Synthesis and SAR studies of a novel series of T-type calcium channel blockers

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3502-3511

  Park, Seong Jun ^a,b   Park, Sung Jun ^c   Lee, Min Joo ^c   Rhim, Hyewhon ^a   Kim, Yoonjee ^a   Lee, Jung Ha ^d   Chung, Bong Young ^b   Lee, Jae Yeol ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Sogang University   (South Korea)

Author keywords

3,4 Dihydroquinazoline; Potency; Selectivity; Sulfonamido group; T type calcium channel blockers

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL T TYPE; MIBEFRADIL; QUINAZOLINE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, T-TYPE; CELL LINE; CELLS, CULTURED; ELECTROPHYSIOLOGY; HUMANS; LETHAL DOSE 50; MIBEFRADIL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; SULFONAMIDES;

EID: 33645860533     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.005     Document Type: Article

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