메뉴 건너뛰기




Volumn 42, Issue 2, 2012, Pages 147-168

A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model

Author keywords

Genotoxicity; Margin of exposure; Maximum limits; Mechanisms; Nephropathy; Ochratoxin A (OTA); Renal tumors; Risk assessment; Threshold

Indexed keywords

ARISTOLOCHIC ACID; OCHRATOXIN; OCHRATOXIN ALPHA; UNCLASSIFIED DRUG;

EID: 84856204525     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2011.636342     Document Type: Review
Times cited : (56)

References (115)
  • 1
    • 64349122512 scopus 로고    scopus 로고
    • Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity
    • Adler M, Müller K, Rached E, Dekant W, Mally A. (2009). Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Carcinogenesis 30:711-719.
    • (2009) Carcinogenesis , vol.30 , pp. 711-719
    • Adler, M.1    Müller, K.2    Rached, E.3    Dekant, W.4    Mally, A.5
  • 3
    • 33947718284 scopus 로고    scopus 로고
    • In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A
    • DOI 10.1016/j.taap.2007.01.008, PII S0041008X07000270
    • Arbillaga L, Azqueta A, van Delft JH, López de Cerain A. (2007). In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A. Toxicol Appl Pharmacol 220:216-224. (Pubitemid 46507575)
    • (2007) Toxicology and Applied Pharmacology , vol.220 , Issue.2 , pp. 216-224
    • Arbillaga, L.1    Azqueta, A.2    Van Delft, J.H.M.3    Lopez De Cerain, A.4
  • 5
    • 0022442217 scopus 로고
    • Evaluation of the genotoxic activity of some mycotoxins using Escherichia coli in the SOS spot test
    • Auffray Y, Boutibonnes P. (1986). Evaluation of the genotoxic activity of some mycotoxins using Escherichia coli in the SOS spot test. Mutat Res 171:79-82. (Pubitemid 16051626)
    • (1986) Mutation Research , vol.171 , Issue.2-3 , pp. 79-82
    • Auffray, Y.1    Boutibonnes, P.2
  • 7
    • 0018833324 scopus 로고
    • Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems
    • Bartsch H, Malaveille C, Camus AM, Martel-Planche G, Brun G, Hautefeuille A, Sabadie N, Barbin A, Kuroki T, Drevon C, Piccoli C, Montesano R. (1980). Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems. Mutat Res 76:1-50. (Pubitemid 10066844)
    • (1980) Mutation Research , vol.76 , Issue.1 , pp. 1-50
    • Bartsch, H.1    Malaveille, C.2    Camus, A.-M.3
  • 8
    • 0022373951 scopus 로고
    • Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays
    • DOI 10.1016/0278-6915(85)90107-3
    • Bendele AM, Neal SB, Oberly TJ, Thompson CZ, Bewsey BJ, Hill LE, Rexroat MA, Carlton WW, Probst GS. (1985). Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays. Food Chem Toxicol 23:911-918. (Pubitemid 16201481)
    • (1985) Food and Chemical Toxicology , vol.23 , Issue.10 , pp. 911-918
    • Bendele, A.M.1    Neal, S.B.2    Oberly, T.J.3
  • 9
    • 0028065122 scopus 로고
    • Modulation of ochratoxin-produced genotoxicity in mice by vitamin C
    • DOI 10.1016/0278-6915(94)90110-4
    • Bose S, Sinha SP. (1994). Modulation of ochratoxin-produced genotoxicity in mice by vitamin C. Food Chem Toxicol 32:533-537. (Pubitemid 24234384)
    • (1994) Food and Chemical Toxicology , vol.32 , Issue.6 , pp. 533-537
    • Bose, S.1    Sinha, S.P.2
  • 10
    • 1242351756 scopus 로고    scopus 로고
    • Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens
    • DOI 10.1016/j.tox.2003.11.003
    • Brambilla G, Martelli A. (2004). Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens. Toxicology 196:1-19. (Pubitemid 38228348)
    • (2004) Toxicology , vol.196 , Issue.1-2 , pp. 1-19
    • Brambilla, G.1    Martelli, A.2
  • 11
    • 0023010822 scopus 로고
    • Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations
    • DOI 10.1002/em.2860080611
    • Brusick D. (1986). Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations. Environ Mutagen 8:879-886. (Pubitemid 17188042)
    • (1986) Environmental Mutagenesis , vol.8 , Issue.6 , pp. 879-886
    • Brusick, D.1
  • 15
    • 34547310548 scopus 로고    scopus 로고
    • Commission Regulation (EC) No 1881/2006 19 December 2006 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance) [L364]
    • Accessed on June 10, 2011 Commission of the European Communities.
    • Commission of the European Communities. (2006). Commission Regulation (EC) No 1881/2006 19 December 2006 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance) [L364]. Off J Eur Union 49:5-24. Available at: http://eur-lex.europa.eu/LexUriServ/site/en/oj/2006/l- 364/l-36420061220en00050024.pdf. Accessed on June 10, 2011.
    • (2006) Off J Eur Union , vol.49 , pp. 5-24
  • 16
    • 0021245969 scopus 로고
    • Effects of some mycotoxins on mitogen-induced blastogenesis and SCE frequency in human lymphocytes
    • DOI 10.1016/0278-6915(84)90222-9
    • Cooray R. (1984). Effects of some mycotoxins on mitogen-induced blastogenesis and SCE frequency in human lymphocytes. Food Chem Toxicol 22:529-534. (Pubitemid 14096839)
    • (1984) Food and Chemical Toxicology , vol.22 , Issue.7 , pp. 529-534
    • Cooray, R.1
  • 17
    • 77953481406 scopus 로고    scopus 로고
    • Review. Ochratoxin A: Presence in human plasma and intake estimation
    • Coronel MB, Sanchis V, Ramos AJ, Marin S. (2010). Review. Ochratoxin A: presence in human plasma and intake estimation. Food Sci Technol Int 16:5-18.
