Induction of HIV transcription by Nef involves Lck activation and protein kinase Cθ raft recruitment leading to activation of ERK1/2 but not NFκB

Journal of Immunology

Volumn 181, Issue 12, 2008, Pages 8425-8432

  Witte, Vanessa ^a   Laffert, Bernd ^c,e   Gintschel, Patricia ^a   Krautkrämer, Ellen ^d   Blume, Katja ^c   Fackler, Oliver T ^d   Baur, Andreas S ^b,c  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e CCS Cell Culture Service GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEF PROTEIN; PROTEIN KINASE C THETA; PROTEIN KINASE LCK; ISOENZYME; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS REPLICATION; VIRUS TRANSCRIPTION; CELL LINE; CELL MEMBRANE; COMPARATIVE STUDY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; T LYMPHOCYTE; UPREGULATION; VIROLOGY;

CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, VIRAL; HIV-1; HUMANS; ISOENZYMES; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MAP KINASE SIGNALING SYSTEM; MEMBRANE MICRODOMAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; NF-KAPPA B; PROTEIN KINASE C; PROTEIN TRANSPORT; T-LYMPHOCYTES; UP-REGULATION;

EID: 58849132949     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.12.8425     Document Type: Article

References (38)

1. Kestler, H. W., 3rd, D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662.
2. Kirchhoff, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Desrosiers. 1995. Brief report: absence of intact nef sequences in a longterm survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332: 228-232.
3. Deacon, N. J., A. Tsykin, A. Solomon, K. Smith, M. Ludford-Menting, D. J. Hooker, D. A. McPhee, A. L. Greenway, A. Ellett, C. Chatfield, et al. 1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270: 988-991.
4. Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef. Nature 350: 508-511.
5. Bell, I., C. Ashman, J. Maughan, E. Hooker, F. Cook, and T. A. Reinhart. 1998. Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation. J. Gen. Virol. 79: 2717-2727. (Pubitemid 28497624)
6. Stumptner-Cuvelette, P., S. Morchoisne, M. Dugast, S. Le Gall, G. Raposo, O. Schwartz, and P. Benaroch. 2001. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc. Natl. Acad. Sci. USA 98: 12144-12149.
7. Swigut, T., N. Shohdy, and J. Skowronski. 2001. Mechanism for down-regulation of CD28 by Nef. EMBO J. 20: 1593-1604.
8. Schwartz, O., V. Marechal, S. Le Gall, F. Lemonnier, and J. M. Heard. 1996. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 2: 338-342. (Pubitemid 26080655)
9. Aiken, C., and D. Trono. 1995. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69: 5048-5056.
10. Schwartz, O., V. Marechal, O. Danos, and J. M. Heard. 1995. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J. Virol. 69: 4053-4059.
11. Schrager, J. A., and J. W. Marsh. 1999. HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc. Natl. Acad. Sci. USA 96: 8167-8172.
12. Wang, J. K., E. Kiyokawa, E. Verdin, and D. Trono. 2000. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc. Natl. Acad. Sci. USA 97: 394-399. (Pubitemid 30055842)
13. Witte, V., B. Laffert, O. Rosorius, P. Lischka, K. Blume, G. Galler, A. Stilper, D. Willbold, P. D'Aloja, M. Sixt, et al. 2004. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol. Cell 13: 179-190.
14. Baur, A. S., G. Sass, B. Laffert, D. Willbold, C. Cheng-Mayer, and B. M. Peterlin. 1997. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6: 283-291.
15. Wolf, D., S. I. Giese, V. Witte, E. Krautkramer, S. Trapp, G. Sass, C. Haller, K. Blume, O. T. Fackler, and A. S. Baur. 2007. Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication, and perinuclear targeting. Virology 370: 45-54. (Pubitemid 350179909)
16. Baur, A. S., E. T. Sawai, P. Dazin, W. J. Fantl, C. Cheng-Mayer, and B. M. Peterlin. 1994. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1: 373-384.
