Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11340-11347

  Runge, Steffen ^a   Thøgersen, Henning ^a   Madsen, Kjeld ^a   Lau, Jesper ^a   Rudolph, Rainer ^b  

^a NOVO NORDISK A S   (Denmark)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CELL MEMBRANES; GLUCOSE; HORMONES; HYDROPHILICITY; HYDROPHOBICITY; INDUSTRIAL LABORATORIES; LIGANDS; MEDICAL PROBLEMS; ORGANIC ACIDS; PHYSIOLOGY; PORT TERMINALS;

AMINO ACID RESIDUES; AMPHIPATHIC; COUPLED RECEPTORS; EXTRACELLULAR DOMAINS; G PROTEINS; GLUCOSE HOMEOSTASISES; HOMOLOGOUS PEPTIDES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROPHOBIC BINDING SITES; INSULIN SECRETIONS; LIGAND BINDINGS; MOLECULAR INSIGHTS; MULTIWAVELENGTH ANOMALOUS DISPERSIONS; N TERMINUSES; PEPTIDE HORMONES; PLASMA MEMBRANES; TRANSMEMBRANE; TYPE 2 DIABETES;

CRYSTAL STRUCTURE;

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PROTEIN FAMILY B1 RECEPTOR; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; LIGAND; PEPTIDE; TRYPTOPHAN; VENOM;

ALPHA HELIX; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMISTRY; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANCREAS ISLET BETA CELL; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN-SECRETING CELLS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GLUCAGON; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN; VENOMS;

EID: 45549086826     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708740200     Document Type: Article

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