메뉴 건너뛰기




Volumn 12, Issue 2, 2010, Pages 199-211

The functional role of Notch signaling in human gliomas

Author keywords

Angiogenesis; Cancer stem cells; EGFR; Glioma; Notch

Indexed keywords

NOTCH RECEPTOR;

EID: 75849133698     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nop022     Document Type: Review
Times cited : (103)

References (109)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;10:987-996.
    • (2005) N Engl J Med , vol.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 2
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binda E, Orfanelli U, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004;19:7011-7021.
    • (2004) Cancer Res , vol.19 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3
  • 3
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;18:5821-5828.
    • (2003) Cancer Res , vol.18 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 4
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 5
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999;5415:770-776.
    • (1999) Science , vol.5415 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 6
    • 38549148417 scopus 로고    scopus 로고
    • Notch and cancer: A double-edged sword
    • Koch U, Radtke F. Notch and cancer: a double-edged sword. Cell Mol Life Sci. 2007;21:2746-2762.
    • (2007) Cell Mol Life Sci , vol.21 , pp. 2746-2762
    • Koch, U.1    Radtke, F.2
  • 7
    • 0036304110 scopus 로고    scopus 로고
    • The role of notch in promoting glial and neural stem cell fates
    • Gaiano N, Fishell G. The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci. 2002;25:471-490.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 471-490
    • Gaiano, N.1    Fishell, G.2
  • 8
    • 33745092023 scopus 로고    scopus 로고
    • Notch signaling in the regulation of tumor angiogenesis
    • Rehman AO, Wang CY. Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol. 2006;6:293-300.
    • (2006) Trends Cell Biol , vol.6 , pp. 293-300
    • Rehman, A.O.1    Wang, C.Y.2
  • 9
    • 56049092014 scopus 로고    scopus 로고
    • Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
    • Poellinger L, Lendahl U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr Opin Genet Dev. 2008;18:449-454.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 449-454
    • Poellinger, L.1    Lendahl, U.2
  • 11
    • 0032493302 scopus 로고    scopus 로고
    • The Notch1 receptor is cleaved constitutively by a furin-like convertase
    • Logeat F, Bessia C, Brou C, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA. 1998;14:8108-8112.
    • (1998) Proc Natl Acad Sci USA , vol.14 , pp. 8108-8112
    • Logeat, F.1    Bessia, C.2    Brou, C.3
  • 12
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • Blaumueller CM, Qi H, Zagouras P, Rtavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997;2:281-291.
    • (1997) Cell , vol.2 , pp. 281-291
    • Blaumueller, C.M.1    Qi, H.2    Zagouras, P.3    Rtavanis-Tsakonas, S.4
  • 14
    • 0030840415 scopus 로고    scopus 로고
    • Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
    • Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol. 1997;10:6057-6067.
    • (1997) Mol Cell Biol , vol.10 , pp. 6057-6067
    • Luo, B.1    Aster, J.C.2    Hasserjian, R.P.3    Kuo, F.4    Sklar, J.5
  • 15
    • 0032996755 scopus 로고    scopus 로고
    • Human ligands of the Notch receptor
    • Gray GE, Mann RS, Mitsiadis E, et al. Human ligands of the Notch receptor. Am J Pathol. 1999;3:785-794.
    • (1999) Am J Pathol , vol.3 , pp. 785-794
    • Gray, G.E.1    Mann, R.S.2    Mitsiadis, E.3
  • 16
    • 0030961091 scopus 로고    scopus 로고
    • Mouse Dll3: A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
    • Dunwoodie SL, Henrique D, Harrison SM, Beddington RS. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development. 1997;16:3065-3076.
    • (1997) Development , vol.16 , pp. 3065-3076
    • Dunwoodie, S.L.1    Henrique, D.2    Harrison, S.M.3    Beddington, R.S.4
  • 17
    • 0034195220 scopus 로고    scopus 로고
    • Dll4, a novel Notch ligand expressed in arterial endothelium
    • Shutter JR, Scully S, Fan W, et al. Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 2000;11:1313-1318.
    • (2000) Genes Dev , vol.11 , pp. 1313-1318
    • Shutter, J.R.1    Scully, S.2    Fan, W.3
  • 18
    • 0033867521 scopus 로고    scopus 로고
    • A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
    • Mumm JS, Schroeter EH, Saxena MT, et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell. 2000;2:197-206.
