Regions of human immunodeficiency virus type 1 nef required for function in vivo

Journal of Virology

Volumn 72, Issue 9, 1998, Pages 7032-7039

  Aldrovandi, Grace M ^a   Gao, Lianying ^b   Bristol, Gregory ^b   Zack, Jerome A ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; T LYMPHOCYTE; VIRUS GENE; VIRUS MUTATION; VIRUS PATHOGENESIS;

EID: 0031872106     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.9.7032-7039.1998     Document Type: Article

References (55)

1. Aldrovandi, G. M., G. Feuer, L. Gao, M. Kristeva, I. S. Y. Chen, B. Jamieson, and J. A. Zack. 1993. HIV-1 infection of the SCID-hu mouse: an animal model for virus pathogenesis. Nature 363:732-736.
2. Aldrovandi, G. M., and J. A. Zack. 1996. Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J. Virol. 70:1505-1511.
3. Bachelerie, F., J. Alcami, U. Hazan, N. Israel, B. Goud, F. Arenzana-Seisdedos, and J.-L. Virelizier. 1990. Constitutive expression of human immunodeficiency virus (HIV) nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity. J. Virol. 64:3059-3062.
4. Baur, A. S., E. T. Sawai, P. Dazin, W. J. Fantl, C. Cheng-Mayer, and B. M. Peterlin. 1994. HIV-1 Net leads to inhibition or activation of T cells, depending on its intracellular localization. Immunity 1:373-384.
5. Bodeus, M., A. Marie-Cardine, C. Bougeret, F. Ramos-Morales, and R. Benarous. 1995. In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by seríne/threoníne protein kinase. J. Gen. Virol. 76:1337-1344.
6. Bonyhadi, M. L., L. Rabin, S. Salimi, D. A. Brown, J. Kosek, J. M. McCune, and H. Kaneshima. 1993. HIV induces thymus depletion in vivo. Nature 363:728-736.
7. Cann, A. J., Y. Koyanagi, and I. S. Y. Chen. 1988. High efficiency transfection of primary human lymphocytes and studies of gene expression. Oncogene 3:123-128.
8. Chowers, M. Y., C. A. Spina, T. J. Kwoh, N. J. S. Fitch, D. D. Richman, and J. C. Guatelli. 1994. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol. 68:2906-2914.
9. Deacon, N. J., A. Tsykin, A. Solomon, K. Smith, M. Ludford-Meming, D. J. Hooker, D. A. McPhee, A. L. Greenway, A. Ellett, C. Chatfield, V. A. Lawson, S. Crowe, A. Maerz, S. Sonza, J. Learmont, J. S. Sullivan, A. Cunningham, D. Dwyer, D. Dowton, and J. Mills. 1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270:988-991.
10. Du, Z., S. M. Lang, V. G. Sasseville, A. A. Lackner, P. O. Ilyinskii, M. D. Daniel, J. U. Jung, and R. C. Desrosiers. 1995. Identification of a nef allele that causes lymphocyte activation and acute dísease ín macaque monkeys. Cell 82:665-674.
11. Franchini, G., M. Robert-Guroff, J. Ghrayeb, N. T. Chang, and F. WongStaal. 1986. Cytoplasmic localization of the HTLV-III 3' orf protein in cultured T cells. Virology 155:593-599.
12. Freund, J., R. Kellner, T. Houthaeve, and H. R. Kalbitzer. 1994. Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1. Eur. J. Biochem. 221:811-819.
13. Fultz, P. N. 1991. Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes. J. Virol. 65:4902-4909.
14. Gaedigk-Nitschko, K., A. Schon, G. Wachinger, V. Erfle, and B. Kohleisen. 1995. Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV-1) Nef protein by HIV-1 protease. FEBS Lett. 357:275-278.
15. Garcia, J. V., and A. D. Miller. 1992. Downregulation of cell surface CD4 by nef. Res. Virol. 143:52-55.
16. Gibbs, J. S., D. A. Regier, and R. C. Desrosiers. 1994. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res. Human Retroviruses 10:343-350.
17. Goldsmith, M. A., M. T. Warmerdam, R. E. Atchison, M. D. Miller, and W. C. Greene. 1995. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 69:4112-4121.
18. Grzesiek, S., A. Bax, G. M. Clore, A. Groneborn, J.-S. Hu, J. Kaufman, I. Palmer, S. Stahl, and P. Wingfield. 1996. The solution structure of HlV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nat. Struct. Biol. 3:340-344.
19. Guy, B., M. P. Kieny, Y. Riviere, C. Le Peuch, K. Dott, M. Girard, L. Montagnie, and J.-P. Lecocq. 1987. HlV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330:266-269.
20. Hammes, S. R., E. P. Dixon, M. H. Malim, B. R. Cullen, and W. C. Greene. 1989. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc. Natl. Acad. Sci. USA 86:9549-9553.
21. Huang, Y., L. Zhang, and D. D. Ho. 1995. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 69:93-100.
22. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. M. Jowett, L. Gao, L. M. Bloch, I. S. Y. Chen, and J. A. Zack. 1994. Requirement of HIV-1 nef for in vivo replication and pathogenesis. J. Virol. 68:3478-3485.
23. Kaminchik, J., R. Margalit, S. Yaish, H. Drummer, B. Amit, N. Sarver, M. Gorecki, and A. Panet. 1994. Cellular distribution of HlV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix. AIDS Res. Human Retroviruses 10:1003-1010.
24. + T cells in vitro and in vivo. J. Virol. 71:8456-8466.
25. Kestler, H. W., III, D. J. Ringler, M. Kazuyasu, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
26. Kirchoff, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Desrosiers. 1995. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332:228-232.
