-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956; 123 (3191): 309-314.
-
(1956)
Science
, vol.123
, Issue.3191
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4(11): 891-9.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
3
-
-
34548317034
-
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
-
Gatenby RA, Smallbone K, Maini PK et al. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 2007; 97 (5): 646-653.
-
(2007)
Br J Cancer
, vol.97
, Issue.5
, pp. 646-653
-
-
Gatenby, R.A.1
Smallbone, K.2
Maini, P.K.3
-
4
-
-
3142631966
-
The human tumor microenvironment: Invasive (needle) measurement of oxygen and interstitial fluid pressure
-
Milosevic M, Fyles A, Hedley D et al. The human tumor microenvironment: Invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 2004; 14 (3): 249-258.
-
(2004)
Semin Radiat Oncol
, vol.14
, Issue.3
, pp. 249-258
-
-
Milosevic, M.1
Fyles, A.2
Hedley, D.3
-
5
-
-
0024396368
-
Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature
-
Dewhirst MW, Tso CY, Oliver R et al. Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. Int J Radiat Oncol Biol Phys 1989; 17 (1): 91-99.
-
(1989)
Int J Radiat Oncol Biol Phys
, vol.17
, Issue.1
, pp. 91-99
-
-
Dewhirst, M.W.1
Tso, C.Y.2
Oliver, R.3
-
6
-
-
0023956748
-
Characterization of solid tumor microvasculature: A three-dimensional analysis using the polymer casting technique
-
Shah-Yukich AA, Nelson AC. Characterization of solid tumor microvasculature: a three-dimensional analysis using the polymer casting technique. Lab Invest 1988; 58 (2): 236-244.
-
(1988)
Lab Invest
, vol.58
, Issue.2
, pp. 236-244
-
-
Shah-Yukich, A.A.1
Nelson, A.C.2
-
7
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
Wu M, Neilson A, Swift AL et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007; 292 (1): C125-C136.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, Issue.1
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
-
8
-
-
33745623631
-
Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: Mechanism of tumorigenesis
-
Bi X, Lin Q, Foo TW et al. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Mol Cell Proteomics 2006; 5 (6): 1119-1130.
-
(2006)
Mol Cell Proteomics
, vol.5
, Issue.6
, pp. 1119-1130
-
-
Bi, X.1
Lin, Q.2
Foo, T.W.3
-
9
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxiainducible factor 1 alpha
-
Iyer NV, Kotch LE, Agani F et al. Cellular and developmental control of O2 homeostasis by hypoxiainducible factor 1 alpha. Genes Dev 1998; 12 (2): 149-162.
-
(1998)
Genes Dev
, vol.12
, Issue.2
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
-
10
-
-
0032190614
-
Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
-
Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998; 8 (5): 588-594.
-
(1998)
Curr Opin Genet Dev
, vol.8
, Issue.5
, pp. 588-594
-
-
Semenza, G.L.1
-
12
-
-
0036359548
-
Hypoxia--a key regulatory factor in tumour growth
-
Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2 (1): 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.1
, pp. 38-47
-
-
Harris, A.L.1
-
13
-
-
33748152298
-
Oncological implications of hypoxia inducible factor- 1alpha (HIF-1alpha) expression
-
O'Donnell JL, Joyce MR, Shannon AM et al. Oncological implications of hypoxia inducible factor- 1alpha (HIF-1alpha) expression. Cancer Treat Rev 2006; 32 (6): 407-416.
-
(2006)
Cancer Treat Rev
, vol.32
, Issue.6
, pp. 407-416
-
-
O'Donnell, J.L.1
Joyce, M.R.2
Shannon, A.M.3
-
14
-
-
43049171554
-
Cellular life span and the Warburg effect
-
Kondoh H. Cellular life span and the Warburg effect. Exp Cell Res 2008; 314 (9): 1923-1928.
-
(2008)
Exp Cell Res
, vol.314
, Issue.9
, pp. 1923-1928
-
-
Kondoh, H.1
-
15
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3 (3): 187-197.