    • (2000) Mol Cell , vol.2 , pp. 197-206
    • Mumm, J.S.1    Schroeter, E.H.2    Saxena, M.T.3
  • 19
    • 0033868818 scopus 로고    scopus 로고
    • A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
    • Brou C, Logeat F, Gupta N, et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell. 2000;2:207-216.
    • (2000) Mol Cell , vol.2 , pp. 207-216
    • Brou, C.1    Logeat, F.2    Gupta, N.3
  • 20
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    • De SB, Annaert W, Cupers P, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;6727:518-522.
    • (1999) Nature , vol.6727 , pp. 518-522
    • SB, D.1    Annaert, W.2    Cupers, P.3
  • 22
    • 0032145527 scopus 로고    scopus 로고
    • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
    • Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev. 1998;15:2269-2277.
    • (1998) Genes Dev , vol.15 , pp. 2269-2277
    • Kao, H.Y.1    Ordentlich, P.2    Koyano-Nakagawa, N.3
  • 23
    • 0034595665 scopus 로고    scopus 로고
    • Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
    • Kurooka H, Honjo T. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem. 2000;22:17211-17220.
    • (2000) J Biol Chem , vol.22 , pp. 17211-17220
    • Kurooka, H.1    Honjo, T.2
  • 24
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: Multiple effectors of the Notch signaling pathway
    • Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003;3:237-255.
    • (2003) J Cell Physiol , vol.3 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 25
  • 26
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): Implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini C, Capobianco AJ. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol. 2001;17:5925-5934.
    • (2001) Mol Cell Biol , vol.17 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 27
    • 17844384528 scopus 로고    scopus 로고
    • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    • Rangarajan A, Talora C, Okuyama R, et al. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 2001;13:3427-3436.
    • (2001) EMBO J , vol.13 , pp. 3427-3436
    • Rangarajan, A.1    Talora, C.2    Okuyama, R.3
  • 28
    • 0037106147 scopus 로고    scopus 로고
    • Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation
    • Ge W, Martinowich K, Wu X, et al. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res. 2002;6:848-860.
    • (2002) J Neurosci Res , vol.6 , pp. 848-860
    • Ge, W.1    Martinowich, K.2    Wu, X.3
  • 29
    • 0036778127 scopus 로고    scopus 로고
    • CSL-independent Notch signalling: A checkpoint in cell fate decisions during development?
    • Martinez AA, Zecchini V, Brennan K. CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? Curr Opin Genet Dev. 2002;5:524-533.
    • (2002) Curr Opin Genet Dev , vol.5 , pp. 524-533
    • Martinez, A.A.1    Zecchini, V.2    Brennan, K.3
  • 30
  • 31
    • 17844410115 scopus 로고    scopus 로고
    • Notch signaling, brain development, and human disease
    • Lasky JL, Wu H. Notch signaling, brain development, and human disease. Pediatr Res. 2005;5(pt 2):p104R-109R.
    • (2005) Pediatr Res , vol.5 , Issue.PART 2
    • Lasky, J.L.1    Wu, H.2
  • 32
    • 0027966977 scopus 로고
    • An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
    • Nye JS, Kopan R, Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development. 1994;9:2421-2430.
    • (1994) Development , vol.9 , pp. 2421-2430
    • Nye, J.S.1    Kopan, R.2    Axel, R.3
  • 33
    • 0034716909 scopus 로고    scopus 로고
    • Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
    • Morrison SJ, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell. 2000;5:499-510.
    • (2000) Cell , vol.5 , pp. 499-510
    • Morrison, S.J.1    Perez, S.E.2    Qiao, Z.3
  • 34
    • 0032126751 scopus 로고    scopus 로고
    • Notch receptor activation inhibits oligodendrocyte differentiation
    • Wang S, Sdrulla AD, diSibio G, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. 1998;1:63-75.
    • (1998) Neuron , vol.1 , pp. 63-75
    • Wang, S.1    Sdrulla, A.D.2    diSibio, G.3
  • 35
    • 0042286558 scopus 로고    scopus 로고
    • Notch and cancer: Best to avoid the ups and downs
    • Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell. 2003;3:203-205.
