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Volumn 7, Issue 1, 2012, Pages 71-86

Lipid-based nanocarriers for CNS-targeted drug delivery

Author keywords

Blood brain barrier; CNS; Drug delivery; Gene delivery; Liposome; Micelle; Nanocapsule; Nanocarrier; Targeting

Indexed keywords

BOROCAPTATE; CENTRAL NERVOUS SYSTEM AGENTS; DOXORUBICIN; LIPID; LIPOSOME; N,N,N TRIMETHYLTEMPAMINE; NANOCAPSULE; NANOCARRIER; OLIGONUCLEOTIDE; RIVASTIGMINE; TOPOTECAN;

EID: 84857423416     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488912798842241     Document Type: Review
Times cited : (56)

References (192)
  • 1
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • Begley DJ. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol Ther 2004; 104: 29-45.
    • (2004) Pharmacol Ther , vol.104 , pp. 29-45
    • Begley, D.J.1
  • 2
    • 24644474375 scopus 로고    scopus 로고
    • Drug delivery across the bloodbrain barrier
    • Chen Y, Dalwadi G, Benson HAE. Drug delivery across the bloodbrain barrier. Curr Drug Deliv 2004; 1: 361-76.
    • (2004) Curr Drug Deliv , vol.1 , pp. 361-376
    • Chen, Y.1    Dalwadi, G.2    Benson, H.A.E.3
  • 3
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2005; 2: 3-14.
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 5
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • Pardridge WM. Blood-brain barrier delivery. Drug Discov Today 2007; 12: 54-61.
    • (2007) Drug Discov Today , vol.12 , pp. 54-61
    • Pardridge, W.M.1
  • 6
    • 0642342131 scopus 로고    scopus 로고
    • Morphology and molecular properties of cellular components of normal cerebral vessels
    • In: Nag S, editor, Totowa (NJ): Humana Press, (Methods in Molecular Medicine; vol 89)
    • Nag S. Morphology and molecular properties of cellular components of normal cerebral vessels. In: Nag S, editor. The blood-brain barrier: biology and research protocols. Totowa (NJ): Humana Press; 2003. P. 3-36. (Methods in Molecular Medicine; vol 89).
    • (2003) The blood-brain barrier: Biology and research protocols , pp. 3-36
    • Nag, S.1
  • 9
    • 77955466238 scopus 로고    scopus 로고
    • Nanoparticle-mediated brain-specific drug delivery, imaging and diagnosis
    • Yang H. Nanoparticle-mediated brain-specific drug delivery, imaging and diagnosis. Pharm Res 2010; 27: 1759-71.
    • (2010) Pharm Res , vol.27 , pp. 1759-1771
    • Yang, H.1
  • 10
    • 77953687516 scopus 로고    scopus 로고
    • Nano-intervention for neurodegenerative disorders
    • Fernandes C, Soni U, Patravale V. Nano-intervention for neurodegenerative disorders. Pharmacol Res 2010; 62: 166-78.
    • (2010) Pharmacol Res , vol.62 , pp. 166-178
    • Fernandes, C.1    Soni, U.2    Patravale, V.3
  • 11
    • 79961168855 scopus 로고    scopus 로고
    • Barriers to nonviral vector-mediated gene delivery in the nervous system
    • Perez-Martinez FC, Guerra J, Posadas I, Ceña V. Barriers to nonviral vector-mediated gene delivery in the nervous system. Pharm Res 2011; 28: 1843-58.
    • (2011) Pharm Res , vol.28 , pp. 1843-1858
    • Perez-Martinez, F.C.1    Guerra, J.2    Posadas, I.3    Ceña, V.4
  • 13
    • 77949884839 scopus 로고    scopus 로고
    • Advances in the treatment of neurodegenerative disorders employing nanotechnology
    • Modi G, Pillay V, Choonara YE. Advances in the treatment of neurodegenerative disorders employing nanotechnology. Ann N Y Acad Sci 2010; 1184: 154-72.
    • (2010) Ann N Y Acad Sci , vol.1184 , pp. 154-172
    • Modi, G.1    Pillay, V.2    Choonara, Y.E.3
  • 14
    • 77951246386 scopus 로고    scopus 로고
    • Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: Perspectives on tracking and neuroimaging
    • Bhaskar S, Tian F, Stoeger T, Kreyling W, de la Fuente JM, Grazú V et al. Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Part Fibre Toxicol 2010; 7: 3-27.
    • (2010) Part Fibre Toxicol , vol.7 , pp. 3-27
    • Bhaskar, S.1    Tian, F.2    Stoeger, T.3    Kreyling, W.4    de la Fuente, J.M.5    Grazú, V.6
  • 17
    • 78651415887 scopus 로고    scopus 로고
    • The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy
    • Roger M, Clavreul A, Venier-Julienne MC, Passirani C, Montero-Menei C, Menei P. The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy. Biomaterials 2011; 32: 2106-16.
    • (2011) Biomaterials , vol.32 , pp. 2106-2116
    • Roger, M.1    Clavreul, A.2    Venier-Julienne, M.C.3    Passirani, C.4    Montero-Menei, C.5    Menei, P.6
  • 18
    • 33646673555 scopus 로고    scopus 로고
    • A review of nanocarrier-based CNS delivery systems
    • Tiwari SB, Amiji MM. A review of nanocarrier-based CNS delivery systems. Curr Drug Deliv 2006; 3: 219-32.
    • (2006) Curr Drug Deliv , vol.3 , pp. 219-232
    • Tiwari, S.B.1    Amiji, M.M.2
  • 19
    • 33748498232 scopus 로고    scopus 로고
    • Pros and cons of the liposome platform in cancer drug targeting
    • Gabizon AA, Shmeeda H, Zalipsky S. Pros and cons of the liposome platform in cancer drug targeting. J Liposome Res 2006; 16:175-83.