    • (2010) Food Sci Technol Int , vol.16 , pp. 5-18
    • Coronel, M.B.1    Sanchis, V.2    Ramos, A.J.3    Marin, S.4
  • 19
    • 0022202239 scopus 로고
    • Genotoxicity of ochratoxin in mice: DNA single-strand break evaluation in spleen, liver and kidney
    • DOI 10.1016/0378-4274(85)90006-2
    • Creppy EE, Kane A, Dirheimer G, Lafarge-Frayssinet C, Mousset S, Frayssinet C. (1985). Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. Toxicol Lett 28:29-35. (Pubitemid 16249999)
    • (1985) Toxicology Letters , vol.28 , Issue.1 , pp. 29-35
    • Creppy, E.E.1    Kane, A.2    Dirheimer, G.3
  • 21
    • 0030925538 scopus 로고    scopus 로고
    • Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures
    • DOI 10.1007/s002040050400
    • Degen GH, Gerber MM, Obrecht-Pflumio S, Dirheimer G. (1997). Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Arch Toxicol 71:365-371. (Pubitemid 27214469)
    • (1997) Archives of Toxicology , vol.71 , Issue.6 , pp. 365-371
    • Degen, G.H.1    Gerber, M.M.2    Obrecht-Pflumio, S.3    Dirheimer, G.4
  • 23
    • 33645471606 scopus 로고    scopus 로고
    • Ochratoxin A: Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans)
    • DOI 10.1080/02652030500309327, PII R734107438216487, ILSI Supplement on Ochratoxin A in Food
    • Dietrich DR, Heussner AH, O'Brien E. (2005). Ochratoxin A: comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans). Food Addit Contam 22 Suppl 1:45-52. (Pubitemid 44574573)
    • (2005) Food Additives and Contaminants , vol.22 , Issue.SUPPL. 1 , pp. 45-52
    • Dietrich, D.R.1    Heussner, A.H.2    O'Brien, E.3
  • 24
    • 0345466411 scopus 로고    scopus 로고
    • Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian Hamster Embryo (SHE) fibroblasts caused by ochratoxin A
    • DOI 10.1016/S0278-6915(99)00057-5, PII S0278691599000575
    • Dopp E, Müller J, Hahnel C, Schiffmann D. (1999). Induction of genotoxic effects and modulation of the intracellular calcium level in syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A. Food Chem Toxicol 37:713-721. (Pubitemid 29397359)
    • (1999) Food and Chemical Toxicology , vol.37 , Issue.7 , pp. 713-721
    • Dopp, E.1    Muller, J.2    Hahnel, C.3    Schiffmann, D.4
  • 25
    • 79952615143 scopus 로고    scopus 로고
    • Human ochratoxin a biomarkers-from exposure to effect
    • Duarte SC, Pena A, Lino CM. (2011). Human ochratoxin a biomarkers-from exposure to effect. Crit Rev Toxicol 41:187-212.
    • (2011) Crit Rev Toxicol , vol.41 , pp. 187-212
    • Duarte, S.C.1    Pena, A.2    Lino, C.M.3
  • 26
    • 33847112240 scopus 로고    scopus 로고
    • Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin a in food (Question number: EFSA-Q-2005-154, adopted on 4 April 2006 by European food safety authority)
    • Available at:. Accessed on June 10, 2011
    • EFSA (2006). Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to ochratoxin A in food (Question number: EFSA-Q-2005-154, adopted on 4 April 2006 by European Food Safety Authority). EFSA J 365:1-56. Available at: http://www.efsa.europa.eu/en/scdocs/ scdoc/365.htm. Accessed on June 10, 2011.
    • (2006) EFSA J , vol.365 , pp. 1-56
  • 28
    • 0034070895 scopus 로고    scopus 로고
    • Phenobarbital increases DNA adduct and metabolites formed by ochratoxin A: Role of CYP 2C9 and microsomal glutathione-S-transferase
    • DOI 10.1002/(SICI)1098-2280(2000)35:2<123::AID-EM7>3.0.CO;2-L
    • El Adlouni C, Pinelli E, Azémar B, Zaoui D, Beaune P, Pfohl-Leszkowicz A. (2000). Phenobarbital increases DNA adduct and metabolites formed by ochratoxin A: role of CYP 2C9 and microsomal glutathione-S- transferase. Environ Mol Mutagen 35:123-131. (Pubitemid 30171821)
    • (2000) Environmental and Molecular Mutagenesis , vol.35 , Issue.2 , pp. 123-131
    • El Adlouni, C.1    Pinelli, E.2    Azemar, B.3    Zaoui, D.4    Beaune, P.5    Pfohl-Leszkowicz, A.6
  • 29
    • 4644268330 scopus 로고    scopus 로고
    • Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig
    • DOI 10.1021/tx049877s
    • Faucet V, Pfohl-Leszkowicz A, Dai J, Castegnaro M, Manderville RA. (2004). Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig. Chem Res Toxicol 17:1289-1296. (Pubitemid 39265886)
    • (2004) Chemical Research in Toxicology , vol.17 , Issue.9 , pp. 1289-1296
    • Faucet, V.1    Pfohl-Leszkowicz, A.2    Dai, J.3    Castegnaro, M.4    Manderville, R.A.5
  • 30
    • 0038470827 scopus 로고    scopus 로고
    • Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system
    • Föllmann W, Lucas S. (2003). Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system. Arch Toxicol 77:298-304. (Pubitemid 36714077)
    • (2003) Archives of Toxicology , vol.77 , Issue.5 , pp. 298-304
    • Follmann, W.1    Lucas, S.2
  • 31
    • 0028936253 scopus 로고
    • Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha
    • Föllmann W, Hillebrand IE, Creppy EE, Bolt HM. (1995). Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha. Arch Toxicol 69:280-286.
