SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5557-5561

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Ca v3.2) inhibitors

(15) Giordanetto, Fabrizio a Knerr, Laurent a Selmi, Nidhal a Llins, Antonio a Lindqvist, Anders a Wang, Qing Dong a Sthlberg, Pernilla a Thorstensson, Fredrik a Ullah, Victoria a Nilsson, Kristina a O'Mahony, Gavin a Högberg, Got a Lindhardt, Emma a Strand, Annika a Duker, Göran a

a ASTRAZENECA R AND D (Sweden)

Author keywords

Ca v3.2; Calcium channel inhibition; T type calcium channels

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE CAV3.2 BLOCKING AGENT; MIBEFRADIL; N (1 ADAMANTYL) 2 (4 ALKYLPIPERAZIN 1 YL) ACETAMIDE DERIVATIVE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; IC 50; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNELS, T-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ETHER-A-GO-GO POTASSIUM CHANNELS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR STRUCTURE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80051928867 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.092 Document Type: Article

Times cited : (7)

References (20)

1
- 0033713292
- E.A. Ertel, K.P. Campbell, M.M. Harpold, F. Hofmann, Y. Mori, E. Perez-Reyes, A. Schwartz, T.P. Snutch, T. Tanabe, L. Birnbaumer, R.W. Tsien, and W.A. Catterall Neuron 25 2000 533
- (2000) Neuron , vol.25 , pp. 533
- Ertel, E.A.¹ Campbell, K.P.² Harpold, M.M.³ Hofmann, F.⁴ Mori, Y.⁵ Perez-Reyes, E.⁶ Schwartz, A.⁷ Snutch, T.P.⁸ Tanabe, T.⁹ Birnbaumer, L.¹⁰ Tsien, R.W.¹¹ Catterall, W.A.¹²

2
- 0033560089
- E.M. Talley, L.L. Cribbs, J.H. Lee, A. Daud, E. Perez-Reyes, and D.A. Bayliss J. Neurosci. 19 1999 1895
- (1999) J. Neurosci. , vol.19 , pp. 1895
- Talley, E.M.¹ Cribbs, L.L.² Lee, J.H.³ Daud, A.⁴ Perez-Reyes, E.⁵ Bayliss, D.A.⁶

3
- 0032791883
- J.A. Van der Vring, T.J. Cleophas, E.E. Van der Wall, and M.G. Niemeyer Am. J. Ther. 6 1999 229
- (1999) Am. J. Ther. , vol.6 , pp. 229
- Van Der Vring, J.A.¹ Cleophas, T.J.² Van Der Wall, E.E.³ Niemeyer, M.G.⁴

4
- 0028183227
- L. Sen, and T.W. Smith Circ. Res. 75 1999 149
- (1999) Circ. Res. , vol.75 , pp. 149
- Sen, L.¹ Smith, T.W.²

5
- 0345440145
- S. Fareh, A. Benardeau, B. Thibault, and S. Nattel Circulation 100 1999 2191
- (1999) Circulation , vol.100 , pp. 2191
- Fareh, S.¹ Benardeau, A.² Thibault, B.³ Nattel, S.⁴

6
- 0035113546
- S. Fareh, A. Benardeau, and S. Nattel Cardiovasc. Res. 49 2001 762
- (2001) Cardiovasc. Res. , vol.49 , pp. 762
- Fareh, S.¹ Benardeau, A.² Nattel, S.³

7
- 0028985780
- H. Satoh Gen. Pharmacol. 26 1995 581
- (1995) Gen. Pharmacol. , vol.26 , pp. 581
- Satoh, H.¹

8
- 73049092068
- K. Ono, and T. Iijima J. Mol. Cell. Cardiol. 48 2010 65
- (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 65
- Ono, K.¹ Iijima, T.²

9
- 0025194171
- T. Kuga, J. Sadoshima, and H. Tomoike Circ. Res. 67 1990 469
- (1990) Circ. Res. , vol.67 , pp. 469
- Kuga, T.¹ Sadoshima, J.² Tomoike, H.³

10
- 0344875643
- C.-C. Chen, K.G. Lamping, D.W. Nuno, R. Barresi, S.J. Prouty, J.L. Lavoie, L.L. Cribbs, S.K. England, C.D. Sigmund, R.M. Weiss, R.A. Williamson, J.A. Hill, and K.P. Campbell Science 302 2003 1416
- (2003) Science , vol.302 , pp. 1416
- Chen, C.-C.¹ Lamping, K.G.² Nuno, D.W.³ Barresi, R.⁴ Prouty, S.J.⁵ Lavoie, J.L.⁶ Cribbs, L.L.⁷ England, S.K.⁸ Sigmund, C.D.⁹ Weiss, R.M.¹⁰ Williamson, R.A.¹¹ Hill, J.A.¹² Campbell, K.P.¹³

11
- 78650468385
- F. Giordanetto, L. Knerr, and A. Wllberg Exp. Op. Ther. Pat. 21 2011 85
- (2011) Exp. Op. Ther. Pat. , vol.21 , pp. 85
- Giordanetto, F.¹ Knerr, L.² Wllberg, A.³

12
- 33745391787
- G. Vassort, K. Talavera, and J.L. Alvarez Cell Calcium 40 2006 205
- (2006) Cell Calcium , vol.40 , pp. 205
- Vassort, G.¹ Talavera, K.² Alvarez, J.L.³

