Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

British Journal of Cancer

Volumn 89, Issue 5, 2003, Pages 877-885

  Koukourakis, M I ^a,d   Giatromanolaki, A ^a   Sivridis, E ^a   Bougioukas, G ^a   Didilis, V ^a   Gatter, K C ^b   Harris, A L ^c  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Tumor and Angiogenesis Research Group Alexandroupolis   (Greece)

Author keywords

CA9; HIF; Lactate dehydrogenase; Non small cell lung cancer

Indexed keywords

ANGIOGENIC FACTOR; ANTIBODY; BIOLOGICAL MARKER; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE IX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIPOPROTEIN BLOOD LEVEL; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

ADULT; AGED; ANGIOGENESIS INDUCING AGENTS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARBONIC ANHYDRASES; CARCINOMA, NON-SMALL-CELL LUNG; CELL HYPOXIA; DNA-BINDING PROTEINS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; ISOENZYMES; L-LACTATE DEHYDROGENASE; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NECROSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; PROGNOSIS; RATS; SURVIVAL RATE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 0141730410     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601205     Document Type: Article

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