메뉴 건너뛰기




Volumn 92, Issue 1, 2011, Pages 141-150

CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; ENVELOPE PROTEIN; MUTANT PROTEIN; NEF PROTEIN;

EID: 78651244198     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.026005-0     Document Type: Article
Times cited : (10)

References (50)
  • 2
    • 0029015330 scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
    • Aiken, C. & Trono, D. (1995). Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 69, 5048-5056.
    • (1995) J Virol , vol.69 , pp. 5048-5056
    • Aiken, C.1    Trono, D.2
  • 3
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E. & Trono, D. (1994). Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76, 853-864.
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 4
    • 0027158904 scopus 로고
    • Downregulation of cell-surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection
    • Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C. & Cullen, B. R. (1993). Downregulation of cell-surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection. J Exp Med 177, 1561-1566.
    • (1993) J Exp Med , vol.177 , pp. 1561-1566
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 5
  • 6
    • 0142060865 scopus 로고    scopus 로고
    • CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression
    • Casartelli, N., Di Matteo, G., Potestà, M., Rossi, P. & Doria, M. (2003). CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression. J Virol 77, 11536-11545.
    • (2003) J Virol , vol.77 , pp. 11536-11545
    • Casartelli, N.1    Di Matteo, G.2    Potestà, M.3    Rossi, P.4    Doria, M.5
  • 7
    • 33746838437 scopus 로고    scopus 로고
    • The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner
    • Casartelli, N., Giolo, G., Neri, F., Haller, C., Potestà, M., Rossi, P., Fackler, O. T. & Doria, M. (2006). The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner. J Gen Virol 87, 2291-2296.
    • (2006) J Gen Virol , vol.87 , pp. 2291-2296
    • Casartelli, N.1    Giolo, G.2    Neri, F.3    Haller, C.4    Potestà, M.5    Rossi, P.6    Fackler, O.T.7    Doria, M.8
  • 8
    • 33846141778 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
    • Cerboni, C., Neri, F., Casartelli, N., Zingoni, A., Cosman, D., Rossi, P., Santoni, A. & Doria, M. (2007). Human immunodeficiency virus 1 nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J Gen Virol 88, 242-250.
    • (2007) J Gen Virol , vol.88 , pp. 242-250
    • Cerboni, C.1    Neri, F.2    Casartelli, N.3    Zingoni, A.4    Cosman, D.5    Rossi, P.6    Santoni, A.7    Doria, M.8
  • 9
    • 0035088135 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require nef for optimal infectivity
    • Chazal, N., Singer, G., Aiken, C., Hammarskjold, M. L. & Rekosh, D. (2001). Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require nef for optimal infectivity. J Virol 75, 4014-4018.
    • (2001) J Virol , vol.75 , pp. 4014-4018
    • Chazal, N.1    Singer, G.2    Aiken, C.3    Hammarskjold, M.L.4    Rekosh, D.5
  • 10
    • 0029793620 scopus 로고    scopus 로고
    • CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef
    • Chen, B. K., Gandhi, R. T. & Baltimore, D. (1996). CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J Virol 70, 6044-6053.
    • (1996) J Virol , vol.70 , pp. 6044-6053
    • Chen, B.K.1    Gandhi, R.T.2    Baltimore, D.3
  • 11
    • 0028302998 scopus 로고
    • Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
    • Chowers, M. Y., Spina, C. A., Kwoh, T. J., Fitch, N. J., Richman, D. D. & Guatelli, J. C. (1994). Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J Virol 68, 2906-2914.
    • (1994) J Virol , vol.68 , pp. 2906-2914
    • Chowers, M.Y.1    Spina, C.A.2    Kwoh, T.J.3    Fitch, N.J.4    Richman, D.D.5    Guatelli, J.C.6
  • 12
    • 0028820530 scopus 로고
    • The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
    • Chowers, M. Y., Pandori, M. W., Spina, C. A., Richman, D. D. & Guatelli, J. C. (1995). The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 212, 451-457.