13
- 54549099278
- Z.Q. Yang, J.C. Barrow, W.D. Shipe, K.A. Schlegel, Y. Shu, F.V. Yang, C.W. Lindsley, K.E. Rittle, M.G. Bock, G.D. Hartman, V.N. Uebele, C.E. Nuss, S.V. Fox, R.L. Kraus, S.M. Doran, T.M. Connolly, C. Tang, J.E. Ballard, Y. Kuo, E.D. Adarayan, T. Prueksaritanont, M.M. Zrada, M.J. Marino, V.K. Graufelds, A.G. DiLella, I.J. Reynolds, H.M. Vargas, P.B. Bunting, R.F. Woltmann, M.M. Magee, K.S. Koblan, and J. Renger J. Med. Chem. 51 2008 6471
- (2008) J. Med. Chem. , vol.51 , pp. 6471
- Yang, Z.Q.¹ Barrow, J.C.² Shipe, W.D.³ Schlegel, K.A.⁴ Shu, Y.⁵ Yang, F.V.⁶ Lindsley, C.W.⁷ Rittle, K.E.⁸ Bock, M.G.⁹ Hartman, G.D.¹⁰ Uebele, V.N.¹¹ Nuss, C.E.¹² Fox, S.V.¹³ Kraus, R.L.¹⁴ Doran, S.M.¹⁵ Connolly, T.M.¹⁶ Tang, C.¹⁷ Ballard, J.E.¹⁸ Kuo, Y.¹⁹ Adarayan, E.D.²⁰ more..

14
- 0037777695
- E.B. Villhauer, J.A. Brinkman, G.B. Naderi, B.F. Burkey, B.E. Dunning, K. Prasad, B.L. Mangold, M.E. Russell, and T.E. Hughes J. Med. Chem. 46 2003 2774
- (2003) J. Med. Chem. , vol.46 , pp. 2774
- Villhauer, E.B.¹ Brinkman, J.A.² Naderi, G.B.³ Burkey, B.F.⁴ Dunning, B.E.⁵ Prasad, K.⁶ Mangold, B.L.⁷ Russell, M.E.⁸ Hughes, T.E.⁹

15
- 66249138835
- S.D. Guile, L. Alcaraz, T.N. Birkinshaw, K.C. Bowers, M.R. Ebden, M. Furber, and M.J. Stocks J. Med. Chem. 52 2009 3123
- (2009) J. Med. Chem. , vol.52 , pp. 3123
- Guile, S.D.¹ Alcaraz, L.² Birkinshaw, T.N.³ Bowers, K.C.⁴ Ebden, M.R.⁵ Furber, M.⁶ Stocks, M.J.⁷

16
- 33751045345
- B. Sorensen, J. Rohde, J. Wang, S. Fung, K. Monzon, W. Chiou, L. Pan, X. Deng, D. Stolarik, E.U. Frevert, P. Jacobsona, and J.T. Linka Bioorg. Med. Chem. Lett. 16 2006 5958
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5958
- Sorensen, B.¹ Rohde, J.² Wang, J.³ Fung, S.⁴ Monzon, K.⁵ Chiou, W.⁶ Pan, L.⁷ Deng, X.⁸ Stolarik, D.⁹ Frevert, E.U.¹⁰ Jacobsona, P.¹¹ Linka, J.T.¹²

17
- 23944454884
- S. Olson, S.D. Aster, K. Brown, L. Carbin, D.W. Graham, A. Hermanowski-Vosatka, C.B. LeGrand, S.S. Mundt, M.A. Robbins, J.M. Schaeffer, L.H. Slossberg, M.J. Szymonifka, R. Thieringer, S.D. Wright, and J.M. Balkoveca Bioorg. Med. Chem. Lett. 15 2005 4359
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4359
- Olson, S.¹ Aster, S.D.² Brown, K.³ Carbin, L.⁴ Graham, D.W.⁵ Hermanowski-Vosatka, A.⁶ Legrand, C.B.⁷ Mundt, S.S.⁸ Robbins, M.A.⁹ Schaeffer, J.M.¹⁰ Slossberg, L.H.¹¹ Szymonifka, M.J.¹² Thieringer, R.¹³ Wright, S.D.¹⁴ Balkoveca, J.M.¹⁵

18
- 71049126548
- F. Lovering, J. Bikker, and C. Humblet J. Med. Chem. 52 2009 6752
- (2009) J. Med. Chem. , vol.52 , pp. 6752
- Lovering, F.¹ Bikker, J.² Humblet, C.³

19
- 70350409235
- T.J. Ritchie, and S.J. Macdonald Drug Discovery Today 14 2009 1011
- (2009) Drug Discovery Today , vol.14 , pp. 1011
- Ritchie, T.J.¹ MacDonald, S.J.²

20
- 80051931404
- S. Dilbaghi, N. Abi-Gerges, M.J. Morton, M.H. Bridgland-Taylor, C.E. Pollard, and J.-P. Valentin J. Pharmacol. Toxicol. Methods 62 2010 e1
- (2010) J. Pharmacol. Toxicol. Methods , vol.62 , pp. 1
- Dilbaghi, S.¹ Abi-Gerges, N.² Morton, M.J.³ Bridgland-Taylor, M.H.⁴ Pollard, C.E.⁵ Valentin, J.-P.⁶

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