Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism

Human Gene Therapy

Volumn 14, Issue 1, 2003, Pages 1-12

  Zhang, Yun ^a   Calon, Frederic ^a   Zhu, Chunni ^a   Boado, Ruben J ^a   Pardridge, William M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G2; IMMUNOLIPOSOME; MONOCLONAL ANTIBODY; NEUROTOXIN; OXIDOPAMINE; PLASMID DNA; TRANSFERRIN RECEPTOR; TYROSINE 3 MONOOXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOTOR DYSFUNCTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARKINSONISM; PLASMID; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM NEOPLASMS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE THERAPY; GLIOMA; HUMANS; INJECTIONS, INTRAVENOUS; LIPOSOMES; LIVER; MALE; MOTOR ACTIVITY; PARKINSON DISEASE; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; RECOVERY OF FUNCTION; TIME FACTORS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; MURINAE;

EID: 0037249449     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340360464660     Document Type: Article

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