    • (1995) Virology , vol.212 , pp. 451-457
    • Chowers, M.Y.1    Pandori, M.W.2    Spina, C.A.3    Richman, D.D.4    Guatelli, J.C.5
  • 14
    • 70749142026 scopus 로고    scopus 로고
    • Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection
    • Doria, M., Neri, F., Gallo, A., Farace, M. G. & Michienzi, A. (2009). Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection. Nucleic Acids Res 37, 5848-5858.
    • (2009) Nucleic Acids Res , vol.37 , pp. 5848-5858
    • Doria, M.1    Neri, F.2    Gallo, A.3    Farace, M.G.4    Michienzi, A.5
  • 16
    • 0028339186 scopus 로고
    • Cell surface down-modulation of CD4 after infection by HIV-1
    • Geleziunas, R., Bour, S. & Wainberg, M. A. (1994). Cell surface down-modulation of CD4 after infection by HIV-1. FASEB J 8, 593-600.
    • (1994) FASEB J , vol.8 , pp. 593-600
    • Geleziunas, R.1    Bour, S.2    Wainberg, M.A.3
  • 18
    • 0034894379 scopus 로고    scopus 로고
    • Structure-function relationships in HIV-1 nef
    • Geyer, M., Fackler, O. T. & Peterlin, B. M. (2001). Structure-function relationships in HIV-1 nef. EMBO Rep 2, 580-585.
    • (2001) EMBO Rep , vol.2 , pp. 580-585
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 19
    • 36248950722 scopus 로고    scopus 로고
    • Internalization and intracellular retention of CD4 are two separate functions of the human immunodeficiency virus type 1 nef protein
    • Giolo, G., Neri, F., Casartelli, N., Potestà, M., Belleudi, F., Torrisi, M. R. & Doria, M. (2007). Internalization and intracellular retention of CD4 are two separate functions of the human immunodeficiency virus type 1 nef protein. J Gen Virol 88, 3133-3138.
    • (2007) J Gen Virol , vol.88 , pp. 3133-3138
    • Giolo, G.1    Neri, F.2    Casartelli, N.3    Potestà, M.4    Belleudi, F.5    Torrisi, M.R.6    Doria, M.7
  • 21
    • 0029046227 scopus 로고
    • Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 nef
    • Goldsmith, M. A., Warmerdam, M. T., Atchison, R. E., Miller, M. D. & Greene, W. C. (1995). Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 nef. J Virol 69, 4112-4121.
    • (1995) J Virol , vol.69 , pp. 4112-4121
    • Goldsmith, M.A.1    Warmerdam, M.T.2    Atchison, R.E.3    Miller, M.D.4    Greene, W.C.5
  • 22
    • 0030587831 scopus 로고    scopus 로고
    • Molecular analysis of the cytoplasmic domain of CD4: Overlapping but noncompetitive requirement for lck association and down-regulation by Nef
    • Gratton, S., Yao, X. J., Venkatesan, S., Cohen, E. A. & Sékaly, R. P. (1996). Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef. J Immunol 157, 3305-3311.
    • (1996) J Immunol , vol.157 , pp. 3305-3311
    • Gratton, S.1    Yao, X.J.2    Venkatesan, S.3    Cohen, E.A.4    Sékaly, R.P.5
  • 23
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • Hanna, Z., Kay, D. G., Rebai, N., Guimond, A., Jothy, S. & Jolicoeur, P. (1998). Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95, 163-175.
    • (1998) Cell , vol.95 , pp. 163-175
    • Hanna, Z.1    Kay, D.G.2    Rebai, N.3    Guimond, A.4    Jothy, S.5    Jolicoeur, P.6
  • 24
    • 32844464362 scopus 로고    scopus 로고
    • HIV-1 nef mutations abrogating downregulation of CD4 affect other nef functions and show reduced pathogenicity in transgenic mice
    • Hanna, Z., Priceputu, E., Hu, C., Vincent, P. & Jolicoeur, P. (2006). HIV-1 nef mutations abrogating downregulation of CD4 affect other nef functions and show reduced pathogenicity in transgenic mice. Virology 346, 40-52.
