An agonist-like monoclonal antibody against the human β2-adrenoceptor

European Journal of Pharmacology

Volumn 348, Issue 1, 1998, Pages 123-133

  Lebesgue, Diane ^a   Wallukat, Gerd ^b   Mijares, Alfredo ^c   Granier, Claude ^d   Argibay, Jorge ^c   Hoebeke, Johan ^a  

^a Equipe d'Immunol des Recepteurs   (France)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITÉ DE TOURS   (France)

^d UMR 9921   (France)

Author keywords

2 Adrenoceptor; Agonist, Surface plasmon resonance; Anti peptide antibody; Ca2+ channel, L type; Epitope mapping

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6H8; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; ELECTROPHYSIOLOGY; ENZYME IMMUNOASSAY; EPITOPE MAPPING; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LIGAND BINDING; MUSCLE EXCITATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT;

ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HEART RATE; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE POTENTIALS; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-2; TRYPANOSOMA CRUZI; TUMOR CELLS, CULTURED;

EID: 0032078709     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00136-8     Document Type: Article

References (43)

1. Abd Alla S., Quitterer U., Grigoriev S., Maidhof A., Haasemann M., Jarnagin K., Müller-Esterl W. Extracellular domains of the bradykinin B2 receptor involves in ligand binding agonist sensing defined by anti-peptide antibodies. J. Biol. Chem. 271:1996;1748-1755.
2. Altschuh D., Dubs M.C., Weiss E., Zeder-Lutz G., Van Regenmortel M.H.V. Determination of kinetic constants for the interaction between a monoclonal antibody and peptides using surface plasmon resonance. Biochemistry. 31:1992;6298-6304.
3. 2-adrenergic receptors in patients with primary electrical cardiac disturbances. J. Am. Coll. Cardiol. 26:1995;864-869.
4. Dixon R.A.F., Kobilka B.K., Strader D.J., Benovic J.L., Dohlman H.G., Frielle T., Bolanowski M.A., Bennett C.D., Rands E., Diehl R.E., Munford R.A., Slater I.S., Caron M.G., Lefkowitz R.J., Strader C.D. Cloning gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin. Nature. 321:1986;75-79.
5. 2-adrenergic receptor. EMBO J. 6:1987;3269-3275.
6. Dohlman H.G., Bouvier M., Benovic J.L., Caron M.G., Lefkowitz J.R. The multiple membrane spanning topography of the beta-2 adrenergic receptor. J. Biol. Chem. 262:1987;16655-16662.
7. Elies R., Ferrari I., Wallukat G., Lebesgue D., Chiale P., Elizari M., Rosenbaum M., Hoebeke J., Levin M.J. Structural and functional analysis of the B cell epitope recognized by anti-receptor antibodies in patients with Chagas' disease. J. Immunol. 157:1996;4203-4211.
8. 2-adrenergic receptor: Expression and promotor regulation. Proc. Natl. Acad. Sci. USA. 84:1987;6995-6999.
9. 1-adrenergic receptor. J. Exp. Med. 182:1995;59-65.
10. Frank R. Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron. 48:1992;9217-9232.
11. Fraser C.M. Site-directed mutagenesis of β-adrenergic receptor. Identification of conserved cystein residues that independently affect ligand binding and receptor activation. J. Biol. Chem. 264:1989;9266-9270.
12. 1-adrenergic receptor. Proc. Natl. Acad. Sci. USA. 84:1987;9494-9498.
13. Fu L.X., Magnusson Y., Bergh C.H., Liljeqvist J.A., Waagstein F., Hjalmarson Å., Hoebeke J. Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 91:1993;1964-1968.
14. 1-adrenergic receptors in patients with malignant hypertension. Lancet. 344:1994;1660-1663.
15. Fu M.L.X., Schultze W., Wallukat G., Hjalmarson Å., Hoebeke J. Functional epitope analysis of the second extracellular loop of the human heart muscarinic acetylcholine receptor. J. Mol. Cell. Cardiol. 27:1995;427-436.
16. Galfre G., Milstein C. Preparation of monoclonal antibodies: Strategies and procedures. Methods Enzymol. 73:1981;3-46.
17. 2-adrenergic receptor. Eur. J. Biochem. 224:1994;761-770.