    • (1995) Arch Toxicol , vol.69 , pp. 280-286
    • Föllmann, W.1    Hillebrand, I.E.2    Creppy, E.E.3    Bolt, H.M.4
  • 32
    • 0026062312 scopus 로고
    • Genotoxicity under extreme culture conditions a report from ICPEMC task group 9 (international commission for protection against environmental mutagens and carcinogens)
    • Galloway SM, Marshall RR, Ishidate M Jr, Brusick D, Ashby J, Myhr BC. (1991). Genotoxicity under extreme culture conditions. a report from ICPEMC Task Group 9 (International Commission for Protection Against Environmental Mutagens and Carcinogens). Mutat Res 257:147-204.
    • (1991) Mutat Res , vol.257 , pp. 147-204
    • Galloway, S.M.1    Marshall, R.R.2    Ishidate Jr., M.3    Brusick, D.4    Ashby, J.5    Myhr, B.C.6
  • 35
    • 0017293377 scopus 로고
    • Mutagen testing using TRP+ reversion in Escherichia coli
    • Green MH, Muriel WJ. (1976). Mutagen testing using TRP+ reversion in Escherichia coli. Mutat Res 38:3-32.
    • (1976) Mutat Res , vol.38 , pp. 3-32
    • Green, M.H.1    Muriel, W.J.2
  • 36
    • 35948966844 scopus 로고    scopus 로고
    • Role of environmental toxins in endemic (Balkan) nephropathy
    • DOI 10.1681/ASN.2007050537
    • Grollman AP, Jelakovic B. (2007). Role of environmental toxins in endemic (Balkan) nephropathy. October 2006, Zagreb, Croatia. J Am Soc Nephrol 18:2817-2823. (Pubitemid 350064082)
    • (2007) Journal of the American Society of Nephrology , vol.18 , Issue.11 , pp. 2817-2823
    • Grollman, A.P.1    Jelakovic, B.2
  • 38
    • 0037070059 scopus 로고    scopus 로고
    • Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin A in cultured rat and human primary hepatocytes
    • DOI 10.1021/jf0111817
    • Gross-Steinmeyer K, Weymann J, Hege HG, Metzler M. (2002). Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes. J Agric Food Chem 50:938-945. (Pubitemid 34163649)
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , Issue.4 , pp. 938-945
    • Gross-Steinmeyer, K.1    Weymann, J.2    Hege, H.-G.3    Metzler, M.4
  • 40
    • 0024597101 scopus 로고
    • Toxicokinetics of ochratoxin A in several species and its plasma-binding properties
    • DOI 10.1002/jat.2550090204
    • Hagelberg S, Hult K, Fuchs R. (1989). Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J Appl Toxicol 9:91-96. (Pubitemid 19108620)
    • (1989) Journal of Applied Toxicology , vol.9 , Issue.2 , pp. 91-96
    • Hagelberg, S.1    Hult, K.2    Fuchs, R.3
  • 41
    • 0033752638 scopus 로고    scopus 로고
    • Reevaluating cancer risk estimates for short-term exposure scenarios
    • Halmes NC, Roberts SM, Tolson JK, Portier CJ. (2000). Reevaluating cancer risk estimates for short-term exposure scenarios. Toxicol Sci 58:32-42.
    • (2000) Toxicol Sci , vol.58 , pp. 32-42
    • Halmes, N.C.1    Roberts, S.M.2    Tolson, J.K.3    Portier, C.J.4
  • 42
    • 78049270455 scopus 로고    scopus 로고
    • Ottawa, ON: Health Canada, Water Quality and Health Bureau, Healthy Environments and Consumer Safety Branch. Available at: http://www.hc-sc.gc.ca/ ewh-semt/alt-formats/hecs-sesc/pdf/pubs/water-eau/arsenic/arsenic-eng.pdf. Accessed on June 10, 2011 Health Canada
    • Health Canada. (2006). Guidelines for Canadian Drinking Water Quality: Guideline Technical Document-Arsenic. Ottawa, ON: Health Canada, Water Quality and Health Bureau, Healthy Environments and Consumer Safety Branch. Available at: http://www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/arsenic/index-eng.php http://www.hc-sc.gc.ca/ewh-semt/alt-formats/hecs-sesc/pdf/pubs/water-eau/ arsenic/arsenic-eng.pdf. Accessed on June 10, 2011.
    • (2006) Guidelines for Canadian Drinking Water Quality: Guideline Technical Document-Arsenic
  • 45
    • 0000120660 scopus 로고
    • IARC (International Agency for Research on Cancer). IARC Working Group on the Evaluation of Carcinogen Risks to Humans Meeting, June 9-16, 1992, Lyon, France, 1992. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 56. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer,. Available at:. Accessed on June 10, 2011
    • IARC (International Agency for Research on Cancer). (1993). Ochratoxin A. In: Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. IARC Working Group on the Evaluation of Carcinogen Risks to Humans Meeting, June 9-16, 1992, Lyon, France, 1992. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 56. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer, 489-521. Available at: http://monographs.iarc.fr/ENG/ Monographs/vol56/index. php. Accessed on June 10, 2011.
    • (1993) Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins , pp. 489-521
    • Ochratoxin, A.1
  • 46
    • 79952096804 scopus 로고    scopus 로고
    • Ochratoxin A (addendum)
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives). Prepared by the Sixty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives, June 19-28, 2007, Geneva, Switz. WHO Food Additive Series,. Geneva, Switz.: Food and Agriculture Organization of the United Nations (FAO), World Health Organization (WHO), , 454. Available at:. Accessed on June 10, 2011
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives). (2008). Ochratoxin A (addendum). In: Safety Evaluation of Certain Food Additives and Contaminants. Prepared by the Sixty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives, June 19-28, 2007, Geneva, Switz. WHO Food Additive Series, vol 59. Geneva, Switz.: Food and Agriculture Organization of the United Nations (FAO), World Health Organization (WHO), 357-429, 454. Available at: http://whqlibdoc.who.int/publications/2008/9789241660594-eng.pdf. Accessed on June 10, 2011.