    • (2003) Cancer Cell , vol.3 , pp. 203-205
    • Maillard, I.1    Pear, W.S.2
  • 36
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;4:649-661.
    • (1991) Cell , vol.4 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 37
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;5694:269-271.
    • (2004) Science , vol.5694 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 38
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas M, Wolfer A, Raj K, et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet. 2003;3:416-421.
    • (2003) Nat Genet , vol.3 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3
  • 39
    • 7444224783 scopus 로고    scopus 로고
    • Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    • Fan X, Mikolaenko I, Elhassan I, et al. Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res. 2004;21:7787-7793.
    • (2004) Cancer Res , vol.21 , pp. 7787-7793
    • Fan, X.1    Mikolaenko, I.2    Elhassan, I.3
  • 40
    • 0035974898 scopus 로고    scopus 로고
    • Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
    • Solecki DJ, Liu XL, Tomoda T, Fang Y, Hatten ME. Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron. 2001;4:557-568.
    • (2001) Neuron , vol.4 , pp. 557-568
    • Solecki, D.J.1    Liu, X.L.2    Tomoda, T.3    Fang, Y.4    Hatten, M.E.5
  • 41
    • 0035939462 scopus 로고    scopus 로고
    • Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development
    • Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. J Comp Neurol. 2001;2:167-181.
    • (2001) J Comp Neurol , vol.2 , pp. 167-181
    • Irvin, D.K.1    Zurcher, S.D.2    Nguyen, T.3    Weinmaster, G.4    Kornblum, H.I.5
  • 42
    • 27644590261 scopus 로고    scopus 로고
    • Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
    • Somasundaram K, Reddy SP, Vinnakota K, et al. Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene. 2005;47:7073-7083.
    • (2005) Oncogene , vol.47 , pp. 7073-7083
    • Somasundaram, K.1    Reddy, S.P.2    Vinnakota, K.3
  • 43
    • 33751315519 scopus 로고    scopus 로고
    • Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif
    • Castro DS, Skowronska-Krawczyk D, Armant O, et al. Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell. 2006;6:831-844.
    • (2006) Dev Cell , vol.6 , pp. 831-844
    • Castro, D.S.1    Skowronska-Krawczyk, D.2    Armant, O.3
  • 44
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 2006;3:157-173.
    • (2006) Cancer Cell , vol.3 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 45
    • 24944501849 scopus 로고    scopus 로고
    • The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
    • Ladi E, Nichols JT, Ge W, et al. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol. 2005;6:983-992.
    • (2005) J Cell Biol , vol.6 , pp. 983-992
    • Ladi, E.1    Nichols, J.T.2    Ge, W.3
  • 46
    • 33749366427 scopus 로고    scopus 로고
    • Primary glioblastomas express mesenchymal stem-like properties
    • Tso CL, Shintaku P, Chen J, et al. Primary glioblastomas express mesenchymal stem-like properties. Mol Cancer Res. 2006;9:607-619.
    • (2006) Mol Cancer Res , vol.9 , pp. 607-619
    • Tso, C.L.1    Shintaku, P.2    Chen, J.3
  • 47
    • 0025816205 scopus 로고
    • The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons
    • Boulianne GL, de la CA, Campos-Ortega JA, Jan LY, Jan YN. The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1991;10:2975-2983.
    • (1991) EMBO J , vol.10 , pp. 2975-2983
    • Boulianne, G.D.L.C.1    Campos-Ortega, J.A.2    Jan, L.Y.3    Jan, Y.N.4
  • 48
    • 0037154292 scopus 로고    scopus 로고
    • Protein degradation: Four E3s for the notch pathway
    • Lai EC. Protein degradation: four E3s for the notch pathway. Curr Biol. 2002;2:R74-R78.
    • (2002) Curr Biol , vol.2
    • Lai, E.C.1
  • 49
    • 14444271600 scopus 로고    scopus 로고
    • Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region
    • Nakamura H, Yoshida M, Tsuiki H, et al. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. Oncogene. 1998;8:1009-1019.
    • (1998) Oncogene , vol.8 , pp. 1009-1019
    • Nakamura, H.1    Yoshida, M.2    Tsuiki, H.3
  • 50
    • 0036897569 scopus 로고    scopus 로고
    • Asymmetric segregation of Numb: A mechanism for neural specification from Drosophila to mammals
    • Cayouette M, Raff M. Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals. Nat Neurosci. 2002;12:1265-1269.