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
-
16
-
-
57649130593
-
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
-
Lu CW, Lin SC, Chen KF et al. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem 2008; 283 (42): 28106-28114.
-
(2008)
J Biol Chem
, vol.283
, Issue.42
, pp. 28106-28114
-
-
Lu, C.W.1
Lin, S.C.2
Chen, K.F.3
-
17
-
-
33644614520
-
HIF-1- mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL et al. HIF-1- mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3 (3): 177-185.
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
-
18
-
-
0141730410
-
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
-
Koukourakis MI, Giatromanolaki A, Sivridis E et al. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer 2003; 89 (5): 877-885.
-
(2003)
Br J Cancer
, vol.89
, Issue.5
, pp. 877-885
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
-
19
-
-
23944498840
-
Lactate dehydrogenase 5 (LDH5) relates to upregulated hypoxia inducible factor pathway and metastasis in colorectal cancer
-
Koukourakis MI, Giatromanolaki A, Simopoulos C et al. Lactate dehydrogenase 5 (LDH5) relates to upregulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin Exp Metastasis 2005; 22(1): 25-30.
-
(2005)
Clin Exp Metastasis
, vol.22
, Issue.1
, pp. 25-30
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Simopoulos, C.3
-
20
-
-
70449122565
-
Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases
-
Rajaganeshan R, Prasad R, Guillou PJ et al. Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases. Eur J Surg Oncol 2009.
-
(2009)
Eur J Surg Oncol
-
-
Rajaganeshan, R.1
Prasad, R.2
Guillou, P.J.3
-
21
-
-
54049122927
-
The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer
-
Rajaganeshan R, Prasad R, Guillou PJ et al. The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer. Int J Colorectal Dis 2008; 23 (11): 1049-1055.
-
(2008)
Int J Colorectal Dis
, vol.23
, Issue.11
, pp. 1049-1055
-
-
Rajaganeshan, R.1
Prasad, R.2
Guillou, P.J.3
-
22
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, Burri P, Beer KT et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001; 61(7): 2911-2916.
-
(2001)
Cancer Res
, vol.61
, Issue.7
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
23
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59(22): 5830-5835.
-
(1999)
Cancer Res
, vol.59
, Issue.22
, pp. 5830-5835
-
-
Zhong, H.1
de Marzo, A.M.2
Laughner, E.3
-
24
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF- 1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC et al. The expression and distribution of the hypoxia-inducible factors HIF- 1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157 (2): 411-421.
-
(2000)
Am J Pathol
, vol.157
, Issue.2
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
-
25
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D, Zhong H, Scalzitti JM et al. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 2000; 88 (11): 2606-2618.
-
(2000)
Cancer
, vol.88
, Issue.11
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
-
26
-
-
0037500967
-
Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
-
Bachtiary B, Schindl M, Potter R et al. Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 2003; 9 (6): 2234-2240.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.6
, pp. 2234-2240
-
-
Bachtiary, B.1
Schindl, M.2
Potter, R.3
-
27
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph nodepositive breast cancer
-
Schindl M, Schoppmann SF, Samonigg H et al. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph nodepositive breast cancer. Clin Cancer Res 2002; 8 (6): 1831-1837.
-
(2002)
Clin Cancer Res
, vol.8
, Issue.6
, pp. 1831-1837
-
-
Schindl, M.1
Schoppmann, S.F.2
Samonigg, H.3
-
28
-
-
0034896068
-
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
Birner P, Schindl M, Obermair A et al. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 2001; 7 (6): 1661-1668.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.6
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
-
29
-
-
0035395098
-
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
-
Birner P, Gatterbauer B, Oberhuber G et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 2001; 92 (1): 165-171.
