메뉴 건너뛰기




Volumn 20, Issue 7, 2007, Pages 1031-1037

Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; OCHRATOXIN; THYMIDINE KINASE;

EID: 34547632542     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700027j     Document Type: Article
Times cited : (80)

References (81)
  • 1
    • 2042533500 scopus 로고    scopus 로고
    • Occurrence of fruit rot fungi (Aspergillus section Nigri) on some drying varieties of irrigated grapes
    • Leong, S. L., Hocking, A. D., and Pitt, J. I. (2004) Occurrence of fruit rot fungi (Aspergillus section Nigri) on some drying varieties of irrigated grapes. Aust. J. Grape Wine Res. 10, 83-88.
    • (2004) Aust. J. Grape Wine Res , vol.10 , pp. 83-88
    • Leong, S.L.1    Hocking, A.D.2    Pitt, J.I.3
  • 4
    • 0016816491 scopus 로고
    • Spontaneous toxic nephropathy in poultry associated with ochratoxin A
    • Elling, F., Hald, B., Jacobsen, C., and Krogh, P. (1975) Spontaneous toxic nephropathy in poultry associated with ochratoxin A. Acta Pathol. Microbiol. Scand. A 83, 739-741.
    • (1975) Acta Pathol. Microbiol. Scand. A , vol.83 , pp. 739-741
    • Elling, F.1    Hald, B.2    Jacobsen, C.3    Krogh, P.4
  • 5
    • 0020186631 scopus 로고
    • Natural occurrences of ochratoxicosis in poultry
    • Hamilton, P. B., Huff, W. E., Harris, J. R., and Wyatt, R. D. (1982) Natural occurrences of ochratoxicosis in poultry. Poult. Sci. 61, 1832-1841.
    • (1982) Poult. Sci , vol.61 , pp. 1832-1841
    • Hamilton, P.B.1    Huff, W.E.2    Harris, J.R.3    Wyatt, R.D.4
  • 7
    • 34547619889 scopus 로고    scopus 로고
    • NTP (1989) National Toxicological Program. Toxicology and carcinogenesis studies of ochratoxin A (CAS no. 303-47-9) in F344/N rats (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 358, 1-142.
    • NTP (1989) National Toxicological Program. Toxicology and carcinogenesis studies of ochratoxin A (CAS no. 303-47-9) in F344/N rats (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 358, 1-142.
  • 11
    • 0027504933 scopus 로고
    • Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin A
    • Pfohl-Leszkowicz, A., Grosse, Y., Kane, A., Creppy, E. E., and Dirheimer, G. (1993) Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin A. Mutat. Res. 289, 265-273.
    • (1993) Mutat. Res , vol.289 , pp. 265-273
    • Pfohl-Leszkowicz, A.1    Grosse, Y.2    Kane, A.3    Creppy, E.E.4    Dirheimer, G.5
  • 13
    • 0037070059 scopus 로고    scopus 로고
    • Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes
    • Gross-Steinmeyer, K., Weymann, J., Hege, H. G., and Metzler, M. (2002) Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes. J. Agric. Food Chem. 50, 938-945.
    • (2002) J. Agric. Food Chem , vol.50 , pp. 938-945
    • Gross-Steinmeyer, K.1    Weymann, J.2    Hege, H.G.3    Metzler, M.4
  • 15
    • 0030462648 scopus 로고    scopus 로고
    • Carcinogenicity and kinetic aspects of ochratoxin A
    • Schlatter, C., Studer-Rohr, J., and Rasonyi, T. (1996) Carcinogenicity and kinetic aspects of ochratoxin A. Food Addit. Contam. 13 (Suppl.), 43-44.
    • (1996) Food Addit. Contam , vol.13 , Issue.SUPPL. , pp. 43-44
    • Schlatter, C.1    Studer-Rohr, J.2    Rasonyi, T.3
  • 18
    • 12744273504 scopus 로고    scopus 로고
    • Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment
    • Knasmuller, S., Cavin, C., Chakraborty, A., Darroudi, F., Majer, B. J., Huber, W. W., and Ehrlich, V. A. (2004) Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment. Nutr Cancer 50, 190-197.