    • (2002) Nat Neurosci , vol.12 , pp. 1265-1269
    • Cayouette, M.1    Raff, M.2
  • 51
    • 0037080811 scopus 로고    scopus 로고
    • LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation
    • Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J. 2002;1-2:93-102.
    • (2002) EMBO J
    • Nie, J.1    McGill, M.A.2    Dermer, M.3    Dho, S.E.4    Wolting, C.D.5    McGlade, C.J.6
  • 52
    • 23944435388 scopus 로고    scopus 로고
    • Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas
    • Chen J, Xu J, Zhao W, et al. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol. 2005;11:2273-2283.
    • (2005) Int J Biochem Cell Biol , vol.11 , pp. 2273-2283
    • Chen, J.1    Xu, J.2    Zhao, W.3
  • 53
    • 20144387679 scopus 로고    scopus 로고
    • Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation
    • Purow BW, Haque RM, Noel MW, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 2005;6:2353-2363.
    • (2005) Cancer Res , vol.6 , pp. 2353-2363
    • Purow, B.W.1    Haque, R.M.2    Noel, M.W.3
  • 54
    • 33847666952 scopus 로고    scopus 로고
    • Contribution of Notch signaling activation to human glioblastoma multiforme
    • Kanamori M, Kawaguchi T, Nigro JM, et al. Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg. 2007;3:417-427.
    • (2007) J Neurosurg , vol.3 , pp. 417-427
    • Kanamori, M.1    Kawaguchi, T.2    Nigro, J.M.3
  • 55
    • 34547621658 scopus 로고    scopus 로고
    • Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling
    • Gao X, Deeb D, Jiang H, Liu Y, Dulchavsky SA, Gautam SC. Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. J Neurooncol. 2007;2:147-157.
    • (2007) J Neurooncol , vol.2 , pp. 147-157
    • Gao, X.1    Deeb, D.2    Jiang, H.3    Liu, Y.4    Dulchavsky, S.A.5    Gautam, S.C.6
  • 56
    • 36949031706 scopus 로고    scopus 로고
    • Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
    • Zhang XP, Zheng G, Zou L, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol Cell Biochem. 2008;1-2:101-108.
    • (2008) Mol Cell Biochem
    • Zhang, X.P.1    Zheng, G.2    Zou, L.3
  • 57
    • 58649120268 scopus 로고    scopus 로고
    • A role for the transcription factor HEY1 in glioblastoma
    • Hulleman E, Quarto M, Vernell R, et al. A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med. 2009;13:136-146.
    • (2009) J Cell Mol Med , vol.13 , pp. 136-146
    • Hulleman, E.1    Quarto, M.2    Vernell, R.3
  • 58
    • 33645325623 scopus 로고    scopus 로고
    • DLK1: Increased expression in gliomas and associated with oncogenic activities
    • Yin D, Xie D, Sakajiri S, et al. DLK1: increased expression in gliomas and associated with oncogenic activities. Oncogene. 2006;13:1852-1861.
    • (2006) Oncogene , vol.13 , pp. 1852-1861
    • Yin, D.1    Xie, D.2    Sakajiri, S.3
  • 59
    • 0027467416 scopus 로고    scopus 로고
    • Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993;6:3817-3820.
    • Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993;6:3817-3820.
  • 60
    • 22844437215 scopus 로고    scopus 로고
    • Isolation of neural stem cells from the postnatal cerebellum
    • Lee A, Kessler JD, Read TA, et al. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005;6:723-729.
    • (2005) Nat Neurosci , vol.6 , pp. 723-729
    • Lee, A.1    Kessler, J.D.2    Read, T.A.3
  • 61
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell
    • Reynolds BA, Weiss S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol. 1996;1:1-13.
    • (1996) Dev Biol , vol.1 , pp. 1-13
    • Reynolds, B.A.1    Weiss, S.2
  • 62
    • 0032409396 scopus 로고    scopus 로고
    • A new method for the rapid and long term growth of human neural precursor cells
    • Svendsen CN, ter Borg MG, Armstrong RJ, et al. A new method for the rapid and long term growth of human neural precursor cells. J Neurosci Methods. 1998;2:141-152.
