Importance of each residue within secretin for receptor binding and biological activity

Biochemistry

Volumn 50, Issue 14, 2011, Pages 2983-2993

  Dong, Maoqing ^a   Le, Angela ^a   Te, Jerez A ^a   Pinon, Delia I ^a   Bordner, Andrew J ^a   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO-TERMINAL REGION; BIOLOGICAL ACTIVITIES; CARBOXYL TERMINUS; CARBOXYL-TERMINAL; G PROTEIN COUPLED RECEPTORS; HIGH AFFINITY BINDING; HYDROPHOBIC RESIDUES; MOLECULAR DYNAMICS SIMULATIONS; PEPTIDE HORMONES; RECEPTOR ACTIVATION; RECEPTOR BINDING; SOLVENT-ACCESSIBLE SURFACE AREA;

AMINO ACIDS; BIOACTIVITY; PEPTIDES;

MOLECULAR DYNAMICS;

ALANINE; ASPARTIC ACID; GLYCINE; HISTIDINE; LEUCINE; PHENYLALANINE; SECRETIN; SERINE; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; FEMALE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SIMULATION;

ALANINE; AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; IODINE RADIOISOTOPES; LEUCINE; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN; THERMODYNAMICS;

EID: 79953688273     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200133u     Document Type: Article

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