-
1
-
-
48749098903
-
The role of kinases in the Hedgehog signalling pathway
-
Aikin R.A., Ayers K.L., Therond P.P. The role of kinases in the Hedgehog signalling pathway. EMBO Rep. 2008, 9:330-336.
-
(2008)
EMBO Rep.
, vol.9
, pp. 330-336
-
-
Aikin, R.A.1
Ayers, K.L.2
Therond, P.P.3
-
2
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J.E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232.
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
3
-
-
0031647941
-
Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs
-
Alves G., Limbourg-Bouchon B., Tricoire H., Brissard-Zahraoui J., Lamour-Isnard C., Busson D. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech. Dev. 1998, 78:17-31.
-
(1998)
Mech. Dev.
, vol.78
, pp. 17-31
-
-
Alves, G.1
Limbourg-Bouchon, B.2
Tricoire, H.3
Brissard-Zahraoui, J.4
Lamour-Isnard, C.5
Busson, D.6
-
4
-
-
12344305145
-
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
-
Apionishev S., Katanayeva N.M., Marks S.A., Kalderon D., Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat. Cell Biol. 2005, 7:86-92.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 86-92
-
-
Apionishev, S.1
Katanayeva, N.M.2
Marks, S.A.3
Kalderon, D.4
Tomlinson, A.5
-
5
-
-
0036173545
-
The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling
-
Ascano M., Nybakken K.E., Sosinski J., Stegman M.A., Robbins D.J. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Mol. Cell. Biol. 2002, 22:1555-1566.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1555-1566
-
-
Ascano, M.1
Nybakken, K.E.2
Sosinski, J.3
Stegman, M.A.4
Robbins, D.J.5
-
6
-
-
77952546990
-
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
-
Ayers K.L., Therond P.P. Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. Trends Cell Biol. 2010, 20:287-298.
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 287-298
-
-
Ayers, K.L.1
Therond, P.P.2
-
7
-
-
0031587830
-
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
-
Aza-Blanc P., Ramirez-Weber F.A., Laget M.P., Schwartz C., Kornberg T.B. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 1997, 89:1043-1053.
-
(1997)
Cell
, vol.89
, pp. 1043-1053
-
-
Aza-Blanc, P.1
Ramirez-Weber, F.A.2
Laget, M.P.3
Schwartz, C.4
Kornberg, T.B.5
-
8
-
-
0033761448
-
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
-
Aza-Blanc P., Lin H.Y., Ruiz i Altaba A., Kornberg T.B. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 2000, 127:4293-4301.
-
(2000)
Development
, vol.127
, pp. 4293-4301
-
-
Aza-Blanc, P.1
Lin, H.Y.2
Ruiz i Altaba, A.3
Kornberg, T.B.4
-
9
-
-
0035691773
-
Gli1 can rescue the in vivo function of Gli2
-
Bai C.B., Joyner A.L. Gli1 can rescue the in vivo function of Gli2. Development 2001, 128:5161-5172.
-
(2001)
Development
, vol.128
, pp. 5161-5172
-
-
Bai, C.B.1
Joyner, A.L.2
-
10
-
-
0036801765
-
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
-
Bai C.B., Auerbach W., Lee J.S., Stephen D., Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 2002, 129:4753-4761.
-
(2002)
Development
, vol.129
, pp. 4753-4761
-
-
Bai, C.B.1
Auerbach, W.2
Lee, J.S.3
Stephen, D.4
Joyner, A.L.5
-
11
-
-
0347764480
-
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
-
Bai C.B., Stephen D., Joyner A.L. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 2004, 6:103-115.
-
(2004)
Dev. Cell
, vol.6
, pp. 103-115
-
-
Bai, C.B.1
Stephen, D.2
Joyner, A.L.3
-
12
-
-
0033143881
-
The specification of neuronal identity by graded Sonic Hedgehog signalling
-
Briscoe J., Ericson J. The specification of neuronal identity by graded Sonic Hedgehog signalling. Semin. Cell Dev. Biol. 1999, 10:353-362.
-
(1999)
Semin. Cell Dev. Biol.
, vol.10
, pp. 353-362
-
-
Briscoe, J.1
Ericson, J.2
-
13
-
-
0035252990
-
Specification of neuronal fates in the ventral neural tube
-
Briscoe J., Ericson J. Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 2001, 11:43-49.
-
(2001)
Curr. Opin. Neurobiol.
, vol.11
, pp. 43-49
-
-
Briscoe, J.1
Ericson, J.2
-
14
-
-
0001010573
-
The enzymatic phosphorylation of proteins
-
Burnett G., Kennedy E.P. The enzymatic phosphorylation of proteins. J. Biol. Chem. 1954, 211:969-980.
-
(1954)
J. Biol. Chem.
, vol.211
, pp. 969-980
-
-
Burnett, G.1
Kennedy, E.P.2
-
15
-
-
0346888543
-
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
-
Buttitta L., Mo R., Hui C.C., Fan C.M. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 2003, 130:6233-6243.
