Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery

Journal of Controlled Release

Volumn 133, Issue 2, 2009, Pages 132-138

  Ko, Young Tag ^a   Kale, Amit ^a   Hartner, William C ^a   Papahadjopoulos Sternberg, Brigitte ^b   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b NanoAnalytical Laboratory   (United States)

Author keywords

Gene delivery; Long circulating nanoparticles; Polyethylene glycol (PEG); Polyethylenimine (PEI); Self assembly

Indexed keywords

AGGLOMERATION; CARDIOVASCULAR SYSTEM; COLLOIDS; DNA; ETHYLENE GLYCOL; GENE TRANSFER; GENES; GENETIC ENGINEERING; GLYCOLS; MICELLES; NANOPARTICLES; ORGANIC ACIDS; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENES; THERMOPLASTICS;

BLOOD CIRCULATIONS; CLINICAL APPLICATIONS; DELIVERY SYSTEMS; ENZYMATIC DEGRADATIONS; ETHANOLAMINE; GENE DELIVERIES; GENE DELIVERY; GENE THERAPIES; GREEN FLUORESCENCE PROTEINS; INTRAVENOUS INJECTIONS; LIPID MONOLAYERS; LOCAL ADMINISTRATIONS; LONG-CIRCULATING NANOPARTICLES; NON-VIRAL GENE DELIVERIES; PLASMID DNAS; POLYETHYLENE IMINES; POLYETHYLENIMINE; POLYETHYLENIMINE (PEI); SELF-ASSEMBLY;

NUCLEIC ACIDS;

GREEN FLUORESCENT PROTEIN; NANOPARTICLE; PHOSPHOLIPID; PHOSPHOLIPID POLYETHYLENEIMINE CONJUGATE; PLASMID DNA; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG HALF LIFE; GENETIC TRANSFECTION; LIPID MONOLAYER; MALE; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL;

ANIMALS; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DNA; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICELLES; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NIH 3T3 CELLS; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; PHOSPHORYLCHOLINE; PLASMIDS; POLYETHYLENEIMINE; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 57349184166     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.079     Document Type: Article

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