-
(2001)
Cancer
, vol.92
, Issue.1
, pp. 165-171
-
-
Birner, P.1
Gatterbauer, B.2
Oberhuber, G.3
-
30
-
-
0036515618
-
Cell metabolism in the regulation of programmed cell death
-
Plas DR, Thompson CB. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 2002; 13 (2): 75-78.
-
(2002)
Trends Endocrinol Metab
, vol.13
, Issue.2
, pp. 75-78
-
-
Plas, D.R.1
Thompson, C.B.2
-
31
-
-
0024148694
-
Mitochondrial membrane potential in living cells
-
Chen LB. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 1988; 4: 155-181.
-
(1988)
Annu Rev Cell Biol
, vol.4
, pp. 155-181
-
-
Chen, L.B.1
-
32
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
Michelakis ED, Webster L, Mackey JR. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 2008; 99 (7): 989-994.
-
(2008)
Br J Cancer
, vol.99
, Issue.7
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
Mackey, J.R.3
-
33
-
-
0035229427
-
The mitochondrion in apoptosis: How Pandora's box opens
-
Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2001; 2 (1): 67-71.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, Issue.1
, pp. 67-71
-
-
Zamzami, N.1
Kroemer, G.2
-
34
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006; 66(18): 8927-30.
-
(2006)
Cancer Res
, vol.66
, Issue.18
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
35
-
-
66949122181
-
Cancer's craving for sugar: An opportunity for clinical exploitation
-
Yeluri S, Madhok B, Prasad KR et al. Cancer's craving for sugar: an opportunity for clinical exploitation. J Cancer Res Clin Oncol 2009; 135 (7): 867-877.
-
(2009)
J Cancer Res Clin Oncol
, vol.135
, Issue.7
, pp. 867-877
-
-
Yeluri, S.1
Madhok, B.2
Prasad, K.R.3
-
36
-
-
79958239986
-
Targeting Glucose Metabolism: An Emerging Concept for Anticancer Therapy
-
Madhok BM, Yeluri S, Perry SL et al. Targeting Glucose Metabolism: An Emerging Concept for Anticancer Therapy. Am J Clin Oncol 2010.
-
(2010)
Am J Clin Oncol
-
-
Madhok, B.M.1
Yeluri, S.2
Perry, S.L.3
-
37
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18 (6): 598-608.
-
(2006)
Curr Opin Cell Biol
, vol.18
, Issue.6
, pp. 598-608
-
-
Shaw, R.J.1
-
38
-
-
66249108601
-
Understanding the Warburg effect: The metabolic require ments of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic require ments of cell proliferation. Science 2009; 324 (5930): 1029-1033.
-
(2009)
Science
, vol.324
, Issue.5930
, pp. 1029-1033
-
-
Vander, H.M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
39
-
-
61649098857
-
Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype
-
Thorn CC, Freeman TC, Scott N et al. Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype. Gut 2009; 58 (3): 404-412.
-
(2009)
Gut
, vol.58
, Issue.3
, pp. 404-412
-
-
Thorn, C.C.1
Freeman, T.C.2
Scott, N.3
-
40
-
-
44449147036
-
Tumor cell metabolism: Cancer's Achilles' heel
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008; 13 (6): 472-482.
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
41
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
Pelicano H, Martin DS, Xu RH et al. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25 (34): 4633-4646.
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.S.2
Xu, R.H.3
-
43
-
-
0035123284
-
Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study
-
De LM, Lorusso V, Latorre A et al. Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. Eur J Cancer 2001; 37 (3): 364-368.
-
(2001)
Eur J Cancer
, vol.37
, Issue.3
, pp. 364-368
-
-
de, L.M.1
Lorusso, V.2
Latorre, A.3
-
44
-
-
7344255198
-
Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: Results from a multicenter prospective randomized trial
-
Amadori D, Frassineti GL, De MA et al. Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: results from a multicenter prospective randomized trial. Breast Cancer Res Treat 1998; 49 (3): 209-217.
