosi, L. Spaggiari, G. Mazzarol, G. Viale, S. Pece, and P.P. Di Fiore Proc. Natl. Acad. Sci. U.S.A. 106 2009 22293
107. J. O'Neil, J. Grim, P. Strack, S. Rao, D. Tibbitts, C. Winter, J. Hardwick, M. Welcker, J.P. Meijerink, R. Pieters, G. Draetta, R. Sears, B.E. Clurman, and A.T. Look J. Exp. Med. 204 2007 1813
108. G. Bompard, G. Rabeharivelo, and N. Morin BMC Cell Biol. 9 2008 42
109. C.J. Guerriero, and O.A. Weisz Am. J. Physiol. Cell Physiol. 292 2007 C1562
110. U. Peters, and T.M. Kapoor Chem. Biol. 11 2004 14
111. T.U. Mayer, T.M. Kapoor, S.J. Haggarty, R.W. King, S.L. Schreiber, and T.J. Mitchison Science 286 1999 971
112. Z. Maliga, T.M. Kapoor, and T.J. Mitchison Chem. Biol. 9 2002 989
113. T.M. Kapoor, T.U. Mayer, M.L. Coughlin, and T.J. Mitchison J. Cell Biol. 150 2000 975
114. A.C. Groen, D. Needleman, C. Brangwynne, C. Gradinaru, B. Fowler, R. Mazitschek, and T.J. Mitchison J. Cell Sci. 121 2008 2293