Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4- fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5628-5638

  Watanuki, Susumu ^a   Matsuura, Keisuke ^a   Tomura, Yuichi ^a   Okada, Minoru ^a   Okazaki, Toshio ^a   Ohta, Mitsuaki ^a   Tsukamoto, Shin Ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antihypertensive agent; Mibefradil; Piperidine 4 carboxamide; T type Ca 2+ channel

Indexed keywords

1 (1 BENZYLPIPERIDIN 4 YL) 3 [1 (4 FLUOROPHENYL)CYCLOHEXYL]PROPAN 1 ONE FUMARATE; 1 (1 BENZYLPIPERIDIN 4 YL) N [[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]METHANAMINE; 1 ALKYL N [2 ETHYL 2 (4 FLUOROPHENYL)BUTYL]PIPERIDINE 4 CARBOXAMIDE DERIVATIVE; 1 BENZYL N [2 (4 FLUOROPHENYL) 2 METHYLPROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 BENZYL N [2 ETHYL 2 (4 FLUOROPHENYL)BUTYL]PIPERIDINE 4 CARBOXAMIDE; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOBUTYL]METHYL]PIPERIDINE 4 CARBOXAMIDE; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL] N METHYLPIPERIDINE 4 CARBOXAMIDE OXYLIC ACID; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]PIPERIDINE 2 CARBOXAMIDE; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]PIPERIDINE 3 CARBOXAMIDE; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 BENZYL N [[1 (4 FLUOROPHENYL)CYCLOPENTYL]METHYL]PIPERIDINE 4 CARBOXAMIDE; 1 BENZYL N [[4 (4 FLUOROPHENYL)TETRAHYDRO 2H PYRAN 4 YL]METHYL]PIPERIDINE 4 CARBOXAMIDE; 3 [1 (4 FLUOROPHENYL)CYCLOHEXYL]PROPANE 1,2 DIOL; [1 (4 FLUOROPHENYL)CYCLOHEXYL]ACETIC ACID; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; MIBEFRADIL; N (1 BENZYLPIPERIDIN 4 YL) 2 [1 (4 FLUOROPHENYL)CYCLOHEXYL]ACETAMIDE OXYLIC ACID; N [2 ETHYL 2 (4 FLUOROPHENYL)BUTYL] 1 (2 PHENYLETHYL)PIPERIDINE 4 CARBOXAMIDE; TERT BUTYL 2 [[[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 3 [[[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [3 [1 (4 FLUOROPHENYL)CYCLOHEXYL]PROPANOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[2 (4 FLUOROPHENYL) 2 METHYLPROPYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[2 (4 FLUOROPHENYL) 2 PROPYLPENTYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[2 ETHYL 2 (4 FLUOROPHENYL)BUTYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[[1 (4 FLUOROPHENYL)CYCLOBUTYL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[[1 (4 FLUOROPHENYL)CYCLOHEXYL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[[1 (4 FLUOROPHENYL)CYCLOPENTYL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 [[[4 (4 FLUOROPHENYL)TETRAHYDRO 2H PYRAN 4 YL]METHYL]CARBAMOYL]PIPERIDINE 1 CARBOXYLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERTENSION; IC 50; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TACHYCARDIA;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ATRIAL FUNCTION, RIGHT; BLOOD PRESSURE; CALCIUM CHANNELS, T-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MALE; MOLECULAR STRUCTURE; PIPERIDINES; RATS; RATS, INBRED SHR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 80052604404     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.030     Document Type: Article

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