    • (2008) Safety Evaluation of Certain Food Additives and Contaminants , vol.59 , pp. 357-429
  • 49
    • 11144322896 scopus 로고    scopus 로고
    • In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3- methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate
    • DOI 10.1002/mc.20061
    • Kanki K, Nishikawa A, Masumura K, Umemura T, Imazawa T, Kitamura Y, Nohmi T, Hirose M. (2005). In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo [4,5-f]quinoline, and di(2-ethylhexyl)phthalate. Mol Carcinog 42:9-17. (Pubitemid 40041481)
    • (2005) Molecular Carcinogenesis , vol.42 , Issue.1 , pp. 9-17
    • Kanki, K.1    Nishikawa, A.2    Masumura, K.-I.3    Umemura, T.4    Imazawa, T.5    Kitamura, Y.6    Nohmi, T.7    Hirose, M.8
  • 50
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity
    • DOI 10.1016/j.mrgentox.2005.02.004, PII S1383571805000835
    • Kirkland D, Aardema M, Henderson L, Müller L. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat Res 584:1-256. (Pubitemid 40922793)
    • (2005) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.584 , Issue.1-2 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3    Muller, L.4
  • 51
    • 77956228826 scopus 로고    scopus 로고
    • Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: Single and combined genotoxic action
    • Klaric MS, Darabos D, Rozgaj R, Kasuba V, Pepeljnjak S. (2010). Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action. Arch Toxicol 84:641-650.
    • (2010) Arch Toxicol , vol.84 , pp. 641-650
    • Klaric, M.S.1    Darabos, D.2    Rozgaj, R.3    Kasuba, V.4    Pepeljnjak, S.5
  • 52
    • 0023616804 scopus 로고
    • Study of the genotoxic potential of 17 mycotoxins with the SOS chromotest
    • Krivobok S, Olivier P, Marzin DR, Seigle-Murandi F, Steiman R. (1987). Study of the genotoxic potential of 17 mycotoxins with the SOS Chromotest. Mutagenesis 2:433-439. (Pubitemid 17162174)
    • (1987) Mutagenesis , vol.2 , Issue.6 , pp. 433-439
    • Krivobok, S.1    Olivier, Ph.2    Marzin, D.R.3    Seigle-Murandi, F.4    Steiman, R.5
  • 54
    • 0018779242 scopus 로고
    • Porcine nephropathy induced by long-term ingestion of ochratoxin A
    • Krogh P, Elling F, Friis C, Hald B, Larsen AE, Lillehøj EB, Madsen A, Mortensen HP, Rasmussen F, Ravnskov U. (1979). Porcine nephropathy induced by long-term ingestion of ochratoxin A. Vet Pathol 16:466-475. (Pubitemid 9219861)
    • (1979) Veterinary Pathology , vol.16 , Issue.4 , pp. 466-475
    • Krogh, P.1    Elling, F.2    Friis, C.3
  • 55
    • 85153825804 scopus 로고    scopus 로고
    • Risk assessment and risk management of mycotoxins in food
    • Magan N, Olsen M, eds.. Boca Raton, FL: CRC Press
    • Kuiper-Goodman T. (2004). Risk assessment and risk management of mycotoxins in food. In: Magan N, Olsen M, eds. Mycotoxins in Food: Detection and Control. Boca Raton, FL: CRC Press, 3-31.
    • (2004) Mycotoxins in Food: Detection and Control , pp. 3-31
    • Kuiper-Goodman, T.1
  • 56
    • 0024723238 scopus 로고
    • Risk assessment of the mycotoxin ochratoxin A
    • Kuiper-Goodman T, Scott PM. (1989). Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179-248.
    • (1989) Biomed Environ Sci , vol.2 , pp. 179-248
    • Kuiper-Goodman, T.1    Scott, P.M.2
  • 58
    • 0028352997 scopus 로고
    • Effect of retinol on ochratoxin-produced genotoxicity in mice
    • DOI 10.1016/0278-6915(94)90044-2
    • Kumari D, Sinha SP. (1994). Effect of retinol on ochratoxin-produced genotoxicity in mice. Food Chem Toxicol 32:471-475. (Pubitemid 24205014)
    • (1994) Food and Chemical Toxicology , vol.32 , Issue.5 , pp. 471-475
    • Kumari, D.1    Sinha, S.P.2
  • 59
    • 33745223511 scopus 로고    scopus 로고
    • Glutathione S-transferase polymorphisms and ochratoxin A toxicity in primary human urothelial cells
    • Lebrun S, Golka K, Schulze H, Föllmann W. (2006). Glutathione S-transferase polymorphisms and ochratoxin A toxicity in primary human urothelial cells. Toxicology 224:81-90.
    • (2006) Toxicology , vol.224 , pp. 81-90
    • Lebrun, S.1    Golka, K.2    Schulze, H.3    Föllmann, W.4
  • 60
    • 79960835656 scopus 로고    scopus 로고
    • P53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation
    • Li J, Yin S, Dong Y, Fan L, Hu H. (2011). p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochem Biophys Res Commun 411:458-463.
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 458-463
    • Li, J.1    Yin, S.2    Dong, Y.3    Fan, L.4    Hu, H.5
  • 61
    • 0026265779 scopus 로고
    • Genotoxicity of ochratoxin A and structurally related compounds in Escheriehia coli strains: Studies on their mode of action
    • Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H, eds.. IARC Scientific Publications no 115. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC)
    • Malaveile C, Brun G, Bartsch H. (1991). Genotoxicity of ochratoxin A and structurally related compounds in Escheriehia coli strains: studies on their mode of action. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H, eds. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. IARC Scientific Publications no 115. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC), 261-266.