    • (2006) J Liposome Res , vol.16 , pp. 175-183
    • Gabizon, A.A.1    Shmeeda, H.2    Zalipsky, S.3
  • 20
    • 33745458519 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel: A next-generation taxane
    • Gradishar WJ. Albumin-bound paclitaxel: a next-generation taxane. Expert Opin Pharmacother 2006; 7:1041-53.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 1041-1053
    • Gradishar, W.J.1
  • 21
    • 1942470679 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer
    • Danson S, Ferry D, Alakhov V, Margison J, Kerr D, Jowle D, et al. Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. Br J Cancer 2004; 90: 2085-91.
    • (2004) Br J Cancer , vol.90 , pp. 2085-2091
    • Danson, S.1    Ferry, D.2    Alakhov, V.3    Margison, J.4    Kerr, D.5    Jowle, D.6
  • 22
    • 33751565348 scopus 로고    scopus 로고
    • SP1049C as first-line therapy in advanced (inoperable or metastatic) adenocarcinoma of the oesophagus: A phase II window study
    • Armstrong A, Brewer J, Newman C, Alakhov V, Pietrzynski G, Campbell S, et al. SP1049C as first-line therapy in advanced (inoperable or metastatic) adenocarcinoma of the oesophagus: a phase II window study. J Clin Oncol 2006; 24: 4080.
    • (2006) J Clin Oncol , vol.24 , pp. 4080
    • Armstrong, A.1    Brewer, J.2    Newman, C.3    Alakhov, V.4    Pietrzynski, G.5    Campbell, S.6
  • 23
    • 33644852944 scopus 로고    scopus 로고
    • Micelle carrier system in clinical trial
    • Matsumura Y. Micelle carrier system in clinical trial. Nippon Rinsho 2006; 64: 316-21.
    • (2006) Nippon Rinsho , vol.64 , pp. 316-321
    • Matsumura, Y.1
  • 24
    • 4644233768 scopus 로고    scopus 로고
    • Enhanced delivery of octreotide to the brain via transnasal iontophoretic administration
    • Lerner EN, van Zanten EH, Stewart GR. Enhanced delivery of octreotide to the brain via transnasal iontophoretic administration. J Drug Target 2004; 12: 273-80.
    • (2004) J Drug Target , vol.12 , pp. 273-280
    • Lerner, E.N.1    van Zanten, E.H.2    Stewart, G.R.3
  • 25
    • 55149091591 scopus 로고    scopus 로고
    • From nose to brain: Understanding transport capacity and transport rate of drugs
    • Wu H, Hu K, Jiang X. From nose to brain: understanding transport capacity and transport rate of drugs. Expert Opin Drug Deliv 2008; 5: 1159-68.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 1159-1168
    • Wu, H.1    Hu, K.2    Jiang, X.3
  • 26
    • 68649090916 scopus 로고    scopus 로고
    • Nanoparticles for direct nose-to-brain delivery of drugs
    • Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm 2009; 379: 146-57.
    • (2009) Int J Pharm , vol.379 , pp. 146-157
    • Mistry, A.1    Stolnik, S.2    Illum, L.3
  • 28
    • 77949793045 scopus 로고    scopus 로고
    • Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations
    • Migliore MM, Vyas TK, Campbell RB, Amiji MM, Waszczak BL. Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations. J Pharm Sci 2009; 99: 1745-61.
    • (2009) J Pharm Sci , vol.99 , pp. 1745-1761
    • Migliore, M.M.1    Vyas, T.K.2    Campbell, R.B.3    Amiji, M.M.4    Waszczak, B.L.5
  • 29
    • 0026505698 scopus 로고
    • Influence of the surface properties of the low contact angle surfactants on the body distribution of 14C poly(methylmethacrylate) nanoparticles
    • Tröster SD, Kreuter J. Influence of the surface properties of the low contact angle surfactants on the body distribution of 14C poly(methylmethacrylate) nanoparticles. J Microencapsul 1992; 9: 19-28.
    • (1992) J Microencapsul , vol.9 , pp. 19-28
    • Tröster, S.D.1    Kreuter, J.2
  • 30
    • 0031954707 scopus 로고    scopus 로고
    • Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer
    • Peracchia MT, Vauthier C, Desmaële D, Gulik A, Dedieu JC, Demoy M, et al. Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer. Pharm Res 1998; 15: 550-6.
    • (1998) Pharm Res , vol.15 , pp. 550-556
    • Peracchia, M.T.1    Vauthier, C.2    Desmaële, D.3    Gulik, A.4    Dedieu, J.C.5    Demoy, M.6
  • 31
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 2001; 47: 65-81.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 32
    • 0037335187 scopus 로고    scopus 로고
    • Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs of the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    • Kreuter J, Ramge P, Petrov V, Hamm S, Gelperino SE, Engelhardt B, et al. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs of the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm Res 2003; 20: 409-16.
    • (2003) Pharm Res , vol.20 , pp. 409-416
    • Kreuter, J.1    Ramge, P.2    Petrov, V.3    Hamm, S.4    Gelperino, S.E.5    Engelhardt, B.6
  • 33
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticulatemediated transport of drugs to the brain
    • Kreuter J. Influence of the surface properties on nanoparticulatemediated transport of drugs to the brain. J Nanosci Nanotechnol 2004; 4: 484-8.
    • (2004) J Nanosci Nanotechnol , vol.4 , pp. 484-488
    • Kreuter, J.1
  • 34
    • 33646796753 scopus 로고    scopus 로고
    • Covalent linkage of apolipoprotein E to albumin nanoparticles strongly enhances drug transport into the brain
    • Michaelis K, Hoffmann MM, Dreis S, Herbert E, Alyautdin RN, Michaelis M, et al. Covalent linkage of apolipoprotein E to albumin nanoparticles strongly enhances drug transport into the brain. J Pharmacol Exp Ther 2006; 317: 1246-53.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1246-1253
    • Michaelis, K.1    Hoffmann, M.M.2    Dreis, S.3    Herbert, E.4    Alyautdin, R.N.5    Michaelis, M.6
  • 35
  • 36
    • 0027984463 scopus 로고
    • Insulin-like growth factors cross the blood-brain barrier
    • Reinhardt RR, Bondy CA. Insulin-like growth factors cross the blood-brain barrier. Endocrinology 1994; 135: 1753-61.
