Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo

Diabetologia

Volumn 54, Issue 2, 2011, Pages 380-389

  Cantley, J ^a   Boslem, E ^a,b   Laybutt, D R ^a,b   Cordery, D V ^a   Pearson, G ^a   Carpenter, L ^a,e   Leitges, M ^c,d   Biden, T J ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF OSLO   (Norway)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Beta cell; Cytokines; Islets of Langerhans; mRNA stabilisation; NOS2; Protein kinase C; Streptozotocin; Toll like receptor; Type 1 diabetes

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INDUCIBLE NITRIC OXIDE SYNTHASE; INITIATION FACTOR 2; INSULIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C DELTA; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; IMMUNOGENETICS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NONHUMAN; NOS2 GENE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CYTOKINES; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; ISOENZYMES; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN KINASE C-DELTA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78951485569     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1962-y     Document Type: Article

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