    • (1991) Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours , pp. 261-266
    • Malaveile, C.1    Brun, G.2    Bartsch, H.3
  • 62
    • 65749089980 scopus 로고    scopus 로고
    • Mycotoxins and the kidney: Modes of action for renal tumor formation by ochratoxin A in rodents
    • Mally A, Dekant W. (2009). Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Mol Nutr Food Res 53:467-478.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 467-478
    • Mally, A.1    Dekant, W.2
  • 65
    • 23844438306 scopus 로고    scopus 로고
    • Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats
    • DOI 10.1021/tx049651p
    • Mally A, Völkel W, Amberg A, Kurz M, Wanek P, Eder E, Hard G, Dekant W. (2005b). Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem Res Toxicol 18:1242-1252. (Pubitemid 41170248)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.8 , pp. 1242-1252
    • Mally, A.1    Volkel, W.2    Amberg, A.3    Kurz, M.4    Wanek, P.5    Eder, E.6    Hard, G.7    Dekant, W.8
  • 66
    • 34548832725 scopus 로고    scopus 로고
    • Ochratoxin A as a potential etiologic factor in endemic nephropathy: Lessons from toxicity studies in rats
    • DOI 10.1016/j.fct.2007.05.021, PII S0278691507001858
    • Mally A, Hard GC, Dekant W. (2007). Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats. Food Chem Toxicol 45:2254-2260. (Pubitemid 47451578)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2254-2260
    • Mally, A.1    Hard, G.C.2    Dekant, W.3
  • 67
    • 22544454436 scopus 로고    scopus 로고
    • A case for the genotoxicity of ochratoxin a by bioactivation and covalent DNA adduction
    • DOI 10.1021/tx050070p
    • Manderville RA. (2005). A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction. Chem Res Toxicol 18:1091-1097. (Pubitemid 41022841)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.7 , pp. 1091-1097
    • Manderville, R.A.1
  • 68
    • 0024996262 scopus 로고
    • Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy
    • Manolova Y, Manolov G, Parvanova L, Petkova-Bocharova T, Castegnaro M, Chernozemsky IN. (1990). Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy. Mutat Res 231:143-149. (Pubitemid 20252547)
    • (1990) Mutation Research , vol.231 , Issue.2 , pp. 143-149
    • Manolova, Y.1    Manolov, G.2    Parvanova, L.3    Petkova-Bocharova, T.4    Castegnaro, M.5    Chernozemsky, I.N.6
  • 69
    • 69549114306 scopus 로고    scopus 로고
    • Minimum tolerable exposure period and maximum threshold dietary intake of ochratoxin A for causing renal cancer in male Dark Agouti rats
    • Mantle PG. (2009). Minimum tolerable exposure period and maximum threshold dietary intake of ochratoxin A for causing renal cancer in male Dark Agouti rats. Food Chem Toxicol 47:2419-2424.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2419-2424
    • Mantle, P.G.1
  • 70
  • 71
    • 44649165139 scopus 로고    scopus 로고
    • Binding of ochratoxin A to a urinary globulin: A new concept to account for gender difference in rat nephrocarcinogenic responses
    • DOI 10.3390/ijms9050719
    • Mantle PG, Nagy JM. (2008). Binding of ochratoxin A to a urinary globulin: a new concept to account for gender difference in rat nephrocarcinogenic responses. Int J Mol Sci 9:719-735. (Pubitemid 351776192)
    • (2008) International Journal of Molecular Sciences , vol.9 , Issue.5 , pp. 719-735
    • Mantle, P.G.1    Nagy, J.M.2
  • 72
    • 29544448684 scopus 로고    scopus 로고
    • Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A
    • DOI 10.1080/02652030500358431, PII N024484311PHV660, ILSI Supplement on Ochratoxin A in Food
    • Mantle P, Kulinskaya E, Nestler S. (2005). Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A. Food Addit Contam 22 Suppl 1:58-64. (Pubitemid 44574575)
    • (2005) Food Additives and Contaminants , vol.22 , Issue.SUPPL. 1 , pp. 58-64
    • Mantle, P.1    Kulinskaya, E.2    Nestler, S.3
  • 73
    • 75149113718 scopus 로고    scopus 로고
    • Structures of covalent adducts between DNA and ochratoxin a: A new factor in debate about genotoxicity and human risk assessment
    • Mantle PG, Faucet-Marquis V, Manderville RA, Squillaci B, Pfohl-Leszkowicz A. (2010). Structures of covalent adducts between DNA and ochratoxin a: a new factor in debate about genotoxicity and human risk assessment. Chem Res Toxicol 23:89-98.
    • (2010) Chem Res Toxicol , vol.23 , pp. 89-98
    • Mantle, P.G.1    Faucet-Marquis, V.2    Manderville, R.A.3    Squillaci, B.4    Pfohl-Leszkowicz, A.5
  • 75
    • 49649099057 scopus 로고    scopus 로고
    • Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
    • Marin-Kuan M, Cavin C, Delatour T, Schilter B. (2008). Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 52:195-202.
