-
1
-
-
0347951358
-
Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair
-
DOI 10.1172/JCI200317595
-
Alcalay M et al (2003) Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair. J Clin Invest 112: 1751-1761 (Pubitemid 38063733)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.11
, pp. 1751-1761
-
-
Alcalay, M.1
Meani, N.2
Gelmetti, V.3
Fantozzi, A.4
Fagioli, M.5
Orleth, A.6
Riganelli, D.7
Sebastiani, C.8
Cappelli, E.9
Casciari, C.10
Sciurpi, M.T.11
Mariano, A.R.12
Minardi, S.P.13
Luzi, L.14
Muller, H.15
Di Fiore, P.P.16
Frosina, G.17
Pelicci, P.G.18
-
2
-
-
79951698621
-
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
-
Babaei-Jadidi R et al (2011) FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208: 295-312
-
(2011)
J Exp Med
, vol.208
, pp. 295-312
-
-
Babaei-Jadidi, R.1
-
3
-
-
59649112776
-
Mouse differentiating spermatogonia can generate germinal stem cells in vivo
-
Barroca V, Lassalle B, Coureuil M, Louis JP, Le Page F, Testart J, Allemand I, Riou L, Fouchet P (2009) Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat Cell Biol 11: 190-196
-
(2009)
Nat Cell Biol
, vol.11
, pp. 190-196
-
-
Barroca, V.1
Lassalle, B.2
Coureuil, M.3
Louis, J.P.4
Le Page, F.5
Testart, J.6
Allemand, I.7
Riou, L.8
Fouchet, P.9
-
4
-
-
77952300504
-
Hematopoietic stem cell transplantation for multiple myeloma beyond 2010
-
Blade J, Rosinol L, Cibeira MT, Rovira M, Carreras E (2010) Hematopoietic stem cell transplantation for multiple myeloma beyond 2010. Blood 115: 3655-3663
-
(2010)
Blood
, vol.115
, pp. 3655-3663
-
-
Blade, J.1
Rosinol, L.2
Cibeira, M.T.3
Rovira, M.4
Carreras, E.5
-
5
-
-
38349121930
-
Signaling pathways governing stem? cell fate
-
Blank U, Karlsson G, Karlsson S (2008) Signaling pathways governing stem? cell fate. Blood 111: 492-503
-
(2008)
Blood
, vol.111
, pp. 492-503
-
-
Blank, U.1
Karlsson, G.2
Karlsson, S.3
-
6
-
-
0037135177
-
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
-
DOI 10.1126/science.1074192
-
Chenn A, Walsh CA (2002) Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297: 365-369 (Pubitemid 34790759)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 365-369
-
-
Chenn, A.1
Walsh, C.A.2
-
7
-
-
79958290042
-
A somitic Wnt16/Notch pathway specifies haematopoietic stem cells
-
Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature 474: 220-224
-
(2011)
Nature
, vol.474
, pp. 220-224
-
-
Clements, W.K.1
Kim, A.D.2
Ong, K.G.3
Moore, J.C.4
Lawson, N.D.5
Traver, D.6
-
8
-
-
79952370202
-
The cancer stem cell: Premises, promises and challenges
-
Clevers H (2011) The cancer stem cell: premises, promises and challenges. Nat Med 17: 313-319
-
(2011)
Nat Med
, vol.17
, pp. 313-319
-
-
Clevers, H.1
-
9
-
-
79952900560
-
Turning straw into gold: Directing cell fate for regenerative medicine
-
Cohen DE, Melton D (2011) Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet 12: 243-252
-
(2011)
Nat Rev Genet
, vol.12
, pp. 243-252
-
-
Cohen, D.E.1
Melton, D.2
-
10
-
-
77956342583
-
The ubiquitous nature of cancer: The role of the SCF(Fbw7) complex in development and transformation
-
Crusio KM, King B, Reavie LB, Aifantis I (2010) The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation. Oncogene 29: 4865-4873
-
(2010)
Oncogene
, vol.29
, pp. 4865-4873
-
-
Crusio, K.M.1
King, B.2
Reavie, L.B.3
Aifantis, I.4
-
11
-
-
20144370145
-
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
-
DOI 10.1038/ni1164
-
Duncan AW et al (2005) Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 6: 314-322 (Pubitemid 41724769)
-
(2005)
Nature Immunology
, vol.6
, Issue.3
, pp. 314-322
-
-
Duncan, A.W.1
Rattis, F.M.2
DiMascio, L.N.3
Congdon, K.L.4
Pazianos, G.5
Zhao, C.6
Yoon, K.7
Cook, J.M.8
Willert, K.9
Gaiano, N.10
Reya, T.11
-
