Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

Toxicological Sciences

Volumn 96, Issue 1, 2007, Pages 30-39

  Cavin, Christophe ^a   Delatour, Thierry ^a   Marin Kuan, Maricel ^a   Holzhäuser, Daisy ^a   Higgins, Larry ^b   Bezençon, Claudine ^a   Guignard, Gabriela ^a   Junod, Sylviane ^a   Richoz Payot, Janique ^a   Gremaud, Eric ^a   Hayes, John D ^b   Nestler, Sandra ^c   Mantle, Peter ^d   Schilter, Benoît ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Carcinogenicity; Mycotoxin; Nephrotoxicity; Nuclear factor erythroid 2 p45 related factor 2 (Nrf2); Ochratoxin A; Oxidative stress

Indexed keywords

LUCIFERASE; MESSENGER RNA; OCHRATOXIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE EXPRESSION REGULATION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CANCER; LIVER CELL CULTURE; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RAT; REPORTER GENE;

ANIMALS; CARCINOGENS; CELL LINE; DITERPENES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; KIDNEY; MALE; NF-E2-RELATED FACTOR 2; OCHRATOXINS; OXIDATIVE STRESS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RESPONSE ELEMENTS; RISK ASSESSMENT; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

RATTUS; RODENTIA;

EID: 33847321653     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl169     Document Type: Article

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