Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

Diabetologia

Volumn 52, Issue 6, 2009, Pages 1102-1111

  Hull, R L ^a,b   Zraika, S ^a,b   Udayasankar, J ^a,b   Aston Mourney, K ^a,b   Subramanian, S L ^a,b   Kahn, S E ^a,b  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell death; Endoplasmic reticulum; ER stress; IAPP; Islet amyloid

Indexed keywords

AMYLIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; ATF4 GENE; BIP GENE; CELL CULTURE; CHOP GENE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE; HUMAN; HUMAN CELL; IAPP GENE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; XBP1 GENE;

AMYLOID; ANIMALS; DNA-BINDING PROTEINS; ELECTROPHORESIS, AGAR GEL; ENDOPLASMIC RETICULUM; FEMALE; GLUCOSE; HUMANS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MALE; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; PANCREAS; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 67349160220     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1329-4     Document Type: Article

References (43)

1. P Westermark 1972 Quantitative studies on amyloid in the islets of Langerhans Ups J Med Sci 77 91 94
2. A Clark CA Wells ID Buley 1988 Islet amyloid, increased A-cells, reduced B cells and exocrine fibrosis - quantitative changes in the pancreas in type-2 diabetes Diab Res Clin Exptl 9 151 159 (Pubitemid 19105415)
3. A Lorenzo B Razzaboni GC Weir BA Yankner 1994 Pancreatic islet cell toxicity of amylin associated with type 2 diabetes mellitus Nature 368 756 760 (Pubitemid 24153418)
4. TA Mirzabekov MC Lin BL Kagan 1996 Pore formation by the cytotoxic islet amyloid peptide amylin J Biol Chem 271 1988 1992 (Pubitemid 26047780)
5. J Janson RH Ashley D Harrison S McIntyre PC Butler 1999 The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles Diabetes 48 491 498 (Pubitemid 29106861)
6. 2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells Biochem J 343 53 61 (Pubitemid 29473877)
7. EL Saafi B Konarkowska S Zhang J Kistler GJ Cooper 2001 Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells Cell Biol Int 25 339 350 (Pubitemid 32896778)
8. P Westermark U Engström KH Johnson GT Westermark C Betsholtz 1990 Islet amyloid polypeptide-pinpointing amino acid residues linked to amyloid fibril formation Proc Natl Acad Sci USA 87 5036 5040 (Pubitemid 20224267)
9. AE Butler J Janson WC Soeller PC Butler 2003 Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid Diabetes 52 2304 2314 (Pubitemid 37059501)
10. RL Hull GT Westermark P Westermark SE Kahn 2004 Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes J Clin Endocrinol Metab 89 3629 3643 (Pubitemid 39071447)
11. S Zraika RL Hull J Udayasankar 2007 Glucose- and time-dependence of islet amyloid formation in vitro Biochem Biophys Res Commun 354 234 239 (Pubitemid 46123224)
12. S Zraika RL Hull J Udayasankar 2009 Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis Diabetologia 52 626 635
13. C Betsholtz V Svensson F Rorsman 1989 Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes-mellitus Exp Cell Res 183 484 493 (Pubitemid 19218505)
14. S Ohnishi K Takano 2004 Amyloid fibrils from the viewpoint of protein folding Cell Mol Life Sci 61 511 524 (Pubitemid 38372906)
15. A Horwich 2002 Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions J Clin Invest 110 1221 1232 (Pubitemid 35285746)
16. K Mori 2000 Tripartite management of unfolded proteins in the endoplasmic reticulum Cell 101 451 454
17. RJ Kaufman 2002 Orchestrating the unfolded protein response in health and disease J Clin Invest 110 1389 1398 (Pubitemid 35396907)
18. S Oyadomari K Takeda M Takiguchi 2001 Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway Proc Natl Acad Sci USA 98 10845 10850 (Pubitemid 32878707)