-
(2003)
Development
, vol.130
, pp. 6233-6243
-
-
Buttitta, L.1
Mo, R.2
Hui, C.C.3
Fan, C.M.4
-
16
-
-
59049104614
-
Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity
-
Cai Q., Li J., Gao T., Xie J., Evers B.M. Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. J. Biol. Chem. 2009, 284:2150-2158.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2150-2158
-
-
Cai, Q.1
Li, J.2
Gao, T.3
Xie, J.4
Evers, B.M.5
-
17
-
-
0033582646
-
Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker
-
Campbell G., Tomlinson A. Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker. Cell 1999, 96:553-562.
-
(1999)
Cell
, vol.96
, pp. 553-562
-
-
Campbell, G.1
Tomlinson, A.2
-
18
-
-
45149133817
-
A screen for modifiers of hedgehog signaling in Drosophila melanogaster Identifies swm and mts
-
Casso D.J., Liu S., Iwaki D.D., Ogden S.K., Kornberg T.B. A screen for modifiers of hedgehog signaling in Drosophila melanogaster Identifies swm and mts. Genetics 2008, 178:1399-1413.
-
(2008)
Genetics
, vol.178
, pp. 1399-1413
-
-
Casso, D.J.1
Liu, S.2
Iwaki, D.D.3
Ogden, S.K.4
Kornberg, T.B.5
-
19
-
-
0033529667
-
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
-
Chen C.H., von Kessler D.P., Park W., Wang B., Ma Y., Beachy P.A. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 1999, 98:305-316.
-
(1999)
Cell
, vol.98
, pp. 305-316
-
-
Chen, C.H.1
von Kessler, D.P.2
Park, W.3
Wang, B.4
Ma, Y.5
Beachy, P.A.6
-
20
-
-
0032873774
-
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
-
Chen Y., Cardinaux J.R., Goodman R.H., Smolik S.M. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 1999, 126:3607-3616.
-
(1999)
Development
, vol.126
, pp. 3607-3616
-
-
Chen, Y.1
Cardinaux, J.R.2
Goodman, R.H.3
Smolik, S.M.4
-
21
-
-
11144256194
-
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
-
Chen W., Ren X.R., Nelson C.D., Barak L.S., Chen J.K., Beachy P.A., de Sauvage F., Lefkowitz R.J. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 2004, 306:2257-2260.
-
(2004)
Science
, vol.306
, pp. 2257-2260
-
-
Chen, W.1
Ren, X.R.2
Nelson, C.D.3
Barak, L.S.4
Chen, J.K.5
Beachy, P.A.6
de Sauvage, F.7
Lefkowitz, R.J.8
-
22
-
-
77956805860
-
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
-
Chen Y., Li S., Tong C., Zhao Y., Wang B., Liu Y., Jia J., Jiang J. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev. 2010, 24:2054-2067.
-
(2010)
Genes Dev.
, vol.24
, pp. 2054-2067
-
-
Chen, Y.1
Li, S.2
Tong, C.3
Zhao, Y.4
Wang, B.5
Liu, Y.6
Jia, J.7
Jiang, J.8
-
23
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened
-
Epub June 14
-
Chen Y., Sasai N., Ma G., Yue T., Jia J., Briscoe J., Jiang J. Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened. PLoS Biol. 2011, Epub June 14.
-
(2011)
PLoS Biol.
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
Briscoe, J.6
Jiang, J.7
-
24
-
-
70450221494
-
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
-
Cheng S., Maier D., Neubueser D., Hipfner D.R. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev. Biol. 2010, 337:99-109.
-
(2010)
Dev. Biol.
, vol.337
, pp. 99-109
-
-
Cheng, S.1
Maier, D.2
Neubueser, D.3
Hipfner, D.R.4
-
25
-
-
34547608994
-
Evidence for a novel feedback loop in the hedgehog pathway involving smoothened and fused
-
Claret S., Sanial M., Plessis A. Evidence for a novel feedback loop in the hedgehog pathway involving smoothened and fused. Curr. Biol. 2007, 17:1326-1333.
-
(2007)
Curr. Biol.
, vol.17
, pp. 1326-1333
-
-
Claret, S.1
Sanial, M.2
Plessis, A.3
-
26
-
-
0030790128
-
Novel protein serine/threonine phosphatases: Variety is the spice of life
-
Cohen P.T. Novel protein serine/threonine phosphatases: Variety is the spice of life. Trends Biochem. Sci. 1997, 22:245-251.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 245-251
-
-
Cohen, P.T.1
-
27
-
-
0033583035
-
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
-
Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 1999, 274:8143-8152.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8143-8152
-
-
Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Maekawa, T.4
Nakafuku, M.5
Ishii, S.6
-
28
-
-
28644444440
-
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
-
Davidson G., Wu W., Shen J., Bilic J., Fenger U., Stannek P., Glinka A., Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005, 438:867-872.
-
(2005)
Nature
, vol.438
, pp. 867-872
-
-
Davidson, G.1
Wu, W.2
Shen, J.3
Bilic, J.4
Fenger, U.5
Stannek, P.6
Glinka, A.7
Niehrs, C.8
-
29
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
Denef N., Neubuser D., Perez L., Cohen S.M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000, 102:521-531.
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
Neubuser, D.2
Perez, L.3
Cohen, S.M.4
-
30
-
-
0031855859
-
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
-
Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 1998, 125:2533-2543.