    • (2008) Toxicon , vol.52 , pp. 195-202
    • Marin-Kuan, M.1    Cavin, C.2    Delatour, T.3    Schilter, B.4
  • 76
    • 0037344929 scopus 로고    scopus 로고
    • Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats
    • DOI 10.1078/0940-2993-00262
    • Miljkovic A, Pfohl-Leszkowicz A, Dobrota M, Mantle PG. (2003). Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats. Exp Toxicol Pathol 54:305-312. (Pubitemid 36362236)
    • (2003) Experimental and Toxicologic Pathology , vol.54 , Issue.4 , pp. 305-312
    • Miljkovic, A.1    Pfohl-Leszkowicz, A.2    Dobrota, M.3    Mantle, P.G.4
  • 77
    • 0021243939 scopus 로고
    • Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes
    • Mori H, Kawai K, Ohbayashi F, Kuniyasu T, Yamazaki M, Hamasaki T, Williams GM. (1984). Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. Cancer Res 44:2918-2923. (Pubitemid 14083209)
    • (1984) Cancer Research , vol.44 , Issue.7 , pp. 2918-2923
    • Mori, H.1    Kawai, K.2    Ohbayashi, F.3
  • 78
    • 47049113238 scopus 로고    scopus 로고
    • In vitro cytogenetic results supporting a DNA nonreactive mechanism for ochratoxin A, potentially relevant for its carcinogenicity
    • DOI 10.1021/tx800029f
    • Mosesso P, Cinelli S, Piñero J, Bellacima R, Pepe G. (2008). In vitro cytogenetic results supporting a DNA nonreactive mechanism for ochratoxin A, potentially relevant for its carcinogenicity. Chem Res Toxicol 21:1235-1243. (Pubitemid 351967388)
    • (2008) Chemical Research in Toxicology , vol.21 , Issue.6 , pp. 1235-1243
    • Mosesso, P.1    Cinelli, S.2    Pinero, J.3    Bellacima, R.4    Pepe, G.5
  • 79
    • 0027083378 scopus 로고
    • Cancer risk assessment with intermittent exposure
    • DOI 10.1111/j.1539-6924.1992.tb00713.x
    • Murdoch DJ, Krewski D, Wargo J. (1992). Cancer risk assessment with intermittent exposure. Risk Anal 12:569-577. (Pubitemid 23050544)
    • (1992) Risk Analysis , vol.12 , Issue.4 , pp. 569-577
    • Murdoch, D.J.1    Krewski, D.2    Wargo, J.3
  • 80
    • 58149459327 scopus 로고    scopus 로고
    • TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours
    • Nedelko T, Arlt VM, Phillips DH, Hollstein M. (2009). TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours. Int J Cancer 124:987-990.
    • (2009) Int J Cancer , vol.124 , pp. 987-990
    • Nedelko, T.1    Arlt, V.M.2    Phillips, D.H.3    Hollstein, M.4
  • 81
    • 0029857622 scopus 로고    scopus 로고
    • Toxicological significance of DNA adducts: Summary of discussions with an expert panel
    • Nestmann ER, Bryant DW, Carr CJ. (1996). Toxicological significance of DNA adducts: summary of discussions with an expert panel. Regul Toxicol Pharmacol 24:9-18.
    • (1996) Regul Toxicol Pharmacol , vol.24 , pp. 9-18
    • Nestmann, E.R.1    Bryant, D.W.2    Carr, C.J.3
  • 82
    • 0013519855 scopus 로고
    • NTP (National Toxicology Program). Technical Report Series no 358. Department of Health and Human Services. Research Triangle Park, NC: National Toxicology Program. Available at:. Accessed on June 10, 2011
    • NTP (National Toxicology Program). (1989). Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N rats (Gavage Studies). Technical Report Series no 358. Department of Health and Human Services. Research Triangle Park, NC: National Toxicology Program. Available at: http://ntp.niehs.nih.gov/ntp/htdocs/LT-rpts/tr358.pdf. Accessed on June 10, 2011.
    • (1989) Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies)
  • 83
    • 84856365531 scopus 로고    scopus 로고
    • Aristolochic acids
    • NTP (National Toxicology Program)
    • NTP (National Toxicology Program). (2011) Aristolochic acids. Rep Carcinog 12:45-49.
    • (2011) Rep Carcinog , vol.12 , pp. 45-49
  • 84
    • 0034769180 scopus 로고    scopus 로고
    • Species-, sex-, and cell type-specific effects of ochratoxin A and B
    • DOI 10.1093/toxsci/63.2.256
    • O'Brien E, Heussner AH, Dietrich DR. (2001). Species-, sex-, and cell type-specific effects of ochratoxin A and B. Toxicol Sci 63:256-264. (Pubitemid 32982799)
    • (2001) Toxicological Sciences , vol.63 , Issue.2 , pp. 256-264
    • O'Brien, E.1    Heussner, A.H.2    Dietrich, D.R.3
  • 85
    • 34547632542 scopus 로고    scopus 로고
    • Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress
    • DOI 10.1021/tx700027j
    • Palma N, Cinelli S, Sapora O, Wilson SH, Dogliotti E. (2007). Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress. Chem Res Toxicol 20:1031-1037. (Pubitemid 47204816)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.7 , pp. 1031-1037
    • Palma, N.1    Cinelli, S.2    Sapora, O.3    Wilson, S.H.4    Dogliotti, E.5
  • 86
    • 75449084985 scopus 로고    scopus 로고
    • Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours
    • Pfohl-Leszkowicz A. (2009). Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours. Arh Hig Rada Toksikol 60:465-483.
    • (2009) Arh Hig Rada Toksikol , vol.60 , pp. 465-483
    • Pfohl-Leszkowicz, A.1
  • 87
    • 33645470346 scopus 로고    scopus 로고
    • Further arguments in favour of direct covalent binding of Ochratoxin A (OTA) after metabolic biotransformation
    • DOI 10.1080/02652030500309400, PII X10G742812051479, ILSI Supplement on Ochratoxin A in Food
    • Pfohl-Leszkowicz A, Castegnaro M. (2005). Further arguments in favour of direct covalent binding of Ochratoxin A (OTA) after metabolic biotransformation. Food Addit Contam 22 Suppl 1:75-87. (Pubitemid 44574577)
    • (2005) Food Additives and Contaminants , vol.22 , Issue.SUPPL. 1 , pp. 75-87
    • Pfohl-Leszkowicz, A.1    Castegnaro, M.2
  • 88
    • 0026277330 scopus 로고
    • DNA adduct formation in mice treated with ochratoxin A
    • Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H, eds. (IARC Scientific Publications no 115. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC)
    • Pfohl-Leszkowicz A, Chakor K, Creppy E, Dirheimer G. (1991). DNA adduct formation in mice treated with ochratoxin A. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H, eds. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. (IARC Scientific Publications no 115. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC), 245-253.
