-
2
-
-
0034614637
-
The hallmarks of cancer
-
D. Hanahan R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
R.A. Gatenby R.J. Gillies Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4 2004 891 899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
5
-
-
0032190614
-
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
-
G.L. Semenza Hypoxia-inducible factor 1: master regulator of O2 homeostasis Curr. Opin. Genet. Dev. 8 1998 588 594
-
(1998)
Curr. Opin. Genet. Dev.
, vol.8
, pp. 588-594
-
-
Semenza, G.L.1
-
6
-
-
0030921103
-
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
-
H. Shim C. Dolde B.C. Lewis C.S. Wu G. Dang R.A. Jungmann R. Dalla_Favera C.V. Dang c-Myc transactivation of LDH-A: implications for tumor metabolism and growth Proc. Natl. Acad. Sci. U. S. A. 94 1997 6658 6663
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla_Favera, R.7
Dang, C.V.8
-
8
-
-
14544271907
-
AMP-activated protein kinase: balancing the scales
-
D. Carling AMP-activated protein kinase: balancing the scales Biochimie 87 2005 87 91
-
(2005)
Biochimie
, vol.87
, pp. 87-91
-
-
Carling, D.1
-
9
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
R.L. Elstrom D.E. Bauer M. Buzzai R. Karnauskas M.H. Harris D.R. Plas H. Zhuang R.M. Cinalli A. Alavi C.M. Rudin C.B. Thompson Akt stimulates aerobic glycolysis in cancer cells Cancer res. 64 2004 3892 3899
-
(2004)
Cancer res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
10
-
-
0037175024
-
A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase
-
T. Shalom-Barak U.G. Knaus A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase J. Biol. Chemi. 277 2002 40659 40665
-
(2002)
J. Biol. Chemi.
, vol.277
, pp. 40659-40665
-
-
Shalom-Barak, T.1
Knaus, U.G.2
-
12
-
-
16844371813
-
Immortalization of primary human prostate epithelial cells by c-Myc
-
J. Gil P. Kerai M. Lleonart D. Bernard J.C. Cigudosa G. Peters A. Carnero D. Beach Immortalization of primary human prostate epithelial cells by c-Myc Cancer res. 65 2005 2179 2185
-
(2005)
Cancer res.
, vol.65
, pp. 2179-2185
-
-
Gil, J.1
Kerai, P.2
Lleonart, M.3
Bernard, D.4
Cigudosa, J.C.5
Peters, G.6
Carnero, A.7
Beach, D.8
-
13
-
-
0033028043
-
The role of p53 in tumour suppression: lessons from mouse models
-
L.D. Attardi T. Jacks The role of p53 in tumour suppression: lessons from mouse models Cell Mol. Life Sci. 55 1999 48 63
-
(1999)
Cell Mol. Life Sci.
, vol.55
, pp. 48-63
-
-
Attardi, L.D.1
Jacks, T.2
-
14
-
-
0033622003
-
p16INK4A and p19ARF act in overlapping pathways in cellular immortalization.
-
A. Carnero J.D. Hudson C.M. Price D.H. Beach p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nat. Cell Biol. 2 2000 148 155
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 148-155
-
-
Carnero, A.1
Hudson, J.D.2
Price, C.M.3
Beach, D.H.4
-
16
-
-
33750598394
-
Tumor 18F-FDG incorporation is enhanced by attenuation of P53 function in breast cancer cells in vitro
-
T.A. Smith R.I. Sharma A.M. Thompson F.E. Paulin Tumor 18F-FDG incorporation is enhanced by attenuation of P53 function in breast cancer cells in vitro J. Nucl. Med. 47 2006 1525 1530
-
(2006)
J. Nucl. Med.
, vol.47
, pp. 1525-1530
-
-
Smith, T.A.1
Sharma, R.I.2
Thompson, A.M.3
Paulin, F.E.4
-
17
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
H. Kondoh M.E. Lleonart J. Gil J. Wang P. Degan G. Peters D. Martinez A. Carnero D. Beach Glycolytic enzymes can modulate cellular life span Cancer res. 65 2005 177 185
-
(2005)
Cancer res.
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
19
-
-
0344622606
-
The serial cultivation of human diploid cell strains.
-
L. Hayflick P.S. Moorhead The serial cultivation of human diploid cell strains. Exper. Cell Res. 25 1961 585 621
-
(1961)
Exper. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
20
-
-
0035989631
-
Historical claims and current interpretations of replicative aging
-
W.E. Wright J.W. Shay Historical claims and current interpretations of replicative aging Nat. biotechnol. 20 2002 682 688
-
(2002)
Nat. biotechnol.
, vol.20
, pp. 682-688
-
-
Wright, W.E.1
Shay, J.W.2
-
21
-
-
0034682721
-
Cellular senescence: mitotic clock or culture shock?
