Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration

Toxicology and Applied Pharmacology

Volumn 192, Issue 1, 2003, Pages 36-44

  Zepnik, Herbert ^a   Völkel, Wolfgang ^a   Dekant, Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; MYCOTOXIN; OCHRATOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BIOTRANSFORMATION; BLOOD LEVEL; CONTROLLED STUDY; FECES LEVEL; FEEDING; FEMALE; FLUORESCENCE; FOOD CONTAMINATION; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIVER LEVEL; MALE; METABOLITE; NONHUMAN; RAT; SEX DIFFERENCE; TOXICOKINETICS; URINE LEVEL;

ANIMALIA; ASPERGILLUS; FUNGI; PENICILLIUM; RODENTIA; ZEA MAYS;

EID: 0141671914     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00261-8     Document Type: Article

References (41)

1. Babu E., Takeda M., Narikawa S., Kobayashi Y., Enomoto A., Tojo A., Cha S.H., Sekine T., Sakthisekaran D., Endou H. Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim. Biophys. Acta. 1590:2002;64-75.
2. Boorman G.A., McDonald M.R., Imoto S., Persing R. Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicol. Pathol. 20:1992;236-245.
3. Castegnaro M., Bartsch H., Bereziat J.C., Arvela P., Michelon J., Broussolle L. Polymorphic ochratoxin A hydroxylation in rat strains phenotyped as poor and extensive metabolizers of debrisoquine. Xenobiotica. 19:1989;225-230.
4. Chu F.S. A comparative study of the interaction of ochratoxins with bovine serum albumin. Biochem. Pharmacol. 23:1974;1105-1113.
5. Ciegler A., Fennell D.J., Mintzlaff H.J., Leistner L. Ochratoxin synthesis by Penicillium species. Naturwissenschaften. 59:1972;365-366.
6. Dai J., Park G., Wright M.W., Adams M., Akman S.A., Manderville R.A. Detection and characterization of a glutathione conjugate of ochratoxin A. Chem. Res. Toxicol. 15:2002;1581-1588.
7. Dekant W., Vamvakas S. Biotransformation and membrane transport in nephrotoxicity. Crit. Rev. Toxicol. 26:1996;309-334.
8. Feder G.L., Radovanovic Z., Finkelman R.B. Relationship between weathered coal deposits and the etiology of Balkan endemic nephropathy. Kidney Int. Suppl. 34:1991;S9-S11.
9. Fuchs R., Hult K. Ochratoxin A in blood and its pharmacokinetic properties. Food Chem. Toxicol. 30:1992;201-204.
10. Galtier P., Alvinerie M., Charpenteau J.L. The pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens. Food Cosmet Toxicol. 19:1981;735-738.
11. Gautier J., Richoz J., Welti D.H., Markovic J., Gremaud E., Guengerich F.P., Turesky R.J. Metabolism of ochratoxin A absence of formation of genotoxic derivatives by human and rat enzymes . Chem. Res. Toxicol. 14:2001;34-45.
12. Gillman I.G., Clark T.N., Manderville R.A. Oxidation of ochratoxin A by an Fe-porphyrin system model for enzymatic activation and DNA cleavage . Chem. Res. Toxicol. 12:1999;1066-1076.
13. Gross-Steinmeyer K., Weymann J., Hege H.G., Metzler M. Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes. J. Agric. Food Chem. 50:2002;938-945.
14. Hagelberg S., Hult K., Fuchs R. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J. Appl. Toxicol. 9:1989;91-96.
15. Hult K., Gatenbeck S. A spectrophotometric procedure, using carboxypeptidase A, for the quantitative measurement of ochratoxin A. J. Assoc. Off. Anal. Chem. 59:1976;128-129.
16. Jung K.Y., Takeda M., Kim D.K., Tojo A., Narikawa S., Yoo B.S., Hosoyamada M., Cha S.H., Sekine T., Endou H. Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 69:2001;2123-2135.
17. Kamimura H., Kawai R., Kudo H. Metabolic fate of indeloxazine hydrochloride Alpha-glucoside formation in rats . Xenobiotica. 18:1988;141-149.