13
-
-
47949124748
-
Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug? induced polyploidy
-
Finkin S, Aylon Y, Anzi S, Oren M, Shaulian E (2008) Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug? induced polyploidy. Oncogene 27: 4411-4421
-
(2008)
Oncogene
, vol.27
, pp. 4411-4421
-
-
Finkin, S.1
Aylon, Y.2
Anzi, S.3
Oren, M.4
Shaulian, E.5
-
14
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer
-
DOI 10.1038/nrc2396, PII NRC2396
-
Frescas D, Pagano M (2008) Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 8: 438-449 (Pubitemid 351744963)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
15
-
-
0035860804
-
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
-
Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israel A (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 276: 34371-34378
-
(2001)
J Biol Chem
, vol.276
, pp. 34371-34378
-
-
Gupta-Rossi, N.1
Le Bail, O.2
Gonen, H.3
Brou, C.4
Logeat, F.5
Six, E.6
Ciechanover, A.7
Israel, A.8
-
16
-
-
34248221516
-
FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients
-
Hagedorn M, Delugin M, Abraldes I, Allain N, Belaud-Rotureau MA, Turmo M, Prigent C, Loiseau H, Bikfalvi A, Javerzat S (2007) FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients. Cell Div 2: 9
-
(2007)
Cell Div
, vol.2
, pp. 9
-
-
Hagedorn, M.1
Delugin, M.2
Abraldes, I.3
Allain, N.4
Belaud-Rotureau, M.A.5
Turmo, M.6
Prigent, C.7
Loiseau, H.8
Bikfalvi, A.9
Javerzat, S.10
-
18
-
-
10344264425
-
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
-
DOI 10.1242/dev.01436
-
Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (2004) Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 131: 5539-5550 (Pubitemid 39625198)
-
(2004)
Development
, vol.131
, Issue.22
, pp. 5539-5550
-
-
Hatakeyama, J.1
Bessho, Y.2
Katoh, K.3
Ookawara, S.4
Fujioka, M.5
Guillemot, F.6
Kageyama, R.7
-
19
-
-
78049231370
-
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
-
Hoeck JD, Jandke A, Blake SM, Nye E, Spencer-Dene B, Brandner S, Behrens A (2010) Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci 13: 1365-1372
-
(2010)
Nat Neurosci
, vol.13
, pp. 1365-1372
-
-
Hoeck, J.D.1
Jandke, A.2
Blake, S.M.3
Nye, E.4
Spencer-Dene, B.5
Brandner, S.6
Behrens, A.7
-
20
-
-
0037071398
-
The proto-oncogene c-myc in hematopoietic development and leukemogenesis
-
DOI 10.1038/sj.onc.1205400
-
Hoffman B, Amanullah A, Shafarenko M, Liebermann DA (2002) The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21: 3414-3421 (Pubitemid 34587713)
-
(2002)
Oncogene
, vol.21
, Issue.21 REV. ISSUE 2
, pp. 3414-3421
-
-
Hoffman, B.1
Amanullah, A.2
Shafarenko, M.3
Liebermann, D.A.4
-
21
-
-
0030659821
-
Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
-
Hubbard EJ, Wu G, Kitajewski J, Greenwald I (1997) sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 11: 3182-3193 (Pubitemid 27528058)
-
(1997)
Genes and Development
, vol.11
, Issue.23
, pp. 3182-3193
-
-
Hubbard, E.J.A.1
Wu, G.2
Kitajewski, J.3
Greenwald, I.4
-
22
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
Inuzuka H et al (2011) SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471: 104-109
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
-
23
-
-
79952176472
-
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7á overexpression
-
Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T (2011) Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7á overexpression. Blood 117: 2373-2377
-
(2011)
Blood
, vol.117
, pp. 2373-2377
-
-
Iriuchishima, H.1
Takubo, K.2
Matsuoka, S.3
Onoyama, I.4
Nakayama, K.I.5
Nojima, Y.6
Suda, T.7
-
24
-
-
57649148900
-
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation
-
Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S (2008) Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem 283: 30540-30548