    • (2004) Nutr Cancer , vol.50 , pp. 190-197
    • Knasmuller, S.1    Cavin, C.2    Chakraborty, A.3    Darroudi, F.4    Majer, B.J.5    Huber, W.W.6    Ehrlich, V.A.7
  • 19
    • 0035717799 scopus 로고    scopus 로고
    • Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay)
    • Lebrun, S., and Follmann, W. (2002) Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay). Arch. Toxicol. 75, 734-741.
    • (2002) Arch. Toxicol , vol.75 , pp. 734-741
    • Lebrun, S.1    Follmann, W.2
  • 20
    • 4544295743 scopus 로고    scopus 로고
    • DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney
    • Robbiano, L., Baroni, D., Carrozzino, R., Mereto, E., and Brambilla, G. (2004) DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney. Toxicology 204, 187-195.
    • (2004) Toxicology , vol.204 , pp. 187-195
    • Robbiano, L.1    Baroni, D.2    Carrozzino, R.3    Mereto, E.4    Brambilla, G.5
  • 21
    • 0022202239 scopus 로고
    • Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney
    • Creppy, E. E., Kane, A., Dirheimer, G., Lafarge-Frayssinet, C., Mousset, S., and Frayssinet, C. (1985) Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. Toxicol. Lett. 28, 29-35.
    • (1985) Toxicol. Lett , vol.28 , pp. 29-35
    • Creppy, E.E.1    Kane, A.2    Dirheimer, G.3    Lafarge-Frayssinet, C.4    Mousset, S.5    Frayssinet, C.6
  • 22
    • 0022555463 scopus 로고
    • Distribution of the [3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys
    • Kane, A., Creppy, E. E., Roth, A., Roschenthaler, R., and Dirheimer, G. (1986) Distribution of the [3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys. Arch. Toxicol. 58, 219-224.
    • (1986) Arch. Toxicol , vol.58 , pp. 219-224
    • Kane, A.1    Creppy, E.E.2    Roth, A.3    Roschenthaler, R.4    Dirheimer, G.5
  • 23
  • 24
    • 33646233435 scopus 로고    scopus 로고
    • Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats
    • Domijan, A. M., Zeljezic, D., Kopjar, N., and Peraica, M. (2006) Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats. Toxicology 222, 53-59.
    • (2006) Toxicology , vol.222 , pp. 53-59
    • Domijan, A.M.1    Zeljezic, D.2    Kopjar, N.3    Peraica, M.4
  • 25
    • 0343339906 scopus 로고    scopus 로고
    • Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A
    • Dorrenhaus, A., Flieger, A., Golka, K., Schulze, H., Albrecht, M., Degen, G. H., and Follmann, W. (2000) Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A. Toxicol. Sci. 53, 271-277.
    • (2000) Toxicol. Sci , vol.53 , pp. 271-277
    • Dorrenhaus, A.1    Flieger, A.2    Golka, K.3    Schulze, H.4    Albrecht, M.5    Degen, G.H.6    Follmann, W.7
  • 27
    • 0030882061 scopus 로고    scopus 로고
    • Effects of ochratoxin A on DNA repair in cultures of rat hepatocytes and porcine urinary bladder epithelial cells
    • Dorrenhaus, A., and Follmann, W. (1997) Effects of ochratoxin A on DNA repair in cultures of rat hepatocytes and porcine urinary bladder epithelial cells. Arch. Toxicol. 71, 709-713.
    • (1997) Arch. Toxicol , vol.71 , pp. 709-713
    • Dorrenhaus, A.1    Follmann, W.2
  • 28
    • 0021243939 scopus 로고
    • Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes
    • Mori, H., Kawai, K., Ohbayashi, F., Kuniyasu, T., Yamazaki, M., Hamasaki, T., and Williams, G. M. (1984) Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. Cancer Res. 44, 2918-2923.
    • (1984) Cancer Res , vol.44 , pp. 2918-2923
    • Mori, H.1    Kawai, K.2    Ohbayashi, F.3    Kuniyasu, T.4    Yamazaki, M.5    Hamasaki, T.6    Williams, G.M.7
  • 30
    • 0018071942 scopus 로고
    • Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins
    • Wehner, F. C., Thiel, P. G., van Rensburg, S. J., and Demasius, I. P. (1978) Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins. Mutat. Res. 58, 193-203.