-
(1998)
Development
, vol.125
, pp. 2533-2543
-
-
Ding, Q.1
Motoyama, J.2
Gasca, S.3
Mo, R.4
Sasaki, H.5
Rossant, J.6
Hui, C.C.7
-
31
-
-
33644766718
-
Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs
-
Dussillol-Godar F., Brissard-Zahraoui J., Limbourg-Bouchon B., Boucher D., Fouix S., Lamour-Isnard C., Plessis A., Busson D. Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dev. Biol. 2006, 291:53-66.
-
(2006)
Dev. Biol.
, vol.291
, pp. 53-66
-
-
Dussillol-Godar, F.1
Brissard-Zahraoui, J.2
Limbourg-Bouchon, B.3
Boucher, D.4
Fouix, S.5
Lamour-Isnard, C.6
Plessis, A.7
Busson, D.8
-
32
-
-
44349159118
-
Multiple roles for lipids in the Hedgehog signalling pathway
-
Eaton S. Multiple roles for lipids in the Hedgehog signalling pathway. Nat. Rev. Mol. Cell Biol. 2008, 9:437-445.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 437-445
-
-
Eaton, S.1
-
33
-
-
0000187410
-
Conversion of phosphorylase b to phosphorylase a in muscle extracts
-
Fischer E.H., Krebs E.G. Conversion of phosphorylase b to phosphorylase a in muscle extracts. J. Biol. Chem. 1955, 216:121-132.
-
(1955)
J. Biol. Chem.
, vol.216
, pp. 121-132
-
-
Fischer, E.H.1
Krebs, E.G.2
-
34
-
-
0035914377
-
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells
-
Fukumoto T., Watanabe-Fukunaga R., Fujisawa K., Nagata S., Fukunaga R. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. J. Biol. Chem. 2001, 276:38441-38448.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38441-38448
-
-
Fukumoto, T.1
Watanabe-Fukunaga, R.2
Fujisawa, K.3
Nagata, S.4
Fukunaga, R.5
-
35
-
-
0028008784
-
Drosophila hedgehog acts as a morphogen in cellular patterning
-
Heemskerk J., DiNardo S. Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 1994, 76:449-460.
-
(1994)
Cell
, vol.76
, pp. 449-460
-
-
Heemskerk, J.1
DiNardo, S.2
-
36
-
-
17144402650
-
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused
-
Ho K.S., Suyama K., Fish M., Scott M.P. Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development 2005, 132:1401-1412.
-
(2005)
Development
, vol.132
, pp. 1401-1412
-
-
Ho, K.S.1
Suyama, K.2
Fish, M.3
Scott, M.P.4
-
37
-
-
0041827271
-
Smoothened translates Hedgehog levels into distinct responses
-
Hooper J.E. Smoothened translates Hedgehog levels into distinct responses. Development 2003, 130:3951-3963.
-
(2003)
Development
, vol.130
, pp. 3951-3963
-
-
Hooper, J.E.1
-
39
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev. 2001, 15:3059-3087.
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
40
-
-
79956308325
-
Mechanisms and functions of Hedgehog signalling across the metazoa
-
Ingham P.W., Nakano Y., Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat. Rev. Genet. 2011, 12:393-406.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 393-406
-
-
Ingham, P.W.1
Nakano, Y.2
Seger, C.3
-
41
-
-
0041852606
-
Gli proteins and the control of spinal-cord patterning
-
Jacob J., Briscoe J. Gli proteins and the control of spinal-cord patterning. EMBO Rep. 2003, 4:761-765.
-
(2003)
EMBO Rep.
, vol.4
, pp. 761-765
-
-
Jacob, J.1
Briscoe, J.2
-
42
-
-
79251514651
-
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling
-
Jacob L.S., Wu X., Dodge M.E., Fan C.W., Kulak O., Chen B., Tang W., Wang B., Amatruda J.F., Lum L. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci. Signal. 2011, 4:ra4.
-
(2011)
Sci. Signal.
, vol.4
-
-
Jacob, L.S.1
Wu, X.2
Dodge, M.E.3
Fan, C.W.4
Kulak, O.5
Chen, B.6
Tang, W.7
Wang, B.8
Amatruda, J.F.9
Lum, L.10
-
43
-
-
0034303585
-
Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
-
Jessell T.M. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat. Rev. Genet. 2000, 1:20-29.
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 20-29
-
-
Jessell, T.M.1
-
44
-
-
33646861115
-
Decoding the Hedgehog signal in animal development
-
Jia J., Jiang J. Decoding the Hedgehog signal in animal development. Cell. Mol. Life Sci. 2006, 63:1249-1265.
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 1249-1265
-
-
Jia, J.1
Jiang, J.2
-
45
-
-
0037041470
-
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
-
Jia J., Amanai K., Wang G., Tang J., Wang B., Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 2002, 416:548-552.
-
(2002)
Nature
, vol.416
, pp. 548-552
-
-
Jia, J.1
Amanai, K.2
Wang, G.3
Tang, J.4
Wang, B.5
Jiang, J.6
-
46
-
-
0242361620
-
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
-
Jia J., Tong C., Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 2003, 17:2709-2720.
-
(2003)
Genes Dev.
, vol.17
, pp. 2709-2720
-
-
Jia, J.1
Tong, C.2
Jiang, J.3
-
47
-
-
11144237279
-
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
-
Jia J., Tong C., Wang B., Luo L., Jiang J. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 2004, 432:1045-1050.