    • (2006) Virology , vol.346 , pp. 40-52
    • Hanna, Z.1    Priceputu, E.2    Hu, C.3    Vincent, P.4    Jolicoeur, P.5
  • 25
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • Iafrate, A. J., Carl, S., Bronson, S., Stahl-Hennig, C., Swigut, T., Skowronski, J. & Kirchhoff, F. (2000). Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol 74, 9836-9844.
    • (2000) J Virol , vol.74 , pp. 9836-9844
    • Iafrate, A.J.1    Carl, S.2    Bronson, S.3    Stahl-Hennig, C.4    Swigut, T.5    Skowronski, J.6    Kirchhoff, F.7
  • 27
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff, F., Greenough, T. C., Brettler, D. B., Sullivan, J. L. & Desrosiers, R. C. (1995). Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 332, 228-232.
    • (1995) N Engl J Med , vol.332 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 28
    • 0033578072 scopus 로고    scopus 로고
    • Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking env incorporation in a nef- and vpu-inhibitable manner
    • Lama, J., Mangasarian, A. & Trono, D. (1999). Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking env incorporation in a nef- and vpu-inhibitable manner. Curr Biol 9, 622-631.
    • (1999) Curr Biol , vol.9 , pp. 622-631
    • Lama, J.1    Mangasarian, A.2    Trono, D.3
  • 29
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV1 nef and vacuolar ATPase facilitate the internalization of CD4
    • Lu, X., Yu, H., Liu, S. H., Brodsky, F. M. & Peterlin, B. M. (1998). Interactions between HIV1 nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8, 647-656.
    • (1998) Immunity , vol.8 , pp. 647-656
    • Lu, X.1    Yu, H.2    Liu, S.H.3    Brodsky, F.M.4    Peterlin, B.M.5
  • 30
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist, C. A., Tobiume, M., Zhou, J., Unutmaz, D. & Aiken, C. (2002). Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 76, 4625-4633.
    • (2002) J Virol , vol.76 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 31
    • 2642545601 scopus 로고    scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: Coreceptor-dependent requirement for nef in viral replication
    • Lundquist, C. A., Zhou, J. & Aiken, C. (2004). Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for nef in viral replication. J Virol 78, 6287-6296.
    • (2004) J Virol , vol.78 , pp. 6287-6296
    • Lundquist, C.A.1    Zhou, J.2    Aiken, C.3
  • 32
    • 44649139364 scopus 로고    scopus 로고
    • HIV-1 accessory proteins: Ensuring viral survival in a hostile environment
    • Malim, M. H. & Emerman, M. (2008). HIV-1 accessory proteins: ensuring viral survival in a hostile environment. Cell Host Microbe 3, 388-398.
    • (2008) Cell Host Microbe , vol.3 , pp. 388-398
    • Malim, M.H.1    Emerman, M.2
  • 33
    • 0033013962 scopus 로고    scopus 로고
    • Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of nef selectively regulate MHC-I trafficking
    • Mangasarian, A., Piguet, V., Wang, J. K., Chen, Y. L. & Trono, D. (1999). Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of nef selectively regulate MHC-I trafficking. J Virol 73, 1964-1973.
    • (1999) J Virol , vol.73 , pp. 1964-1973
    • Mangasarian, A.1    Piguet, V.2    Wang, J.K.3    Chen, Y.L.4    Trono, D.5
  • 34
    • 0029846223 scopus 로고    scopus 로고
    • High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection
    • Mariani, R., Kirchhoff, F., Greenough, T. C., Sullivan, J. L., Desrosiers, R. C. & Skowronski, J. (1996). High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol 70, 7752-7764.
