Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

Diabetologia

Volumn 52, Issue 4, 2009, Pages 626-635

  Zraika, S ^a   Hull, R L ^a   Udayasankar, J ^a   Aston Mourney, K ^a   Subramanian, S L ^a   Kisilevsky, R ^b   Szarek, W A ^b   Kahn, S E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Beta cell apoptosis; IAPP; Insulin secretion; Islet amyloid; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; AMYLOID PROTEIN; CONGO RED; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; ENZYME SYNTHESIS; INSULIN RELEASE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET CELL; PREVALENCE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMYLOID; ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 61449123871     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1255-x     Document Type: Article

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