Polyethylene glycol (PEG) modified 99mTc-HMPAO-liposome for improving blood circulation and biodistribution: The effect of the extent of PEGylation

Cancer Biotherapy and Radiopharmaceuticals

Volumn 20, Issue 6, 2005, Pages 620-628

  Lee, Chang Moon ^a   Choi, Yongdoo ^b   Huh, Eun Jeong ^a   Lee, Ki Young ^a   Song, Ho Chun ^b   Sun, Min Jung ^c   Jeong, Hwan Jeong ^d   Cho, Chong Su ^e   Bom, Hee Seung ^a,b  

^a Chonnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

^d Chonbuk National University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

Blood circulation time; Imaging by technetium 99mTc; Liposome; Liposome biodistribution; Poly(ethylene glycol)

Indexed keywords

CHOLESTEROL; DISTEAROYLPHOSPHATIDYLETHANOLAMINE N MACROGOL; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; LIPOSOME; MACROGOL; PHOSPHATIDYLETHANOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; ISOTOPE LABELING; LIGHT SCATTERING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN;

ANIMALS; DRUG STABILITY; GAMMA CAMERAS; HEART; HUMANS; LIPOSOMES; LIVER; PHOSPHATIDYLCHOLINES; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SPLEEN; TECHNETIUM TC 99M EXAMETAZIME; TISSUE DISTRIBUTION;

EID: 30744467688     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2005.20.620     Document Type: Article

References (24)

1. Gregoriadis G, Florence AT. Liposomes in drug delivery. Drugs 1993;45:15.
2. Kim S. Liposomes as carriers for cancer chemotherapy. Current status and future prospects. Drugs 1993;46:618.
3. Torchilin VP, Omelyanenko VG, Papisov MI, et al. Poly(ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta 1994;1195:11.
4. 99mTc-MIBI encapsulated in PEG-liposomes: A promising radiotracer for tumor imaging. Eur J Nucl Med Mol Imaging 2003;30:502.
5. Li H, Song JH, Park JS, et al. Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor. Int J Pharm 2003;258:11.
6. Minato S, Iwanaga K, Kakemi M, et al. Application of polyethylene glycol (PEG)-modified liposomes for oral vaccine: Effect of lipid dose on systemic and mucosal immunity. J Contr Rel 2003;89:189.
7. Sadzuka Y, Nakade A, Tsuruda T, et al. Study on the characterization of mixed polyethyleneglycol-modified liposomes containing doxorubicin. J Contr Rel 2003;91:271.
8. Cao Y, Suresh MR. A simple and efficient method for radiolabeling of preformed liposomes. J Pharm Pharmaceut Sci 1998;1:31.
9. Laverman P, Dams ET, Storm G, et al. Microscopic localization of PEG-liposomes in a rat model of focal infection. J Contr Rel 2001;75:347.
10. Moreira JN, Almeida LM, Geraldes CF, et al. Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoyl pullulan). J Mater Sci: Mater Med 1996;7:301.
11. Awasthi VD, Garcia D, Goins BA, et al. Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits. Int J Pharm 2003;253:121.
12. 99mTc] human serum albumin. Nucl Med Biol 2001;28:435.
13. Allen C, Dos Santos N, Gallagher R, et al. Controlling the physical behavior and biological performance of liposome formulations through use of surface-grafted poly(ethylene glycol). Biosci Rep 2002;22:225.
14. Nicolazzi C, Mignet N, de la Figuera N, et al. Anionic polyethyleneglycol lipids added to cationic lipoplexes increase their plasmatic circulation time. J Contr Rel 2003;88:429.
15. Kim JK, Choi SH, Kim CO, et al. Enhancement of polyethylene glycol (PEG)-modified cationic liposome-mediated gene deliveries: Effects on serum stability and transfection efficiency. J Pharm Pharmacol 2003;55:453.
16. Klibanov AL, Maruyama K, Torchilin VP, et al. Amphipathic polyethylene glycols effectively prolong the circulation time of liposomes. FEBS Lett 1990;268:235.
17. Omori N, Maruyama K, Jin G, et al. Targeting of postischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin. Neurol Res 2003;25:275.
18. Sadzuka Y, Nakade A, Hirama R, et al. Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome. Int J Pharm 2002;238:171.
19. Nicholas AR, Scott MJ, Kennedy NI, et al. Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency, and permeability of vesicles. Biochim Biophys Acta 2000;1463:167.
20. Bakker-Woudenberg IA. Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious foci. Int J Antimicrob Agents 2002;19:299.
21. Woodle MC. Controlling liposome blood clearance by surface-grafted polymers. Adv Drug Deliv Rev 1998;32:139.
22. DeNardo SJ, Yao Z, Lam KS, et al. Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice. Clin Cancer Res 2003;9:3854.
23. Ishida T, Harashima H, Kiwada H. Liposome clearance. Biosci Rep 2002;22:197.
24. Bradley AJ, Devine DV, Ansell SM, et al. Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)-lipids. Arch Biochem Biophys 1998;357:185.