    • (1994) Endocrinology , vol.135 , pp. 1753-1761
    • Reinhardt, R.R.1    Bondy, C.A.2
  • 37
    • 0031017561 scopus 로고    scopus 로고
    • Human blood brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
    • Golden PL, Maccagnan TJ, Pardridge WM. Human blood brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997; 99: 14-8.
    • (1997) J Clin Invest , vol.99 , pp. 14-18
    • Golden, P.L.1    Maccagnan, T.J.2    Pardridge, W.M.3
  • 39
    • 70350200866 scopus 로고    scopus 로고
    • Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
    • Ke W, Shao K, Huang R, Han L, Liu Y, Li J, et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 2009; 30: 6976-85.
    • (2009) Biomaterials , vol.30 , pp. 6976-6985
    • Ke, W.1    Shao, K.2    Huang, R.3    Han, L.4    Liu, Y.5    Li, J.6
  • 40
    • 0035910336 scopus 로고    scopus 로고
    • Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin
    • Zhang Y, Pardridge WM. Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. Brain Res 2001; 889: 49-56.
    • (2001) Brain Res , vol.889 , pp. 49-56
    • Zhang, Y.1    Pardridge, W.M.2
  • 41
    • 0034691050 scopus 로고    scopus 로고
    • Noninvasive gene targeting to the brain
    • Shi N, Pardridge WM. Noninvasive gene targeting to the brain. Proc Natl Acad Sci U S A 2000; 97: 7567-72.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7567-7572
    • Shi, N.1    Pardridge, W.M.2
  • 42
    • 33847148508 scopus 로고    scopus 로고
    • Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain
    • Huang R-q, Ke W-l, Qu Y-h, Zhu J-h, Pei Y-y, Jiang C. Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain. J Biomed Sci 2007; 14: 121-8.
    • (2007) J Biomed Sci , vol.14 , pp. 121-128
    • Huang, R.-Q.1    Ke, W.-L.2    Qu, Y.-H.3    Zhu, J.-H.4    Pei, Y.-Y.5    Jiang, C.6
  • 43
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    • Boado RJ, Zhang Y, Zhang Y, Pardridge WM. Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol Bioeng 2006; 96: 381-391.
    • (2006) Biotechnol Bioeng , vol.96 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 44
    • 85012373035 scopus 로고
    • Diffusion of univalent ions across the lamellae of swollen phospholipids
    • Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965; 13: 238-52.
    • (1965) J Mol Biol , vol.13 , pp. 238-252
    • Bangham, A.D.1    Standish, M.M.2    Watkins, J.C.3
  • 45
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science 2004; 303: 1818-22.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 46
    • 0030681273 scopus 로고    scopus 로고
    • Liposomes. Opportunities in drug delivery
    • Allen TM. Liposomes. Opportunities in drug delivery. Drugs 1997; 54(Suppl 4): 8-14.
    • (1997) Drugs , vol.54 , Issue.SUPPL. 4 , pp. 8-14
    • Allen, T.M.1
  • 47
    • 0016622971 scopus 로고
    • Homing of Liposomes to Target-Cells
    • Gregoriadis G. Homing of Liposomes to Target-Cells. Biochem Soc Trans 1975; 3: 613-8.
    • (1975) Biochem Soc Trans , vol.3 , pp. 613-618
    • Gregoriadis, G.1
  • 48
    • 0030161222 scopus 로고    scopus 로고
    • Liposomes as delivery agents for medical imaging
    • Torchilin VP. Liposomes as delivery agents for medical imaging. Mol Med Today 1996; 2: 242-9.
    • (1996) Mol Med Today , vol.2 , pp. 242-249
    • Torchilin, V.P.1
  • 50
    • 20444430090 scopus 로고    scopus 로고
    • Transport of nerve growth factor encapsulated into liposomes across the bloodbrain barrier: In vitro and in vivo studies
    • Xie Y, Ye L, Zhang X, Cui W, Lou J, Nagai T, et al. Transport of nerve growth factor encapsulated into liposomes across the bloodbrain barrier: in vitro and in vivo studies. J Control Release 2005; 105: 106-119.
    • (2005) J Control Release , vol.105 , pp. 106-119
    • Xie, Y.1    Ye, L.2    Zhang, X.3    Cui, W.4    Lou, J.5    Nagai, T.6
  • 51
    • 24644485229 scopus 로고    scopus 로고
    • Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects
    • Schnyder A, Krahenbuhl S, Drewe J, Huwyler J. Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects. J Drug Target 2005; 13: 325-35.
    • (2005) J Drug Target , vol.13 , pp. 325-335
    • Schnyder, A.1    Krahenbuhl, S.2    Drewe, J.3    Huwyler, J.4
  • 53
    • 45249093445 scopus 로고    scopus 로고
    • Drug delivery systems: Application of liposomal antitumor agents to neuroectodermal cancer treatment
    • Di Paolo D, Pastorino F, Brignole C, Marimpietri D, Loi M, Ponzoni M, et al. Drug delivery systems: application of liposomal antitumor agents to neuroectodermal cancer treatment. Tumori 2008; 94: 246-53.