27. Kohleisen, B., M. Neumann, R. Herrmann, R. Brack-Werner, K. J. Krohn, V. Ovod, A. Ranki, and V. Erfle. 1992. Cellular localization of Nef expressed in persistently HIV-1-infected low-producer astrocytes. AIDS 6:1427-1436.
28. Kollmann, T. R., M. Pettoello-Mantovani, X. Zhuang, A. Kim, M. Hachamovitch, P. Smarnworawong, A. Rubinstein, and H. Goldstein. 1994. Disseminated human immunodeficiency virus type 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J. Exp. Med. 179:513-522.
29. Krohn, K. J. E., V. Ovod, A. Langerstedt, U. Saarialho-Kere, A. Ranki, F. O. Gombert, G. Jong, and K. Molling. 1991. Expression kinetics and cellular localization of HIV tat and nef proteins in relation to expression of viral structural mRNA and viral particles. Vaccines 91:97-101.
30. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
31. Lang, S. M., A. J. Iafrate, C. Stahl-Hennig, E. M. Kuhn, T. Nisslein, F.-J. Kaup, M. Haupt, G. Hunsmann, J. Skowronski, and F. Kirchhoff. 1997. Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nat. Med. 3:860-865.
32. Lee, C., B. Leung, M. A. Lemmon, J. Zheng, D. Cowburn, J. Kuriyan, and K. Saksela. 1995. A single amíno acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14:5006-5015.
33. McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Schultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241:1632-1639.
34. Miller, M. D., M. T. Warmerdam, I. Gaston, W. C. Greene, and M. B. Feinberg. 1994. The human immunodeficíency vírus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179:101-113.
35. Murti, K. G., P. S. Brown, L. Ratner, and J. V. Garcia. 1993. Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line. Proc. Natl. Acad. Sci. USA 90:11895-11899.
36. Namikawa, R., K. N. Weilbaecher, H. Kaneshima, E. J. Yee, and J. M. McCune. 1990. Long-term human hematopoiesis in the SCID-hu mouse. J. Exp. Med. 172:1055-1063.
37. Niederman, T. M., W. R. Hastings, and L. Ratner. 1993. Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix. Virology 197:420-425.
38. Ovod, V., A. Lagerstedt, A. Ranki, F. O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K. J. Krohn. 1992. Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies. AIDS 6:25-34.
39. Pandori, M. W., N. J. S. Fitch, H. M. Craig, D. D. Richman, C. A. Spina, and J. C. Guatelli. 1996. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J. Virol. 70:4283-4290.
40. Planelles, V., A. Haislip, E. S. Withers-Ward, S. A. Stewart, Y. Xie, N. P. Shah, and I. S. Y. Chen. 1995. A new reporter system for detection of viral infection. Gene Ther. 2:369-376.
41. Poulin, L., and J. A. Levy. 1992. The HIV-1 nef gene product is associated with phosphorylation of a 46 kD cellular protein. AIDS 6:787-791.
42. Ranki, A., A. Lagerstedt, V. Ovod, E. Aavik, and K. J. Krohn. 1994. Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid cell lines. Arch. Virol. 139:365-378.
43. Saksela, K., G. Cheng, and D. Baltimore. 1995. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J. 14:484-491.
44. Sawai, E. T., A. S. Baur, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1995. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:15307-15314.
45. Sawai, E. T., A. Baur, H. Struble, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1994. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA 91:1539-1543.
46. Sawai, E. T., E. H. Khan, P. M. Montbriand, B. J. Peterlin, C. Cheng-Mayer, and P. A. Luciw. 1996. Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques. Curr. Biol. 6:1519-1527.
47. Shugars, D. C., M. S. Smith, D. H. Glueck, P. V. Nantermet, F. Seillier-Moiseiwitsch, and R. Swanstrom. 1993. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J. Virol. 67:4639-4650.
48. Spina, C. A., T. J. Kwoh, M. Y. Chowers, J. C. Guatelli, and D. D. Richmond. 1994. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179:115-123.
49. Stanley, S. K., J. M. McCune, H. Kaneshima, J. S. Justement, M. Sullivan, E. Boone, M. Baseler, J. Adelsberger, M. Bonyhadi, J. Orenstein, C. H. Fox, and A. S. Fauci. 1993. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J. Exp. Med. 178:1151-1163.
50. Welker, R., M. Harris, B. Cardel, and H.-G. Krausslich. Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane targeting signal and correlates with enhancement of viral infectivity. Submitted for publication.
51. Welker, R., H. Kottler, H. R. Kalbitzer, and H. G. Krausslich. 1996. Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219:228-236.
52. Wiskerchen, M., and C. Cheng-Mayer. 1996. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology 224:292-301.
53. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Y. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
54. Zack, J. A., A. Haislip, P. Krogstad, and I. S. Y. Chen. 1992. Incompletely reverse transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retrovirus life cycle. J. Virol. 66:1717-1725.
55. Zazopoulos, E., and W. A. Haseltine. 1992. Mutational analysis of the human immunodeficiency virus type 1 Nef function. Proc. Natl. Acad. Sci. USA 89:6634-6638.