Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5244-5248

  Ku, Il Whea ^a,b   Cho, Sangwon ^a   Doddareddy, Munikumar Reddy ^a   Jang, Min Seok ^a   Keum, Gyochang ^a   Lee, Jung Ha ^c   Chung, Bong Young ^b   Kim, Youseung ^a   Rhim, Hyewhon ^a   Kang, Soon Bang ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c Sogang University   (South Korea)

Author keywords

Mibefradil; Morpholinone; T type Ca2+ channel

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT RECEPTOR; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL N TYPE BLOCKING AGENT; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE BLOCKING AGENT; ETHOSUXIMIDE; KETONE DERIVATIVE; KYS 05044; MIBEFRADIL; MORPHOLIN 2 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MEMBRANE CHANNEL; NONHUMAN;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, T-TYPE; CELL LINE; HUMANS; INHIBITORY CONCENTRATION 50; MORPHOLINES; OOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 33747330904     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.031     Document Type: Article

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