    • (2008) Tumori , vol.94 , pp. 246-253
    • Di Paolo, D.1    Pastorino, F.2    Brignole, C.3    Marimpietri, D.4    Loi, M.5    Ponzoni, M.6
  • 54
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carrier
    • Torchilin VP. Recent advances with liposomes as pharmaceutical carrier. Nat Rev Drug Discov 2005; 4; 145-60.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 55
    • 0034193310 scopus 로고    scopus 로고
    • Therapeutic applications of colloidal drug carriers
    • Barratt G. Therapeutic applications of colloidal drug carriers. Pharm Sci Technolo Today 2000; 3: 163-71.
    • (2000) Pharm Sci Technolo Today , vol.3 , pp. 163-171
    • Barratt, G.1
  • 56
    • 0008817404 scopus 로고    scopus 로고
    • Polysaccharide coated liposomes for oral drug delivery: Development and characterization
    • In: Vyas SP, Dixit VK, editors, New Delhi: CBS Publishers
    • Sihorkar V, Vyas SP. Polysaccharide coated liposomes for oral drug delivery: Development and characterization. In: Vyas SP, Dixit VK, editors. Advances in Liposomal Therapeutics. New Delhi: CBS Publishers; 2001.
    • (2001) Advances in Liposomal Therapeutics
    • Sihorkar, V.1    Vyas, S.P.2
  • 57
    • 35048842305 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: An update review
    • Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: an update review. Curr Drug Deliv 2007; 4: 297-305.
    • (2007) Curr Drug Deliv , vol.4 , pp. 297-305
    • Samad, A.1    Sultana, Y.2    Aqil, M.3
  • 58
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis F, Pridgen E, Molnar L, Farokhzad O. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharmacol 2008; 5: 505-15.
    • (2008) Mol Pharmacol , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.3    Farokhzad, O.4
  • 59
    • 33745605771 scopus 로고    scopus 로고
    • Nanotechnology: Intelligent design to treat complex disease
    • Couvreur P, Vauthier C. Nanotechnology: intelligent design to treat complex disease. Pharm Res 2006; 23: 1417-50.
    • (2006) Pharm Res , vol.23 , pp. 1417-1450
    • Couvreur, P.1    Vauthier, C.2
  • 60
    • 34250819325 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery
    • Van Vlerken L, Vyas T, Amiji M. Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery. Pharm Res 2007; 24: 1405-14.
    • (2007) Pharm Res , vol.24 , pp. 1405-1414
    • van Vlerken, L.1    Vyas, T.2    Amiji, M.3
  • 61
    • 0032588348 scopus 로고    scopus 로고
    • Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting
    • Peracchia MT, Fattal E, Desmaële D, Besnard M, Noël JP, Gomis JM, et al. Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting. J Control Release 1999; 60: 121-8.
    • (1999) J Control Release , vol.60 , pp. 121-128
    • Peracchia, M.T.1    Fattal, E.2    Desmaële, D.3    Besnard, M.4    Noël, J.P.5    Gomis, J.M.6
  • 63
    • 0037681850 scopus 로고    scopus 로고
    • Pharmacokinetics of pegylated liposomal doxorubicin: Review of animal and human studies
    • Gabizon A, Shmeeda H, Barenholz Y. Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies. Clin Pharmacokinet 2003; 42: 419-36.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 419-436
    • Gabizon, A.1    Shmeeda, H.2    Barenholz, Y.3
  • 64
    • 30744467688 scopus 로고    scopus 로고
    • Polyethylene glycol (PEG) modified 99mTc-HMPAO-liposome for improving blood circulation and biodistribution: The effect of the extent of PEGylation
    • Lee CM, Choi Y, Huh EJ, Lee KY, Song HC, Sun MJ, et al. Polyethylene glycol (PEG) modified 99mTc-HMPAO-liposome for improving blood circulation and biodistribution: the effect of the extent of PEGylation. Cancer Biother Radiopharm 2005; 20: 620-8.
    • (2005) Cancer Biother Radiopharm , vol.20 , pp. 620-628
    • Lee, C.M.1    Choi, Y.2    Huh, E.J.3    Lee, K.Y.4    Song, H.C.5    Sun, M.J.6
  • 65
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens D, Peppas N. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006; 307: 93-102.
    • (2006) Int J Pharm , vol.307 , pp. 93-102
    • Owens, D.1    Peppas, N.2
  • 66
    • 12344262085 scopus 로고    scopus 로고
    • Drug transport to brain with targeted liposomes
    • Schnyder A, Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2005; 2: 99-107.
    • (2005) NeuroRx , vol.2 , pp. 99-107
    • Schnyder, A.1    Huwyler, J.2
  • 67
    • 11944271728 scopus 로고    scopus 로고
    • Coupling of Metal Containing Homing Devices to Liposomes via a Maleimide Linker: Use of TCEP to Stabilize Thiol-groups without Scavenging Metals
    • Visser CC, Voorwinden LH, Harders LR, Eloualid M, van Bloois L, Crommelin DJA, et al. Coupling of Metal Containing Homing Devices to Liposomes via a Maleimide Linker: Use of TCEP to Stabilize Thiol-groups without Scavenging Metals. J Drug Target 2004; 12: 569-73.
    • (2004) J Drug Target , vol.12 , pp. 569-573
    • Visser, C.C.1    Voorwinden, L.H.2    Harders, L.R.3    Eloualid, M.4    van Bloois, L.5    Crommelin, D.J.A.6
  • 71
    • 0021818675 scopus 로고
    • Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
    • Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface; Science 1985; 228: 1315-7.
    • (1985) Science , vol.228 , pp. 1315-1317
    • Smith, G.P.1
  • 96
    • 0035981099 scopus 로고    scopus 로고
    • Phototriggering of liposomal drug delivery systems
    • Shum P, Kim JM, Thompson DH. Phototriggering of liposomal drug delivery systems. Adv Drug Deliv Rev 2001; 53: 273-84.