    • (1978) Mutat. Res , vol.58 , pp. 193-203
    • Wehner, F.C.1    Thiel, P.G.2    van Rensburg, S.J.3    Demasius, I.P.4
  • 31
    • 0025937573 scopus 로고
    • Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102
    • Wurgler, F. E., Friederich, U., and Schlatter, J. (1991) Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102. Mutat. Res. 261, 209-216.
    • (1991) Mutat. Res , vol.261 , pp. 209-216
    • Wurgler, F.E.1    Friederich, U.2    Schlatter, J.3
  • 32
    • 0035147426 scopus 로고    scopus 로고
    • Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites?
    • Zepnik, H., Pahler, A., Schauer, U., and Dekant, W. (2001) Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites? Toxicol. Sci. 59, 59-67.
    • (2001) Toxicol. Sci , vol.59 , pp. 59-67
    • Zepnik, H.1    Pahler, A.2    Schauer, U.3    Dekant, W.4
  • 33
    • 0026271907 scopus 로고
    • Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation
    • Hennig, A., Fink-Gremmels, J., and Leistner, L. (1991) Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation. IARC Sci. Publ. 255-260.
    • (1991) IARC Sci. Publ , pp. 255-260
    • Hennig, A.1    Fink-Gremmels, J.2    Leistner, L.3
  • 34
    • 0032699716 scopus 로고    scopus 로고
    • Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes
    • Obrecht-Pflumio, S., Chassat, T., Dirheimer, G., and Marzin, D. (1999) Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes. Mutat. Res. 446, 95-102.
    • (1999) Mutat. Res , vol.446 , pp. 95-102
    • Obrecht-Pflumio, S.1    Chassat, T.2    Dirheimer, G.3    Marzin, D.4
  • 35
    • 0038470827 scopus 로고    scopus 로고
    • Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system
    • Follmann, W., and Lucas, S. (2003) Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system. Arch. Toxicol. 77, 298-304.
    • (2003) Arch. Toxicol , vol.77 , pp. 298-304
    • Follmann, W.1    Lucas, S.2
  • 37
    • 0030925538 scopus 로고    scopus 로고
    • Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures
    • Degen, G. H., Gerber, M. M., Obrecht-Pflumio, S., and Dirheimer, G. (1997) Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Arch. Toxicol. 71, 365-371.
    • (1997) Arch. Toxicol , vol.71 , pp. 365-371
    • Degen, G.H.1    Gerber, M.M.2    Obrecht-Pflumio, S.3    Dirheimer, G.4
  • 38
    • 0345466411 scopus 로고    scopus 로고
    • Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A
    • Dopp, E., Muller, J., Hahnel, C., and Schiffmann, D. (1999) Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A. Food Chem. Toxicol. 37, 713-721.
    • (1999) Food Chem. Toxicol , vol.37 , pp. 713-721
    • Dopp, E.1    Muller, J.2    Hahnel, C.3    Schiffmann, D.4
  • 39
    • 0028936253 scopus 로고
    • Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha
    • Follmann, W., Hillebrand, I. E., Creppy, E. E., and Bolt, H. M. (1995) Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha. Arch. Toxicol. 69, 280-286.
    • (1995) Arch. Toxicol , vol.69 , pp. 280-286
    • Follmann, W.1    Hillebrand, I.E.2    Creppy, E.E.3    Bolt, H.M.4
  • 40
    • 0021763935 scopus 로고
    • Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle
    • Butler, W. B. (1984) Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle. Anal. Biochem. 141, 70-73.
    • (1984) Anal. Biochem , vol.141 , pp. 70-73
    • Butler, W.B.1
  • 41
    • 0024398561 scopus 로고
    • Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram
    • Hoy, C. A., Seamer, L. C., and Schimke, R. T. (1989) Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram. Cytometry 10, 718-725.
    • (1989) Cytometry , vol.10 , pp. 718-725
    • Hoy, C.A.1    Seamer, L.C.2    Schimke, R.T.3
  • 42
    • 0021015467 scopus 로고
    • A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells
    • Cole, J., Arlett, C. F., Green, M. H., Lowe, J., and Muriel, W. (1983) A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells. Mutat. Res. 111, 371-386.
