DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay

Brazilian Journal of Medical and Biological Research

Volumn 39, Issue 12, 2006, Pages 1563-1568

  Zeljezic D ^a   Domijan, A M ^a   Peraica, M ^a  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

Author keywords

Comet assay; DNA adducts; Experimental animals; Mycotoxin

Indexed keywords

AGAROSE; ETHIDIUM BROMIDE; MESYLIC ACID METHYL ESTER; OCHRATOXIN; SOLVENT; TROMETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DNA DAMAGE; FEMALE; GENOTOXICITY; KIDNEY HOMOGENATE; NONHUMAN; RAT; RAT STRAIN;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 33847626418     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006001200006     Document Type: Article

References (18)

1. Speijers GJA, van Egmond H. Worldwide ochratoxin A levels in food and feeds. In: Creppy EE, Castegnaro M, Dirheimer G (Editors), Human ochratoxicosis and its pathologies. Paris: John Libbey Eurotox Ltd.; 1993. p 85-100.
2. Krogh P. Mycotoxin porcine nephropathy: a possible model for Balkan endemic nephropathy. Second International Symposium on Endemic Nephropathy. 1974 March 25-31; Sofia. 1974.
3. Boorman GA. Technical Report on the Toxicology and Carcinogenesis Studies of Ochratoxin A in F344/N Rats. Durham: Research Triangle Park, National Institute of Health; 1989.
4. IPCS. WHO Food Additives Series. Safety evaluation of certain mycotoxins in food. Geneva: World Health Organization; 2001.
5. Robbiano L, Carrozzino R, Bacigalupo M, Corbu C, Brambilla G. Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity. Toxicology 2002; 179: 115-128.
6. Pfohl-Leszkowicz A, Chakor K, Creppy EE, Dirheimer G. DNA adduct formation in mice treated with ochratoxin A. in: Castegnaro M, Pleština R, Dirheimer G, Chernozemsky IN, Bartsch H (Editors), Mycotoxins, endemic nephropathy and urinary tract tumours. Lyon: IARC Scientific Publications No. 115. International Agency for Research on Cancer; 1991. p 245-253.
7. Petkova-Bocharova T, Stoichev II, Chernozemsky IN, Castegnaro M, Pfohl-Leszkowicz A. Formation of DNA adducts in tissues of mouse progeny through transplacental contamination and/or lactation after administration of a single dose of ochratoxin A to the pregnant mother. Environ Mol Mutagen 1998; 32: 155-162.
8. Robbiano L, Baroni D, Carrozzino R, Mereto E, Brambilla G. DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney. Toxicology 2004; 204: 187-195.
9. Bondy G, Suzuki C, Barker M, Armstrong C, Fernie S, Hierlihy L, et al. Toxicity of fumonisin B1 administered intraperitoneally to male Sprague-Dawley rats. Food Chem Toxicol 1995; 33: 653-665.
10. Peraica M, Domijan AM, Fuchs R, Lucic A, Radic B. The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol Lett 1999; 110: 105-112.
11. Bauer J, Gareis M, Gedek B. Determination and occurrence of ochratoxin A in slaughtered swine. Berl Munch Tierarztl Wochenschr 1984; 97: 279-283.
12. Sasaki YF, Nishidate E, Izumiyama F, Matsusaka N, Tsuda S. Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutat Res 1997; 391: 215-231.
13. Lebrun S, Follmann W. Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay). Arch Toxicol 2002; 75: 734-741.
14. Russo A, La Fauci L, Acquaviva R, Campisi A, Raciti G, Scifo C, et al. Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. J Nutr Biochem 2005; 16: 31-37.
15. Ehrlich V, Darroudi F, Uhl M, Steinkellner H, Gann M, Maier BJ, et al. Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells. Food Chem Toxicol 2002; 40: 1085-1090.
16. Faucet V, Pfohl-Leszkowicz A, Dai J, Castegnaro M, Manderville RA. Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig. Chem Res Toxicol 2004; 17: 1289-1296.
17. Mally A, Zepnik H, Wanek P, Eder E, Dingley K, Ihmels H, et al. Ochratoxin A: lack of formation of covalent DNA adducts. Chem Res Toxicol 2004; 17: 234-242.
18. Collins AR, Dobson VL, Dusinska M, Kennedy G, Stetina R. The comet assay: what can it really tell us? Mutat Res 1997; 375: 183-193.