Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide derivatives as novel antihypertensive agents

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 2, 2012, Pages 223-234

  Watanuki, Susumu ^a   Matsuura, Keisuke ^a   Tomura, Yuichi ^a   Okada, Minoru ^a   Okazaki, Toshio ^a   Ohta, Mitsuaki ^a   Tsukamoto, Shin Ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

2 (piperidin 4 yl)acetamide; Antihypertensive agent; Mibefradil; T type Ca 2+ channel

Indexed keywords

2(1 ALKYLPIPERIDIN 4 YL) N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE DERIVATIVE; 2[1(2(3 FLUORO 2(2 METHOXYETHOXY) PHENYL) ETHYL) PIPERIDIN 4 YL] N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE OXALATE; 2[1(2(3,4 DIMETHOXYPHENYL) ETHYL) PIPERIDIN 4 YL] N [1(4FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE OXALATE; 2[1(2(4 FLUORO 2(2 METHOXYETHOXY) PHENYL) ETHYL) PIPERIDIN 4 YL] N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE; 2[1(2(5 FLUORO 2(2 METHOXYETHOXY) PHENYL) ETHYL) PIPERIDIN-4-YL] N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE; 2[1(2(6 FLUORO 2(2 METHOXYETHOXY) PHENYL) ETHYL) PIPERIDIN 4 YL] N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] ACETAMIDE; AMIDE; ANTIHYPERTENSIVE AGENT; BENZENE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; MIBEFRADIL; N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] 2[1(2(2 METHOXYPHENYL) ETHYL) PIPERIDIN 4 YL] ACETAMIDE OXALATE; N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] 2[1(2(2(2 METHOXYETHOXY) PHENYL) ETHYL) PIPERIDIN 4 YL] ACETAMIDE; N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] 2[1(2(3 METHOXYPHENYL) ETHYL) PIPERIDIN 4 YL] ACETAMIDE OXALATE; N [1(4 FLUOROPHENYL) 2 METHYLPROPYL] 2[1(2(4 METHOXYPHENYL) ETHYL) PIPERIDIN 4 YL] ACETAMIDE OXALATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EXPERIMENTAL PIG; HUMAN; HUMAN CELL; IC 50; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; FLUORINE; MALE; MIBEFRADIL; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856583556     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.60.223     Document Type: Article

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