    • (1983) Mutat. Res , vol.111 , pp. 371-386
    • Cole, J.1    Arlett, C.F.2    Green, M.H.3    Lowe, J.4    Muriel, W.5
  • 43
    • 0034693714 scopus 로고    scopus 로고
    • The mouse lymphoma assay
    • Clements, J. (2000) The mouse lymphoma assay. Mutat. Res. 455, 97-110.
    • (2000) Mutat. Res , vol.455 , pp. 97-110
    • Clements, J.1
  • 45
    • 0030921694 scopus 로고    scopus 로고
    • Design and testing of beta-actin primers for RT-PCR that do not co-amplify processed pseudogenes
    • Raff, T., van der Giet, M., Endemann, D., Wiederholt, T., and Paul, M. (1997) Design and testing of beta-actin primers for RT-PCR that do not co-amplify processed pseudogenes. Biotechniques 23, 456-460.
    • (1997) Biotechniques , vol.23 , pp. 456-460
    • Raff, T.1    van der Giet, M.2    Endemann, D.3    Wiederholt, T.4    Paul, M.5
  • 46
    • 0027292126 scopus 로고
    • Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells
    • Xu, Z., Yu, Y., Gibbs, R. A., Caskey, C. T., and Hsie, A. W. (1993) Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells. Mutat. Res. 288, 237-248.
    • (1993) Mutat. Res , vol.288 , pp. 237-248
    • Xu, Z.1    Yu, Y.2    Gibbs, R.A.3    Caskey, C.T.4    Hsie, A.W.5
  • 47
    • 0026049536 scopus 로고
    • Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene
    • Zhang, L. H., and Jenssen, D. (1991) Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene. Carcinogenesis 12, 1903-1909.
    • (1991) Carcinogenesis , vol.12 , pp. 1903-1909
    • Zhang, L.H.1    Jenssen, D.2
  • 49
    • 0018327785 scopus 로고
    • Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system
    • Clive, D., Johnson, K. O., Spector, J. F., Batson, A. G., and Brown, M. M. (1979) Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system. Mutat. Res. 59, 61-108.
    • (1979) Mutat. Res , vol.59 , pp. 61-108
    • Clive, D.1    Johnson, K.O.2    Spector, J.F.3    Batson, A.G.4    Brown, M.M.5
  • 50
    • 0026531901 scopus 로고
    • Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells
    • Zhang, L. H., Vrieling, H., van Zeeland, A. A., and Jenssen, D. (1992) Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells. J. Mol. Biol. 223, 627-635.
    • (1992) J. Mol. Biol , vol.223 , pp. 627-635
    • Zhang, L.H.1    Vrieling, H.2    van Zeeland, A.A.3    Jenssen, D.4
  • 51
    • 10044237965 scopus 로고    scopus 로고
    • Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells
    • Kamp, H. G., Eisenbrand, G., Schlatter, J., Wurth, K., and Janzowski, C. (2005) Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. Toxicology 206, 413-425.
    • (2005) Toxicology , vol.206 , pp. 413-425
    • Kamp, H.G.1    Eisenbrand, G.2    Schlatter, J.3    Wurth, K.4    Janzowski, C.5
  • 52
    • 0032586788 scopus 로고    scopus 로고
    • The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats
    • Rasonyi, T., Schlatter, J., and Dietrich, D. R. (1999) The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats. Toxicol. Lett. 104, 83-92.
    • (1999) Toxicol. Lett , vol.104 , pp. 83-92
    • Rasonyi, T.1    Schlatter, J.2    Dietrich, D.R.3
  • 53
    • 0034768453 scopus 로고    scopus 로고
    • Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line
    • Horvath, A., Upham, B. L., Ganev, V., and Trosko, J. E. (2002) Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40, 273-282.
    • (2002) Toxicon , vol.40 , pp. 273-282
    • Horvath, A.1    Upham, B.L.2    Ganev, V.3    Trosko, J.E.4
  • 55
    • 0042863397 scopus 로고    scopus 로고
    • Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells
    • Wang, C., Trudel, L. J., Wogan, G. N., and Deen, W. M. (2003) Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells. Chem. Res. Toxicol. 16, 1004-1013.
