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Volumn 18, Issue 6, 2004, Pages 627-636

The enigmatic protein kinase Cδ: Complex roles in cell proliferation and survival

Author keywords

Cell cycle; Tumor promotion; Tumor suppressor; Tyrosine kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C DELTA; RAF PROTEIN; RAS PROTEIN;

EID: 1842454982     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-0979rev     Document Type: Review
Times cited : (181)

References (97)
  • 1
    • 0023762467 scopus 로고
    • Chemical carcinogenesis: From animal models to molecular models in one decade
    • Yupsa, S. H., and Poirier, M. C. (1988) Chemical carcinogenesis: from animal models to molecular models in one decade. Adv. Cancer Res. 50, 25-70
    • (1988) Adv. Cancer Res. , vol.50 , pp. 25-70
    • Yupsa, S.H.1    Poirier, M.C.2
  • 2
    • 0020634260 scopus 로고
    • Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters
    • Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., and Nishizuka, Y. (1983) Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J. Biol. Chem. 258, 11442-11445
    • (1983) J. Biol. Chem. , vol.258 , pp. 11442-11445
    • Kikkawa, U.1    Takai, Y.2    Tanaka, Y.3    Miyake, R.4    Nishizuka, Y.5
  • 3
    • 0024412493 scopus 로고
    • The protein kinase C family: Heterogeneity and its implications
    • Kikkawa, U., Kishimoto, A., and Nishizuka, Y. (1989) The protein kinase C family: heterogeneity and its implications. Annu. Rev. Biochem. 58, 31-44
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 31-44
    • Kikkawa, U.1    Kishimoto, A.2    Nishizuka, Y.3
  • 4
    • 0029812896 scopus 로고    scopus 로고
    • Ubiquitination of protein kinase C-α and degradation by the proteasome
    • Lee, H. W., Smith, L., Pettit, G. R., Vinitsky, A., and Smith, J. B. (1996) Ubiquitination of protein kinase C-α and degradation by the proteasome. J. Biol. Chem. 271, 20973-20976
    • (1996) J. Biol. Chem. , vol.271 , pp. 20973-20976
    • Lee, H.W.1    Smith, L.2    Pettit, G.R.3    Vinitsky, A.4    Smith, J.B.5
  • 5
    • 0031907117 scopus 로고    scopus 로고
    • Activation of protein kinase C triggers its ubiquitination and degradation
    • Lu, Z., Liu, D., Hornia, A., Devonish, W., Pagano, M., and Foster, D. A. (1998) Activation of protein kinase C triggers its ubiquitination and degradation. Mol. Cell. Biol. 18, 839-845
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 839-845
    • Lu, Z.1    Liu, D.2    Hornia, A.3    Devonish, W.4    Pagano, M.5    Foster, D.A.6
  • 6
    • 0037246123 scopus 로고    scopus 로고
    • Regulation of cell apoptosis by protein kinase C δ
    • Brodie, C., and Blumberg, P. M. (2003) Regulation of cell apoptosis by protein kinase C δ. Apoptosis 8, 19-27
    • (2003) Apoptosis , vol.8 , pp. 19-27
    • Brodie, C.1    Blumberg, P.M.2
  • 11
    • 0027418816 scopus 로고
    • Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
    • Mischak, H., Goodnight, J., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H., and Mushinski, J. F. (1993) Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem. 268, 6090-6096
    • (1993) J. Biol. Chem. , vol.268 , pp. 6090-6096
    • Mischak, H.1    Goodnight, J.2    Kolch, W.3    Martiny-Baron, G.4    Schaechtle, C.5    Kazanietz, M.G.6    Blumberg, P.M.7    Pierce, J.H.8    Mushinski, J.F.9
  • 12
    • 0342657745 scopus 로고    scopus 로고
    • Effect of a tyrosine 155 to phenylalanine mutation of protein kinase C δ on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts
    • Acs, P., Beheshti, M., Szallasi, Z., Li, L., Yuspa, S. H., and Blumberg, P. M. (2000) Effect of a tyrosine 155 to phenylalanine mutation of protein kinase C δ on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis 21, 887-891