-
(2004)
Nature
, vol.432
, pp. 1045-1050
-
-
Jia, J.1
Tong, C.2
Wang, B.3
Luo, L.4
Jiang, J.5
-
48
-
-
28444449828
-
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
-
Jia J., Zhang L., Zhang Q., Tong C., Wang B., Hou F., Amanai K., Jiang J. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 2005, 9:819-830.
-
(2005)
Dev. Cell
, vol.9
, pp. 819-830
-
-
Jia, J.1
Zhang, L.2
Zhang, Q.3
Tong, C.4
Wang, B.5
Hou, F.6
Amanai, K.7
Jiang, J.8
-
49
-
-
62349102527
-
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
-
Jia H., Liu Y., Yan W., Jia J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 2009, 136:307-316.
-
(2009)
Development
, vol.136
, pp. 307-316
-
-
Jia, H.1
Liu, Y.2
Yan, W.3
Jia, J.4
-
50
-
-
78549236202
-
Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus
-
Jia H., Liu Y., Xia R., Tong C., Yue T., Jiang J., Jia J. Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J. Biol. Chem. 2010, 285:37218-37226.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37218-37226
-
-
Jia, H.1
Liu, Y.2
Xia, R.3
Tong, C.4
Yue, T.5
Jiang, J.6
Jia, J.7
-
51
-
-
0037106234
-
Degrading Ci: Who is Cul-pable?
-
Jiang J. Degrading Ci: Who is Cul-pable?. Genes Dev. 2002, 16:2315-2321.
-
(2002)
Genes Dev.
, vol.16
, pp. 2315-2321
-
-
Jiang, J.1
-
52
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev. Cell 2008, 15:801-812.
-
(2008)
Dev. Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
53
-
-
0028918468
-
Protein kinase A and hedgehog signaling in Drosophila limb development
-
Jiang J., Struhl G. Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 1995, 80:563-572.
-
(1995)
Cell
, vol.80
, pp. 563-572
-
-
Jiang, J.1
Struhl, G.2
-
54
-
-
0032576777
-
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
-
Jiang J., Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 1998, 391:493-496.
-
(1998)
Nature
, vol.391
, pp. 493-496
-
-
Jiang, J.1
Struhl, G.2
-
55
-
-
0029967209
-
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
-
Lecuit T., Brook W.J., Ng M., Callega M., Sun H., Cohen S.M. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 1996, 381:387-393.
-
(1996)
Nature
, vol.381
, pp. 387-393
-
-
Lecuit, T.1
Brook, W.J.2
Ng, M.3
Callega, M.4
Sun, H.5
Cohen, S.M.6
-
56
-
-
0030805592
-
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
-
Lee J., Platt K.A., Censullo P., Altaba A.R. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997, 124:2537-2552.
-
(1997)
Development
, vol.124
, pp. 2537-2552
-
-
Lee, J.1
Platt, K.A.2
Censullo, P.3
Altaba, A.R.4
-
57
-
-
0028952718
-
Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
-
Lepage T., Cohen S.M., Diaz-Benjumea F.J., Parkhurst S.M. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 1995, 373:711-715.
-
(1995)
Nature
, vol.373
, pp. 711-715
-
-
Lepage, T.1
Cohen, S.M.2
Diaz-Benjumea, F.J.3
Parkhurst, S.M.4
-
58
-
-
0028897883
-
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
-
Li W., Ohlmeyer J.T., Lane M.E., Kalderon D. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 1995, 80:553-562.
-
(1995)
Cell
, vol.80
, pp. 553-562
-
-
Li, W.1
Ohlmeyer, J.T.2
Lane, M.E.3
Kalderon, D.4
-
59
-
-
0033808256
-
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
-
Litingtung Y., Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 2000, 3:979-985.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 979-985
-
-
Litingtung, Y.1
Chiang, C.2
-
60
-
-
34547621412
-
Fused Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation
-
Liu Y., Cao X., Jiang J., Jia J. Fused Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev. 2007, 21:1949-1963.
-
(2007)
Genes Dev.
, vol.21
, pp. 1949-1963
-
-
Liu, Y.1
Cao, X.2
Jiang, J.3
Jia, J.4
-
61
-
-
2942738996
-
The Hedgehog response network: Sensors, switches, and routers
-
Lum L., Beachy P.A. The Hedgehog response network: Sensors, switches, and routers. Science 2004, 304:1755-1759.
-
(2004)
Science
, vol.304
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
62
-
-
10744233219
-
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
-
Lum L., Zhang C., Oh S., Mann R.K., von Kessler D.P., Taipale J., Weis-Garcia F., Gong R., Wang B., Beachy P.A. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 2003, 12:1261-1274.
-
(2003)
Mol. Cell
, vol.12
, pp. 1261-1274
-
-
Lum, L.1
Zhang, C.2
Oh, S.3
Mann, R.K.4
von Kessler, D.P.5
Taipale, J.6
Weis-Garcia, F.7
Gong, R.8
Wang, B.9
Beachy, P.A.10
-
63
-
-
77449084158
-
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway
-
Maloverjan A., Piirsoo M., Michelson P., Kogerman P., Osterlund T. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp. Cell Res. 2010, 316:627-637.