    • (2003) Chem. Res. Toxicol , vol.16 , pp. 1004-1013
    • Wang, C.1    Trudel, L.J.2    Wogan, G.N.3    Deen, W.M.4
  • 56
    • 0003029213 scopus 로고    scopus 로고
    • Antiproliferative effects and cell-cycle specific effects of ochratoxin A in LLC-PK1, NRK-52E and porcine primary proximal kidney cells
    • Dreger, S., O'Brien, E., Stack, M., and Dietrich, D. (2000) Antiproliferative effects and cell-cycle specific effects of ochratoxin A in LLC-PK1, NRK-52E and porcine primary proximal kidney cells. In The Toxicologist, Toxicological Science, Vol. 54, pp 70.
    • (2000) The Toxicologist, Toxicological Science , vol.54 , pp. 70
    • Dreger, S.1    O'Brien, E.2    Stack, M.3    Dietrich, D.4
  • 57
    • 33745614599 scopus 로고    scopus 로고
    • Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics?
    • Rached, E., Pfeiffer, E., Dekant, W., and Mally, A. (2006) Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Toxicol. Sci. 92, 78-86.
    • (2006) Toxicol. Sci , vol.92 , pp. 78-86
    • Rached, E.1    Pfeiffer, E.2    Dekant, W.3    Mally, A.4
  • 59
    • 0017283881 scopus 로고
    • Mycotoxic nephropathy
    • Krogh, P. (1976) Mycotoxic nephropathy. Adv. Vet. Sci. Comp. Med. 20, 147-170.
    • (1976) Adv. Vet. Sci. Comp. Med , vol.20 , pp. 147-170
    • Krogh, P.1
  • 60
    • 14744272406 scopus 로고    scopus 로고
    • Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
    • Dahle, J., Noordhuis, P., Stokke, T., Svendsrud, D. H., and Kvam, E. (2005) Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells. Photochem. Photobiol. 81, 114-119.
    • (2005) Photochem. Photobiol , vol.81 , pp. 114-119
    • Dahle, J.1    Noordhuis, P.2    Stokke, T.3    Svendsrud, D.H.4    Kvam, E.5
  • 61
    • 0029868051 scopus 로고    scopus 로고
    • Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A
    • Telleman, P., Overkamp, W. J., and Zdzienicka, M. Z. (1996) Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A. Mutagenesis 11, 155-159.
    • (1996) Mutagenesis , vol.11 , pp. 155-159
    • Telleman, P.1    Overkamp, W.J.2    Zdzienicka, M.Z.3
  • 62
    • 0034002220 scopus 로고    scopus 로고
    • Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium
    • Zhuang, J. C., Wright, T. L., deRojas-Walker, T., Tannenbaum, S. R., and Wogan, G. N. (2000) Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium. Environ. Mol. Mutagen. 35, 39-47.
    • (2000) Environ. Mol. Mutagen , vol.35 , pp. 39-47
    • Zhuang, J.C.1    Wright, T.L.2    deRojas-Walker, T.3    Tannenbaum, S.R.4    Wogan, G.N.5
  • 64
    • 0032750345 scopus 로고    scopus 로고
    • Oxidation of ochratoxin A by an Fe-porphyrin system: Model for enzymatic activation and DNA cleavage
    • Gillman, I. G., Clark, T. N., and Manderville, R. A. (1999) Oxidation of ochratoxin A by an Fe-porphyrin system: Model for enzymatic activation and DNA cleavage. Chem. Res. Toxicol. 12, 1066-1076.
    • (1999) Chem. Res. Toxicol , vol.12 , pp. 1066-1076
    • Gillman, I.G.1    Clark, T.N.2    Manderville, R.A.3
  • 65
    • 0030926268 scopus 로고    scopus 로고
    • Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs
    • Hoehler, D., Marquardt, R. R., McIntosh, A. R., and Hatch, G. M. (1997) Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Biochim. Biophys. Acta 1357, 225-233.
    • (1997) Biochim. Biophys. Acta , vol.1357 , pp. 225-233
    • Hoehler, D.1    Marquardt, R.R.2    McIntosh, A.R.3    Hatch, G.M.4
  • 66
    • 0029959825 scopus 로고    scopus 로고
    • Free radical generation as induced by ochratoxin A and its analogs in bacteria (Bacillus brevis)
    • Hoehler, D., Marquardt, R. R., McIntosh, A. R., and Xiao, H. (1996) Free radical generation as induced by ochratoxin A and its analogs in bacteria (Bacillus brevis). J. Biol. Chem. 271, 27388-27394.
