A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

Genes and Development

Volumn 20, Issue 1, 2006, Pages 47-64

  Besson, Arnaud ^a   Gurian West, Mark ^a   Chen, Xueyan ^b   Kelly Spratt, Karen S ^b   Kemp, Christopher J ^b   Roberts, James M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

CDK; Cyclin; Lung cancer; p27kip1; Ras; Tumor suppressor; Tumorigenesis

Indexed keywords

ALANINE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; PROTEASOME; SERINE;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CANCER INHIBITION; CARCINOGENESIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EXPERIMENTAL MODEL; FEMALE; MALE; MOUSE; MUTATION; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN STABILITY; REGULATORY MECHANISM; TUMOR RESISTANCE;

AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; CYTOPLASM; LUNG NEOPLASMS; MICE; MICE, MUTANT STRAINS; PHOSPHORYLATION; POINT MUTATION; PROTEIN TRANSPORT; RAS GTPASE-ACTIVATING PROTEINS; SERINE; SIGNAL TRANSDUCTION; URETHANE;

ANIMALIA;

EID: 29944440513     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1384406     Document Type: Article

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