    • (1991) Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours , pp. 245-253
    • Pfohl-Leszkowicz, A.1    Chakor, K.2    Creppy, E.3    Dirheimer, G.4
  • 89
    • 0027346918 scopus 로고
    • Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects
    • Phillips DH, Castegnaro M, Bartsch H, eds. IARC Scientific Publications no 124. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC)
    • Pfohl-Leszkowicz A, Grosse Y, Castegnaro M, Nicolov IG, Chernozemsky IN, Bartsch H, Betbeder AM, Creppy EE, Dirheimer G (1993). Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects. In: Phillips DH, Castegnaro M, Bartsch H, eds. Postlabelling Methods for the Detection of DNA Adducts. IARC Scientific Publications no 124. Lyon, France: World Health Organization (WHO), International Agency for Research on Cancer (IARC), 141-148.
    • (1993) Postlabelling Methods for the Detection of DNA Adducts , pp. 141-148
    • Pfohl-Leszkowicz, A.1    Grosse, Y.2    Castegnaro, M.3    Nicolov, I.G.4    Chernozemsky, I.N.5    Bartsch, H.6    Betbeder, A.M.7    Creppy, E.E.8    Dirheimer, G.9
  • 90
    • 33745614599 scopus 로고    scopus 로고
    • Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics?
    • DOI 10.1093/toxsci/kfj213
    • Rached E, Pfeiffer E, Dekant W, Mally A. (2006). Ochratoxin A: apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Toxicol Sci 92:78-86. (Pubitemid 43985792)
    • (2006) Toxicological Sciences , vol.92 , Issue.1 , pp. 78-86
    • Rached, E.1    Pfeiffer, E.2    Dekant, W.3    Mally, A.4
  • 91
    • 84856185557 scopus 로고    scopus 로고
    • Risk assessment of ochratoxin A (OTA)
    • Rai M, Varma A, eds., Germany: Springer-Verlag
    • Ringot D, Chango A. (2010). Risk assessment of ochratoxin A (OTA). In: Rai M, Varma A, eds. Mycotoxins in Food, Feed and Bioweapons. Heidelberg, Germany: Springer-Verlag, 307-328.
    • (2010) Mycotoxins in Food, Feed and Bioweapons. Heidelberg , pp. 307-328
    • Ringot, D.1    Chango, A.2
  • 92
    • 33645468875 scopus 로고    scopus 로고
    • Ochratoxin A: Potential epigenetic mechanisms of toxicity and carcinogenicity
    • DOI 10.1080/02652030500309319, PII G822686501R1H218, ILSI Supplement on Ochratoxin A in Food
    • Schilter B, Marin-Kuan M, Delatour T, Nestler S, Mantle P, Cavin C. (2005). Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity. Food Addit Contam 22 Suppl 1:88-93. (Pubitemid 44574578)
    • (2005) Food Additives and Contaminants , vol.22 , Issue.SUPPL. 1 , pp. 88-93
    • Schilter, B.1    Marin-Kuan, M.2    Delatour, T.3    Nestler, S.4    Mantle, P.5    Cavin, C.6
  • 94
    • 28944449329 scopus 로고    scopus 로고
    • Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay
    • DOI 10.1016/j.fct.2005.07.009, PII S0278691505002383
    • Simarro Doorten Y, Nijmeijer S, de Nijs-Tjon L, Fink-Gremmels J. (2006). Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay. Food Chem Toxicol 44:261-270. (Pubitemid 41781984)
    • (2006) Food and Chemical Toxicology , vol.44 , Issue.2 , pp. 261-270
    • Simarro Doorten, Y.1    Nijmeijer, S.2    De Nijs-Tjon, L.3    Fink-Gremmels, J.4
  • 95
    • 63549124370 scopus 로고    scopus 로고
    • P53 mutations as fingerprints for aristolochic acid: An environmental carcinogen in endemic (Balkan) nephropathy
    • Slade N, Moll UM, Brdar B, Zoric A, Jelakovic B. (2009). p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy. Mutat Res 663:1-6.
    • (2009) Mutat Res , vol.663 , pp. 1-6
    • Slade, N.1    Moll, U.M.2    Brdar, B.3    Zoric, A.4    Jelakovic, B.5
  • 96
    • 79958016049 scopus 로고    scopus 로고
    • Aristolochic acid i and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells-the involvement of SP-1 and HIFs transcription factors
    • Stachurska A, Kozakowska M, Jozkowicz A, Dulak J, Loboda A. (2011). Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells-the involvement of SP-1 and HIFs transcription factors. Toxicol Lett 204:118-126.
    • (2011) Toxicol Lett , vol.204 , pp. 118-126
    • Stachurska, A.1    Kozakowska, M.2    Jozkowicz, A.3    Dulak, J.4    Loboda, A.5
  • 97
    • 65449118063 scopus 로고    scopus 로고
    • Fifty years of research in Balkan endemic nephropathy: Where are we now?
    • Stefanovic V, Polenakovic M. (2009). Fifty years of research in Balkan endemic nephropathy: where are we now? Nephron Clin Pract 112:c51-c56.
    • (2009) Nephron Clin Pract , vol.112
    • Stefanovic, V.1    Polenakovic, M.2
  • 98
    • 80053589601 scopus 로고    scopus 로고
    • Urothelial carcinoma associated with Balkan endemic nephropathy. A worldwide disease
    • Stefanovic V, Polenakovic M, Toncheva D. (2011). Urothelial carcinoma associated with Balkan endemic nephropathy. A worldwide disease. Pathol Biol 59:286-291.