    • (1998) J Neurosci Methods , vol.2 , pp. 141-152
    • Svendsen, C.N.1    ter Borg, M.G.2    Armstrong, R.J.3
  • 63
    • 0037199105 scopus 로고    scopus 로고
    • A method for clonal analysis of epidermal growth factor-responsive neural progenitors
    • Engstrom CM, Demers D, Dooner M, et al. A method for clonal analysis of epidermal growth factor-responsive neural progenitors. J Neurosci Methods. 2002;2:111-121.
    • (2002) J Neurosci Methods , vol.2 , pp. 111-121
    • Engstrom, C.M.1    Demers, D.2    Dooner, M.3
  • 64
    • 0032909852 scopus 로고    scopus 로고
    • Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain
    • Kukekov VG, Laywell ED, Suslov O, et al. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol. 1999;2:333-344.
    • (1999) Exp Neurol , vol.2 , pp. 333-344
    • Kukekov, V.G.1    Laywell, E.D.2    Suslov, O.3
  • 65
    • 0034687840 scopus 로고    scopus 로고
    • Direct isolation of human central nervous systemstemcells
    • Uchida N, Buck DW, He D, et al. Direct isolation of human central nervous systemstemcells. Proc Natl Acad Sci USA. 2000;26:14720-14725.
    • (2000) Proc Natl Acad Sci USA , vol.26 , pp. 14720-14725
    • Uchida, N.1    Buck, D.W.2    He, D.3
  • 66
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 2006;5:391-403.
    • (2006) Cancer Cell , vol.5 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3
  • 67
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature. 2004;7015:396-401.
    • (2004) Nature , vol.7015 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 68
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X, Curtin J, Xiong Y, et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene. 2004;58:9392-9400.
    • (2004) Oncogene , vol.58 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 69
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. 2002;3: 193-206.
    • (2002) Glia , vol.3 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 70
    • 42949149114 scopus 로고    scopus 로고
    • Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria
    • Gunther HS, Schmidt NO, Phillips HS, et al. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene. 2008;20:2897-2909.
    • (2008) Oncogene , vol.20 , pp. 2897-2909
    • Gunther, H.S.1    Schmidt, N.O.2    Phillips, H.S.3
  • 71
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006;16:7843-7848.
    • (2006) Cancer Res , vol.16 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 72
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 2006:5:67
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 73
    • 0002390849 scopus 로고
    • The subependymal cell plate (matrix) and its relationship to brain tumors of the ependymal type
    • Globus JH, Kuhlenbeck H. The subependymal cell plate (matrix) and its relationship to brain tumors of the ependymal type. J Neuropathol Exp Neurol. 1944;1:1-35.
    • (1944) J Neuropathol Exp Neurol , vol.1 , pp. 1-35
    • Globus, J.H.1    Kuhlenbeck, H.2
  • 74
    • 34547095240 scopus 로고    scopus 로고
    • Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma
    • Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR, Shastry P. Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells. 2007;6:1478-1489.
    • (2007) Stem Cells , vol.6 , pp. 1478-1489
    • Shiras, A.1    Chettiar, S.T.2    Shepal, V.3    Rajendran, G.4    Prasad, G.R.5    Shastry, P.6
  • 75
    • 0036011255 scopus 로고    scopus 로고
    • Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain
    • Stump G, Durrer A, Klein AL, Lutolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev. 2002; 1-2:153-159.
    • (2002) Mech Dev
    • Stump, G.1    Durrer, A.2    Klein, A.L.3    Lutolf, S.4    Suter, U.5    Taylor, V.6
  • 76
    • 22844440114 scopus 로고    scopus 로고
    • Notch signaling in the mammalian central nervous system: Insights from mouse mutants
    • Yoon K, Gaiano N. Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci. 2005;6:709-715.
    • (2005) Nat Neurosci , vol.6 , pp. 709-715
    • Yoon, K.1    Gaiano, N.2
  • 77
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan X, Matsui W, Khaki L, et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 2006;15:7445-7452.
    • (2006) Cancer Res , vol.15 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3
  • 78
    • 0031840405 scopus 로고    scopus 로고
    • PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas
    • Tohma Y, Gratas C, Biernat W, et al. PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J Neuropathol Exp Neurol. 1998;7:684-689.
    • (1998) J Neuropathol Exp Neurol , vol.7 , pp. 684-689
    • Tohma, Y.1    Gratas, C.2    Biernat, W.3
  • 79
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA. 1987;19:6899-6903.