-
(2008)
J Biol Chem
, vol.283
, pp. 30540-30548
-
-
Kanei-Ishii, C.1
Nomura, T.2
Takagi, T.3
Watanabe, N.4
Nakayama, K.I.5
Ishii, S.6
-
25
-
-
67649933397
-
Fbw7 promotes ubiquitin-dependent degradation of c-Myb: Involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb
-
Kitagawa K, Hiramatsu Y, Uchida C, Isobe T, Hattori T, Oda T, Shibata K, Nakamura S, Kikuchi A, Kitagawa M (2009) Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene 28: 2393-2405
-
(2009)
Oncogene
, vol.28
, pp. 2393-2405
-
-
Kitagawa, K.1
Hiramatsu, Y.2
Uchida, C.3
Isobe, T.4
Hattori, T.5
Oda, T.6
Shibata, K.7
Nakamura, S.8
Kikuchi, A.9
Kitagawa, M.10
-
26
-
-
0035812709
-
Fbw7 ubiquitin ligase
-
DOI 10.1126/science.1065203
-
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ (2001) Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294: 173-177 (Pubitemid 32952972)
-
(2001)
Science
, vol.294
, Issue.5540
, pp. 173-177
-
-
Koepp, D.M.1
Schaefer, L.K.2
Ye, X.3
Keyomarsi, K.4
Chu, C.5
Harper, J.W.6
Elledge, S.J.7
-
27
-
-
84855339687
-
Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer
-
[in the press]
-
Kondratyev M, Kreso A, Hallett RM, Girgis-Gabardo A, Barcelon ME, Ilieva D, Ware C, Majumder PK, Hassell JA (2011) Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer. Oncogene [in the press]
-
(2011)
Oncogene
-
-
Kondratyev, M.1
Kreso, A.2
Hallett, R.M.3
Girgis-Gabardo, A.4
Barcelon, M.E.5
Ilieva, D.6
Ware, C.7
Majumder, P.K.8
Hassell, J.A.9
-
28
-
-
79956334658
-
Heart regeneration
-
Laflamme MA, Murry CE (2011) Heart regeneration. Nature 473: 326-335
-
(2011)
Nature
, vol.473
, pp. 326-335
-
-
Laflamme, M.A.1
Murry, C.E.2
-
29
-
-
24644495693
-
The role of Smad signaling in hematopoiesis
-
DOI 10.1038/sj.onc.1208920, PII 1208920
-
Larsson J, Karlsson S (2005) The role of Smad signaling in hematopoiesis. Oncogene 24: 5676-5692 (Pubitemid 43086128)
-
(2005)
Oncogene
, vol.24
, Issue.37
, pp. 5676-5692
-
-
Larsson, J.1
Karlsson, S.2
-
30
-
-
56549084319
-
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity
-
Laurenti E et al (2008) Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3: 611-624
-
(2008)
Cell Stem Cell
, vol.3
, pp. 611-624
-
-
Laurenti, E.1
-
31
-
-
79959923295
-
MiRNA-27a controls FBW7/hCDC4-dependent cyclin e degradation and cell cycle progression
-
Lerner M et al (2011) miRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle 10: 2172-2183
-
(2011)
Cell Cycle
, vol.10
, pp. 2172-2183
-
-
Lerner, M.1
-
32
-
-
0036894182
-
The stem-cell niche theory: Lessons from flies
-
DOI 10.1038/nrg952
-
Lin H (2002) The stem-cell niche theory: lessons from flies. Nat Rev Genet 3: 931-940 (Pubitemid 35423505)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.12
, pp. 931-940
-
-
Lin, H.1
-
33
-
-
77953310667
-
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
-
Liu N et al (2010) The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem 285: 18858-18867
-
(2010)
J Biol Chem
, vol.285
, pp. 18858-18867
-
-
Liu, N.1
-
35
-
-
51749095471
-
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
-
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321: 1499-1502
-
(2008)
Science
, vol.321
, pp. 1499-1502
-
-
Mao, J.H.1
Kim, I.J.2
Wu, D.3
Climent, J.4
Kang, H.C.5
Delrosario, R.6
Balmain, A.7
-
36
-
-
79953899846
-
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
-
Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI (2011) Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem 286: 13754-13764
-
(2011)
J Biol Chem
, vol.286
, pp. 13754-13764
-
-
Matsumoto, A.1
Onoyama, I.2
Sunabori, T.3
Kageyama, R.4
Okano, H.5
Nakayama, K.I.6
-
37
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