    • (2011) Pathol Biol , vol.59 , pp. 286-291
    • Stefanovic, V.1    Polenakovic, M.2    Toncheva, D.3
  • 99
    • 0022606082 scopus 로고
    • Induction of DNA single-strand breaks and DNA synthesis inhibition by patulin, ochratoxin A, citrinin, and aflatoxin B1 in cell lines CHO and AWRF
    • Stetina R, Votava M. (1986). Induction of DNA single-strand breaks and DNA synthesis inhibition by patulin, ochratoxin A, citrinin, and aflatoxin B1 in cell lines CHO and AWRF. Folia Biol (Praha) 32:128-144.
    • (1986) Folia Biol (Praha) , vol.32 , pp. 128-144
    • Stetina, R.1    Votava, M.2
  • 101
    • 22544479430 scopus 로고    scopus 로고
    • Perspective: Ochratoxin A is not a genotoxic carcinogen
    • DOI 10.1021/tx050076e
    • Turesky RJ. (2005). Perspective: ochratoxin A is not a genotoxic carcinogen. Chem Res Toxicol 18:1082-1090. (Pubitemid 41022840)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.7 , pp. 1082-1090
    • Turesky, R.J.1
  • 103
    • 30344443429 scopus 로고    scopus 로고
    • US EPA (US Environmental Protection Agency). EPA/630/P-03/001B. Washington, DC: US Environmental Protection Agency, Risk Assessment Forum, National Center for Environmental Assessment (NCEA). Available at:. Accessed on June 10, 2011
    • US EPA (US Environmental Protection Agency). (2005a). Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B. Washington, DC: US Environmental Protection Agency, Risk Assessment Forum, National Center for Environmental Assessment (NCEA). Available at: http://www.epa.gov/raf/publications/pdfs/ CANCER-GUIDELINES-FINAL-3-25-05.PDF. Accessed on June 10, 2011.
    • (2005) Guidelines for Carcinogen Risk Assessment
  • 104
    • 33645229436 scopus 로고    scopus 로고
    • US EPA (US Environmental Protection Agency). EPA/630/R-03/003F. Washington, DC: US Environmental Protection Agency, Risk Assessment Forum. Available at:. Accessed on June 10, 2011
    • US EPA (US Environmental Protection Agency). (2005b). Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. EPA/630/R-03/003F. Washington, DC: US Environmental Protection Agency, Risk Assessment Forum. Available at: http://www.epa.gov/ttn/atw/childrens-supplement- final.pdf. Accessed on June 10, 2011.
    • (2005) Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens
  • 106
    • 33746540007 scopus 로고    scopus 로고
    • Critique of dose response in carcinogenesis
    • DOI 10.1191/0960327106ht633oa
    • Waddell WJ. (2006). Critique of dose response in carcinogenesis. Hum Exp Toxicol 25:413-436. (Pubitemid 44139568)
    • (2006) Human and Experimental Toxicology , vol.25 , Issue.7 , pp. 413-436
    • Waddell, W.J.1
  • 107
    • 0018071942 scopus 로고
    • Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins
    • Wehner FC, Thiel PG, van Rensburg SJ, Demasius IP. (1978). Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins. Mutat Res 58:193-203. (Pubitemid 9054916)
    • (1978) Mutation Research , vol.58 , Issue.2-3 , pp. 193-203
    • Wehner, F.C.1    Thiel, P.G.2    Van Rensburg, S.J.3    Demasius, I.P.C.4
  • 108
    • 3543014950 scopus 로고    scopus 로고
    • Mycotoxin risk assessment for the purpose of setting international regulatory standards
    • DOI 10.1021/es035353n
    • Wu F. (2004). Mycotoxin risk assessment for the purpose of setting international regulatory standards. Environ Sci Technol 38:4049-4055. (Pubitemid 39014185)
    • (2004) Environmental Science and Technology , vol.38 , Issue.15 , pp. 4049-4055
    • Wu, F.1
  • 110
    • 0025937573 scopus 로고
    • Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102
    • Würgler FE, Friederich U, Schlatter J. (1991). Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102. Mutat Res 261:209-216.
    • (1991) Mutat Res , vol.261 , pp. 209-216
    • Würgler, F.E.1    Friederich, U.2    Schlatter, J.3
  • 111
    • 0023704076 scopus 로고
    • Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals
    • Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. (1988). Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen 11 Suppl 12:1-157.
    • (1988) Environ Mol Mutagen , vol.11 , Issue.SUPPL. 12 , pp. 1-157
    • Zeiger, E.1    Anderson, B.2    Haworth, S.3    Lawlor, T.4    Mortelmans, K.5
  • 113
    • 0035147426 scopus 로고    scopus 로고
    • Ochratoxin A-induced tumor formation: Is there a role of reactive Ochratoxin A metabolites?
    • DOI 10.1093/toxsci/59.1.59
    • Zepnik H, Pähler A, Schauer U, Dekant W. (2001). Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites? Toxicol Sci 59, 59-67. (Pubitemid 32117981)
    • (2001) Toxicological Sciences , vol.59 , Issue.1 , pp. 59-67
    • Zepnik, H.1    Pahler, A.2    Schauer, U.3    Dekant, W.4
  • 114
    • 0141671914 scopus 로고    scopus 로고
    • Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration
    • DOI 10.1016/S0041-008X(03)00261-8
    • Zepnik H, Völkel W, Dekant W. (2003). Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration. Toxicol Appl Pharmacol 192:36-44. (Pubitemid 37205116)
    • (2003) Toxicology and Applied Pharmacology , vol.192 , Issue.1 , pp. 36-44
    • Zepnik, H.1    Volkel, W.2    Dekant, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.