    • (1996) J Virol , vol.70 , pp. 7752-7764
    • Mariani, R.1    Kirchhoff, F.2    Greenough, T.C.3    Sullivan, J.L.4    Desrosiers, R.C.5    Skowronski, J.6
  • 35
    • 0028936207 scopus 로고
    • Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
    • Miller, M. D., Warmerdam, M. T., Page, K. A., Feinberg, M. B. & Greene, W. C. (1995). Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol 69, 579-584.
    • (1995) J Virol , vol.69 , pp. 579-584
    • Miller, M.D.1    Warmerdam, M.T.2    Page, K.A.3    Feinberg, M.B.4    Greene, W.C.5
  • 36
    • 38549095979 scopus 로고    scopus 로고
    • Tetherin inhibits retrovirus release and is antagonized by HIV-1 vpu
    • Neil, S. J., Zang, T. & Bieniasz, P. D. (2008). Tetherin inhibits retrovirus release and is antagonized by HIV-1 vpu. Nature 451, 425-430.
    • (2008) Nature , vol.451 , pp. 425-430
    • Neil, S.J.1    Zang, T.2    Bieniasz, P.D.3
  • 37
    • 0032147182 scopus 로고    scopus 로고
    • Nef: An adaptor adaptor?
    • Oldridge, J. & Marsh, M. (1998). Nef: an adaptor adaptor? Trends Cell Biol 8, 302-305.
    • (1998) Trends Cell Biol , vol.8 , pp. 302-305
    • Oldridge, J.1    Marsh, M.2
  • 38
    • 0036281905 scopus 로고    scopus 로고
    • Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens
    • Patel, P. G., Yu Kimata, M. T., Biggins, J. E., Wilson, J. M. & Kimata, J. T. (2002). Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens. J Virol 76, 6425-6434.
    • (2002) J Virol , vol.76 , pp. 6425-6434
    • Patel, P.G.1    Yu Kimata, M.T.2    Biggins, J.E.3    Wilson, J.M.4    Kimata, J.T.5
  • 39
    • 14844322164 scopus 로고    scopus 로고
    • CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) nef proteins involves both internalization and intracellular retention mechanisms
    • Rose, J. J., Janvier, K., Chandrasekhar, S., Sekaly, R. P., Bonifacino, J. S. & Venkatesan, S. (2005). CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) nef proteins involves both internalization and intracellular retention mechanisms. J Biol Chem 280, 7413-7426.
    • (2005) J Biol Chem , vol.280 , pp. 7413-7426
    • Rose, J.J.1    Janvier, K.2    Chandrasekhar, S.3    Sekaly, R.P.4    Bonifacino, J.S.5    Venkatesan, S.6
  • 40
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral nef protein
    • Ross, T. M., Oran, A. E. & Cullen, B. R. (1999). Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral nef protein. Curr Biol 9, 613-621.
    • (1999) Curr Biol , vol.9 , pp. 613-621
    • Ross, T.M.1    Oran, A.E.2    Cullen, B.R.3
  • 41
    • 2542492063 scopus 로고    scopus 로고
    • HIV-1 nef enhances both membrane expression and virion incorporation of env products. A model for the nef-dependent increase of HIV-1 infectivity
    • Schiavoni, I., Trapp, S., Santarcangelo, A. C., Piacentini, V., Pugliese, K., Baur, A. & Federico, M. (2004). HIV-1 nef enhances both membrane expression and virion incorporation of env products. A model for the nef-dependent increase of HIV-1 infectivity. J Biol Chem 279, 22996-23006.
    • (2004) J Biol Chem , vol.279 , pp. 22996-23006
    • Schiavoni, I.1    Trapp, S.2    Santarcangelo, A.C.3    Piacentini, V.4    Pugliese, K.5    Baur, A.6    Federico, M.7
  • 43
    • 0029045360 scopus 로고
    • Human immunodeficiency virus type 1 nef increases the efficiency of reverse transcription in the infected cell
    • Schwartz, O., Marechal, V., Danos, O. & Heard, J. M. (1995). Human immunodeficiency virus type 1 nef increases the efficiency of reverse transcription in the infected cell. J Virol 69, 4053-4059.
