Mitochondrial dysfunction: Glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic β-cells

Cellular Signalling

Volumn 21, Issue 1, 2009, Pages 69-78

  Lee, June Woo ^a,c   Kim, Won Ho ^a   Lim, Joo Hyun ^a   Song, Eun Hyeon ^a   Song, Jihyun ^a   Choi, Kang Yuel ^c   Jung, Myeong Ho ^a,b  

^a Korea National Institute of Health   (South Korea)

^b Pusan National University   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Apoptosis; Glucokinase (GCK); Mitochondrial dysfunction; Pancreatic cells; Reactive oxygen species (ROS); Retrograde signaling

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 3; ADENOSINE TRIPHOSPHATE; CITRININ; CYTOCHROME C; GLUCOKINASE; INSULIN; OLIGOMYCIN; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL FUNCTION; CYTOPLASM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; INSULIN RELEASE; METABOLIC STRESS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CELLS, CULTURED; DOWN-REGULATION; GLUCOKINASE; IMMUNOPRECIPITATION; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 56949108344     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.09.015     Document Type: Article

References (33)

1. Enns G.M. Molec. Genet. Metab. 80 (2003) 11
2. Mathis D., Vence L., and Benoist C. Nature 414 (2001) 792
3. Lowell B.B., and Shulman G.I. Science 307 (2005) 384
4. Cho Y.M., Park K.S., and Lee H.K. Diabetes Res. Clin. Pract. 77S (2007) S172
5. Maassen J.A., Hart L.M., Essen E.V., Heine R.J., Nijpels G., Tafrechi R.S.J., Raap A.K., Janssen G.M.C., and Lemkes H.H.P.J. Diabetes 53 Suppl 1 (2004) S103
6. Morino K., Petersen K.F., and Shulman G.I. Diabetes 55 (2006) S9
7. Duchen M.R. Diabetes 53 (2004) S96
8. Park S.Y., Choi G.H., Choi H.I., Ryu J.W., Jung C.Y., and Lee W. J. Biol. Chem. 280 (2005) 9855
9. Lim J.H., Lee J.I., Suh Y.H., Kim W.H., Song J.H., and Jung M.H. Diabetologia 49 (2006) 1924
10. Hayakawa T., Noda M., Yasuda K., Yorifuji H., Taniguchi S., Miwa I., Sakura H., Terauchi Y., Hayashi J.I., Sharp G.W.G., Kanazawa Y., Akanuma Y., Yazaki Y., and Kadowaki T. J. Biol. Chem. 273 (1998) 20300
11. Simmons R.A., Suponitsky-Kroyter I., and Selak M.A. J. Biol. Chem. 280 (2005) 28785
12. Tsuruzoe K., Araki M.E., Furukawa N., Shirotani T., Matsumoto K., Kaneto K., Motoshima H., Yoshizato K., Shriakami A., Kishikawa H., Miyazaki J., and Shichiri M. Diabetes 47 (1998) 621
13. Kennedy E.D., Maechler P., and Wollheim C.B. Diabetes 47 (1998) 374
14. Robey R.B., and Hay N. Oncogene 25 (2006) 4683
15. Downward J. Nature 424 (2003) 896
16. Pastorino J.G., and Hoek J.B. Curr. Med. Chem. 10 (2003) 1535
17. Rostovtseva T.K., Tan W., and Colombini M. J. Bioenerg. Biomembr. 37 (2005) 129
18. Matschinsky F.M. Diabetes 51 (2002) S394
19. Arden C., Baltrusch S., and Agius L. FEBS Lett. 580 (2006) 2065
20. Kim W.H., Lee J.W., Suh Y.H., Hong S.H., Choi J.S., Lim J.H., Song J.H., Gao B., and Jung M.H. Diabetes 54 (2005) 2602
21. Murphy E., Imahashi K., and Steenbergen C. Trends Cardiovasc. Med. 15 (2005) 283
22. McKinnon C.M., and Docherty K. Diabetologia 44 (2001) 1203
23. Kaneto H., Kawamori D., Matsuoka T.A., Kajimoto Y., and Yamasaki Y. Am. J. Ther. 12 (2005) 529
24. Kang D.C., and Hamasaki N. Curr. Med. Chem. 12 (2005) 429
25. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothaman D.L., Dipietro L., Cline G.W., and Shulman G.I. Science 300 (2003) 1140
26. Zhang D., Liu Z.X., Choi C.S., Tian L., Kibbey R., Dong J., Cline G.W., Wood P.A., and Shulman G.I. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 17075
27. Befroy D.E., Petersen K.F., Dufour S., Mason G.F., de Graaf R.A., Rothman D.L., and Shulman G.I. Diabetes 56 (2007) 1376
28. Maechler P., and Wollheim C.B. Nature 414 (2001) 807
29. Butow R.A., and Avadhani N.G. Mol. Cell. 14 (2004) 1
30. Amuthan G., Biswas G., Zhang S.Y., Klein-Szanto A., Vijayasarathy C., and Avadhani N.G. EMBO 20 (2001) 1910
31. Jazwinski S.M. Exp. Gerontol. 35 (2000) 671
32. Biswas G., Guha M., and Avadhani N.G. Gene 354 (2005) 132
33. Ohneda K., Mirmira R.G., Wang J., Johnson J.D., and German M.S. Mol. Cell. Biol. 20 (2000) 900