DOI 10.1101/gad.1621808
-
Matsuoka S et al (2008) Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22: 986-991 (Pubitemid 351544237)
-
(2008)
Genes and Development
, vol.22
, Issue.8
, pp. 986-991
-
-
Matsuoka, S.1
Oike, Y.2
Onoyama, I.3
Iwama, A.4
Arai, F.5
Takubo, K.6
Mashimo, Y.7
Oguro, H.8
Nitta, E.9
Ito, K.10
Miyamoto, K.11
Yoshiwara, H.12
Hosokawa, K.13
Nakamura, Y.14
Gomei, Y.15
Iwasaki, H.16
Hayashi, Y.17
Matsuzaki, Y.18
Nakayama, K.19
Ikeda, Y.20
Hata, A.21
Chiba, S.22
Nakayama, K.I.23
Suda, T.24
more..
-
38
-
-
79959714872
-
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL
-
Mavrakis KJ et al (2011) A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nat Genet 43: 673-678
-
(2011)
Nat Genet
, vol.43
, pp. 673-678
-
-
Mavrakis, K.J.1
-
39
-
-
79960668961
-
AF (2011) Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer
-
Chambers
-
McGowan PM, Simedrea C, Ribot EJ, Foster PJ, Palmieri D, Steeg PS, Allan AL, Chambers AF (2011) Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Mol Cancer Res 9: 834-844
-
Mol Cancer Res
, vol.9
, pp. 834-844
-
-
McGowan, P.M.1
Simedrea, C.2
Ribot, E.J.3
Foster, P.J.4
Palmieri, D.5
Steeg, P.S.6
Allan, A.L.7
-
40
-
-
0035921928
-
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
-
DOI 10.1038/35095068
-
Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK (2001) Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413: 311-316 (Pubitemid 32905852)
-
(2001)
Nature
, vol.413
, Issue.6853
, pp. 311-316
-
-
Moberg, K.H.1
Bell, D.W.2
Wahrer, D.C.R.3
Haber, D.A.4
Hariharan, I.K.5
-
41
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6: 369-381
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
42
-
-
0030010591
-
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
-
Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY (1996) Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-720
-
(1996)
Cell
, vol.85
, pp. 707-720
-
-
Nakayama, K.1
Ishida, N.2
Shirane, M.3
Inomata, A.4
Inoue, T.5
Shishido, N.6
Horii, I.7
Loh, D.Y.8
-
43
-
-
33745674468
-
Drug discovery in the ubiquitin-proteasome system
-
Nalepa G, Rolfe M, Harper JW (2006) Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov 5: 596-613
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 596-613
-
-
Nalepa, G.1
Rolfe, M.2
Harper, J.W.3
-
44
-
-
1342275412
-
Fbw7 antagonizes apoptotic JNK signaling
-
DOI 10.1126/science.1092880
-
Nateri AS, Riera-Sans L, Da Costa C, Behrens A (2004) The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303: 1374-1378 (Pubitemid 38269431)
-
(2004)
Science
, vol.303
, Issue.5662
, pp. 1374-1378
-
-
Nateri, A.S.1
Riera-Sans, L.2
Da Costa, C.3
Behrens, A.4
-
45
-
-
79960022317
-
Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling
-
Nishina S et al (2011) Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling. Oncol Rep 26: 523-531
-
(2011)
Oncol Rep
, vol.26
, pp. 523-531
-
-
Nishina, S.1
-
46
-
-
0035929669
-
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
-
Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 276: 35847-35853
-
(2001)
J Biol Chem
, vol.276
, pp. 35847-35853
-
-
Oberg, C.1
Li, J.2
Pauley, A.3
Wolf, E.4
Gurney, M.5
Lendahl, U.6
-
47
-
-
0141918786
-
Neurogenesis and the cell cycle
-
DOI 10.1016/S0896-6273(03)00632-9
-
Ohnuma S, Harris WA (2003) Neurogenesis and the cell cycle. Neuron 40: 199-208 (Pubitemid 37244092)
-
(2003)
Neuron
, vol.40
, Issue.2
, pp. 199-208
-
-
Ohnuma, S.-I.1
Harris, W.A.2
-
48
-
-
36549071481
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
-
DOI 10.1084/jem.20062299
-
Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Alboran IM, Nakayama K, Nakayama KI (2007) Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204: 2875-2888 (Pubitemid 350179557)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.12