    • (1995) J Virol , vol.69 , pp. 4053-4059
    • Schwartz, O.1    Marechal, V.2    Danos, O.3    Heard, J.M.4
  • 44
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • Spina, C. A., Kwoh, T. J., Chowers, M. Y., Guatelli, J. C. & Richman, D. D. (1994). The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 179, 115-123.
    • (1994) J Exp Med , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3    Guatelli, J.C.4    Richman, D.D.5
  • 45
    • 0037302331 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 nef-mediated downregulation of CD4 correlates with nef enhancement of viral pathogenesis
    • Stoddart, C. A., Geleziunas, R., Ferrell, S., Linquist-Stepps, V., Moreno, M. E., Bare, C., Xu, W., Yonemoto, W., Bresnahan, P. A. & other authors (2003). Human immunodeficiency virus type 1 nef-mediated downregulation of CD4 correlates with nef enhancement of viral pathogenesis. J Virol 77, 2124-2133.
    • (2003) J Virol , vol.77 , pp. 2124-2133
    • Stoddart, C.A.1    Geleziunas, R.2    Ferrell, S.3    Linquist-Stepps, V.4    Moreno, M.E.5    Bare, C.6    Xu, W.7    Yonemoto, W.8    Bresnahan, P.A.9
  • 46
    • 0038309969 scopus 로고    scopus 로고
    • Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1
    • Tanaka, M., Ueno, T., Nakahara, T., Sasaki, K., Ishimoto, A. & Sakai, H. (2003). Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1. Virology 311, 316-325.
    • (2003) Virology , vol.311 , pp. 316-325
    • Tanaka, M.1    Ueno, T.2    Nakahara, T.3    Sasaki, K.4    Ishimoto, A.5    Sakai, H.6
  • 47
    • 0036109518 scopus 로고    scopus 로고
    • Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 nef from japanese long-term nonprogressors
    • Tobiume, M., Takahoko, M., Yamada, T., Tatsumi, M., Iwamoto, A. & Matsuda, M. (2002). Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 nef from japanese long-term nonprogressors. J Virol 76, 5959-5965.
    • (2002) J Virol , vol.76 , pp. 5959-5965
    • Tobiume, M.1    Takahoko, M.2    Yamada, T.3    Tatsumi, M.4    Iwamoto, A.5    Matsuda, M.6
  • 48
    • 41849116366 scopus 로고    scopus 로고
    • The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral vpu protein
    • Van Damme, N., Goff, D., Katsura, C., Jorgenson, R. L., Mitchell, R., Johnson, M. C., Stephens, E. B. & Guatelli, J. (2008). The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral vpu protein. Cell Host Microbe 3, 245-252.
    • (2008) Cell Host Microbe , vol.3 , pp. 245-252
    • Van Damme, N.1    Goff, D.2    Katsura, C.3    Jorgenson, R.L.4    Mitchell, R.5    Johnson, M.C.6    Stephens, E.B.7    Guatelli, J.8
  • 49
    • 33746799703 scopus 로고    scopus 로고
    • Contribution of vpu, env, and nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection
    • Wildum, S., Schindler, M., Munch, J. & Kirchhoff, F. (2006). Contribution of vpu, env, and nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. J Virol 80, 8047-8059.
    • (2006) J Virol , vol.80 , pp. 8047-8059
    • Wildum, S.1    Schindler, M.2    Munch, J.3    Kirchhoff, F.4
  • 50
    • 0026452726 scopus 로고
    • Human immunodeficiency virus type 1 vpu protein induces rapid degradation of CD4
    • Willey, R. L., Maldarelli, F., Martin, M. A. & Strebel, K. (1992). Human immunodeficiency virus type 1 vpu protein induces rapid degradation of CD4. J Virol 66, 7193-7200.
    • (1992) J Virol , vol.66 , pp. 7193-7200
    • Willey, R.L.1    Maldarelli, F.2    Martin, M.A.3    Strebel, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.