19. I Kharroubi L Ladriere AK Cardozo Z Dogusan M Cnop DL Eizirik 2004 Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress Endocrinology 145 5087 5096 (Pubitemid 39551129)
20. DR Laybutt AM Preston MC Akerfeldt 2007 Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes Diabetologia 50 752 763 (Pubitemid 46355827)
21. S Oyadomari M Mori 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress Cell Death Differ 11 381 389 (Pubitemid 38489416)
22. CJ Huang CY Lin L Haataja 2007 High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes Diabetes 56 2016 2027 (Pubitemid 47201819)
23. P Marchetti M Bugliani R Lupi 2007 The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients Diabetologia 50 2486 2494 (Pubitemid 350060637)
24. T Nakagawa H Zhu N Morishima 2000 Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta Nature 403 98 103 (Pubitemid 30038529)
25. C Hetz M Russelakis-Carneiro K Maundrell J Castilla C Soto 2003 Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein Embo J 22 5435 5445 (Pubitemid 37279953)
26. S Casas R Gomis FM Gribble J Altirriba S Knuutila A Novials 2007 Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis Diabetes 56 2284 2294 (Pubitemid 47358235)
27. CJ Huang L Haataja T Gurlo 2007 Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide Am J Physiol Endocrinol Metab 293 E1656 E1662 (Pubitemid 350255116)
28. RL Hull Z Shen MR Watts 2005 Long term treatment with rosiglitazone and metformin reduce the extent of, but do not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide Diabetes 54 2235 2244 (Pubitemid 40911289)
29. S Zraika RL Hull J Udayasankar 2007 Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis Diabetes 56 304 310 (Pubitemid 46263065)
30. RL Hull S Andrikopoulos CB Verchere 2003 Increased dietary fat promotes islet amyloid formation and ß-cell secretory dysfunction in a transgenic mouse model of islet amyloid Diabetes 52 372 379 (Pubitemid 36173192)
31. MC Åkerfeldt J Howes JY Chan 2008 Cytokine-induced β-cell death is independent of endoplasmic reticulum stress signaling Diabetes 57 3034 3044
32. DA Cunha P Hekerman L Ladriere 2008 Initiation and execution of lipotoxic ER stress in pancreatic beta-cells J Cell Sci 121 2308 2318
33. H Elouil M Bensellam Y Guiot 2007 Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets Diabetologia 50 1442 1452 (Pubitemid 46879004)
34. KL Lipson SG Fonseca S Ishigaki 2006 Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1 Cell Metab 4 245 254 (Pubitemid 44283955)
35. DL Eizirik A Bjorklund E Cagliero 1993 Genotoxic agents increase expression of growth arrest and DNA damage-inducible genes gadd 153 and gadd 45 in rat pancreatic islets Diabetes 42 738 745 (Pubitemid 23127165)
36. L Haataja T Gurlo CJ Huang PC Butler 2008 Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation Cell Biochem Biophys 51 105 107
37. NG Knowles MA Landchild WY Fujimoto SE Kahn 2002 Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes Diabetes Care 25 292 297 (Pubitemid 41079624)
38. PC Butler J Chou WB Carter 1990 Effects of meal ingestion on plasma amylin concentration in NIDDM and non-diabetic humans Diabetes 39 752 756 (Pubitemid 20218978)
39. SE Kahn CB Verchere S Andrikopoulos 1998 Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans Diabetes 47 640 645 (Pubitemid 28160456)
40. M Yoshioka T Kayo T Ikeda A Koizumi 1997 A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice Diabetes 46 887 894 (Pubitemid 27188269)
41. N Herbach B Rathkolb E Kemter 2007 Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice Diabetes 56 1268 1276 (Pubitemid 46715607)
42. JR Riordan 1999 Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein Am J Hum Genet 64 1499 1504 (Pubitemid 30481502)
43. JH Teckman D Qu DH Perlmutter 1996 Molecular pathogenesis of liver disease in alpha1-antitrypsin deficiency Hepatology 24 1504 1516 (Pubitemid 26399057)