    • (2000) Carcinogenesis , vol.21 , pp. 887-891
    • Acs, P.1    Beheshti, M.2    Szallasi, Z.3    Li, L.4    Yuspa, S.H.5    Blumberg, P.M.6
  • 13
    • 0037811184 scopus 로고    scopus 로고
    • Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: Use of isozyme-selective inhibitors
    • Braun, M. U., and Mochly-Rosen, D. (2003) Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors. J. Mol. Cell. Cardiol. 35, 895-903
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 895-903
    • Braun, M.U.1    Mochly-Rosen, D.2
  • 15
    • 0030973402 scopus 로고    scopus 로고
    • Protein kinase C δ inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression
    • Fukumoto, S., Nishizawa, Y., Hosoi, M., Koyama, H., Yamakawa, K., Ohno, S., and Morii, H. (1997) Protein kinase C δ inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J. Biol. Chem. 272, 13816-13822
    • (1997) J. Biol. Chem. , vol.272 , pp. 13816-13822
    • Fukumoto, S.1    Nishizawa, Y.2    Hosoi, M.3    Koyama, H.4    Yamakawa, K.5    Ohno, S.6    Morii, H.7
  • 16
    • 0031001002 scopus 로고    scopus 로고
    • Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells
    • Harrington, E. O., Loffler, J., Nelson, P. R., Kent, K. C., Simons, M., and Ware, J. A. (1997) Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells. J. Biol. Chem. 272, 7390-7397
    • (1997) J. Biol. Chem. , vol.272 , pp. 7390-7397
    • Harrington, E.O.1    Loffler, J.2    Nelson, P.R.3    Kent, K.C.4    Simons, M.5    Ware, J.A.6
  • 22
    • 0141446032 scopus 로고    scopus 로고
    • Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes
    • Soh, J. W., and Weinstein, I. B. (2003) Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J. Biol. Chem. 278, 34709-34716
    • (2003) J. Biol. Chem. , vol.278 , pp. 34709-34716
    • Soh, J.W.1    Weinstein, I.B.2
  • 24
    • 0037397365 scopus 로고    scopus 로고
    • The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression
    • Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K., and Ohno, S. (2003) The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression. Genes Cells 8, 311-324
    • (2003) Genes Cells , vol.8 , pp. 311-324
    • Kitamura, K.1    Mizuno, K.2    Etoh, A.3    Akita, Y.4    Miyamoto, A.5    Nakayama, K.6    Ohno, S.7
  • 27
    • 0031684848 scopus 로고    scopus 로고
    • Protein kinase C-δ is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation
    • Li, W., Jiang, Y. X., Zhang, J., Soon, L., Flechner, L., Kapoor, V., Pierce, J. H., and Wang, L. H. (1998) Protein kinase C-δ is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation. Mol. Cell. Biol. 18, 5888-5898
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5888-5898
    • Li, W.1    Jiang, Y.X.2    Zhang, J.3    Soon, L.4    Flechner, L.5    Kapoor, V.6    Pierce, J.H.7    Wang, L.H.8
  • 28
    • 0030735367 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways
    • Pal, S., Claffey, K. P., Dvorak, H. F., and Mukhopadhyay, D. (1997) The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. Biol. Chem. 272, 27509-27512
    • (1997) J. Biol. Chem. , vol.272 , pp. 27509-27512
    • Pal, S.1    Claffey, K.P.2    Dvorak, H.F.3    Mukhopadhyay, D.4
  • 29
    • 0034617086 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor-1-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer
    • Datta, K., Nambudripad, R., Pal, S., Zhou, M., Cohen, H. T., and Mukhopadhyay, D. (2000) Inhibition of insulin-like growth factor-1-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer. J. Biol. Chem. 275, 20700-20706
    • (2000) J. Biol. Chem. , vol.275 , pp. 20700-20706
    • Datta, K.1    Nambudripad, R.2    Pal, S.3    Zhou, M.4    Cohen, H.T.5    Mukhopadhyay, D.6