-
(1998)
Breast Cancer Res Treat
, vol.49
, Issue.3
, pp. 209-217
-
-
Amadori, D.1
Frassineti, G.L.2
de, M.A.3
-
45
-
-
17444448833
-
FEC (5- fluorouracil, epidoxorubicin and cyclophosphamide) versus EM (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results
-
Pacini P, Rinaldini M, Algeri R et al. FEC (5- fluorouracil, epidoxorubicin and cyclophosphamide) versus EM (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results. Eur J Cancer 2000; 36 (8): 966-975.
-
(2000)
Eur J Cancer
, vol.36
, Issue.8
, pp. 966-975
-
-
Pacini, P.1
Rinaldini, M.2
Algeri, R.3
-
46
-
-
0037108676
-
Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: Final results of a phase III study with a factorial design
-
Berruti A, Bitossi R, Gorzegno G et al. Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. J Clin Oncol 2002; 20 (20): 4150-4159.
-
(2002)
J Clin Oncol
, vol.20
, Issue.20
, pp. 4150-4159
-
-
Berruti, A.1
Bitossi, R.2
Gorzegno, G.3
-
47
-
-
0142058027
-
Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide
-
Papaldo P, Lopez M, Cortesi E et al. Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide. J Clin Oncol 2003; 21 (18): 3462-3468.
-
(2003)
J Clin Oncol
, vol.21
, Issue.18
, pp. 3462-3468
-
-
Papaldo, P.1
Lopez, M.2
Cortesi, E.3
-
48
-
-
60149093542
-
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model
-
Kamlah F, Eul BG, Li S et al. Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model. Cancer Gene Ther 2009; 16 (3): 195-205.
-
(2009)
Cancer Gene Ther
, vol.16
, Issue.3
, pp. 195-205
-
-
Kamlah, F.1
Eul, B.G.2
Li, S.3
-
49
-
-
2942685341
-
Role of hypoxia- inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation
-
Stoeltzing O, McCarty MF, Wey JS et al. Role of hypoxia- inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 2004; 96 (12): 946-956.
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.12
, pp. 946-956
-
-
Stoeltzing, O.1
McCarty, M.F.2
Wey, J.S.3
-
50
-
-
66149164442
-
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
-
Kizaka-Kondoh S, Itasaka S, Zeng L et al. Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clin Cancer Res 2009; 15 (10): 3433-3441.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.10
, pp. 3433-3441
-
-
Kizaka-Kondoh, S.1
Itasaka, S.2
Zeng, L.3
-
51
-
-
4944229705
-
Scheduledependent inhibition of hypoxia-inducible factor- 1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
-
Rapisarda A, Zalek J, Hollingshead M et al. Scheduledependent inhibition of hypoxia-inducible factor- 1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res 2004; 64 (19): 6845-6848.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 6845-6848
-
-
Rapisarda, A.1
Zalek, J.2
Hollingshead, M.3
-
52
-
-
67651166780
-
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
-
Rapisarda A, Hollingshead M, Uranchimeg B et al. Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther 2009; 8 (7): 1867-77.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.7
, pp. 1867-1877
-
-
Rapisarda, A.1
Hollingshead, M.2
Uranchimeg, B.3
-
53
-
-
79960989122
-
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors
-
Kummar S, Raffeld M, Juwara L et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors. Clin Cancer Res 2011; 17 (15): 5123-5131.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.15
, pp. 5123-5131
-
-
Kummar, S.1
Raffeld, M.2
Juwara, L.3
-
54
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A 2008; 105 (50): 19579-1986.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.50
, pp. 19579-21986
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
-
55
-
-
9544245935
-
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human
-
Rowles J, Scherer SW, Xi T et al. Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem 1996; 271 (37): 22376-22382.