    • (2001) Adv Drug Deliv Rev , vol.53 , pp. 273-284
    • Shum, P.1    Kim, J.M.2    Thompson, D.H.3
  • 98
    • 0035981024 scopus 로고    scopus 로고
    • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors
    • Needham D, Dewhirst MW. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev 2001; 53: 285-305.
    • (2001) Adv Drug Deliv Rev , vol.53 , pp. 285-305
    • Needham, D.1    Dewhirst, M.W.2
  • 100
    • 0036148372 scopus 로고    scopus 로고
    • AC-magnetic field controlled drug release from magnetoliposomes: Design of a method for site-specific chemotherapy
    • Babincová M, Cicmanec P, Altanerová V, Altaner C, Babinec P. AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy. Bioelectrochemistry 2002; 55: 17-9.
    • (2002) Bioelectrochemistry , vol.55 , pp. 17-19
    • Babincová, M.1    Cicmanec, P.2    Altanerová, V.3    Altaner, C.4    Babinec, P.5
  • 102
    • 0034662609 scopus 로고    scopus 로고
    • Hyperthermia enables tumorspecific nanoparticle delivery: Effect of particle size
    • Kong G, Braun RD, Dewhirst MW. Hyperthermia enables tumorspecific nanoparticle delivery: effect of particle size. Cancer Res 2000; 60: 4440-5.
    • (2000) Cancer Res , vol.60 , pp. 4440-4445
    • Kong, G.1    Braun, R.D.2    Dewhirst, M.W.3
  • 103
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • Huwyler J, Wu D, Pardridge WM. Brain drug delivery of small molecules using immunoliposomes. Proc Natl Acad Sci U S A 1996; 93: 14164-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14164-9
    • Huwyler, J.1    Wu, D.2    Pardridge, W.M.3
  • 104
    • 34848883058 scopus 로고    scopus 로고
    • Decreased circulation time offsets increased efficacy of PEGylated nanocarriers targeting folate receptors of glioma
    • McNeeley KM, Annapragada A, Bellamkonda RV. Decreased circulation time offsets increased efficacy of PEGylated nanocarriers targeting folate receptors of glioma. Nanotechnology 2007; 18: 385101.
    • (2007) Nanotechnology , vol.18 , pp. 385101
    • McNeeley, K.M.1    Annapragada, A.2    Bellamkonda, R.V.3
  • 105
    • 67349259953 scopus 로고    scopus 로고
    • Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors
    • McNeeley KM, Karathanasis E, Annapragada AV, Bellamkonda RV. Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors. Biomaterials 2009; 30: 3986-95.
    • (2009) Biomaterials , vol.30 , pp. 3986-3995
    • McNeeley, K.M.1    Karathanasis, E.2    Annapragada, A.V.3    Bellamkonda, R.V.4
  • 106
    • 58549114669 scopus 로고    scopus 로고
    • Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting
    • Ko YT, Bhattacharya R, Bickel U. Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting. J Control Release 2009; 133: 230-7.
    • (2009) J Control Release , vol.133 , pp. 230-237
    • Ko, Y.T.1    Bhattacharya, R.2    Bickel, U.3
  • 107
    • 58849127706 scopus 로고    scopus 로고
    • Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His
    • Feng B, Tomizawa K, Michiue H, Miyatake S, Han XJ, Fujimura A et al. Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His. Biomaterials 2009; 30: 1746-55.
    • (2009) Biomaterials , vol.30 , pp. 1746-1755
    • Feng, B.1    Tomizawa, K.2    Michiue, H.3    Miyatake, S.4    Han, X.J.5    Fujimura, A.6
  • 108
    • 68049102034 scopus 로고    scopus 로고
    • Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis
    • Kizelsztein P, Ovadia H, Garbuzenko O, Sigal A, Barenholz Y. Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis. J Neuroimmunol 2009; 213: 20-5.
    • (2009) J Neuroimmunol , vol.213 , pp. 20-25
    • Kizelsztein, P.1    Ovadia, H.2    Garbuzenko, O.3    Sigal, A.4    Barenholz, Y.5
  • 109
    • 70350026365 scopus 로고    scopus 로고
    • Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: Initial experience
    • Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA et al. Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol 2009; 95: 185-97.
    • (2009) J Neurooncol , vol.95 , pp. 185-197
    • Grahn, A.Y.1    Bankiewicz, K.S.2    Dugich-Djordjevic, M.3    Bringas, J.R.4    Hadaczek, P.5    Johnson, G.A.6
  • 110
    • 0034221644 scopus 로고    scopus 로고
    • Lipid-DNA and lipid polyelectrolyte mesophases: Structure and exchange kinetics
    • Artzner F, Zantl R, Radler JO. Lipid-DNA and lipid polyelectrolyte mesophases: structure and exchange kinetics. Cell Mol Biol 2000; 46: 967-78.
    • (2000) Cell Mol Biol , vol.46 , pp. 967-978
    • Artzner, F.1    Zantl, R.2    Radler, J.O.3
  • 111
    • 1842764711 scopus 로고    scopus 로고
    • Improving lipoplex mediated gene transfer into C6 glioma cells and primary neurons
    • da Cruz MT, Simoes S, de Lima MC. Improving lipoplex mediated gene transfer into C6 glioma cells and primary neurons. Exp Neurol 2004; 187: 65-75.
    • (2004) Exp Neurol , vol.187 , pp. 65-75
    • da Cruz, M.T.1    Simoes, S.2    de Lima, M.C.3
  • 112
    • 0037249449 scopus 로고    scopus 로고
    • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism
    • Zhang Y, Calon F, Zhu C, Boado RJ, Pardridge WM. Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism. Hum Gene Ther 2003; 14: 1-12.
    • (2003) Hum Gene Ther , vol.14 , pp. 1-12
    • Zhang, Y.1    Calon, F.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5
  • 113
    • 77349098528 scopus 로고    scopus 로고
    • Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo
    • Cardoso AL, Costa P, de Almeida LP, Simoes S, Plesnila N, Culmsee C, et al. Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo. J Control Release 2010; 142: 392-403.
