Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5938-5944

  Kam, Yoo Lim ^a   Rhee, Hee Kyung ^b   Rhim, Hyewhon ^c   Back, Seung Keun ^d   Na, Heung Sik ^d   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Korea University College of Medicine   (South Korea)

Author keywords

Diphenylpiperazine; Formalin test; Neuropathic pain; T type calcium channel blocker

Indexed keywords

1 ( 4 (( 4 CHLOROPHENYL)(PHENYL)METHYL)PIPERAZIN 1 YL) 4 (CYCLOHEXYLMETHYLAMINO)BUTAN 1 ONE; 4 AMINO 1 ( 4 (( 4 CHLOROPHENYL)(PHENYL)METHYL)PIPERAZIN 1 YL)BUTAN 1 ONE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; FORMALDEHYDE; GABAPENTIN; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG SYNTHESIS; IN VIVO STUDY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PATCH CLAMP; RAT; WHOLE CELL;

ANALGESICS; ANIMALS; CALCIUM CHANNELS, T-TYPE; HUMANS; NEURALGIA; PAIN MEASUREMENT; PIPERAZINES; RATS;

RATTUS;

EID: 77955471833     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.082     Document Type: Article

References (20)

1. W.A. Catterall Annu. Rev. Cell Dev. Biol. 16 2000 521
2. E. Perez-Reyes Physiol. Rev. 83 2003 117
3. H.-S. Shin, E.-J. Cheong, S. Choi, J. Lee, and H.S. Na Curr. Opin. Pharmacol. 8 2008 33
4. D. Kim, D. Park, S. Choi, S. Lee, M. Sun, C. Kim, and H.-S. Shin Science 302 2003 117
5. T.P. Snutch, and L.S. David Drug Dev. Res. 67 2006 404
6. M.E. Barton, E.L. Eberle, and H.E. Shannon Eur. J. Pharmacol. 521 2005 79
7. J.G. McGiven Drug Discovery Today 11 2006 245
8. B.M. Massie Am. J. Cardiol. 80 1997 231
9. M.E. Mullins, B.Z. Horowitz, D.H. Linden, G.W. Smith, R.L. Norton, and J. Stump JAMA 280 1998 157
10. D. Dubuisson, and S.G. Dennis Pain 4 1977 161
11. N. Akaike Comp. Biochem. Physiol. C 98 1991 31
12. C.M. Santi, F.S. Cayabyab, K.G. Sutton, J.E. McRory, J. Mezeyova, K.S. Hamming, D. Parker, A. Stea, and T.P. Snutch J. Neurosci. 22 2002 396
13. E. Richelson, and T. Souder Life Sci. 68 2000 29
14. P.M. Newton, L. Zeng, V. Wang, J. Connolly, M.J. Wallace, C. Kim, H.-S. Shin, F. Belardetti, T.P. Snutch, and R.O. Messing J. Neurosci. 28 2008 11712
15. T. Kim, J. Choi, S. Kim, O. Kwon, S.Y. Nah, Y.S. Han, and H. Rhim Biochem. Biophys. Res. Commun. 324 2004 401
16. J. Haley, S. Ketchum, and A. Dickenson Eur. J. Pharmacol. 191 1990 437
17. S.K. Back, J.S. Kim, S.K. Hong, and H.S. Na Neuroreport 14 2003 1623
18. H.S. Na, J.S. Han, K.H. Ko, and S.K. Hong Neurosci. Lett. 177 1994 50
19. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh J. Neurosci. Methods 53 1994 55
20. W.J. Dixon Annu. Rev. Pharmacol. Toxicol. 20 1980 441