  • 30
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I and type 1 IGF receptor
    • Liu, J.-P., Baker, J., Perkins, A. S., Robertson, E. J., and Efstratiadis, A. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I and type 1 IGF receptor. Cell 75, 59-72
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.-P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 33
    • 0027970754 scopus 로고
    • Protein kinase C isozymes in progressively transformed rat embryo fibroblasts
    • Liao, L., Ramsay, K., and Jaken, S. (1994) Protein kinase C isozymes in progressively transformed rat embryo fibroblasts. Cell Growth Differ. 5, 1185-1194
    • (1994) Cell Growth Differ. , vol.5 , pp. 1185-1194
    • Liao, L.1    Ramsay, K.2    Jaken, S.3
  • 34
    • 0033581954 scopus 로고    scopus 로고
    • Increased protein kinase Cδ in mammary tumor cells: Relationship to transformation and metastatic progression
    • Kiley, S. C., Clark, K. J., Duddy, S. K., Welch, D. R., and Jaken, S. (1999) Increased protein kinase Cδ in mammary tumor cells: relationship to transformation and metastatic progression. Oncogene 18, 6748-6757
    • (1999) Oncogene , vol.18 , pp. 6748-6757
    • Kiley, S.C.1    Clark, K.J.2    Duddy, S.K.3    Welch, D.R.4    Jaken, S.5
  • 35
    • 0033168515 scopus 로고    scopus 로고
    • Protein kinase Cδ involvement in mammary tumor cell metastasis
    • Kiley, S. C., Clark, K. J., Goodnough, M., Welch, D. R., and Jaken, S. (1999) Protein kinase Cδ involvement in mammary tumor cell metastasis. Cancer Res. 59, 3230-3238
    • (1999) Cancer Res. , vol.59 , pp. 3230-3238
    • Kiley, S.C.1    Clark, K.J.2    Goodnough, M.3    Welch, D.R.4    Jaken, S.5
  • 36
    • 0141542627 scopus 로고    scopus 로고
    • Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells
    • Kruger, J. S., and Reddy, K. B. (2003) Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. Mol. Cancer Res. 1, 801-809
    • (2003) Mol. Cancer Res. , vol.1 , pp. 801-809
    • Kruger, J.S.1    Reddy, K.B.2
  • 37
    • 0348231006 scopus 로고    scopus 로고
    • Protein kinase C δ is a prosurvival factor in human breast tumor cell lines
    • McCracken, M. A., Miraglia, L. J., McKay, R. A., and Strobl, J. S. (2003) Protein kinase C δ is a prosurvival factor in human breast tumor cell lines. Mol. Cancer Ther. 2, 273-281
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 273-281
    • McCracken, M.A.1    Miraglia, L.J.2    McKay, R.A.3    Strobl, J.S.4
  • 38
    • 0034161545 scopus 로고    scopus 로고
    • Functional interaction between RAFT1/FRAP/mTOR and protein kinase C δ in the regulation of cap-dependent initiation of translation
    • Kumar, V., Pandey, P., Sabatini, D., Kumar, M., Majumder, P. K., Bharti, A., Carmichael, G., Kufe, D., and Kharbanda, S. (2000) Functional interaction between RAFT1/FRAP/mTOR and protein kinase C δ in the regulation of cap-dependent initiation of translation. EMBO J. 19, 1087-1097
    • (2000) EMBO J. , vol.19 , pp. 1087-1097
    • Kumar, V.1    Pandey, P.2    Sabatini, D.3    Kumar, M.4    Majumder, P.K.5    Bharti, A.6    Carmichael, G.7    Kufe, D.8    Kharbanda, S.9
  • 39
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a controller of cell growth
    • Schmelzie, T., and Hall, M. N. (2000) TOR, a controller of cell growth. Cell 103, 253-262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzie, T.1    Hall, M.N.2
  • 40
    • 0037151034 scopus 로고    scopus 로고
    • Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 and PKC-δ
    • Keshamouni, V. G., Mattingly, R. R., and Reddy, K. B. (2002) Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 and PKC-δ. J. Biol. Chem. 277, 22558-22565
    • (2002) J. Biol. Chem. , vol.277 , pp. 22558-22565