-
(1996)
J Biol Chem
, vol.271
, Issue.37
, pp. 22376-22382
-
-
Rowles, J.1
Scherer, S.W.2
Xi, T.3
-
56
-
-
0028851739
-
Diversity of the pyruvate dehydrogenase kinase gene family in humans
-
Gudi R, Bowker-Kinley MM, Kedishvili NY et al. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J Biol Chem 1995; 270 (48): 28989-28994
-
(1995)
J Biol Chem
, vol.270
, Issue.48
, pp. 28989-28994
-
-
Gudi, R.1
Bowker-Kinley, M.M.2
Kedishvili, N.Y.3
-
57
-
-
0028149769
-
Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase
-
Popov KM, Kedishvili NY, Zhao Y et al. Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase. J Biol Chem 1994; 269 (47): 29720-29724.
-
(1994)
J Biol Chem
, vol.269
, Issue.47
, pp. 29720-29724
-
-
Popov, K.M.1
Kedishvili, N.Y.2
Zhao, Y.3
-
58
-
-
0031972736
-
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
-
Bowker-Kinley MM, Davis WI, Wu P et al. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 1998; 329 (Pt 1): 191-196.
-
(1998)
Biochem J
, vol.329
, Issue.Pt 1
, pp. 191-196
-
-
Bowker-Kinley, M.M.1
Davis, W.I.2
Wu, P.3
-
59
-
-
0031973056
-
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
-
Wu P, Sato J, Zhao Y et al. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J 1998; 329 (Pt 1): 197-201.
-
(1998)
Biochem J
, vol.329
, Issue.Pt 1
, pp. 197-201
-
-
Wu, P.1
Sato, J.2
Zhao, Y.3
-
60
-
-
2942724616
-
Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise
-
Pilegaard H, Neufer PD. Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise. Proc Nutr Soc 2004; 63(2): 221-226.
-
(2004)
Proc Nutr Soc
, vol.63
, Issue.2
, pp. 221-226
-
-
Pilegaard, H.1
Neufer, P.D.2
-
61
-
-
0036634105
-
Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia
-
Sugden MC, Holness MJ. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr Drug Targets Immune Endocr Metabol Disord 2002; 2 (2): 151-165.
-
(2002)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.2
, Issue.2
, pp. 151-165
-
-
Sugden, M.C.1
Holness, M.J.2
-
62
-
-
44949127039
-
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
-
Wigfield SM, Winter SC, Giatromanolaki A et al. PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer 2008; 98 (12): 1975-1984.
-
(2008)
Br J Cancer
, vol.98
, Issue.12
, pp. 1975-1984
-
-
Wigfield, S.M.1
Winter, S.C.2
Giatromanolaki, A.3
-
63
-
-
13444272912
-
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor- associated stroma
-
Koukourakis MI, Giatromanolaki A, Sivridis E et al. Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor- associated stroma. Neoplasia 2005; 7 (1): 1-6.
-
(2005)
Neoplasia
, vol.7
, Issue.1
, pp. 1-6
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
-
64
-
-
80052845698
-
Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer
-
Lu CW, Lin SC, Chien CW et al. Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol 2011; 179 (3): 1405-1414.
-
(2011)
Am J Pathol
, vol.179
, Issue.3
, pp. 1405-1414
-
-
Lu, C.W.1
Lin, S.C.2
Chien, C.W.3
-
65
-
-
33748324485
-
Oxygen and glucose consumption in gastrointestinal adenocarcinomas: Correlation with markers of hypoxia, acidity and anaerobic glycolysis
-
Koukourakis MI, Pitiakoudis M, Giatromanolaki A et al. Oxygen and glucose consumption in gastrointestinal adenocarcinomas: correlation with markers of hypoxia, acidity and anaerobic glycolysis. Cancer Sci 2006; 97 (10): 1056-1060.
-
(2006)
Cancer Sci
, vol.97
, Issue.10
, pp. 1056-1060
-
-
Koukourakis, M.I.1
Pitiakoudis, M.2
Giatromanolaki, A.3
-
66
-
-
53049087909
-
Pyruvate dehydrogenase complex activity controls metabolic and malig nant phenotype in cancer cells
-
McFate T, Mohyeldin A, Lu H et al. Pyruvate dehydrogenase complex activity controls metabolic and malig nant phenotype in cancer cells. J Biol Chem 2008; 283 (33): 22700-22708.
