Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 34-45

  Gautier, Jean Charles ^a   Richoz, Janique ^a   Welti, Dieter H ^a   Markovic, Jovanka ^a   Gremaud, Eric ^a   Peter Guengerich, F ^b   Turesky, Robert J ^a,c  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 4 HYDROXYOCHRATOXIN A; AFLATOXIN B1; BENZO[A]PYRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DNA; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HORSERADISH PEROXIDASE; OCHRATOXIN; PENTACHLOROPHENOL; PROSTAGLANDIN SYNTHASE; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CHEMICAL STRUCTURE; CYTOTOXICITY; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; RAT; XENOBIOTIC METABOLISM;

ANIMALS; BIOTRANSFORMATION; CARCINOGENS; CATTLE; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA DAMAGE; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; KIDNEY; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MICROSOMES, LIVER; MYCOTOXINS; OCHRATOXINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEINS; RATS; RATS, INBRED F344; STIMULATION, CHEMICAL;

EID: 0035148577     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000070j     Document Type: Article

References (5)

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5. World Health Organization (1996) Europe Evaluation of Certain Food Additives and Contaminants. Prepared by the 44th Meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series 35, pp 363-376, World Health Organization, Geneva.