, pp. 2875-2888
-
-
Onoyama, I.1
Tsunematsu, R.2
Matsumoto, A.3
Kimura, T.4
De Alboran, I.M.5
Nakayama, K.6
Nakayama, K.I.7
-
49
-
-
78650928027
-
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
-
Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI (2011) Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest 121: 342-354
-
(2011)
J Clin Invest
, vol.121
, pp. 342-354
-
-
Onoyama, I.1
Suzuki, A.2
Matsumoto, A.3
Tomita, K.4
Katagiri, H.5
Oike, Y.6
Nakayama, K.7
Nakayama, K.I.8
-
51
-
-
43249087214
-
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis
-
DOI 10.1101/gad.1670708
-
Perry JM, Li L (2008) Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. Genes Dev 22: 1107-1109 (Pubitemid 351656570)
-
(2008)
Genes and Development
, vol.22
, Issue.9
, pp. 1107-1109
-
-
Perry, J.M.1
Li, N.2
-
52
-
-
79955460636
-
Notch signalling in solid tumours: A little bit of everything but not all the time
-
Ranganathan P, Weaver KL, Capobianco AJ (2011) Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-351
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 338-351
-
-
Ranganathan, P.1
Weaver, K.L.2
Capobianco, A.J.3
-
53
-
-
79957622341
-
Concise review: Emerging concepts in clinical targeting of cancer stem cells
-
Rasheed ZA, Kowalski J, Smith BD, Matsui W (2011) Concise review: emerging concepts in clinical targeting of cancer stem cells. Stem Cells 29: 883-887
-
(2011)
Stem Cells
, vol.29
, pp. 883-887
-
-
Rasheed, Z.A.1
Kowalski, J.2
Smith, B.D.3
Matsui, W.4
-
54
-
-
76949085686
-
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
-
Reavie L et al (2010) Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol 11: 207-215
-
(2010)
Nat Immunol
, vol.11
, pp. 207-215
-
-
Reavie, L.1
-
55
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
DOI 10.1038/35102167
-
Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111 (Pubitemid 33041634)
-
(2001)
Nature
, vol.414
, Issue.6859
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
56
-
-
77952673813
-
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
-
Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-2961
-
(2010)
Oncogene
, vol.29
, pp. 2950-2961
-
-
Rocher-Ros, V.1
Marco, S.2
Mao, J.H.3
Gines, S.4
Metzger, D.5
Chambon, P.6
Balmain, A.7
Saura, C.A.8
-
57
-
-
67349132223
-
Physiological functions of the HECT family of ubiquitin ligases
-
Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10: 398-409
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
58
-
-
77954862426
-
Stem cell therapies for spinal cord injury
-
Sahni V, Kessler JA (2010) Stem cell therapies for spinal cord injury. Nat Rev Neurol 6: 363-372
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 363-372
-
-
Sahni, V.1
Kessler, J.A.2
-
59
-
-
77956165036
-
F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
-
Sancho R, Jandke A, Davis H, Diefenbacher ME, Tomlinson I, Behrens A (2010) F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139: 929-941
-
(2010)
Gastroenterology
, vol.139
, pp. 929-941
-
-
Sancho, R.1
Jandke, A.2
Davis, H.3
Diefenbacher, M.E.4
Tomlinson, I.5
Behrens, A.6
-
60
-
-
77449093887
-
Hematopoietic stem cell heterogeneity: Subtypes, not unpredictable behavior
-
Schroeder T (2010) Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior. Cell Stem Cell 6: 203-207
-
(2010)
Cell Stem Cell
, vol.6
, pp. 203-207
-
-
Schroeder, T.1
-
62
-
-
0035921849
-
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
-
DOI 10.1038/35095076
-
Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413: 316-322 (Pubitemid 32905853)
-
(2001)
Nature
, vol.413
, Issue.6853
, pp. 316-322
-
-
Strohmaier, H.1
Spruck, C.H.2
Kaiser, P.3
Won, K.-A.4
Sangfelt, O.5
Reed, S.I.6
-
63
-
-
