Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2705-2708

  Gu, Su Jin ^a,b   Lee, Jae Kyun ^a   Pae, Ae Nim ^a   Chung, Hye Jin ^a   Rhim, Hyewon ^a   Han, So Yeob ^b   Min, Sun Joon ^a   Cho, Yong Seo ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

1,4 Diazepane; Pharmacokinetics; T type calcium channel blockers

Indexed keywords

1,4 DIAZEPANE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL T TYPE; MIBEFRADIL; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG PENETRATION; DRUG SELECTIVITY; DRUG SYNTHESIS; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AZEPINES; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL LINE; HUMANS; RATS; TRANS-ACTIVATORS;

EID: 77950943791     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.084     Document Type: Article

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