Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide

Journal of Biological Chemistry

Volumn 272, Issue 46, 1997, Pages 28861-28868

  Bergwitz, Clemens ^a   Jusseaume, Scott A ^a   Luck, Michael D ^a   Jüppner, Harald ^a   Gardella, Thomas J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; HISTIDINE; ISOLEUCINE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ARTICLE; CHIMERA; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; COS CELLS; CYCLIC AMP; HISTIDINE; HUMANS; ISOLEUCINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; PROTEINS; RECEPTOR, PARATHYROID HORMONE, TYPE 2; RECEPTORS, PARATHYROID HORMONE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030703626     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.46.28861     Document Type: Article

References (32)

1. Usdin, T., Gruber, C., and Bonner, T. (1995) J. Biol Chem. 270, 15455-15458
2. Segre, G. V., and Goldring, S. R. (1993) Trends Endocrinol. Metab. 4, 309-314
3. Lee, C., Gardella, T., Abou-Samra, A.-B., Nussbaum, S., Segre, G., Potts, J., Kronenberg, H., and Jüppner, H. (1994) Endocrinology 135, 1488-1495
4. Lee, C., Luck, M., Jüppner, H., Potts, J., Kronenberg, H., and Gardella, T. (1995) Mol. Endocrinol. 9, 1269-1278
5. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts, J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. (1994) Endocrinology 134, 879-884
6. Gardella, T., Luck, M., Fan, M., and Lee, C. (1996) J. Biol. Chem. 271, 12820-12825
7. Gardella, T. J., Jüppner, H., Wilson, A. K., Keutmann, H. T., Abou-Samra, A. B., Segre, G. V., Bringhurst, F. R., Potts, J. T., Jr., Nussbaum, S. R., and Kronenberg, H. M. (1994) Endocrinology 135, 1186-1194
8. Bergwitz, C., Gardella, T., Flannery, M., Potts, J. T., Jr., Kronenberg, H., Goldring, S., and Jüppner, H. (1996) J. Biol. Chem. 271, 26469-26472
9. Holtmann, M., Hadac, E., and Miller, L. (1995) J. Biol. Chem. 270, 14394-14398
10. Stroop, S., Kuestner, R., Serwold, T., Chen, L., and Moore, E. (1994) Biochemistry 34, 1050-1057
11. Turner, P., Bambino, T., and Nissenson, R. (1996) Mol. Endocrinol. 10, 132-139
12. Turner, P. R., Bambino, T., and Nissenson, R. A. (1996) J. Biol. Chem. 271, 9205-9208
13. Schwartz, T. W., Gether. U., Schambye, H. T., and Hjorth, S. A. (1995) Current Pharmaceutical Design 1, 325-342
14. Gardella, T., Luck, M., Jensen, G., Usdin, T., and Jüppner, H. (1996) J. Biol. Chem. 271, 19888-19893
15. Behar, V., Nakamoto, C., Greenberg, Z., Bisello, A., Suva, L. J., Rosenblatt, M., and Chorev, M. (1996) Endocrinology 137, 4217-4224
16. Shigeno, C., Hiraki, Y., Westerberg, D. P., Potts, J. T., Jr., and Segre, G. V. (1988) J. Biol. Chem. 263, 3872-3878
17. Schipani, E., Karga, H., Karaplis, A. C., Potts, J. T., Jr., Kronenberg, H. M., Segre, G. V., Abou-Samra, A. B., and Jüppner, H. (1993) Endocrinology 132, 2157-2165
18. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
19. Abell, A., Liu, X., and Segaloff, D. (1996) J. Biol. Chem. 271, 4518-4527
20. Abou-Samra, A. B., Jüppner, H., Force, T., Freeman, M., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr, Kronenberg, H. M., and Segre, G. V. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 2732-2736
21. Abou-Samra, A.-B., Uneno, S., Jüppner, H., Keutmann, H. T., Potts, J. T., Jr, Segre, G. V., and Nussbaum, S. R. (1989) Endocrinology 125, 2215-2217
22. Caulfield, M. P., McKee, R. L., Goldman, M. E., Duong, L. T., Fisher, J. E., Gay, C. T., DeHaven, P. A., Levy. J. J., Roubini, E., Nutt, R. F., Chorev, M., and Rosenblatt, M. (1990) Endocrinology 127, 83-87
23. Nissenson, R. A., Diep, D., and Strewler, G. J. (1988) J. Biol. Chem, 263, 12866-12871
24. Schertler, G., Villa, C., and Henderson, R. (1995) Nature 362, 770-772
25. Rost, B., Casadio, R., Fariselli, P., and Sander, C. (1995) Protein Sci. 4, 521-533
26. Suva, L. J., Winslow, G. A., Wettenhall, R. E., Hammonds, R. G., Moseley, J. M., Diefenbach, J. H., Rodda, C. P., Kemp, B. E., Rodriguez, H., Chen, E. Y., et al. (1987) Science 237, 893-896
27. Usdin, T., Bonner, T., Harta, G., and Mezey, E. (1996) Endocrinology 137, 4285-4297
28. Lanske, B., Karaplis, A., Lee, K., Luz, A., Vortkamp, A., Pirro, A., Karperien, M., Defize, L., Ho, C., Mulligan, R., Abou-Samra, A., Jüppner, H., Segre, G., and Kronenberg, H. (1996) Science 273, 663-666
29. Vortkamp, A., Lee, K., Lanske, B., Segre, G., Kronenberg, H., and Tabin, C. (1996) Science 273, 613-622
30. Usdin, T. (1997) Endocrinology 138, 831-834
31. Cao, Y.-J., Gimpl, G., and Fahrenholz, F. (1995) Biochem, Biophys. Res. Comm. 212, 673-680
32. Zhou, A., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3644-3649