18. Kamimura H., Ogata H., Takahara H. Alpha-glucoside formation of xenobiotics by rat liver alpha-glucosidases. Drug Metab. Dispos. 20:1992;309-315.
19. Kuiper-Goodman T., Scott P.M. Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci. 2:1989;179-248.
20. Li S., Marquardt R.R., Frohlich A.A., Vitti T.G., Crow G. Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145:1997;82-90.
21. Li S., Marquardt R.R., Frohlich A.A. Confirmation of ochratoxins in biological samples by conversion into methyl esters in acidified methanol. J. Agric. Food Chem. 46:1998;4307-4312.
22. Li S., Marquardt R.R., Fröhlich A.A. Identification of ochratoxins and some of their metabolites in bile and urine of rats. Fd Chem. Toxic. 38:2000;141-152.
23. Peraica M., Radic B., Lucic A., Pavlovic M. Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77:1999;754-766.
24. Pfohl-Leszkowicz A., Grosse Y., Castegnaro M., Nicolov I.G., Chernozemsky I.N., Bartsch H., Betbeder A.M., Creppy E.E., Dirheimer G. Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects. IARC-Scientific Publications. 124:1993;141-148.
25. Plestina R. Some features of Balkan endemic nephropathy. Fd Chem. Toxic. 30:1992;177-181.
26. Radovanovic Z., Markovic-Denic L., Marinkovic J., Jevremovic I., Jankovic S. Well water characteristics and the Balkan nephropathy. Nephron. 57:1991;52-54.
27. Sattler T.A., Dimitrov T., Hall P.W. Relation between endemic (Balkan) nephropathy and urinary-tract tumours. Lancet. 1:1977;278-280.
28. Schwerdt G., Bauer K., Gekle M., Silbernagl S. Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro. Toxicology. 114:1996;177-185.
29. Smith A.G., Francis J.E. Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats. Biochem. Pharmacol. 32:1983;3797-3801.
30. Stojkovic R., Hult K., Gamulin S., Plestina R. High affinity binding of ochratoxin A to plasma constituents. Biochem. Int. 9:1984;33-38.
31. Storen O., Holm H., Stormer F.C. Metabolism of ochratoxin A by rats. Appl. Environ. Microbiol. 44:1982;785-789.
32. Studer-Rohr I., Schlatter J., Dietrich D.R. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch. Toxicol. 74:2000;499-510.
33. Suzuki S., Satoh T., Yamazaki M. The pharmacokinetics of ochratoxin A in rats. Jpn. J. Pharmacol. 27:1977;735-744.
34. Tatu C.A., Orem W.H., Finkelman R.B., Feder G.L. The etiology of Balkan endemic nephropathy Still more questions than answers . Environ. Health Perspect. 106:1998;689-700.
35. van der Merwe K.J., Steyn P.S., Fourie L., Scott D.B., Theron J.J. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 205:1965;1112-1113.
36. van Walbeek W., Scott P.M., Harwig J., Lawrence J.W. Penicillium viridicatum Westling A new source of ochratoxin A . Can. J. Microbiol. 15:1969;1281-1285.
37. Wedeen R.P. Environmental renal disease lead, cadmium and Balkan endemic nephropathy . Kidney Int. Suppl. 34:1991;S4-S8.
38. WHO, Food Additives Series 2001. Evaluation of certain mycotoxins in food. World Health Organisation, Technical Report Series 906, fifty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives 47.
39. Völkel W., Colnot T., Csanady G.A., Filser J.G., Dekant W. Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem. Res. Toxicol. 15:2002;1281-1287.
40. Xiao H., Madhyastha S., Marquardt R.R., Li S., Vodela J.K., Frohlich A.A., Kemppainen B.W. Toxicity of ochratoxin A, its opened lactone form and several of its analogs Structure-activity relationships . Toxicol. Appl. Pharmacol. 137:1996;182-192.
41. Zepnik H., Pahler A., Schauer U., Dekant W. Ochratoxin A-induced tumor formation Is there a role of reactive ochratoxin A metabolites? Toxicol. Sci. 59:2001;59-67.