-
(2008)
J Biol Chem
, vol.283
, Issue.33
, pp. 22700-22708
-
-
McFate, T.1
Mohyeldin, A.2
Lu, H.3
-
67
-
-
33846002728
-
A mitochondria- K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, lalunis-Turner J et al. A mitochondria- K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11 (1): 37-51.
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Lalunis-Turner, J.3
-
69
-
-
0031036856
-
Lactic acidosis and other mitochondrial disorders
-
Stacpoole PW. Lactic acidosis and other mitochondrial disorders. Metabolism 1997; 46 (3): 306-321.
-
(1997)
Metabolism
, vol.46
, Issue.3
, pp. 306-321
-
-
Stacpoole, P.W.1
-
70
-
-
0023881210
-
Dichloroacetate in the treatment of lactic acidosis
-
Stacpoole PW, Lorenz AC, Thomas RG et al. Dichloroacetate in the treatment of lactic acidosis. Ann Intern Med 1988; 108 (1): 58-63.
-
(1988)
Ann Intern Med
, vol.108
, Issue.1
, pp. 58-63
-
-
Stacpoole, P.W.1
Lorenz, A.C.2
Thomas, R.G.3
-
71
-
-
0037636003
-
Efficacy of dichloroacetate as a lactate-lowering drug
-
Stacpoole PW, Nagaraja NV, Hutson AD. Efficacy of dichloroacetate as a lactate-lowering drug. J Clin Pharmacol 2003; 43 (7): 683-691.
-
(2003)
J Clin Pharmacol
, vol.43
, Issue.7
, pp. 683-691
-
-
Stacpoole, P.W.1
Nagaraja, N.V.2
Hutson, A.D.3
-
72
-
-
0018263913
-
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia
-
Stacpoole PW, Moore GW, Kornhauser DM. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia. N Engl J Med 1978; 298 (10): 526-530.
-
(1978)
N Engl J Med
, vol.298
, Issue.10
, pp. 526-530
-
-
Stacpoole, P.W.1
Moore, G.W.2
Kornhauser, D.M.3
-
73
-
-
0024452528
-
The pharmacology of dichloroacetate
-
Stacpoole PW. The pharmacology of dichloroacetate. Metabolism 1989; 38 (11): 1124-1144.
-
(1989)
Metabolism
, vol.38
, Issue.11
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
74
-
-
0018749554
-
Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate
-
Moore GW, Swift LL, Rabinowitz D et al. Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate. Atherosclerosis 1979; 33 (3): 285-293.
-
(1979)
Atherosclerosis
, vol.33
, Issue.3
, pp. 285-293
-
-
Moore, G.W.1
Swift, L.L.2
Rabinowitz, D.3
-
75
-
-
0035005609
-
Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak
-
Taniguchi M, Wilson C, Hunter CA et al. Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak. Am J Physiol Heart Circ Physiol 2001; 280 (4): H1762-H1769.
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.280
, Issue.4
-
-
Taniguchi, M.1
Wilson, C.2
Hunter, C.A.3
-
76
-
-
0033814687
-
Dichloroacetate improves postischemic function of hypertrophied rat hearts
-
Wambolt RB, Lopaschuk GD, Brownsey RW et al. Dichloroacetate improves postischemic function of hypertrophied rat hearts. J Am Coll Cardiol 2000; 36 (4): 1378-1385.
-
(2000)
J Am Coll Cardiol
, vol.36
, Issue.4
, pp. 1378-1385
-
-
Wambolt, R.B.1
Lopaschuk, G.D.2
Brownsey, R.W.3
-
77
-
-
34250363136
-
The beneficial effects of dichloroacetate in acute limb ischemia
-
Platz TA, Wilson JS, Kline JA et al. The beneficial effects of dichloroacetate in acute limb ischemia. Mil Med 2007; 172 (6): 628-633.
