Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor

Journal of Biological Chemistry

Volumn 285, Issue 1, 2010, Pages 723-730

  Underwood, Christina Rye ^a,b   Garibay, Patrick ^a   Knudsen, Lotte Bjerre ^a   Hastrup, Sven ^a   Peters, Günther H ^b   Rudolph, Rainer ^c   Reedtz Runge, Steffen ^a  

^a NOVO NORDISK A S   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; BINDING PROPERTIES; CLASS B; DATA SUPPORT; EXTRACELLULAR DOMAINS; EXTRACELLULAR LIGANDS; FOOD INTAKE; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC LIGAND; LARGE N; LIGAND-BINDING SITES; SITE DIRECTED MUTAGENESIS; STRUCTURAL INFORMATION;

ACTIVATION ANALYSIS; BINDING ENERGY; COMPLEXATION; CONFORMATIONS; ENZYME ACTIVITY; GLUCOSE; INDUSTRIAL LABORATORIES; LIGANDS; PEPTIDES;

CRYSTAL STRUCTURE;

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; THREONINE; VALINE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; HYDROPHILICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; EXTRACELLULAR SPACE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCAGON; SOLUTIONS;

EID: 73649107900     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.033829     Document Type: Article

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