    • Keshamouni, V.G.1    Mattingly, R.R.2    Reddy, K.B.3
  • 41
    • 0029789967 scopus 로고    scopus 로고
    • Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
    • Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K., and Ohno, S. (1996) Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271, 23512-23519
    • (1996) J. Biol. Chem. , vol.271 , pp. 23512-23519
    • Ueda, Y.1    Hirai, S.2    Osada, S.3    Suzuki, A.4    Mizuno, K.5    Ohno, S.6
  • 42
    • 0032588943 scopus 로고    scopus 로고
    • Protein kinase Cδ mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells
    • Corbit, K. C., Foster, D. A., and Rosner, M. R. (1999) Protein kinase Cδ mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. Mol. Cell. Biol. 19, 4209-4218
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4209-4218
    • Corbit, K.C.1    Foster, D.A.2    Rosner, M.R.3
  • 43
    • 0034830767 scopus 로고    scopus 로고
    • Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCδ
    • 2001
    • Jackson, T. A., Schweppe, R. E., Koterwas, D. M., and Bradford, A. P. (2001) Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCδ. (2001). Mol. Endocrinol. 15, 1517-1528
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1517-1528
    • Jackson, T.A.1    Schweppe, R.E.2    Koterwas, D.M.3    Bradford, A.P.4
  • 44
    • 0030976892 scopus 로고    scopus 로고
    • Interaction between v-Src and protein kinase C δ in v-Src-transformed fibroblasts
    • Zang, Q., Lu, Z., Curto, M., Barile, N., Shalloway, D., and Foster, D. A. (1997) Interaction between v-Src and protein kinase C δ in v-Src-transformed fibroblasts. J. Biol. Chem. 272, 13275-13280
    • (1997) J. Biol. Chem. , vol.272 , pp. 13275-13280
    • Zang, Q.1    Lu, Z.2    Curto, M.3    Barile, N.4    Shalloway, D.5    Foster, D.A.6
  • 47
    • 0032474741 scopus 로고    scopus 로고
    • Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-δ with Src family kinases in the RBL-2H3 mast cell line: Regulation of Src family kinase activity by protein kinase C-δ
    • Song, J. S., Swann, P. G., Szallasi, Z., Blank, U., Blumberg, P. M., and Rivera, J. (1998) Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-δ with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-δ. Oncogene 16, 3357-3368
    • (1998) Oncogene , vol.16 , pp. 3357-3368
    • Song, J.S.1    Swann, P.G.2    Szallasi, Z.3    Blank, U.4    Blumberg, P.M.5    Rivera, J.6
  • 49
    • 0034634651 scopus 로고    scopus 로고
    • Phosphorylation of PKCδ on distinct tyrosine residues regulates specific cellular functions
    • Kronfeld, I., Kazimirsky, G., Lorenzo, P. S., Garfield, S. H., Blumberg, P. M., and Brodie, C. (2000) Phosphorylation of PKCδ on distinct tyrosine residues regulates specific cellular functions. J. Biol. Chem. 275, 35491-35498
    • (2000) J. Biol. Chem. , vol.275 , pp. 35491-35498
    • Kronfeld, I.1    Kazimirsky, G.2    Lorenzo, P.S.3    Garfield, S.H.4    Blumberg, P.M.5    Brodie, C.6
  • 51
    • 0033082319 scopus 로고    scopus 로고
    • Protein kinase C δ
    • Gschwendt, M. (1999) Protein kinase C δ. Eur. J. Biochem. 259, 555-564
    • (1999) Eur. J. Biochem. , vol.259 , pp. 555-564
    • Gschwendt, M.1
  • 52
    • 0032933797 scopus 로고    scopus 로고
    • c-Src, receptor tyrosine kinases, and human cancer
    • Biscardi, J. S., Tice, D. A., and Parsons, S. J. (1999) c-Src, receptor tyrosine kinases, and human cancer. Adv. Cancer Res. 76, 61-119
    • (1999) Adv. Cancer Res. , vol.76 , pp. 61-119
    • Biscardi, J.S.1    Tice, D.A.2    Parsons, S.J.3
  • 53
    • 0027332733 scopus 로고
    • Ha gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ
    • Ha gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268, 26079-26081
