Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2640-2643

  Gelling, Richard W ^a   Wheeler, Michael B ^b   Xue, Jiaping ^b   Gyomorey, Sandor ^b   Nian, Cuilan ^a   Pederson, Raymond A ^a   Mcintosh, Christopher H S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHIMERA; CHO CELL; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; GLUCOSE UTILIZATION; INSULIN LIKE ACTIVITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SECOND MESSENGER;

EID: 0030913105     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.9104     Document Type: Article

References (19)

1. Pederson, RA 1993 Gastric inhibitory polypeptide. In: Walsh, J, Dockray, G (eds) Gut Peptides. Raven Press, New York pp. 217-259.
2. Holst JJ 1994 Glucagonlike peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology 107: 1848-1855.
3. Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI 1993 Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133: 2861-2870.
4. Wheeler MB, Gelling RW, McIntosh CHS, Georgiou J, Brown JC, Pederson RA 1995. Functional cloning of the rat pancreatic islet glucose-dependent polypeptide receptors: ligand binding and intracellular signaling properties. Endocrinology 136: 4629-4639.
5. Thorens B 1992 Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89: 8641-8645.
6. Segre GV, Goldring SR. 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagon-like peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends in Endocrinol. 4: 309-314.
7. Strader C, Fong T, Tota M, Underwood D, Dixon R 1994 Structure and function of G protein-coupled receptors. Ann Rev Biochem 63: 101-132
8. Fukuda K, Kato S, Mori, K 1995 Location of regions of the opioid receptor involved in selective agonist binding. J Biol Chem 270: 6702-6709.
9. Combarnous Y 1992 Molecular basis of the specificity of binding of glycoprotein hormones to their receptors. Endocrine Rev 13: 670-691.
10. Buggy JL, Livingston JN, Rabin DU, Yoo-Warren H 1995. Glucagon-glucagon-like peptide 1 receptor chimeras reveal domains that determine specificity of glucagon binding. J Biol Chem 270: 7474-7478.
11. Carruthers CJL, Unson CG, Hyang NK, Sakmar TP 1994. Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding. J Biol Chem. 269: 29321-29328.
12. Unson CG, Cypess AM, Kim HN, Goldsmith PK, Carruthers CJL, Merrifield RB, Sakmar TP 1995 Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding. J Biol Chem 270: 27720-27727.
13. Holtmann MH, Hadac WM, Miller LJ 1995 Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. J Biol Chem 270: 14394-14398.
14. Lu M, Wheeler MB, Leng XH, Boyd III AE 1993 The role of free cytosolic calcium level in ß-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I (7-37). Endocrinology 132: 94-100.
15. Wheeler MB, Lu M, Dillon JS, Leng X-H, Chen C, Boyd AE 1993 Functional expression of the rat glucagon-like peptide-1 receptor, evidence for coupling to both adenylyl cyclase and phospholipase C. Endocrinology 133: 57-62.
16. Dillon JS, Tanizawa Y, Wheeler MB, Leng X-H, Ligon BB, Rabin DU, Warren HY, Permutt MA, Boyd III AE. 1993 Cloning and expression of the human GLP-1 receptor. Endocrinology 133: 1907-1910.
17. Takhar S, Gyomorey S, Su R-C, Mathi SK, Li X, Wheeler M. 1996 The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system. Endocrinology 137: 2175-2178.
18. Gutniak MK, Holst JJ, Linde B, Efendic S. Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM. 1994 Diabetes Care 17:1039-1044.
19. Lee C, Gardella TJ, Abou-Samra A-B, Nussbaum SR, Segre GV, Potts Jr JT, Kronenberg HM, Jüppner H 1994 Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding. Endocrinology 135: 1488-1495.