    • (1987) Proc Natl Acad Sci USA , vol.19 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzler, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 80
    • 0034738965 scopus 로고    scopus 로고
    • Ras pathway signals are required for notch-mediated oncogenesis
    • Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 2000;37: 4191-4198.
    • (2000) Oncogene , vol.37 , pp. 4191-4198
    • Fitzgerald, K.1    Harrington, A.2    Leder, P.3
  • 81
    • 25844517958 scopus 로고    scopus 로고
    • Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells
    • Stockhausen MT, Sjolund J, Axelson H. Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells. Exp Cell Res. 2005;1:218-228.
    • (2005) Exp Cell Res , vol.1 , pp. 218-228
    • Stockhausen, M.T.1    Sjolund, J.2    Axelson, H.3
  • 82
    • 0036734148 scopus 로고    scopus 로고
    • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
    • Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002;9:979-986.
    • (2002) Nat Med , vol.9 , pp. 979-986
    • Weijzen, S.1    Rizzo, P.2    Braid, M.3
  • 83
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Miyamoto Y, Maitra A, Ghosh B, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 2003;6:565-576.
    • (2003) Cancer Cell , vol.6 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3
  • 84
    • 22244460522 scopus 로고    scopus 로고
    • Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    • Zeng Q, Li S, Chepeha DB, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell. 2005;1:13-23.
    • (2005) Cancer Cell , vol.1 , pp. 13-23
    • Zeng, Q.1    Li, S.2    Chepeha, D.B.3
  • 85
    • 0034738747 scopus 로고    scopus 로고
    • Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zone
    • Weickert CS, Webster MJ, Colvin SM, et al. Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zone. J Comp Neurol. 2000;3:359-372.
    • (2000) J Comp Neurol , vol.3 , pp. 359-372
    • Weickert, C.S.1    Webster, M.J.2    Colvin, S.M.3
  • 86
    • 33747513134 scopus 로고    scopus 로고
    • Notch signalling regulates stem cell numbers in vitro and in vivo
    • Androutsellis-Theotokis A, Leker RR, Soldner F, et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature. 2006; 7104:823-826.
    • (2006) Nature , vol.7104 , pp. 823-826
    • Androutsellis-Theotokis, A.1    Leker, R.R.2    Soldner, F.3
  • 87
    • 33845595633 scopus 로고    scopus 로고
    • Notch signaling enhances nestin expression in gliomas
    • Shih AH, Holland EC. Notch signaling enhances nestin expression in gliomas. Neoplasia. 2006;12:1072-1082.
    • (2006) Neoplasia , vol.12 , pp. 1072-1082
    • Shih, A.H.1    Holland, E.C.2
  • 88
    • 0242361561 scopus 로고    scopus 로고
    • Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
    • Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell. 2003;4:889-901.
    • (2003) Mol Cell , vol.4 , pp. 889-901
    • Rajasekhar, V.K.1    Viale, A.2    Socci, N.D.3    Wiedmann, M.4    Hu, X.5    Holland, E.C.6
  • 89
    • 47249124118 scopus 로고    scopus 로고
    • Notch-1 regulates transcription of the epidermal growth factor receptor through p53
    • Purow BW, Sundaresan TK, Burdick MJ, et al. Notch-1 regulates transcription of the epidermal growth factor receptor through p53. Carcinogenesis. 2008;5:918-925.
    • (2008) Carcinogenesis , vol.5 , pp. 918-925
    • Purow, B.W.1    Sundaresan, T.K.2    Burdick, M.J.3
  • 90
    • 0030772250 scopus 로고    scopus 로고
    • The autocrine loop of TGF-alpha/EGFR and brain tumors
    • Tang P, Steck PA, Yung WK. The autocrine loop of TGF-alpha/EGFR and brain tumors. J Neurooncol. 1997;3:303-314.
    • (1997) J Neurooncol , vol.3 , pp. 303-314
    • Tang, P.1    Steck, P.A.2    Yung, W.K.3
  • 92
    • 52649144884 scopus 로고    scopus 로고
    • TGF-alpha induces upregulation and nuclear translocation of Hes1 in glioma cell
    • Zheng Y, Lin L, Zheng Z. TGF-alpha induces upregulation and nuclear translocation of Hes1 in glioma cell. Cell Biochem Funct. 2008; 6:692-700.