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 627-637
-
-
Maloverjan, A.1
Piirsoo, M.2
Michelson, P.3
Kogerman, P.4
Osterlund, T.5
-
64
-
-
0033106149
-
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways
-
Maniatis T. A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev. 1999, 13:505-510.
-
(1999)
Genes Dev.
, vol.13
, pp. 505-510
-
-
Maniatis, T.1
-
65
-
-
79957637188
-
Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation
-
Marks S.A., Kalderon D. Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development 2011, 138:2533-2542.
-
(2011)
Development
, vol.138
, pp. 2533-2542
-
-
Marks, S.A.1
Kalderon, D.2
-
66
-
-
0031679850
-
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
-
Matise M.P., Epstein D.J., Park H.L., Platt K.A., Joyner A.L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 1998, 125:2759-2770.
-
(1998)
Development
, vol.125
, pp. 2759-2770
-
-
Matise, M.P.1
Epstein, D.J.2
Park, H.L.3
Platt, K.A.4
Joyner, A.L.5
-
67
-
-
13944284208
-
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
-
McDermott A., Gustafsson M., Elsam T., Hui C.C., Emerson C.P., Borycki A.G. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development 2005, 132:345-357.
-
(2005)
Development
, vol.132
, pp. 345-357
-
-
McDermott, A.1
Gustafsson, M.2
Elsam, T.3
Hui, C.C.4
Emerson, C.P.5
Borycki, A.G.6
-
68
-
-
33749590571
-
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
-
Meloni A.R., Fralish G.B., Kelly P., Salahpour A., Chen J.K., Wechsler-Reya R.J., Lefkowitz R.J., Caron M.G. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol. Cell. Biol. 2006, 26:7550-7560.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7550-7560
-
-
Meloni, A.R.1
Fralish, G.B.2
Kelly, P.3
Salahpour, A.4
Chen, J.K.5
Wechsler-Reya, R.J.6
Lefkowitz, R.J.7
Caron, M.G.8
-
69
-
-
0033582908
-
Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
-
Methot N., Basler K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 1999, 96:819-831.
-
(1999)
Cell
, vol.96
, pp. 819-831
-
-
Methot, N.1
Basler, K.2
-
70
-
-
0033789068
-
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
-
Methot N., Basler K. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 2000, 127:4001-4010.
-
(2000)
Development
, vol.127
, pp. 4001-4010
-
-
Methot, N.1
Basler, K.2
-
71
-
-
34249950014
-
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
-
Molnar C., Holguin H., Mayor F., Ruiz-Gomez A., de Celis J.F. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci. USA 2007, 104:7963-7968.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 7963-7968
-
-
Molnar, C.1
Holguin, H.2
Mayor, F.3
Ruiz-Gomez, A.4
de Celis, J.F.5
-
72
-
-
0013014880
-
Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2
-
Monnier V., Ho K.S., Sanial M., Scott M.P., Plessis A. Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev. Biol. 2002, 2:4.
-
(2002)
BMC Dev. Biol.
, vol.2
, pp. 4
-
-
Monnier, V.1
Ho, K.S.2
Sanial, M.3
Scott, M.P.4
Plessis, A.5
-
73
-
-
0037706929
-
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
-
Motoyama J., Milenkovic L., Iwama M., Shikata Y., Scott M.P., Hui C.C. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 2003, 259:150-161.
-
(2003)
Dev. Biol.
, vol.259
, pp. 150-161
-
-
Motoyama, J.1
Milenkovic, L.2
Iwama, M.3
Shikata, Y.4
Scott, M.P.5
Hui, C.C.6
-
74
-
-
0029894568
-
Direct and long-range action of a DPP morphogen gradient
-
Nellen D., Burke R., Struhl G., Basler K. Direct and long-range action of a DPP morphogen gradient. Cell 1996, 85:357-368.
-
(1996)
Cell
, vol.85
, pp. 357-368
-
-
Nellen, D.1
Burke, R.2
Struhl, G.3
Basler, K.4
-
75
-
-
0037025382
-
Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused
-
Nybakken K.E., Turck C.W., Robbins D.J., Bishop J.M. Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. J. Biol. Chem. 2002, 277:24638-24647.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24638-24647
-
-
Nybakken, K.E.1
Turck, C.W.2
Robbins, D.J.3
Bishop, J.M.4
-
76
-
-
28444451148
-
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
-
Nybakken K., Vokes S.A., Lin T.Y., McMahon A.P., Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat. Genet. 2005, 37:1323-1332.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1323-1332
-
-
Nybakken, K.1
Vokes, S.A.2
Lin, T.Y.3
McMahon, A.P.4
Perrimon, N.5
-
77
-
-
0242625184
-
Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
-
Ogden S.K., Ascano M., Stegman M.A., Suber L.M., Hooper J.E., Robbins D.J. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr. Biol. 2003, 13:1998-2003.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1998-2003
-
-
Ogden, S.K.1
Ascano, M.2
Stegman, M.A.3
Suber, L.M.4
Hooper, J.E.5
Robbins, D.J.6
-
78
-
-
57049085407
-
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
-
Ogden S.K., Fei D.L., Schilling N.S., Ahmed Y.F., Hwa J., Robbins D.J. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature 2008, 456:967-970.
