Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix

Journal of Virology

Volumn 76, Issue 13, 2002, Pages 6857-6862

  Dorfman, Tatyana ^a   Popova, Elena ^a   Pizzato, Massimo ^a   Göttlinger, Heinrich G ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; NEF PROTEIN; SERINE;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS TRANSMISSION;

CELL LINE; GENE DELETION; GENE PRODUCTS, NEF; HIV-1; HUMANS; PHOSPHORYLATION; T-LYMPHOCYTES; VIRAL MATRIX PROTEINS;

EID: 0036282059     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.13.6857-6862.2002     Document Type: Article

References (56)

1. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
2. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
3. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
4. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation
5. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
6. Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
7. Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity
8. The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
9. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
10. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
11. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
12. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
13. Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein
14. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys
15. A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum
16. p21-activated kinase 1 plays a critical role in cellular activation by Nef
17. Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix
18. Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production
19. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
20. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef
21. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
22. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: Implications for membrane association and assembly
23. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity
24. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
25. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
26. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1
27. Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: Implications for HIV-based gene transfer systems
28. Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains
29. Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity
30. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
31. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
32. Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage
33. Binding of human immunodeficiency virus type 1 Gag to membrane: Role of the matrix amino terminus
34. Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of Gag membrane targeting
35. Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation
36. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
37. Efficient HIV-1 replication can occur in the absence of the viral matrix protein
38. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
39. + viruses but not for down-regulation of CD4
40. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes
41. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
42. HIV-1 Nef increases T cell activation in a stimulus-dependent manner
43. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
44. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
45. Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism
46. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
47. The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
48. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
49. Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant
50. The Nef protein of HIV-1 associates with rafts and primes T cells for activation
51. Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: Analysis of its role in enhancement of viral infectivity
52. Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
53. In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity
54. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
55. The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions
56. Nef increases infectivity of HIV via lipid rafts