    • (2010) J Control Release , vol.142 , pp. 392-403
    • Cardoso, A.L.1    Costa, P.2    de Almeida, L.P.3    Simoes, S.4    Plesnila, N.5    Culmsee, C.6
  • 114
    • 34548812551 scopus 로고    scopus 로고
    • The role of amyloid beta peptide 42 in Alzheimer's disease
    • Findeis MA. The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol Ther 2007; 116: 266-86.
    • (2007) Pharmacol Ther , vol.116 , pp. 266-286
    • Findeis, M.A.1
  • 115
    • 0036975682 scopus 로고    scopus 로고
    • Beta-amyloid production, aggregation, clearance as targets for therapy in Alzheimer's disease
    • De Felice FG, Ferreira ST. Beta-amyloid production, aggregation, clearance as targets for therapy in Alzheimer's disease. Cell Mol Neurobiol 2002; 22: 545-63.
    • (2002) Cell Mol Neurobiol , vol.22 , pp. 545-563
    • de Felice, F.G.1    Ferreira, S.T.2
  • 118
    • 0037223101 scopus 로고    scopus 로고
    • Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
    • Matsuoka Y, Saito M, LaFrancois J, Gaynor K, Olm V, Wang L, et al. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci 2003; 23: 29-33.
    • (2003) J Neurosci , vol.23 , pp. 29-33
    • Matsuoka, Y.1    Saito, M.2    LaFrancois, J.3    Gaynor, K.4    Olm, V.5    Wang, L.6
  • 119
    • 82955195917 scopus 로고    scopus 로고
    • Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide
    • doi:10.1016/j.jbiotec.2011.06.037
    • Re F, Cambianica I, Sesana S, Salvati E, Cagnotto A, Salmona M, et al. Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide. J Biotechnol 2011; doi:10.1016/j.jbiotec.2011.06.037
    • (2011) J Biotechnol
    • Re, F.1    Cambianica, I.2    Sesana, S.3    Salvati, E.4    Cagnotto, A.5    Salmona, M.6
  • 120
    • 80053209371 scopus 로고    scopus 로고
    • Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model
    • doi:10.1016/j.nano.2011.05.004
    • Re F, Cambianica I, Zona C, Sesana S, Gregori M, Rigolio R, et al. Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model. Nanomedicine 2011; doi:10.1016/j.nano.2011.05.004
    • (2011) Nanomedicine
    • Re, F.1    Cambianica, I.2    Zona, C.3    Sesana, S.4    Gregori, M.5    Rigolio, R.6
  • 122
    • 0027121513 scopus 로고
    • Mixed micelles in drug delivery
    • Lasic DD. Mixed micelles in drug delivery. Nature 1992; 355: 279-80.
    • (1992) Nature , vol.355 , pp. 279-280
    • Lasic, D.D.1
  • 126
    • 0032778659 scopus 로고    scopus 로고
    • Polymeric micelles: A new generation of colloidal drug carriers
    • Jones M, Leroux J. Polymeric micelles: a new generation of colloidal drug carriers. Eur J Pharm Biopharm 1999; 48: 101-11.
    • (1999) Eur J Pharm Biopharm , vol.48 , pp. 101-111
    • Jones, M.1    Leroux, J.2
  • 127
    • 0035850224 scopus 로고    scopus 로고
    • Structure and design of polymeric surfactant based drug delivery systems
    • Torchilin VP. Structure and design of polymeric surfactant based drug delivery systems. J Control Release 2001; 73: 137-72.
    • (2001) J Control Release , vol.73 , pp. 137-172
    • Torchilin, V.P.1
  • 128
    • 0029360757 scopus 로고
    • Block copolymer micelles as long circulating drug vehicles
    • Kwon GS, Kataoka K. Block copolymer micelles as long circulating drug vehicles. Adv Drug Deliv Rev 1995; 16: 295-309.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 295-309
    • Kwon, G.S.1    Kataoka, K.2
  • 131
    • 1642541103 scopus 로고    scopus 로고
    • Polymeric micelles for delivery of poorly watersoluble compounds
    • Kwon GS. Polymeric micelles for delivery of poorly watersoluble compounds. Crit Rev Ther Drug Carr Syst 2003; 20: 357-403.
    • (2003) Crit Rev Ther Drug Carr Syst , vol.20 , pp. 357-403
    • Kwon, G.S.1
  • 133
    • 0035994313 scopus 로고    scopus 로고
    • Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model
    • Le Garrec D, Taillefer J, Van Lier JE, Lenaerts V, Leroux JC. Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model. J Drug Target 2002; 10: 429-37.
    • (2002) J Drug Target , vol.10 , pp. 429-437
    • Le Garrec, D.1    Taillefer, J.2    van Lier, J.E.3    Lenaerts, V.4    Leroux, J.C.5
  • 134
    • 0024351519 scopus 로고
    • The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting
    • Kabanov AV, Chekhonin VP, Alakhov V, Batrakova EV, Lebedev AS, Melik-Nubarov NS, et al. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett 1989; 258: 343-5.
    • (1989) FEBS Lett , vol.258 , pp. 343-345
    • Kabanov, A.V.1    Chekhonin, V.P.2    Alakhov, V.3    Batrakova, E.V.4    Lebedev, A.S.5    Melik-Nubarov, N.S.6
  • 135
    • 0031239096 scopus 로고    scopus 로고
    • Interactions of pluronic block copolymers with brain microvessel endothelial cells: Evidence of two potential pathways for drug absorption
    • Miller DW, Batrakova EV, Waltner TO, Alakhov VY, Kabanov AV. Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. Bioconjug Chem 1997; 8: 649-57.