    • (1993) J. Biol. Chem. , vol.268 , pp. 26079-26081
    • Denning, M.F.1    Dlugosz, A.A.2    Howett, M.K.3    Yuspa, S.H.4
  • 54
    • 0028229299 scopus 로고
    • Tyrosine phosphorylation and stimulation of protein kinase C δ from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C δ
    • Gschwendt, M., Kielbassa, K., Kittstein, W., and Marks, F. (1994) Tyrosine phosphorylation and stimulation of protein kinase C δ from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C δ. FEBS Lett. 347, 85-89
    • (1994) FEBS Lett. , vol.347 , pp. 85-89
    • Gschwendt, M.1    Kielbassa, K.2    Kittstein, W.3    Marks, F.4
  • 56
    • 0027941342 scopus 로고
    • Stimulation of the platelet-derived growth factor β receptor signaling pathway activates protein kinase C-δ
    • Li, W., Yu, J. C., Michieli, P., Beeler, J. F., Ellmore, N., Heidaran, M. A., and Pierce J. H. (1994) Stimulation of the platelet-derived growth factor β receptor signaling pathway activates protein kinase C-δ. Mol. Cell. Biol. 14, 6727-6735
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6727-6735
    • Li, W.1    Yu, J.C.2    Michieli, P.3    Beeler, J.F.4    Ellmore, N.5    Heidaran, M.A.6    Pierce, J.H.7
  • 58
    • 0029924152 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C δ
    • Denning, M. F., Dlugosz, A. A., Threadgill, D. W., Magnuson, T., and Yuspa, S. H. (1996) Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C δ. J. Biol. Chem. 271, 5325-5331
    • (1996) J. Biol. Chem. , vol.271 , pp. 5325-5331
    • Denning, M.F.1    Dlugosz, A.A.2    Threadgill, D.W.3    Magnuson, T.4    Yuspa, S.H.5
  • 59
    • 0043092028 scopus 로고    scopus 로고
    • Physical and functional interaction between protein kinase C δ and Fyn tyrosine kinase in human platelets
    • Crosby, D., and Poole, A. W. (2003) Physical and functional interaction between protein kinase C δ and Fyn tyrosine kinase in human platelets. J. Biol. Chem. 278, 24533-24541
    • (2003) J. Biol. Chem. , vol.278 , pp. 24533-24541
    • Crosby, D.1    Poole, A.W.2
  • 60
    • 0028851535 scopus 로고
    • Development of a rapid approach to identification of tyrosine phosphorylation sites: Application to PKC δ phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells
    • Szallasi, Z., Denning, M. F., Chang, E. Y., Rivera, J., Yuspa, S. H., Lehel, C., Olah, Z., Anderson, W. B., and Blumberg, P. M. (1995) Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC δ phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem. Biophys. Res. Commun. 214, 888-894
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 888-894
    • Szallasi, Z.1    Denning, M.F.2    Chang, E.Y.3    Rivera, J.4    Yuspa, S.H.5    Lehel, C.6    Olah, Z.7    Anderson, W.B.8    Blumberg, P.M.9
  • 61
    • 0029025924 scopus 로고
    • Tyrosine phosphorylation of protein kinase C-δ in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition
    • Haleem-Smith, H., Chang, E. Y., Szallasi, Z., Blumberg, P. M., and Rivera, J. (1995) Tyrosine phosphorylation of protein kinase C-δ in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition. Proc. Natl. Acad. Sci. USA 92, 9112-9116
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9112-9116
    • Haleem-Smith, H.1    Chang, E.Y.2    Szallasi, Z.3    Blumberg, P.M.4    Rivera, J.5
  • 62
    • 0034677930 scopus 로고    scopus 로고
    • Interaction between protein kinase C δ and the c-Abl tyrosine kinase in the cellular response to oxidative stress
    • Sun, X., Wu, F., Datta, R., Kharbanda, S., and Kufe, D. (2000) Interaction between protein kinase C δ and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275, 7470-7473
    • (2000) J. Biol. Chem. , vol.275 , pp. 7470-7473
    • Sun, X.1    Wu, F.2    Datta, R.3    Kharbanda, S.4    Kufe, D.5