18. Guillet J.G., Hoebeke J., Lengagne R., Tate K., Borras-Herreras F., Strosberg A.D., Borras-Cuesta F. Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences. J. Mol. Recognit. 4:1991;17-25.
19. 2-adrenergic receptor. Clin. Exp. Immunol. 89:1992;461-467.
20. Halle W., Wollenberger A. Differentiation and behavior of isolated embryonic and neonatal heart cells in a chemically defined medium. Am. J. Cardiol. 25:1970;292-299.
21. Hartzell H.C. Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems. Prog. Biophys. Mol. Biol. 52:1988;165-247.
22. Henderson R., Baldwin J.M., Ceska T.A., Zemlin F., Beckmann E., Downing K.H. Model for the structure of bacteriorhodopsin based on hight-resolution electron cryo-microscopy. J. Mol. Biol. 213:1990;899-929.
23. Hoebeke J. La seconde boucle extracellulaire des récepteurs couplés aux protéines G: une cible préferentielle pour des autoanticorps fonctionnels. Medecine/Sciences. 12:1995;1661-1667.
24. Kenakin T.P. Receptor conformation induction versus selection: all part of the same original landscape. Trends Pharmacol. Sci. 17:1996;190-191.
25. 2-adrenegic receptor: a protein with multiple membrane spanning domains and encode by a gene whose location is shared with that of the receptor for platelet derived growth factor. Proc. Natl. Acad. Sci. USA. 84:1987;46-50.
26. Le Guennec J.Y., Peineau N., Esnard F., La Campagne A., Gannier F., Argibay J., Gauthier F., Garnier D. A simple method for calibration of collagenase/protease E ratio to optimize heart cell isolation. Biol. Cell. 79:1993;161-165.
27. 2-adrenergic receptor enhances agonist promoted phosphorylation and receptor desensitization. Biochem. Biophys. Res. Commun. 165:1989;257-263.
28. 2-adrenergic receptor: Effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy. Biochemistry. 46:1996;14445-14451.
29. MacPherson, GA. 1985. Kinetic, EBDA, LIGAND, Lowry (Manual). Biosoft. Elsevier Science, Amsterdam.
30. Magnusson Y., Höyer S., Lengagne R., Chapot M.P., Guillet J.G., Hjalmarson Å., Strosberg A.D., Hoebeke J. Antigenic analysis of the second extracellular loop of the human β-adrenergic receptor. Clin. Exp. Immunol. 78:1989;42-48.
31. 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 86:1990;1658-1663.
32. Matsui S., Fu M.L.X., Katsuda S., Hayase M., Yamaguchi N., Teraoka K., Kurihara T., Takekoshi N., Murakami E., Hoebeke J., Hjalmarson Å. Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J. Mol. Cell. Cardiol. 29:1997;641-655.
33. 1-adrenergic and M2-muscarinic receptors and regulate calcium channels in isolated cardiomyocytes. Mol. Cell. Biochem. 164:1996;57-62.
34. 2-adrenergic receptor. FEBS Lett. 399:1996;188-191.
35. Molina F., Laune D., Gougat C., Pau B., Granier C. Improved performance of Spot multiple peptide synthesis. Peptide Res. 9:1996;151-155.
36. 2-adrenergic receptor requires unique interaction between conserved and non conserved extracellular loop cysteines. J. Biol. Chem. 269:1994;6743-6752.
37. Oi, V.T., Herzenberg, L.A., 1980. Immunoglobulin producing hybrid cell lines. In: Mishell, R.B., Shiji, S.M. (Eds.), Methods In Cell. Immunol. Freeman, San Francisco, p. 351.
38. 2-adrenoceptors in Chagas' disease. Clin. Exp. Immunol. 74:1988;349-354.
39. Strosberg A.D. Structure, function, and regulation of adrenergic receptor. Protein Sci. 2:1993;1198-1209.
40. Teufel M., Pompejus M., Humbel B., Friedrich K., Fritz H.J. Properties of bacteriorhodopsin derivatives constructed by insertion of exogenous epitope into extramembranar loops. EMBO J. 12:1993;3399-3408.
41. Tsien R.W., Bean B.P., Hess P., Lansman J.B., Nilius B., Nowycky M.C. Mechanism of Ca channel modulation by β-adrenergic agents and dihydropyridine calcium agonist. J. Mol. Cell. Cardiol. 18:1986;691-710.
42. 1 receptor. J. Neurochem. 65:1995;319-328.
43. Wallukat G., Morwinski R., Kühn H. Modulation of the β-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C. J. Biol. Chem. 269:1994;29055-29060.