-
(2008)
Nature
, vol.456
, pp. 967-970
-
-
Ogden, S.K.1
Fei, D.L.2
Schilling, N.S.3
Ahmed, Y.F.4
Hwa, J.5
Robbins, D.J.6
-
79
-
-
0032585515
-
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
-
Ohlmeyer J.T., Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 1998, 396:749-753.
-
(1998)
Nature
, vol.396
, pp. 749-753
-
-
Ohlmeyer, J.T.1
Kalderon, D.2
-
80
-
-
0028911915
-
CAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
-
Pan D., Rubin G.M. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 1995, 80:543-552.
-
(1995)
Cell
, vol.80
, pp. 543-552
-
-
Pan, D.1
Rubin, G.M.2
-
81
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Pan Y., Bai C.B., Joyner A.L., Wang B. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 2006, 26:3365-3377.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
82
-
-
0034055649
-
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
-
Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 2000, 127:1593-1605.
-
(2000)
Development
, vol.127
, pp. 1593-1605
-
-
Park, H.L.1
Bai, C.2
Platt, K.A.3
Matise, M.P.4
Beeghly, A.5
Hui, C.C.6
Nakashima, M.7
Joyner, A.L.8
-
83
-
-
0037111829
-
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
-
Persson M., Stamataki D., te Welscher P., Andersson E., Bose J., Ruther U., Ericson J., Briscoe J. Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002, 16:2865-2878.
-
(2002)
Genes Dev.
, vol.16
, pp. 2865-2878
-
-
Persson, M.1
Stamataki, D.2
te Welscher, P.3
Andersson, E.4
Bose, J.5
Ruther, U.6
Ericson, J.7
Briscoe, J.8
-
84
-
-
59349091148
-
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
-
Philipp M., Fralish G.B., Meloni A.R., Chen W., MacInnes A.W., Barak L.S., Caron M.G. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. Mol. Biol. Cell 2008, 19:5478-5489.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5478-5489
-
-
Philipp, M.1
Fralish, G.B.2
Meloni, A.R.3
Chen, W.4
MacInnes, A.W.5
Barak, L.S.6
Caron, M.G.7
-
85
-
-
0026761497
-
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
-
Preat T. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 1992, 132:725-736.
-
(1992)
Genetics
, vol.132
, pp. 725-736
-
-
Preat, T.1
-
86
-
-
0027383291
-
Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
-
Preat T., Therond P., Limbourg-Bouchon B., Pham A., Tricoire H., Busson D., Lamour-Isnard C. Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 1993, 135:1047-1062.
-
(1993)
Genetics
, vol.135
, pp. 1047-1062
-
-
Preat, T.1
Therond, P.2
Limbourg-Bouchon, B.3
Pham, A.4
Tricoire, H.5
Busson, D.6
Lamour-Isnard, C.7
-
87
-
-
32644451364
-
CKI, there's more than one: Casein kinase I family members in Wnt and Hedgehog signaling
-
Price M.A. CKI, there's more than one: Casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev. 2006, 20:399-410.
-
(2006)
Genes Dev.
, vol.20
, pp. 399-410
-
-
Price, M.A.1
-
88
-
-
0032756914
-
Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
-
Price M.A., Kalderon D. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 1999, 126:4331-4339.
-
(1999)
Development
, vol.126
, pp. 4331-4339
-
-
Price, M.A.1
Kalderon, D.2
-
89
-
-
0037155737
-
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
-
Price M.A., Kalderon D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 2002, 108:823-835.
-
(2002)
Cell
, vol.108
, pp. 823-835
-
-
Price, M.A.1
Kalderon, D.2
-
90
-
-
0027760995
-
Sonic hedgehog mediates the polarizing activity of the ZPA
-
Riddle R.D., Johnson R.L., Laufer E., Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993, 75:1401-1416.
-
(1993)
Cell
, vol.75
, pp. 1401-1416
-
-
Riddle, R.D.1
Johnson, R.L.2
Laufer, E.3
Tabin, C.4
-
91
-
-
0030838880
-
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
-
Robbins D.J., Nybakken K.E., Kobayashi R., Sisson J.C., Bishop J.M., Therond P.P. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 1997, 90:225-234.
-
(1997)
Cell
, vol.90
, pp. 225-234
-
-
Robbins, D.J.1
Nybakken, K.E.2
Kobayashi, R.3
Sisson, J.C.4
Bishop, J.M.5
Therond, P.P.6
-
92
-
-
0029004233
-
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
-
Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., Jessell T.M. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 1995, 81:445-455.
-
(1995)
Cell
, vol.81
, pp. 445-455
-
-
Roelink, H.1
Porter, J.A.2
Chiang, C.3
Tanabe, Y.4
Chang, D.T.5
Beachy, P.A.6
Jessell, T.M.7
-
93
-
-
33846811415
-
PP2A:B56epsilon is required for eye induction and eye field separation
-
Rorick A.M., Mei W., Liette N.L., Phiel C., El-Hodiri H.M., Yang J. PP2A:B56epsilon is required for eye induction and eye field separation. Dev. Biol. 2007, 302:477-493.
-
(2007)
Dev. Biol.