  • 65
    • 0036132855 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide
    • Blass, M., Kronfeld, I., Kazimirsky, G., Blumberg, P. M., and Brodie, C. (2002) Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide. Mol. Cell. Biol. 22, 182-195
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 182-195
    • Blass, M.1    Kronfeld, I.2    Kazimirsky, G.3    Blumberg, P.M.4    Brodie, C.5
  • 66
    • 0037023769 scopus 로고    scopus 로고
    • Src family kinases phosphorylate protein kinase C δ on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes
    • Joseloff, E., Cataisson, C., Aamodt, H., Ocheni, H., Blumberg, P., Kraker, A. J., and Yuspa, S. H. (2002) Src family kinases phosphorylate protein kinase C δ on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J. Biol. Chem. 277, 12318-12323
    • (2002) J. Biol. Chem. , vol.277 , pp. 12318-12323
    • Joseloff, E.1    Cataisson, C.2    Aamodt, H.3    Ocheni, H.4    Blumberg, P.5    Kraker, A.J.6    Yuspa, S.H.7
  • 68
    • 0032745244 scopus 로고    scopus 로고
    • Antagonistic effects of protein kinase C α and δ on both transformation and phospholipase D activity mediated by the EGF receptor
    • Hornia, A., Lu, Z., Sukezane, T., Zhong, M., Joseph, T., Frankel, P., and Foster, D. A. (1999) Antagonistic effects of protein kinase C α and δ on both transformation and phospholipase D activity mediated by the EGF receptor. Mol. Cell. Biol. 19, 7672-7680
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7672-7680
    • Hornia, A.1    Lu, Z.2    Sukezane, T.3    Zhong, M.4    Joseph, T.5    Frankel, P.6    Foster, D.A.7
  • 69
    • 0033571747 scopus 로고    scopus 로고
    • Transgenic mice overexpressing protein kinase Cδ in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
    • Reddig, P. J., Dreckschmidt, N. E., Ahrens, H., Simsiman, R., Tseng, C. P., Zou, J., Oberley, T. D., and Verma, A. K. (1999) Transgenic mice overexpressing protein kinase Cδ in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 59, 5710-5718
    • (1999) Cancer Res. , vol.59 , pp. 5710-5718
    • Reddig, P.J.1    Dreckschmidt, N.E.2    Ahrens, H.3    Simsiman, R.4    Tseng, C.P.5    Zou, J.6    Oberley, T.D.7    Verma, A.K.8
  • 70
    • 0028819359 scopus 로고
    • Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo
    • Gschwendt, M., Furstenberger, G., Leibersperger, H., Kittstein, W., Lindner, D., Rudolph, C., Barth, H., Kleinschroth, J., Marme, D., and Schachtele, C. (1995) Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo. Carcinogenesis 16, 107-111
    • (1995) Carcinogenesis , vol.16 , pp. 107-111
    • Gschwendt, M.1    Furstenberger, G.2    Leibersperger, H.3    Kittstein, W.4    Lindner, D.5    Rudolph, C.6    Barth, H.7    Kleinschroth, J.8    Marme, D.9    Schachtele, C.10
  • 71
    • 0028126624 scopus 로고
    • Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation
    • Szallasi, Z., Denning, M. F., Smith, C. B., Dlugosz, A. A., Yuspa, S. H., Pettit, G. R., and Blumberg, P. M. (1994) Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Mol. Pharmacol. 46, 840-850
    • (1994) Mol. Pharmacol. , vol.46 , pp. 840-850
    • Szallasi, Z.1    Denning, M.F.2    Smith, C.B.3    Dlugosz, A.A.4    Yuspa, S.H.5    Pettit, G.R.6    Blumberg, P.M.7
  • 72
    • 0023253596 scopus 로고
    • Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
    • Hennings, H., Blumberg, P. M., Pettit, G. R., Herald, C. L., Shores, R., and Yuspa, S. H. (1987) Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis 8, 1343-1346
    • (1987) Carcinogenesis , vol.8 , pp. 1343-1346
    • Hennings, H.1    Blumberg, P.M.2    Pettit, G.R.3    Herald, C.L.4    Shores, R.5    Yuspa, S.H.6
  • 75
    • 0033521742 scopus 로고    scopus 로고