    • (1997) Bioconjug Chem , vol.8 , pp. 649-657
    • Miller, D.W.1    Batrakova, E.V.2    Waltner, T.O.3    Alakhov, V.Y.4    Kabanov, A.V.5
  • 136
    • 0031938986 scopus 로고    scopus 로고
    • Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer
    • Katayose S, Kataoka K. Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer. J Pharm Sci 1998; 87: 160-3.
    • (1998) J Pharm Sci , vol.87 , pp. 160-163
    • Katayose, S.1    Kataoka, K.2
  • 137
    • 8544254690 scopus 로고    scopus 로고
    • Blockcopolymer of polyethylene glycol and polylysine as a carrier of organic iodine: Design of long-circulating particulate contrast medium for x-ray computed tomography
    • Trubetskoy VS, Gazelle GS, Wolf GL, Torchilin VP. Blockcopolymer of polyethylene glycol and polylysine as a carrier of organic iodine: design of long-circulating particulate contrast medium for x-ray computed tomography. J Drug Target 1997; 4: 381-8.
    • (1997) J Drug Target , vol.4 , pp. 381-388
    • Trubetskoy, V.S.1    Gazelle, G.S.2    Wolf, G.L.3    Torchilin, V.P.4
  • 138
    • 0025343062 scopus 로고
    • Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
    • Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, et al. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990; 50: 1693-700.
    • (1990) Cancer Res , vol.50 , pp. 1693-1700
    • Yokoyama, M.1    Miyauchi, M.2    Yamada, N.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 139
    • 0031646316 scopus 로고    scopus 로고
    • Novel polyion complex micelles entrapping enzyme molecules in the core. Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium
    • Harada A, Kataoka K. Novel polyion complex micelles entrapping enzyme molecules in the core. Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium. Macromolecules 1998; 31: 288-94.
    • (1998) Macromolecules , vol.31 , pp. 288-294
    • Harada, A.1    Kataoka, K.2
  • 143
    • 0032559233 scopus 로고    scopus 로고
    • Metoxy poly(ethylene glycol) and (-caprolactone amphiphilic block copolymeric micelle containing indomethacin. II. Micelle formation and drug release behaviors
    • Kim SY, Shin IG, Lee YM, Cho CG, Sung YK. Metoxy poly(ethylene glycol) and (-caprolactone amphiphilic block copolymeric micelle containing indomethacin. II. Micelle formation and drug release behaviors. J Control Release 1998; 51: 13-22.
    • (1998) J Control Release , vol.51 , pp. 13-22
    • Kim, S.Y.1    Shin, I.G.2    Lee, Y.M.3    Cho, C.G.4    Sung, Y.K.5
  • 144
    • 0032170975 scopus 로고    scopus 로고
    • Polycaprolactone-bpoly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818
    • Allen C, Yu Y, Maysinger D, Eisenberg A. Polycaprolactone-bpoly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818. Bioconjug Chem 1998; 9: 564-72.
    • (1998) Bioconjug Chem , vol.9 , pp. 564-572
    • Allen, C.1    Yu, Y.2    Maysinger, D.3    Eisenberg, A.4
  • 145
    • 0000952093 scopus 로고    scopus 로고
    • Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. 1. Characterization of water dispersible micelle-forming systems
    • Hagan SA, Coombes AGA, Garnett MC. Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. 1. Characterization of water dispersible micelle-forming systems. Langmuir 1996; 12: 2153-61.
    • (1996) Langmuir , vol.12 , pp. 2153-2161
    • Hagan, S.A.1    Coombes, A.G.A.2    Garnett, M.C.3
  • 146
    • 0030900212 scopus 로고    scopus 로고
    • Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers
    • Ramaswamy M, Zhang X, Burt H, Wasan KM. Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers. J Pharm Sci 1997; 86: 460-4.
    • (1997) J Pharm Sci , vol.86 , pp. 460-464
    • Ramaswamy, M.1    Zhang, X.2    Burt, H.3    Wasan, K.M.4
  • 147
    • 0032473546 scopus 로고
    • Interpolyelectrolyte and block ionomer complexes for gene delivery: Physico-chemical aspects
    • Kabanov AV, Kabanov VA. Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects. Adv Drug Deliv Rev 1990; 30: 49-60.
    • (1990) Adv Drug Deliv Rev , vol.30 , pp. 49-60
    • Kabanov, A.V.1    Kabanov, V.A.2
  • 148
    • 0029875413 scopus 로고    scopus 로고
    • Polyethyleneglycol based micelles as carriers of therapeutic and diagnostic agents
    • Trubetskoy VS, Torchilin VP. Polyethyleneglycol based micelles as carriers of therapeutic and diagnostic agents. STP Pharma Sci 1996; 6: 79-86.
    • (1996) STP Pharma Sci , vol.6 , pp. 79-86
    • Trubetskoy, V.S.1    Torchilin, V.P.2
  • 149
    • 24644438254 scopus 로고    scopus 로고
    • Lipid-core micelles for targeted drug delivery
    • Torchilin VP. Lipid-core micelles for targeted drug delivery. Curr Drug Deliv 2005; 2: 319-27.
    • (2005) Curr Drug Deliv , vol.2 , pp. 319-327
    • Torchilin, V.P.1
  • 150
    • 39149131971 scopus 로고    scopus 로고
    • Lipid-based parenteral drug delivery systems: Biological implications
    • In: Wasan K, editor, Hoboken (NJ): John Wiley & Sons
    • Torchilin VP. Lipid-based parenteral drug delivery systems: biological implications. In: Wasan K, editor. Role of lipid excipients in modifying oral and parenteral drug delivery. Hoboken (NJ): John Wiley & Sons; 2007.
    • (2007) Role of lipid excipients in modifying oral and parenteral drug delivery
    • Torchilin, V.P.1
  • 151
    • 33845388144 scopus 로고    scopus 로고
    • Micellar nanocarriers: Pharmaceutical perspectives
    • Torchilin VP. Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 2007; 24: 1-16.