23844530704
-
Fbw7
-
DOI 10.1016/j.cmet.2005.04.010, PII S155041310500118X
-
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J (2005) Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 1: 379-391 (Pubitemid 43960622)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 379-391
-
-
Sundqvist, A.1
Bengoechea-Alonso, M.T.2
Ye, X.3
Lukiyanchuk, V.4
Jin, J.5
Harper, J.W.6
Ericsson, J.7
-
64
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
-
Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676 (Pubitemid 44233629)
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
65
-
-
79551600015
-
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
-
Takebe N, Harris PJ, Warren RQ, Ivy SP (2011) Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 8: 97-106
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
66
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
DOI 10.1073/pnas.0307875101
-
Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ (2004) Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci USA 101: 3338-3345 (Pubitemid 38338196)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
Yu, W.2
Li, M.3
Zhang, P.4
Finegold, M.5
Mahon, K.6
Harper, J.W.7
Schwartz, R.J.8
Elledge, S.J.9
-
67
-
-
45149123052
-
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
-
DOI 10.1084/jem.20080277
-
Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, Zavadil J, Nimer SD, Aifantis I (2008) Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205: 1395-1408 (Pubitemid 351831495)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.6
, pp. 1395-1408
-
-
Thompson, B.J.1
Jankovic, V.2
Gao, J.3
Buonamici, S.4
Vest, A.5
Lee, J.M.6
Zavadil, J.7
Nimer, S.D.8
Aifantis, I.9
-
69
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
DOI 10.1074/jbc.M312337200
-
Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI (2004) Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279: 9417-9423 (Pubitemid 38296008)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.10
, pp. 9417-9423
-
-
Tsunematsu, R.1
Nakayama, K.2
Oike, Y.3
Nishiyama, M.4
Ishida, N.5
Hatakeyama, S.6
Bessho, Y.7
Kageyama, R.8
Suda, T.9
Nakayama, K.I.10
-
70
-
-
52549087785
-
Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
-
Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
71
-
-
1542328965
-
Plasticity of adult stem cells
-
DOI 10.1016/S0092-8674(04)00208-9, PII S0092867404002089
-
Wagers AJ, Weissman IL (2004) Plasticity of adult stem cells. Cell 116: 639-648 (Pubitemid 38326723)
-
(2004)
Cell
, vol.116
, Issue.5
, pp. 639-648
-
-
Wagers, A.J.1
Weissman, I.L.2
-
72
-
-
80053116244
-
SiRNA targeting Notch-1 decreases glioma stem cell proliferation and tumor growth
-
[in the press]
-
Wang J, Wang C, Meng Q, Li S, Sun X, Bo Y, Yao W (2011) siRNA targeting Notch-1 decreases glioma stem cell proliferation and tumor growth. Mol Biol Rep [in the press]
-
(2011)
Mol Biol Rep
-
-
Wang, J.1
Wang, C.2
Meng, Q.3
Li, S.4
Sun, X.5
Bo, Y.6
Yao, W.7
-
73
-
-
78649466892
-
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
-
Wang Z, Li Y, Ahmad A, Azmi AS, Banerjee S, Kong D, Sarkar FH (2010) Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 1806: 258-267
-
(2010)
Biochim Biophys Acta
, vol.1806
, pp. 258-267
-
-
Wang, Z.1
Li, Y.2
Ahmad, A.3
Azmi, A.S.4
Banerjee, S.5
Kong, D.6
Sarkar, F.H.7
-
74
-
-
22244476115
-
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
-
DOI 10.1016/j.ccr.2005.06.005, PII S1535610805001935
-
Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr (2005) The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25-33 (Pubitemid 40991812)
-
(2005)
Cancer Cell
, vol.8
, Issue.1
, pp. 25-33
-
-
Wei, W.1
Jin, J.2
Schlisio, S.3
Harper, J.W.4
Kaelin Jr., W.G.5
-
75
-
-
38549086019
-
FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
-
DOI 10.1038/nrc2290, PII NRC2290
-
Welcker M, Clurman BE (2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83-93 (Pubitemid 351161321)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.2
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
76
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
DOI 10.1073/pnas.0402770101
-
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 101: 9085-9090 (Pubitemid 38781615)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.24
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.A.4
Harper, J.W.5
Eisenman, R.N.6
Clurman, B.E.7
-
77
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz IE et al (2011) Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471: 110-114
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
-
78
-
-
0033592556
-
A family of mammalian F-box proteins
-
DOI 10.1016/S0960-9822(00)80021-4
-
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999) A family of mammalian F-box proteins. Curr Biol 9: 1180-1182 (Pubitemid 29527104)
-
(1999)
Current Biology
, vol.9
, Issue.20
, pp. 1180-1182
-
-
Winston, J.T.1
Koepp, D.M.2
Cihui, Z.3
Elledge, S.J.4
Harper, J.W.5
-
79
-
-
0034791336
-
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
-
DOI 10.1128/MCB.21.21.7403-7415.2001
-
Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 21: 7403-7415 (Pubitemid 32953491)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.21
, pp. 7403-7415
-
-
Wu, G.1
Lyapina, S.2
Das, I.3
Li, J.4
Gurney, M.5
Pauley, A.6
Chui, I.7
Deshaies, R.J.8
Kitajewski, J.9
-
80
-
-
79955572417
-
Harnessing the potential of induced pluripotent stem cells for regenerative medicine
-
Wu SM, Hochedlinger K (2011) Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol 13: 497-505
-
(2011)
Nat Cell Biol
, vol.13
, pp. 497-505
-
-
Wu, S.M.1
Hochedlinger, K.2
-
81
-
-
2942614705
-
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
-
DOI 10.1038/sj.emboj.7600217
-
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-2125 (Pubitemid 38737738)
-
(2004)
EMBO Journal
, vol.23
, Issue.10
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
Tsunematsu, R.5
Imaki, H.6
Ishida, N.7
Okumura, F.8
Nakayama, K.9
Nakayama, K.I.10
-
82
-
-
34547180739
-
The gastrointestinal tract stem cell niche
-
DOI 10.1007/s12015-006-0048-1, PII SCR23203
-
Yen TH, Wright NA (2006) The gastrointestinal tract stem cell niche. Stem Cell Rev 2: 203-212 (Pubitemid 47109399)
-
(2006)
Stem Cell Reviews
, vol.2
, Issue.3
, pp. 203-212
-
-
Yen, T.-H.1
Wright, N.A.2
-
83
-
-
65949107856
-
P53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases
-
Yokobori T, Mimori K, Iwatsuki M, Ishii H, Onoyama I, Fukagawa T, Kuwano H, Nakayama KI, Mori M (2009) p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 69: 3788-3794
-
(2009)
Cancer Res
, vol.69
, pp. 3788-3794
-
-
Yokobori, T.1
Mimori, K.2
Iwatsuki, M.3
Ishii, H.4
Onoyama, I.5
Fukagawa, T.6
Kuwano, H.7
Nakayama, K.I.8
Mori, M.9
-
84
-
-
79952660821
-
Control of the embryonic stem cell state
-
Young RA (2011) Control of the embryonic stem cell state. Cell 144: 940-954
-
(2011)
Cell
, vol.144
, pp. 940-954
-
-
Young, R.A.1
-
85
-
-
57349112286
-
Generation and regeneration of cells of the liver and pancreas
-
Zaret KS, Grompe M (2008) Generation and regeneration of cells of the liver and pancreas. Science 322: 1490-1494
-
(2008)
Science
, vol.322
, pp. 1490-1494
-
-
Zaret, K.S.1
Grompe, M.2
-
86
-
-
77953158826
-
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
-
Zhao D, Zheng HQ, Zhou Z, Chen C (2010) The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res 70: 4728-4738
-
(2010)
Cancer Res
, vol.70
, pp. 4728-4738
-
-
Zhao, D.1
Zheng, H.Q.2
Zhou, Z.3
Chen, C.4
|