-
C.J. Sherr R.A. DePinho Cellular senescence: mitotic clock or culture shock? Cell 102 2000 407 410
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
23
-
-
40749092119
-
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
-
M. Xu Q. Yu R. Subrahmanyam M.J. Difilippantonio T. Ried J.M. Sen Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo Mol. Cell. Biol. 28 2008 1713 1723
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 1713-1723
-
-
Xu, M.1
Yu, Q.2
Subrahmanyam, R.3
Difilippantonio, M.J.4
Ried, T.5
Sen, J.M.6
-
24
-
-
0031916984
-
The free radical theory of aging matures.
-
K.B. Beckman B.N. Ames The free radical theory of aging matures. Physiol. Rev. 78 1998 547 581
-
(1998)
Physiol. Rev.
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
26
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
-
M. Serrano A.W. Lin M.E. McCurrach D. Beach S.W. Lowe Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 1997 593 602
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
27
-
-
0037214382
-
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.
-
K. Itahana Y. Zou Y. Itahana J.L. Martinez C. Beausejour J.J. Jacobs M. Van Lohuizen V. Band J. Campisi D. GP. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell Biol. 23 2003 389 401
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 389-401
-
-
Itahana, K.1
Zou, Y.2
Itahana, Y.3
Martinez, J.L.4
Beausejour, C.5
Jacobs, J.J.6
Van Lohuizen, M.7
Band, V.8
Campisi, J.9
D. GP.10
-
28
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
-
V. Serra T. von Zglinicki M. Lorenz G. Saretzki Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening J. biol. Chem. 278 2003 6824 6830
-
(2003)
J. biol. Chem.
, vol.278
, pp. 6824-6830
-
-
Serra, V.1
von Zglinicki, T.2
Lorenz, M.3
Saretzki, G.4
-
31
-
-
0034661010
-
Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
-
H.Y. Ho M.L. Cheng F.J. Lu Y.H. Chou A. Stern C.M. Liang D.T. Chiu Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts Free Radic. Biol. Med. 29 2000 156 169
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 156-169
-
-
Ho, H.Y.1
Cheng, M.L.2
Lu, F.J.3
Chou, Y.H.4
Stern, A.5
Liang, C.M.6
Chiu, D.T.7
-
32
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
K. Takahashi S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
33
-
-
33846420629
-
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
-
H. Kondoh M.E. Lleonart Y. Nakashima M. Yokode M. Tanaka D. Bernard J. Gil D. Beach A high glycolytic flux supports the proliferative potential of murine embryonic stem cells Antioxid. Redox Signal. 9 2007 293 299
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 293-299
-
-
Kondoh, H.1
Lleonart, M.E.2
Nakashima, Y.3
Yokode, M.4
Tanaka, M.5
Bernard, D.6
Gil, J.7
Beach, D.8
-
34
-
-
0034672358
-
Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line.
-
A.M. Urbano H. Gillham Y. Groner K.M. Brindle Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line. Biochem. J. 352 Pt 3 2000 921 927
-
(2000)
Biochem. J.
, vol.352
, Issue.Pt 3
, pp. 921-927
-
-
Urbano, A.M.1
Gillham, H.2
Groner, Y.3
Brindle, K.M.4
-
35
-
-
27144510184
-
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
-
M.J. Evans A. Saghatelian E.J. Sorensen B.F. Cravatt Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling Nat. biotechnol. 23 2005 1303 1307
-
(2005)
Nat. biotechnol.
, vol.23
, pp. 1303-1307
-
-
Evans, M.J.1
Saghatelian, A.2
Sorensen, E.J.3
Cravatt, B.F.4
-
36
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.
-
N.V. Iyer L.E. Kotch F. Agani S.W. Leung E. Laughner R.H. Wenger M. Gassmann J.D. Gearhart A.M. Lawler A.Y. Yu G.L. Semenza Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes dev. 12 1998 149 162
-
(1998)
Genes dev.
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
37
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
S. Matoba J.G. Kang W.D. Patino A. Wragg M. Boehm O. Gavrilova P.J. Hurley F. Bunz P.M. Hwang p53 regulates mitochondrial respiration Science 312 2006 1650 1653 (New York, N.Y
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
38
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
A. Matheu A. Maraver P. Klatt I. Flores I. Garcia-Cao C. Borras J.M. Flores J. Vina M.A. Blasco M. Serrano Delayed ageing through damage protection by the Arf/p53 pathway Nature 448 2007 375 379
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Vina, J.8
Blasco, M.A.9
Serrano, M.10
-
39
-
-
33747588775
-
Mutations that increase the life span of C. elegans inhibit tumor growth
-
J.M. Pinkston D. Garigan M. Hansen C. Kenyon Mutations that increase the life span of C. elegans inhibit tumor growth Science 313 2006 971 975 (New York, N.Y
-
(2006)
Science
, vol.313
, pp. 971-975
-
-
Pinkston, J.M.1
Garigan, D.2
Hansen, M.3
Kenyon, C.4
|