    • (1996) J. Biol. Chem , vol.271 , pp. 27388-27394
    • Hoehler, D.1    Marquardt, R.R.2    McIntosh, A.R.3    Xiao, H.4
  • 70
    • 0030956232 scopus 로고    scopus 로고
    • Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame
    • Baudrimont, I., Betbeder, A. M., and Creppy, E. E. (1997) Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame. Arch. Toxicol. 71, 290-298.
    • (1997) Arch. Toxicol , vol.71 , pp. 290-298
    • Baudrimont, I.1    Betbeder, A.M.2    Creppy, E.E.3
  • 72
    • 0030942015 scopus 로고    scopus 로고
    • Retinol, ascorbic acid and alpha-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone
    • Grosse, Y., Chekir-Ghedira, L., Huc, A., Obrecht-Pflumio, S., Dirheimer, G., Bacha, H., and Pfohl-Leszkowicz, A. (1997) Retinol, ascorbic acid and alpha-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone. Cancer Lett. 114, 225-229.
    • (1997) Cancer Lett , vol.114 , pp. 225-229
    • Grosse, Y.1    Chekir-Ghedira, L.2    Huc, A.3    Obrecht-Pflumio, S.4    Dirheimer, G.5    Bacha, H.6    Pfohl-Leszkowicz, A.7
  • 73
    • 0034766390 scopus 로고    scopus 로고
    • Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney
    • Meki, A. R., and Hussein, A. A. (2001) Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 130, 305-313.
    • (2001) Comp. Biochem. Physiol. C Toxicol. Pharmacol , vol.130 , pp. 305-313
    • Meki, A.R.1    Hussein, A.A.2
  • 74
    • 9644254138 scopus 로고    scopus 로고
    • Protective role of melatonin in ochratoxin a toxicity in rat heart and lung
    • Okutan, H., Aydin, G., and Ozcelik, N. (2004) Protective role of melatonin in ochratoxin a toxicity in rat heart and lung. J. Appl. Toxicol. 24, 505-512.
    • (2004) J. Appl. Toxicol , vol.24 , pp. 505-512
    • Okutan, H.1    Aydin, G.2    Ozcelik, N.3
  • 77
    • 22544454436 scopus 로고    scopus 로고
    • A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction
    • Manderville, R. A. (2005) A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction. Chem. Res. Toxicol. 18, 1091-1097.
    • (2005) Chem. Res. Toxicol , vol.18 , pp. 1091-1097
    • Manderville, R.A.1
  • 78
    • 33749033911 scopus 로고    scopus 로고
    • Genotoxicity of the hydroquinone metabolite of ochratoxin A: Structure-activity relationships for covalent DNA adduction
    • Tozlovanu, M., Faucet-Marquis, V., Pfohl-Leszkowicz, A., and Manderville, R. A. (2006) Genotoxicity of the hydroquinone metabolite of ochratoxin A: Structure-activity relationships for covalent DNA adduction. Chem. Res. Toxicol. 19, 1241-1247.
    • (2006) Chem. Res. Toxicol , vol.19 , pp. 1241-1247
    • Tozlovanu, M.1    Faucet-Marquis, V.2    Pfohl-Leszkowicz, A.3    Manderville, R.A.4
  • 79
    • 23644432411 scopus 로고    scopus 로고
    • Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures
    • Zurich, M. G., Lengacher, S., Braissant, O., Monnet-Tschudi, F., Pellerin, L., and Honegger, P. (2005) Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. Neuroscience 134, 771-782.
    • (2005) Neuroscience , vol.134 , pp. 771-782
    • Zurich, M.G.1    Lengacher, S.2    Braissant, O.3    Monnet-Tschudi, F.4    Pellerin, L.5    Honegger, P.6
  • 80
    • 0037834732 scopus 로고    scopus 로고
    • A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: Expression profiling in vivo and in vitro employing cDNA microarrays
    • Luhe, A., Hildebrand, H., Bach, U., Dingermann, T., and Ahr, H. J. (2003) A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: Expression profiling in vivo and in vitro employing cDNA microarrays. Toxicol. Sci. 73, 315-328.
    • (2003) Toxicol. Sci , vol.73 , pp. 315-328
    • Luhe, A.1    Hildebrand, H.2    Bach, U.3    Dingermann, T.4    Ahr, H.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.