    • PKCδ acts as a growth and tumor suppressor in rat colonic epithelial cells
    • Perletti, G. P., Marras, E., Concari, P., Piccinini, F., and Tashjian, A. H., Jr. (1999) PKCδ acts as a growth and tumor suppressor in rat colonic epithelial cells. Oncogene 18, 1251-1256
    • (1999) Oncogene , vol.18 , pp. 1251-1256
    • Perletti, G.P.1    Marras, E.2    Concari, P.3    Piccinini, F.4    Tashjian Jr., A.H.5
  • 76
    • 0035939845 scopus 로고    scopus 로고
    • Involvement of protein kinase Cδ in contact-dependent inhibition of growth in human and murine fibroblasts
    • Heit, I., Wieser, R. J., Herget, T., Faust, D., Borchert-Stuhltrager, M., Oesch, F., and Dietrich, C. (2001) Involvement of protein kinase Cδ in contact-dependent inhibition of growth in human and murine fibroblasts. Oncogene 20, 5143-5154
    • (2001) Oncogene , vol.20 , pp. 5143-5154
    • Heit, I.1    Wieser, R.J.2    Herget, T.3    Faust, D.4    Borchert-Stuhltrager, M.5    Oesch, F.6    Dietrich, C.7
  • 77
    • 0037110732 scopus 로고    scopus 로고
    • Nuclear import of PKCδ is required for apoptosis: Identification of a novel nuclear import sequence
    • DeVries, T. A., Neville, M. C., and Reyland, M. E. (2002) Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence. EMBO J. 21, 6050-6060
    • (2002) EMBO J. , vol.21 , pp. 6050-6060
    • DeVries, T.A.1    Neville, M.C.2    Reyland, M.E.3
  • 78
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
    • Land, H., Parada, L. F., and Weinberg, R. A. (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (London) 304, 596-602
    • (1983) Nature (London) , vol.304 , pp. 596-602
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 79
    • 0022368305 scopus 로고
    • Specific growth response of ras-transformed embryo fibroblasts to tumour promoters
    • Dotto, G. P., Parada, L. F., and Weinberg, R. A. (1985) Specific growth response of ras-transformed embryo fibroblasts to tumour promoters. Nature (London) 318, 472-475
    • (1985) Nature (London) , vol.318 , pp. 472-475
    • Dotto, G.P.1    Parada, L.F.2    Weinberg, R.A.3
  • 80
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • Pardee, A. B. (1974) A restriction point for control of normal animal cell proliferation. Proc. Natl. Acad. Sci. USA 71, 1286-1290
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 81
    • 0036467506 scopus 로고    scopus 로고
    • Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes
    • Ho, A., and Dowdy, S. F. (2002) Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 12, 47-52
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 47-52
    • Ho, A.1    Dowdy, S.F.2
  • 83
    • 0035128901 scopus 로고    scopus 로고
    • Regulation of G1 phase progression by growth factors and the extracellular matrix
    • Hulleman, E., and Boonstra, J. (2001) Regulation of G1 phase progression by growth factors and the extracellular matrix. Cell. Mol. Life Sci. 58, 80-93
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 80-93
    • Hulleman, E.1    Boonstra, J.2
  • 84
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg, A. S., and Weinberg, R. A. (1998) Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18, 753-761
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 85
    • 0035099918 scopus 로고    scopus 로고
    • Role of T antigen interactions with p53 in tumorigenesis
    • Pipas, J. M., and Levine, A. J. (2001) Role of T antigen interactions with p53 in tumorigenesis. Semin. Cancer Biol. 11, 23-30
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 23-30
    • Pipas, J.M.1    Levine, A.J.2
  • 86
    • 1642396348 scopus 로고    scopus 로고
    • Inhibition of human p53 basal transcription by down-regulation of protein kinase C δ
