Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics?

Toxicological Sciences

Volumn 92, Issue 1, 2006, Pages 78-86

  Rached, Eva ^a   Pfeiffer, Erika ^b   Dekant, Wolfgang ^a   Mally, Angela ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Apoptosis; Carcinogenicity; Microtubule; Mitosis; Ochratoxin A

Indexed keywords

ALPHA TUBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OCHRATOXIN; STRESS ACTIVATED PROTEIN KINASE;

ANAPHASE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DIVISION; CELL ENLARGEMENT; CELL IMMORTALIZATION; CELL SURVIVAL; CHROMATIN; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GIANT CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUMOR; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; MOLECULAR DYNAMICS; MULTINUCLEAR CELL; TIME;

APOPTOSIS; CELL LINE, TRANSFORMED; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICROTUBULES; MITOSIS; MYCOTOXINS; OCHRATOXINS;

RODENTIA;

EID: 33745614599     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj213     Document Type: Article

References (50)

1. Andreassen, P. R., Martineau, S. N., and Margolis, R. L. (1996). Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. Mutat. Res. 372, 181-194.
2. Benesic, A., Mildenberger, S., and Gelde, M. (2000). Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells. Pflueg. Arch. Eur. J. Physiol. 439, 278-287.
3. Boorman, G. A., McDonald, M. R., Imoto, S., and Persing, R. (1992). Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicol. Pathol. 20, 236-245.
4. Castedo, M., Perfettini, J. L., Roumier, T., Valent, A., Raslova, H., Yakushijin, K., Horne, D., Feunteun, J., Lenoir, G., Medema, R., et al. (2004). Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene 23, 4362-4370.
5. Chen, F., Castranova, V., and Shi, X. (2001). New insights into the role of nuclear factor-kappaB in cell growth regulation. Am J. Pathol. 159, 387-397.
6. Eder, S., Benesic, A., Freudinger, R., Engert, J., Schwerdt, G., Drumm, K., and Gekle, M. (2000). Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells. Pflueg. Arch. Eur. J. Physiol. 440, 521-529.
7. Frisch, S. M., Vuori, K., Kelaita, D., and Sicks, S. (1996a). A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135, 1377-1382.
8. Frisch, S. M., Vuori, K., Ruoslahti, E., and Chan-Hui, P. Y. (1996b). Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134, 793-799.
9. Gautier, J., Richoz, J., Welti, D. H., Markovic, J., Gremaud, E., Guengerich, F. P., and Turesky, R. J. (2001). Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes. Chem. Res. Toxicol. 14, 34-45.
10. Gekle, M., Schwerdt, G., Freudinger, R., Mildenberger, S., Wilflingseder, D., Pollack, V., Dander, M., and Schramek, H. (2000). Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J. Pharmacol. Exp. Ther. 293, 837-844.
11. Gennari, A., Pazos, P., Boveri, M., Callaghan, R., Casado, J., Maurici, D., Corsini, E., and Prieto, P. (2004). New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxia A. J. Biochem. Mol. Toxicol. 18, 43-49.
12. Giancotti, F. (1999). Integrin signalling. Science 285, 1028-1032.
13. Gross-Steinmeyer, K., Weymann, J., Hege, H. G., and Metzler, M. (2002). Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin A in cultured rat and human primary hepatocytes. J. Agric. Food Chem. 50, 938-945.
14. Hirsch, J. R., Gonska, T., Waldegger, S., Lang, F., and Schlatter, E. (1998). Na(+)-dependent and -independent amino acid transport systems in immortalized human kidney epithelial cells derived from the proximal tubule. Kidney Blood Press. Res. 21, 50-58.
15. Hirsch, J. R., Meyer, M., Magert, H. J., Forssmann, W. G., Mollerup, S., Herter, P., Weber, G., Cermak, R., Ankorina-Stark, I., Schlatter, E., et al. (1999). cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: Molecular and functional studies in human proximal tubule cells. J. Am. Soc. Nephrol. 10, 472-480.
16. Horvath, A., Upham, B. L., Ganev, V., and Trosko, J. E. (2002). Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40, 273-282.
17. JECFA (2001). Safety Evaluation of Certain Mycotoxins in Food. WHO, Geneva.
18. Jessen, H. (1994). Taurine and beta-alanine transport in an established human kidney cell line derived from the proximal tubule. Biochim. Biophys. Acta 1194, 44-52.
19. Jessen, H., Roigaard, H., and Jacobsen, C. (1996). Uptake of neutral alpha- and beta-amino acids by human proximal tubular cells. Biochim. Biophys. Acta 1282, 225-232.
20. Jessen, H., Roigaard, H., Riahi-Esfahani, S., and Jacobsen, C. (1994). A comparative study on the uptake of alpha-ominoisobutyric acid by normal and immortalized human embryonic kidney cells from proximal tubule. Biochim. Biophys. Acta 1190, 279-288.
21. Kamp, H. G., Eisenbrand, G., Schlatter, J., Wurth, K., and Janzowski C. (2005). Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. Toxicology 206, 413-425.
22. Koizumi, Y. Arai, M., Tomoda, H., and Omura, S. (2004). Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim. Biophys. Acta 1693, 47-55.
23. Kook, S., Shim, S. R., Kim, J. I., Ahnn, J. H., Jung, Y. K., Paik, S. G., and Song, W. K. (2000). Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells. Cell Biochem Funct. 18, 1-7.
