The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge

FEBS Letters

Volumn 530, Issue 1-3, 2002, Pages 244-248

  López de Maturana, Rakel ^a   Donnelly, Dan ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Agonist; Antagonist; Exendin; G protein coupled receptor; Glucagon like peptide 1(7 36)amide; Receptor

Indexed keywords

ALANINE; ASPARAGINE; ASPARTIC ACID; EXENDIN 4; EXENDIN[9-39]; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [15-36]AMIDE; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PEPTIDE DERIVATIVE; RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IC 50; MUTATION; PRIORITY JOURNAL;

ASPARTIC ACID; CELL LINE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RADIOLIGAND ASSAY; RECEPTORS, GLUCAGON;

EID: 0037163906     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03492-0     Document Type: Article

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