CJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

Diabetologia

Volumn 55, Issue 1, 2012, Pages 166-174

  Subramanian, S L ^a   Hull R l , ^a   Zraika, S ^a   Aston Mourney, K ^a   Udayasankar, J ^a   Kahn, S E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell apoptosis; HIAPP; Islet amyloid; JNK activation

Indexed keywords

AMYLIN; BIM PROTEIN; CONGO RED; GLUCOSE; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BCL2 GENE; BCL2 LIKE PROTEIN 1 GENE; CASPASE 3 GENE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; FAS ASSOCIATED DEATH DOMAIN GENE; FAS GENE; FEMALE; GENE; GENE FUNCTION; GENE TARGETING; HUMAN; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; TRANSGENIC MOUSE; UPREGULATION;

AMYLOID; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEMIZYGOTE; HUMANS; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; ISLETS OF LANGERHANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES;

EID: 84856735212     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2338-7     Document Type: Article

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