Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

Journal of Biological Chemistry

Volumn 281, Issue 36, 2006, Pages 26602-26614

  Kamei, Nozomu ^a,b   Tobe, Kazuyuki ^a,c   Suzuki, Ryo ^a,c   Ohsugi, Mitsuru ^a   Watanabe, Taku ^a   Kubota, Naoto ^a,c,d   Ohtsuka Kowatari, Norie ^a,c   Kumagai, Katsuyoshi ^a,c   Sakamoto, Kentaro ^a,c   Kobayashi, Masatoshi ^a   Yamauchi, Toshimasa ^a,c   Ueki, Kohjiro ^a   Oishi, Yumiko ^a,d   Nishimura, Satoshi ^a   Manabe, Ichiro ^a,d   Hashimoto, Haruo ^e   Ohnishi, Yasuyuki ^e   Ogata, Hitomi ^f   Tokuyama, Kumpei ^f   Tsunoda, Masaki ^g   Ide, Tomohiro ^g   Murakami, Koji ^g   Nagai, Ryozo ^a   Kadowaki, Takashi ^a,c,d   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^e CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^f UNIVERSITY OF TSUKUBA   (Japan)

^g KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE P2 (AP2); ADIPOSE TISSUES; HYPERINSULINEMIC EUGLYCEMIC; PARACRINE EFFECTS;

BIOASSAY; CONCENTRATION (PROCESS); FATTY ACIDS; INSULIN; RNA; TISSUE; TUMORS;

PROTEINS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; FATTY ACID; GLUCOSE; INSULIN; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOCRINE FUNCTION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERINSULINEMIA; IMMUNOCYTOCHEMISTRY; INFLAMMATION; INSULIN RESISTANCE; LIVER; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; PARACRINE SIGNALING; PATCH CLAMP; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKELETAL MUSCLE; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ADIPOSE TISSUE; ANIMALS; ANTIMETABOLITES; BODY WEIGHT; CELLS, CULTURED; CHEMOKINE CCL2; DEOXYGLUCOSE; DIET; DIETARY FATS; FATTY ACID-BINDING PROTEINS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, OBESE; MICE, TRANSGENIC; MYOBLASTS, SKELETAL; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS MUSCULUS;

EID: 33748750917     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601284200     Document Type: Article

References (42)

1. Flier, J. S. (2004) Cell 116, 337-350
2. Wellen, K. E., and Hotamisligil, G. S. (2005) J. Clin. Investig. 115, 1111-1119
3. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., and Kadowaki, T. (1998) J. Clin. Investig. 101, 1354-1361
4. Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kitamura, T., Fujita, T., Ezaki, O., Aizawa, S., Nagai, R., Tobe, K., Kimura, S., and Kadowaki, T. (1999) Mol. Cell 4, 597-609
5. Kadowaki, T. (2000) J. Clin. Investig. 106, 459-465
6. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., and Kadowaki, T. (2001) Nat. Med. 7, 941-946
7. Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001) Nat. Med. 7, 947-953
8. Soukas, A., Cohen, P., Socci, N. D., and Friedman, J. M. (2000) Genes Dev. 14, 963-980
9. Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., and Ferrante, A. W., Jr. (2003) J. Clin. Investig. 112, 1796-1808
10. Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., and Chen, H. (2003) J. Clin. Investig. 112, 1821-1830
11. Wellen, K. E., and Hotamisligil, G. S. (2003) J. Clin. Investig. 112, 1785-1788
12. Kershaw, E. E., and Flier, J. S. (2004) J. Clin. Endocrinol. Metab. 89, 2548-2556
13. Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993) Science 259, 87-91
14. Fernandez-Real, J. M., and Ricart, W. (2003) Endocr. Rev. 24, 278-301
15. Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., and Kotani, H. (2003) J. Biol. Chem. 278, 46654-46660
16. Christiansen, T., Richelsen, B., and Bruun, J. M. (2005) Int. J. Obes. Relat. Metab. Disord. 29, 146-150
17. Shimomura, I., Funahashi, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., Tokunaga, K., and Matsuzawa, Y. (1996) Nat. Med. 2, 800-803
18. Ashida, N., Arai, H., Yamasaki, M., and Kita, T. (2001) J. Biol. Chem. 276, 16555-16560
19. Boring, L., Gosling, J., Cleary, M., and Charo, I. F. (1998) Nature 394, 894-897
20. Gu, L., Okada, Y., Clinton, S. K., Gerard, C., Sukhova, G. K., Libby, P., and Rollins, B. J. (1998) Mol. Cell 2, 275-281
21. Linton, M. F., and Fazio, S. (2003) Int. J. Obes. Relat. Metab. