Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

Nature

Volumn 396, Issue 6713, 1998, Pages 749-753

  Ohlmeyer, Johanna Talavera ^a   Kalderon, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MICROTUBULE PROTEIN; PROTEIN; PROTEIN KINASE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FEMALE; GENE MUTATION; IMAGINAL DISC; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION;

ANIMALS; CELL CYCLE PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; INSECT PROTEINS; MEMBRANE PROTEINS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 0032585515     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/25533     Document Type: Article

References (30)

1. Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M.-P., Schwarz, C & Kornberg, T. B. Proteolysis that can be inhibited by Hedgehog directs Cubitus interruptus protein to the nucleus and changes its activity as a transcriptional regulator. Cell 89, 1043-1053 (1997).
2. Ingham, P. W. Transducing Hedgehog: the story so for. EMBO J. 17, 3505-2511 (1993).
3. Alexandre, C., Jacinto, A. & Ingham, P. W. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013 (1996).
4. Von Ohlen, T. & Hooper, J. E. Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer. Mech. Dev. 68, 149-156 (1997).
5. Forbes, A. J., Nakano, Y., Taylor, A. M. & Ingham, P. W. Genetic analysis of hedgehog signalling in the Drosophila embryo. Development (suppl.) 115-124 (1993).
6. Akimaru, H. et al. Drosophila CBP is a co-activator of Cubitus interruptus in Hedgehog signalling. Nature 386, 735-738 (1997).
7. Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C & Plessis, A. Suppressor of fused links Fused and Cubitus interrupts on the Hedgehog signalling pathway. Curr. Biol 8, 583-586 (1998).
8. Robbins, D. J. et al. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal 2. Cell 90, 225-234 (1997).
9. Sisson, J. C., Ho, K. S., Suyama, K. & Scott, M. P. Costal2, a novel kinesin-related protein in the hedgehog signaling pathway. Cell 90, 235-245 (1997).
10. Basler, K. & Struhl, G. Compartment boundaries and the control of Drosophila limb pattern by Hedgehog protein. Nature 368, 208-214 (1994).
11. Blair, S. engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Development 115, 21-33 (1992).
12. Strigini, M. & Cohen, S. M. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705 (1997),
13. Sturtevant, M. A., Biehs, B., Marin, E. & Bier, E. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development 124, 21-32 (1997).
14. Hidalgo, A. Three distinct roles for the engrailed gene in Drosophila wing development. Curr. Biol 4, 1087-1098 (1994).
15. Ingham, P. W. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560-562 (1993).
16. Ohlmeyer, J. T. & Kalderon, D. Dual pathways for induction of wingless by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250-2258 (1997).
17. Motzny, C. K. & Holmgren, R. The Drosophila Cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-150 (1995).
18. Jiang, J. & Struhl, G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/ WD40-repeat protein Slimb. Nature 391, 493-496 (1998).
19. Busson, D., Limbourg-Bouchon, B., Mariol, M.-C., Preat, T. & Lamour-Isnard, C. Genetic analysis of viable and lethal fused mutants of Drosophila melanogaster. Roux Arch. Dev. Biol 197, 221-230 (1988).
20. Préat, T. et al. Segmental polarity in Drosophila melanogaster. genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 135, 1047-1062 (1993).
21. Rodriguez, I. & Basler, K. Control of compartmental affinity boundaries by Hedgehog. Nature 389, 614-617 (1997).
22. Blair, S. S. & Ralston, A. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development 124, 4053-4063 (1997).
23. Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. & Hooper, J. E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86, 221-232 (1996).
24. van den Heuvel, M. & Ingham, P. W. smoothened encodes a receptor-like serpentine protein required for Hedgehog signalling. Nature 382, 547-551 (1996).
25. Chen, Y., Gallaher, N., Goodman, R. H. & Smolik, S. M. Protein kinase A directly regulates the activity and proteolysis of Cubitus Interruptus. Proc. Natl Acad, Sci. USA 95, 2349-2354 (1998).
26. Mullor, J. L., Calleja, M., Capdevila, J. & Guerrero, I. Hedgehog activity, independent of Decapenta-plegic, participates in wing disc patterning. Development 124, 1227-1237 (1997).
27. Lane, M. E. & Kalderon, D. Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes Dev. 7, 1229-1243 (1993).
28. Therond, P. et al. Molecular organization and expression pattern of the segment polarity gene fused of Drosophila melanogaster. Meek Dev. 44, 165-180 (1993).
29. Préat, T. Characterization of Supressor of fused, a complete supressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132, 725-736 (1992).
30. Brunner, E., Peter, O., Schweizer, L. & Basler, K. pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385, 829-833 (1997).