, vol.302
, pp. 477-493
-
-
Rorick, A.M.1
Mei, W.2
Liette, N.L.3
Phiel, C.4
El-Hodiri, H.M.5
Yang, J.6
-
94
-
-
0141728540
-
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
-
Ruel L., Rodriguez R., Gallet A., Lavenant-Staccini L., Therond P.P. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat. Cell Biol. 2003, 5:907-913.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 907-913
-
-
Ruel, L.1
Rodriguez, R.2
Gallet, A.3
Lavenant-Staccini, L.4
Therond, P.P.5
-
95
-
-
36148939854
-
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
-
Ruel L., Gallet A., Raisin S., Truchi A., Staccini-Lavenant L., Cervantes A., Therond P.P. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development 2007, 134:3677-3689.
-
(2007)
Development
, vol.134
, pp. 3677-3689
-
-
Ruel, L.1
Gallet, A.2
Raisin, S.3
Truchi, A.4
Staccini-Lavenant, L.5
Cervantes, A.6
Therond, P.P.7
-
96
-
-
0032808138
-
Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
-
Ruiz i Altaba A. Gli proteins encode context-dependent positive and negative functions: Implications for development and disease. Development 1999, 126:3205-3216.
-
(1999)
Development
, vol.126
, pp. 3205-3216
-
-
Ruiz i Altaba, A.1
-
97
-
-
0030754171
-
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
-
Sisson J.C., Ho K.S., Suyama K., Scott M.P. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 1997, 90:235-245.
-
(1997)
Cell
, vol.90
, pp. 235-245
-
-
Sisson, J.C.1
Ho, K.S.2
Suyama, K.3
Scott, M.P.4
-
98
-
-
30044442183
-
Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component slimb
-
Smelkinson M.G., Kalderon D. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component slimb. Curr. Biol. 2006, 16:110-116.
-
(2006)
Curr. Biol.
, vol.16
, pp. 110-116
-
-
Smelkinson, M.G.1
Kalderon, D.2
-
99
-
-
14644401158
-
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
-
Stamataki D., Ulloa F., Tsoni S.V., Mynett A., Briscoe J. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 2005, 19:626-641.
-
(2005)
Genes Dev.
, vol.19
, pp. 626-641
-
-
Stamataki, D.1
Ulloa, F.2
Tsoni, S.V.3
Mynett, A.4
Briscoe, J.5
-
100
-
-
0034698137
-
Identification of a tetrameric hedgehog signaling complex
-
Stegman M.A., Vallance J.E., Elangovan G., Sosinski J., Cheng Y., Robbins D.J. Identification of a tetrameric hedgehog signaling complex. J. Biol. Chem. 2000, 275:21809-21812.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21809-21812
-
-
Stegman, M.A.1
Vallance, J.E.2
Elangovan, G.3
Sosinski, J.4
Cheng, Y.5
Robbins, D.J.6
-
101
-
-
0030663064
-
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
-
Strigini M., Cohen S.M. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 1997, 124:4697-4705.
-
(1997)
Development
, vol.124
, pp. 4697-4705
-
-
Strigini, M.1
Cohen, S.M.2
-
102
-
-
0001268037
-
Inactivation and activation of liver phosphorylase
-
Sutherland E.W., Wosilait W.D. Inactivation and activation of liver phosphorylase. Nature 1955, 175:169-170.
-
(1955)
Nature
, vol.175
, pp. 169-170
-
-
Sutherland, E.W.1
Wosilait, W.D.2
-
103
-
-
33646869503
-
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
-
Tempe D., Casas M., Karaz S., Blanchet-Tournier M.F., Concordet J.P. Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol. Cell. Biol. 2006, 26:4316-4326.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4316-4326
-
-
Tempe, D.1
Casas, M.2
Karaz, S.3
Blanchet-Tournier, M.F.4
Concordet, J.P.5
-
104
-
-
0027771488
-
Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster
-
Therond P., Busson D., Guillemet E., Limbourg-Bouchon B., Preat T., Terracol R., Tricoire H., Lamour-Isnard C. Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster. Mechanisms Of Development 1993, 44:65-80.
-
(1993)
Mechanisms Of Development
, vol.44
, pp. 65-80
-
-
Therond, P.1
Busson, D.2
Guillemet, E.3
Limbourg-Bouchon, B.4
Preat, T.5
Terracol, R.6
Tricoire, H.7
Lamour-Isnard, C.8
-
105
-
-
0029961659
-
Phosphorylation of the fused protein kinase in response to signaling from hedgehog
-
Therond P.P., Knight J.D., Kornberg T.B., Bishop J.M. Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl. Acad. Sci. USA 1996, 93:4224-4228.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4224-4228
-
-
Therond, P.P.1
Knight, J.D.2
Kornberg, T.B.3
Bishop, J.M.4
-
106
-
-
0242331193
-
Patterning the peripheral retina of the fly: Decoding a gradient
-
Tomlinson A. Patterning the peripheral retina of the fly: Decoding a gradient. Dev. Cell 2003, 5:799-809.
-
(2003)
Dev. Cell
, vol.5
, pp. 799-809
-
-
Tomlinson, A.1
-
107
-
-
11144327100
-
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
-
Tyurina O.V., Guner B., Popova E., Feng J., Schier A.F., Kohtz J.D., Karlstrom R.O. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev. Biol. 2005, 277:537-556.
-
(2005)
Dev. Biol.
