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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5910-5915

Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers

(8) Woo, Hyun Min b Lee, Yun Suk b Roh, Eun Joo b Seo, Seon Hee b Song, Chi Man b Chung, Hye Jin b Pae, Ae Nim b Shin, Kye Jung a

a The Catholic University of Korea (South Korea)

b Korea Institute of Science and Technology (South Korea)

Author keywords

Neuropathic pain; T type calcium channel

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; GABAPENTIN; MIBEFRADIL; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NEUROPATHIC PAIN; NONHUMAN; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; HYPERALGESIA; INHIBITORY CONCENTRATION 50; LIGANDS; MIBEFRADIL; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; NEURALGIA; PATCH-CLAMP TECHNIQUES; PIPERIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SPINAL NERVES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052555689 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.087 Document Type: Article

Times cited : (10)

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