    • (2007) Pharm Res , vol.24 , pp. 1-16
    • Torchilin, V.P.1
  • 152
    • 1942486331 scopus 로고    scopus 로고
    • Micelles from lipid derivatives of watersoluble polymers as delivery systems for poorly soluble drugs
    • Lukyanov AN, Torchilin VP. Micelles from lipid derivatives of watersoluble polymers as delivery systems for poorly soluble drugs. Adv Drug Del Rev 2004; 56: 1273-89.
    • (2004) Adv Drug Del Rev , vol.56 , pp. 1273-1289
    • Lukyanov, A.N.1    Torchilin, V.P.2
  • 166
    • 0035795123 scopus 로고    scopus 로고
    • p-Nitrophenylcarbonyl-PEG-PEliposomes: Fast and simple attachment of specific ligands including monoclonal antibodies, to distal ends of PEG chains via pnitrophenylcarbonyl groups
    • Torchilin VP, Levchenko TS, Lukyanov AN, Khaw BA, Klibanov AL, Rammohan R, et al. p-Nitrophenylcarbonyl-PEG-PEliposomes: fast and simple attachment of specific ligands including monoclonal antibodies, to distal ends of PEG chains via pnitrophenylcarbonyl groups. Biochim Biophys Acta 2001; 1511: 397-411.
    • (2001) Biochim Biophys Acta , vol.1511 , pp. 397-411
    • Torchilin, V.P.1    Levchenko, T.S.2    Lukyanov, A.N.3    Khaw, B.A.4    Klibanov, A.L.5    Rammohan, R.6
  • 168
    • 0035902477 scopus 로고    scopus 로고
    • TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
    • Torchilin VP, Rammohan R, Weissig V, Levchenko TS. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci U S A 2001; 98: 8786-91.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8786-8791
    • Torchilin, V.P.1    Rammohan, R.2    Weissig, V.3    Levchenko, T.S.4
  • 169
    • 57349184166 scopus 로고    scopus 로고
    • Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery
    • Ko YT, Kale A, Hartner WC, Papahadjopoulos-Sternberg B, Torchilin VP. Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery. J Control Release 2009; 133: 132-8.
    • (2009) J Control Release , vol.133 , pp. 132-138
    • Ko, Y.T.1    Kale, A.2    Hartner, W.C.3    Papahadjopoulos-Sternberg, B.4    Torchilin, V.P.5
  • 170
    • 77955817254 scopus 로고    scopus 로고
    • Effective stabilization and delivery of siRNA: Reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles
    • Musacchio T, Vaze O, D'Souza G, Torchilin VP. Effective stabilization and delivery of siRNA: reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles. Bioconjug Chem 2010; 21: 1530-6.
    • (2010) Bioconjug Chem , vol.21 , pp. 1530-1536
    • Musacchio, T.1    Vaze, O.2    D'Souza, G.3    Torchilin, V.P.4
  • 171
    • 33750052628 scopus 로고    scopus 로고
    • PEGylated phospholipid nanomicelles interact with α amyloid(1-42) and mitigate its α-sheet formation, aggregation and neurotoxicity in vitro
    • Pai AS, Rubinstein I, Onyuksel H. PEGylated phospholipid nanomicelles interact with α amyloid(1-42) and mitigate its α-sheet formation, aggregation and neurotoxicity in vitro. Peptides 2006; 27: 2858-66.
    • (2006) Peptides , vol.27 , pp. 2858-2866
    • Pai, A.S.1    Rubinstein, I.2    Onyuksel, H.3
  • 173
    • 33847256524 scopus 로고    scopus 로고
    • A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: Micelles, nanospheres, nanocapsules and polymersomes
    • Letchford K, Burt H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur J Pharm Biopharm 2007; 65: 259-69.
    • (2007) Eur J Pharm Biopharm , vol.65 , pp. 259-269
    • Letchford, K.1    Burt, H.2
  • 174
    • 0036297426 scopus 로고    scopus 로고
    • A Novel phase inversion-based process for the preparation of lipid nanocarriers
    • Heurtault B, Saulnier P, Pech B, Proust J-E, Benoit J-P. A Novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm Res 2002; 19: 875-80.
    • (2002) Pharm Res , vol.19 , pp. 875-880
    • Heurtault, B.1    Saulnier, P.2    Pech, B.3    Proust, J.-E.4    Benoit, J.-P.5
  • 187
    • 34548494402 scopus 로고    scopus 로고
    • Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments
    • Beduneau A, Saulnier P, Hindre F, Clavreul A, Leroux JC, Benoit JP. Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments. Biomaterials 2007; 28: 4978-90.
    • (2007) Biomaterials , vol.28 , pp. 4978-4990
    • Beduneau, A.1    Saulnier, P.2    Hindre, F.3    Clavreul, A.4    Leroux, J.C.5    Benoit, J.P.6
  • 191
    • 57649143623 scopus 로고    scopus 로고
    • Inequalities in healthy life years in the 25 countries of the European Union in 2005: A cross-national meta-regression analysis
    • Jagger C, Gillies C, Moscone F, Cambois E, Van Oyen H, Nusselder W, et al. Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis. Lancet 2008; 372: 2124-31.
    • (2008) Lancet , vol.372 , pp. 2124-2131
    • Jagger, C.1    Gillies, C.2    Moscone, F.3    Cambois, E.4    van Oyen, H.5    Nusselder, W.6
  • 192
    • 59649097447 scopus 로고    scopus 로고
    • Lipid nanoparticles for parenteral delivery of actives
    • Joshi MD, Müller RH. Lipid nanoparticles for parenteral delivery of actives. Eur J Pharm Biopharm 2009. 71: 161-72.
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 161-172
    • Joshi, M.D.1    Müller, R.H.2


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