Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4- tetrahydroisoquinoline derivatives as novel antihypertensive agents

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 8, 2011, Pages 1029-1037

  Watanuki, Susumu ^a   Matsuura, Keisuke ^a   Tomura, Yuichi ^a   Okada, Minoru ^a   Okazaki, Toshio ^a   Ohta, Mitsuaki ^a   Tsukamoto, Shin Ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antihypertensive agent; Mibefradil; T type Ca 2+ channel; Tetrahydroisoquinoline

Indexed keywords

1 ISOPROPYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 ISOPROPYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 1 ISOPROPYL 5 METHOXY 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 1 ISOPROPYL 6 METHOXY 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 1 ISOPROPYL 6 METHOXYCARBONYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE FUMARATE; 1 ISOPROPYL 7 METHOXY 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 1 ISOPROPYL 8 METHOXY 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 2 [4 [(6 FLUORO 1 ISOPROPYL 1,2,3,4 DIHYDROISOQUINOLIN 2 YL)CARBONYL]PIPERIDIN 1 YL]N METHYL N PHENYLACETAMIDE FUMARATE; 2 [4 [(6 FLUORO 1 ISOPROPYL 1,2,3,4 DIHYDROISOQUINOLIN 2 YL)CARBONYL]PIPERIDIN 1 YL]N PHENYLACETAMIDE FUMARATE; 5 FLUORO 1 ISOPROPYL 6 METHOXY 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE FUMARATE; 6 CHLORO 1 ISOPROPYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 6 FLUORO 1 ISOPROPYL 2 [(1 BENZYLPIPERIDIN 4 YL)CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 6 FLUORO 1 ISOPROPYL 2 [(1 PHENACYLPIPERIDIN 4 YL)CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 6 FLUORO 1 ISOPROPYL 2 [[1 (2 METHYL 2 PHENYLPROPYL)PIPERIDIN 4 YL]CARBONYL 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 6 FLUORO 1 ISOPROPYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 6 FLUORO 1 ISOPROPYL 2 [[1 (3 PHENYLPROPYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 6 FLUORO 1 ISOPROPYL 2 [[1 (4 PHENYLBUTYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; 6,7 DIMETHOXY 1 ISOPROPYL 2 [[1 (2 PHENYLETHYL)PIPERIDIN 4 YL]CARBONYL] 1,2,3,4 TETRAHYDROISOQUINOLINE OXALATE; ANTIHYPERTENSIVE AGENT; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BRADYCARDIA; DRUG SCREENING; DRUG SYNTHESIS; ESSENTIAL HYPERTENSION; EXPERIMENTAL GUINEA PIG; HEART RIGHT ATRIUM; IN VITRO STUDY; MALE; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; GUINEA PIGS; HYPERTENSION; MALE; RATS; RATS, INBRED SHR; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 79961119307     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1029     Document Type: Article

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