24. Lock, E. A., and Hard, G. C. (2004). Chemically induced renal tubule tumors in the laboratory rat and mouse: Review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Crit. Rev. Toxicol. 34, 211-299.
25. Maaroufi, K., Achour, A., Betbeder, A. M., Hammami, M., Ellouz, F., Creppy, E. E., and Bacha, H. (1995). Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: Correlation with chronic interstitial nephropathy in Tunisia. Arch. Toxicol. 69, 552-558.
26. Maaroufi, K., Zakhama, A., Baudrimont, I., Achour, A., Abid, S., Ellouz, F., Dhouib, S., Creppy, E. E., and Bacha, H. (1999). Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by ochratoxin A in rats. Hum. Exp. Toxicol. 18, 410-415.
27. Mally, A., Decker, M., Bekteshi, M., and Dekant, W. (2006). Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells. Toxicology 223, 15-25.
28. Mally, A., Keim-Heusler, H., Amberg, A., Kurz, M., Zepnik, H., Mantle, P., Volkel, W., Hard, G. C., and Dekant, W. (2005a). Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol. Appl. Pharmacol. 206, 43-53.
29. Mally, A., Pepe, G., Ravoori, S., Fiore, M., Gupta, R. C., Dekant, W., and Mosesso, P. (2005b). Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats. Chem. Res. Toxicol. 18, 1253-1261.
30. Mally, A., Volkel, W., Amberg, A., Kurz, M., Wanek, P., Eder, E., Hard, G., and Dekant, W. (2005c). Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem Res. Toxicol. 18, 1242-1252.
31. Mally, A., Zepnik, H., Wanek, P., Eder, E., Dingley, K., Ihmels, H., Völkel, W., and Dekant, W. (2004). Ochratoxin A: Lack of formation of covalent DNA adducts. Chem. Res. Toxicol. 17, 234-242.
32. Mistry, P., Deacon, K., Mistry, S., Blank, J., and Patel, R. (2004). NF-kappaB promotes survival during mitotic cell cycle arrest. J. Biol. Chem. 279, 1482-1490.
33. NTP (1989). Toxicology and carcinogenesis studies of ochratoxin A (CAS No. 303-47-9) in F344/N rats (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 358, 1-142.
34. Pfeiffer, E., Gross, K., and Metzler, M. (1998). Aneuploidogenic and clastogenicpotential of the mycotoxins citrinin and patulin. Carcinogenesis 19, 1313-1318.
35. Rasonyi, T., Schlatter, J., and Dietrich, D. R. (1999). The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats. Toxicol. Lett. 104, 83-92.
36. Rivedal, E., Mollerup, S., Haugen, A., and Vikhamar, G. (1996). Modulation of gap junctional intercellular communication by EGF in human kidney epithelial cells. Carcinogenesis 17, 2321-2328.
37. Rosette, C., and Karin, M. (1995). Cytoskeletal control of gene expression: Depolymerization of microtubules activates NF-kappa B. J. Cell Biol. 128, 1111-1119.
38. Sauvant, C., Holzinger, H., and Gekle, M. (2005a). The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cell. Physiol. Biochem. 15, 125-134.
39. Sauvant, C., Holzinger, H., and Gekle, M. (2005b). Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2. J. Pharmacol. Exp. Ther. 313, 234-241.
40. Schlatter, C., Studer-Rohr, J., and Rasonyi, T. (1996). Carcinogenicity and kinetic aspects of ochratoxin A. Food Addit. Contam. 13(Suppl.), 43-44.
41. Schramek, H., Wilflingseder, D., Pollack, V., Freudinger, R., Mildenberger, S., and Gekle, M. (1997). Ochratoxin A-induced stimulation of extra-cellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation. J. Pharmacol. Exp. Ther. 283, 1460-1468.
42. Schwerdt, G., Freudinger, R., Mildenberger, S., Silbernagl, S., and Gekle, M. (1999a). The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biol. Toxicol. 15, 405-415.
43. Schwerdt, G., Freudinger, R., Silbernagl, S., and Gekle, M. (1999b). Ochratoxin A-binding proteins in rat organs and plasma and in different cell lines of the kidney. Toxicology 135, 1-10.
44. Scibelli, A., Tafuri, S., Ferrante, M. C., Alimenti, E., Naso, B., Lucisano, A., Staiano, N., and Delia Morte, R. (2003). Ochratoxin A affects COS cell adhesion and signaling. Toxicol. Appl. Pharmacol. 192, 222-230.
45. SCOOP (2002). Reports on Tasks for Scientific Cooperation: Assessment of Dietary Intake of Ochratoxin A by the Population of EU Member States. Directorate-General Health and Consumer Protection. Available at: http://ec.europa.eu/comm/food/food/chemicalsafety/contaminants/ task_3-2-7_en.pdf. Accessed May 20, 2006.
46. Shelanski, M. L., Gaskin, F., and Cantor, C. R. (1973). Microtubule assembly in the absence of added nucleotides. Proc. Natl. Acad. Sci. U.S.A. 70, 765-768.
47. van de Water, B., Nagelkerke, J. F., and Stevens, J. L. (1999). Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells. J. Biol. Chem. 274, 13328-13337.
48. Wang, T. H., Popp, D. M., Wang, H. S., Saitoh, M., Mural, J. G., Henley, D. C., Ichijo, H., and Wimalasena, J. (1999). Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells. J. Biol. Chem. 274, 8208-8216.
49. Wang, T. H., Wang, H. S., Ichijo, H., Giannakakou, P., Foster, J. S., Fojo, T., and Wimalasena, J. (1998). Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273, 4928-4936.
50. Wang, T. H., Wang, H. S., and Soong, Y. K. (2000). Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer 88, 2619-2628.