    • In press
    • Abbas, T., White, D., Hui, L., Yoshida, K., Foster, D. A., and Bargonetti, J. (2004) Inhibition of human p53 basal transcription by down-regulation of protein kinase C δ. J. Biol. Chem. 279 In press
    • (2004) J. Biol. Chem. , vol.279
    • Abbas, T.1    White, D.2    Hui, L.3    Yoshida, K.4    Foster, D.A.5    Bargonetti, J.6
  • 87
    • 0037034186 scopus 로고    scopus 로고
    • Down-regulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
    • Zhong, M., Lu, Z., and Foster, D. A. (2002) Down-regulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 21, 1071-1078
    • (2002) Oncogene , vol.21 , pp. 1071-1078
    • Zhong, M.1    Lu, Z.2    Foster, D.A.3
  • 90
    • 0037072483 scopus 로고    scopus 로고
    • p73β is regulated by protein kinase Cδ catalytic fragment generated in the apoptotic response to DNA damage
    • Ren, J., Datta, R., Shioya, H., Li, Y., Oki, E., Biedermann, V., Bharti, A., and Kufe, D. (2002) p73β is regulated by protein kinase Cδ catalytic fragment generated in the apoptotic response to DNA damage. J. Biol. Chem. 277, 33758-33765
    • (2002) J. Biol. Chem. , vol.277 , pp. 33758-33765
    • Ren, J.1    Datta, R.2    Shioya, H.3    Li, Y.4    Oki, E.5    Biedermann, V.6    Bharti, A.7    Kufe, D.8
  • 91
    • 0642303674 scopus 로고    scopus 로고
    • Mechanical stress-activated PKCδ regulates smooth muscle cell migration
    • Li, C., Wernig, F., Leitges, M., Hu, Y., and Xu, Q. (2003) Mechanical stress-activated PKCδ regulates smooth muscle cell migration. FASEB J.
    • (2003) FASEB J.
    • Li, C.1    Wernig, F.2    Leitges, M.3    Hu, Y.4    Xu, Q.5
  • 92
    • 0028010010 scopus 로고
    • Assignment of the protein kinase Cδ polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14
    • Huppi, K., Siwarski, D., Goodnight, J., and Mischak, H. (1994) Assignment of the protein kinase Cδ polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. Genomics 19, 161-162
    • (1994) Genomics , vol.19 , pp. 161-162
    • Huppi, K.1    Siwarski, D.2    Goodnight, J.3    Mischak, H.4
  • 93
    • 0037037787 scopus 로고    scopus 로고
    • Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
    • Zabarovsky, E. R., Lerman, M. I., and Minna, J. D. (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21, 6915-6916
    • (2002) Oncogene , vol.21 , pp. 6915-6916
    • Zabarovsky, E.R.1    Lerman, M.I.2    Minna, J.D.3
  • 95
    • 0037443030 scopus 로고    scopus 로고
    • Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance
    • Clark, A. S., West, K. A., Blumberg, P. M., and Dennis, P. A. (2003) Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance. Cancer Res. 63, 780-786
    • (2003) Cancer Res. , vol.63 , pp. 780-786
    • Clark, A.S.1    West, K.A.2    Blumberg, P.M.3    Dennis, P.A.4
  • 96
    • 0038268137 scopus 로고    scopus 로고
    • Protein kinase C-δ is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis
    • Ni, H., Ergin, M., Tibudan, S. S., Denning, M. F., Izban, K. F., and Alkan, S. (2003) Protein kinase C-δ is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. Br. J. Haematol. 121, 849-856
    • (2003) Br. J. Haematol. , vol.121 , pp. 849-856
    • Ni, H.1    Ergin, M.2    Tibudan, S.S.3    Denning, M.F.4    Izban, K.F.5    Alkan, S.6
  • 97
    • 0037124099 scopus 로고    scopus 로고
    • Protein kinase C δ regulates function of the DF3/MUC1 carcinoma antigen in β-catenin signaling
    • Ren, J., Li, Y., and Kufe, D. (2002) Protein kinase C δ regulates function of the DF3/MUC1 carcinoma antigen in β-catenin signaling. J. Biol. Chem. 277, 17616-17622
    • (2002) J. Biol. Chem. , vol.277 , pp. 17616-17622
    • Ren, J.1    Li, Y.2    Kufe, D.3


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