    • (2008) Cell Biochem Funct , vol.6 , pp. 692-700
    • Zheng, Y.1    Lin, L.2    Zheng, Z.3
  • 93
    • 33748745934 scopus 로고    scopus 로고
    • Tumour vascularity is of prognostic significance in adult, but not paediatric astrocytomas
    • Birlik B, Canda S, Ozer E. Tumour vascularity is of prognostic significance in adult, but not paediatric astrocytomas. Neuropathol Appl Neurobiol. 2006;5:532-538.
    • (2006) Neuropathol Appl Neurobiol , vol.5 , pp. 532-538
    • Birlik, B.1    Canda, S.2    Ozer, E.3
  • 94
    • 24644443156 scopus 로고    scopus 로고
    • Effects of hypoxia on the proliferation and differentiation of NSCs
    • Zhu LL, Wu LY, Yew DT, Fan M. Effects of hypoxia on the proliferation and differentiation of NSCs. Mol Neurobiol. 2005;1-3:231-242.
    • (2005) Mol Neurobiol
    • Zhu, L.L.1    Wu, L.Y.2    Yew, D.T.3    Fan, M.4
  • 95
    • 27644561755 scopus 로고    scopus 로고
    • Hypoxia requires notch signaling to maintain the undifferentiated cell state
    • Gustafsson MV, Zheng X, Pereira T, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005; 5:617-628.
    • (2005) Dev Cell , vol.5 , pp. 617-628
    • Gustafsson, M.V.1    Zheng, X.2    Pereira, T.3
  • 96
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of deltalike 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • Gale NW, Dominguez MG, Noguera I, et al. Haploinsufficiency of deltalike 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA. 2004;45: 15949-15954.
    • (2004) Proc Natl Acad Sci USA , vol.45 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2    Noguera, I.3
  • 97
    • 0035753241 scopus 로고    scopus 로고
    • Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis
    • Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D. Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation. 2001;2-3: 135-144.
    • (2001) Differentiation
    • Mailhos, C.1    Modlich, U.2    Lewis, J.3    Harris, A.4    Bicknell, R.5    Ish-Horowicz, D.6
  • 98
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res. 2005;19:8690-8697.
    • (2005) Cancer Res , vol.19 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 99
    • 0037216703 scopus 로고    scopus 로고
    • Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis
    • Liu ZJ, Shirakawa T, Li Y, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol. 2003;1:14-25.
    • (2003) Mol Cell Biol , vol.1 , pp. 14-25
    • Liu, Z.J.1    Shirakawa, T.2    Li, Y.3
  • 100
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006;7122:1032-1037.
    • (2006) Nature , vol.7122 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 101
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 2006;7122: 1083-1087.
    • (2006) Nature , vol.7122 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 102
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • Li JL, Sainson RC, Shi W, et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res. 2007;23:11244-11253.
    • (2007) Cancer Res , vol.23 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3
  • 103
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;10:721-732.
    • (2003) Nat Rev Cancer , vol.10 , pp. 721-732
    • Semenza, G.L.1
  • 104
    • 0034667464 scopus 로고    scopus 로고
    • Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia
    • Maity A, Pore N, Lee J, Solomon D, O'Rourke DM. Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia. Cancer Res. 2000;20:5879-5886.
    • (2000) Cancer Res , vol.20 , pp. 5879-5886
    • Maity, A.1    Pore, N.2    Lee, J.3    Solomon, D.4    O'Rourke, D.M.5
  • 106
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
    • Wong GT, Manfra D, Poulet FM, et al. Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem. 2004;13:12876-12882.
    • (2004) J Biol Chem , vol.13 , pp. 12876-12882
    • Wong, G.T.1    Manfra, D.2    Poulet, F.M.3
  • 107
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • Vredenburgh JJ, Desjardins A, Herndon JE, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res. 2007;4:1253-1259.
    • (2007) Clin Cancer Res , vol.4 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.3
  • 108
    • 58149090856 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours
    • Poulsen HS, Grunnet K, Sorensen M, et al. Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours. Acta Oncol. 2008;48:52-58.
    • (2008) Acta Oncol , vol.48 , pp. 52-58
    • Poulsen, H.S.1    Grunnet, K.2    Sorensen, M.3
  • 109
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.