, vol.277
, pp. 537-556
-
-
Tyurina, O.V.1
Guner, B.2
Popova, E.3
Feng, J.4
Schier, A.F.5
Kohtz, J.D.6
Karlstrom, R.O.7
-
108
-
-
43049142654
-
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling
-
Varjosalo M., Bjorklund M., Cheng F., Syvanen H., Kivioja T., Kilpinen S., Sun Z., Kallioniemi O., Stunnenberg H.G., He W.W., et al. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 2008, 133:537-548.
-
(2008)
Cell
, vol.133
, pp. 537-548
-
-
Varjosalo, M.1
Bjorklund, M.2
Cheng, F.3
Syvanen, H.4
Kivioja, T.5
Kilpinen, S.6
Sun, Z.7
Kallioniemi, O.8
Stunnenberg, H.G.9
He, W.W.10
-
109
-
-
0033578020
-
The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
-
Vervoort M., Crozatier M., Valle D., Vincent A. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 1999, 9:632-639.
-
(1999)
Curr. Biol.
, vol.9
, pp. 632-639
-
-
Vervoort, M.1
Crozatier, M.2
Valle, D.3
Vincent, A.4
-
110
-
-
0033404607
-
The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels
-
Wang Q.T., Holmgren R.A. The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels. Development 1999, 126:5097-5106.
-
(1999)
Development
, vol.126
, pp. 5097-5106
-
-
Wang, Q.T.1
Holmgren, R.A.2
-
111
-
-
1942518275
-
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
-
Wang G., Jiang J. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Dev. Biol. 2004, 268:493-505.
-
(2004)
Dev. Biol.
, vol.268
, pp. 493-505
-
-
Wang, G.1
Jiang, J.2
-
112
-
-
30444437000
-
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
-
Wang B., Li Y. Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. USA 2006, 103:33-38.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 33-38
-
-
Wang, B.1
Li, Y.2
-
113
-
-
0032728958
-
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
-
Wang G., Wang B., Jiang J. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 1999, 13:2828-2837.
-
(1999)
Genes Dev.
, vol.13
, pp. 2828-2837
-
-
Wang, G.1
Wang, B.2
Jiang, J.3
-
114
-
-
0034681266
-
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
-
Wang B., Fallon J.F., Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000, 100:423-434.
-
(2000)
Cell
, vol.100
, pp. 423-434
-
-
Wang, B.1
Fallon, J.F.2
Beachy, P.A.3
-
115
-
-
0034669178
-
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
-
Wang G., Amanai K., Wang B., Jiang J. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev. 2000, 14:2893-2905.
-
(2000)
Genes Dev.
, vol.14
, pp. 2893-2905
-
-
Wang, G.1
Amanai, K.2
Wang, B.3
Jiang, J.4
-
116
-
-
77953316514
-
Mechanism and evolution of cytosolic Hedgehog signal transduction
-
Wilson C.W., Chuang P.T. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development 2010, 137:2079-2094.
-
(2010)
Development
, vol.137
, pp. 2079-2094
-
-
Wilson, C.W.1
Chuang, P.T.2
-
117
-
-
28644439005
-
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
-
Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438:873-877.
-
(2005)
Nature
, vol.438
, pp. 873-877
-
-
Zeng, X.1
Tamai, K.2
Doble, B.3
Li, S.4
Huang, H.5
Habas, R.6
Okamura, H.7
Woodgett, J.8
He, X.9
-
118
-
-
11144248964
-
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
-
Zhang C., Williams E.H., Guo Y., Lum L., Beachy P.A. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc. Natl. Acad. Sci. USA 2004, 101:17900-17907.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 17900-17907
-
-
Zhang, C.1
Williams, E.H.2
Guo, Y.3
Lum, L.4
Beachy, P.A.5
-
119
-
-
13344261322
-
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
-
Zhang W., Zhao Y., Tong C., Wang G., Wang B., Jia J., Jiang J. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 2005, 8:267-278.
-
(2005)
Dev. Cell
, vol.8
, pp. 267-278
-
-
Zhang, W.1
Zhao, Y.2
Tong, C.3
Wang, G.4
Wang, B.5
Jia, J.6
Jiang, J.7
-
120
-
-
36049033946
-
Hedgehog regulates smoothened activity by inducing a conformational switch
-
Zhao Y., Tong C., Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007, 450:252-258.
-
(2007)
Nature
, vol.450
, pp. 252-258
-
-
Zhao, Y.1
Tong, C.2
Jiang, J.3
-
121
-
-
58149172091
-
Transducing the Hedgehog signal across the plasma membrane
-
Zhao Y., Tong C., Jiang J. Transducing the Hedgehog signal across the plasma membrane. Fly (Austin) 2007, 1:333-336.
-
(2007)
Fly (Austin)
, vol.1
, pp. 333-336
-
-
Zhao, Y.1
Tong, C.2
Jiang, J.3
-
122
-
-
73549083198
-
Genetic and biochemical definition of the Hedgehog receptor
-
Zheng X., Mann R.K., Sever N., Beachy P.A. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010, 24:57-71.
-
(2010)
Genes Dev.
, vol.24
, pp. 57-71
-
-
Zheng, X.1
Mann, R.K.2
Sever, N.3
Beachy, P.A.4
|