17. Krautkramer, E., S. I. Giese, J. E. Gasteier, W. Muranyi, and O. T. Fackler. 2004. Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J. Virol. 78: 4085-4097. (Pubitemid 38437215)
18. Geyer, M., O. T. Fackler, and B. M. Peterlin. 2001. Structure-function relationships in HIV-1 Nef. EMBO Rep. 2: 580-585.
19. + viruses but not for down-regulation of CD4. EMBO J. 14: 484-491.
20. Collette, Y., H. Dutartre, A. Benziane, M. Ramos, R. Benarous, M. Harris, and D. Olive. 1996. Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects. J. Biol. Chem. 271: 6333-6341.
21. Greenway, A., A. Azad, J. Mills, and D. McPhee. 1996. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. J. Virol. 70: 6701-6708. (Pubitemid 26307376)
22. Lu, X., H. Yu, S. H. Liu, F. M. Brodsky, and B. M. Peterlin. 1998. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8: 647-656. (Pubitemid 28264755)
23. Liu, Y., S. Witte, Y. C. Liu, M. Doyle, C. Elly, and A. Altman. 2000. Regulation of protein kinase Cθ function during T cell activation by Lck-mediated tyrosine phosphorylation. J. Biol. Chem. 275: 3603-3609. (Pubitemid 30083070)
24. Bi, K., Y. Tanaka, N. Coudronniere, K. Sugie, S. Hong, M. J. van Stipdonk, and A. Altman. 2001. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nat. Immunol. 2: 556-563. (Pubitemid 33705859)
25. Simmons, A., V. Aluvihare, and A. McMichael. 2001. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14: 763-777.
26. Kabouridis, P. S., J. Janzen, A. L. Magee, and S. C. Ley. 2000. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur. J. Immunol. 30: 954-963.
27. Khoshnan, A., D. Bae, C. A. Tindell, and A. E. Nel. 2000. The physical association of protein kinase C θ with a lipid raft-associated inhibitor of κB factor kinase (IKK) complex plays a role in the activation of the NF-κB cascade by TCR and CD28. J. Immunol. 165: 6933-6940.
28. Sun, L., L. Deng, C. K. Ea, Z. P. Xia, and Z. J. Chen. 2004. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14: 289-301. (Pubitemid 38591401)
29. Sommer, K., B. Guo, J. L. Pomerantz, A. D. Bandaranayake, M. E. Moreno-Garcia, Y. L. Ovechkina, and D. J. Rawlings. 2005. Phosphorylation of the CARMA1 linker controls NF-κB activation. Immunity 23: 561-574. (Pubitemid 41779479)
30. Matsumoto, R., D. Wang, M. Blonska, H. Li, M. Kobayashi, B. Pappu, Y. Chen, and X. Lin. 2005. Phosphorylation of CARMA1 plays a critical role in T Cell receptor- mediated NF-κB activation. Immunity 23: 575-585. (Pubitemid 41779480)
31. Lee, K. Y., F. D'Acquisto, M. S. Hayden, J. H. Shim, and S. Ghosh. 2005. PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation. Science 308: 114-118.
32. Roose, J. P., M. Mollenauer, V. A. Gupta, J. Stone, and A. Weiss. 2005. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol. Cell. Biol. 25: 4426-4441.
33. Puente, L. G., J. S. He, and H. L. Ostergaard. 2006. A novel PKC regulates ERK activation and degranulation of cytotoxic T lymphocytes: plasticity in PKC regulation of ERK. Eur. J. Immunol. 36: 1009-1018.
34. Schrager, J. A., V. Der Minassian, and J. W. Marsh. 2002. HIV Nef increases T cell ERK MAP kinase activity. J. Biol. Chem. 277: 6137-6142.
35. Hara, H., C. Bakal, T. Wada, D. Bouchard, R. Rottapel, T. Saito, and J. M. Penninger. 2004. The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse. J. Exp. Med. 200: 1167-1177. (Pubitemid 39507056)
36. Wang, D., R. Matsumoto, Y. You, T. Che, X. Y. Lin, S. L. Gaffen, and X. Lin. 2004. CD3/CD28 costimulation-induced NF-κB activation is mediated by recruitment of protein kinase C-θ, Bcl10, and IκB kinase β to the immunological synapse through CARMA1. Mol. Cell. Biol. 24: 164-171. (Pubitemid 38010044)
37. Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17: 3101-3111. (Pubitemid 28254382)
38. Ylisastigui, L., R. Kaur, H. Johnson, J. Volker, G. He, U. Hansen, and D. Margolis. 2005. Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter. J. Virol. 79: 5952-5962. (Pubitemid 40617201)