-
(2007)
Mil Med
, vol.172
, Issue.6
, pp. 628-633
-
-
Platz, T.A.1
Wilson, J.S.2
Kline, J.A.3
-
78
-
-
0001362535
-
Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)
-
Whitehouse S, Randle PJ. Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication). Biochem J 1973; 134 (2): 651-653.
-
(1973)
Biochem J
, vol.134
, Issue.2
, pp. 651-653
-
-
Whitehouse, S.1
Randle, P.J.2
-
79
-
-
44549083746
-
Dichloroacetate induces apoptosis in endometrial cancer cells
-
Wong JY, Huggins GS, Debidda M et al. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol 2008; 109 (3): 394-402.
-
(2008)
Gynecol Oncol
, vol.109
, Issue.3
, pp. 394-402
-
-
Wong, J.Y.1
Huggins, G.S.2
Debidda, M.3
-
80
-
-
74849137483
-
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
-
Sun RC, Fadia M, Dahlstrom JE et al. Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat 2010; 120 (1): 253-260.
-
(2010)
Breast Cancer Res Treat
, vol.120
, Issue.1
, pp. 253-260
-
-
Sun, R.C.1
Fadia, M.2
Dahlstrom, J.E.3
-
81
-
-
84857157902
-
Dichloroacetate (DCA) inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
-
Vella S, Conti M, Tasso R et al. Dichloroacetate (DCA) inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells. Int J Cancer 2011.
-
(2011)
Int J Cancer
-
-
Vella, S.1
Conti, M.2
Tasso, R.3
-
82
-
-
77953285316
-
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
-
Madhok BM, Yeluri S, Perry SL et al. Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer 2010; 102 (12): 1746-1752.
-
(2010)
Br J Cancer
, vol.102
, Issue.12
, pp. 1746-1752
-
-
Madhok, B.M.1
Yeluri, S.2
Perry, S.L.3
-
83
-
-
79953291925
-
Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer
-
2011
-
Tong J, Xie G, He J et al. Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. J Biomed Biotechnol 2011; 2011: 740564.
-
(2011)
J Biomed Biotechnol
, pp. 740564
-
-
Tong, J.1
Xie, G.2
He, J.3
-
84
-
-
79551519970
-
In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
-
Fiebiger W, Olszewski U, Ulsperger E et al. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol 2011; 13 (1): 43-49.
-
(2011)
Clin Transl Oncol
, vol.13
, Issue.1
, pp. 43-49
-
-
Fiebiger, W.1
Olszewski, U.2
Ulsperger, E.3
-
85
-
-
78651235027
-
Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells
-
Xie J, Wang BS, Yu DH et al. Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. Int J Oncol 2011; 38 (2): 409-417.
-
(2011)
Int J Oncol
, vol.38
, Issue.2
, pp. 409-417
-
-
Xie, J.1
Wang, B.S.2
Yu, D.H.3
-
86
-
-
48749093935
-
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
-
Cao W, Yacoub S, Shiverick KT et al. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 2008; 68 (11): 1223-1231.
-
(2008)
Prostate
, vol.68
, Issue.11
, pp. 1223-1231
-
-
Cao, W.1
Yacoub, S.2
Shiverick, K.T.3
-
87
-
-
79961234149
-
Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: A case report
-
Khan A. Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report. J Palliat Med 2011; 14 (8): 973-7.
-
(2011)
J Palliat Med
, vol.14
, Issue.8
, pp. 973-977
-
-
Khan, A.1
-
88
-
-
77957835522
-
Non-Hodgkin's Lymphoma Reversal with Dichloroacetate
-
Flavin DF. Non-Hodgkin's Lymphoma Reversal with Dichloroacetate. J Oncol 2010; 2010.
-
(2010)
J Oncol
, pp. 2010
-
-
Flavin, D.F.1
|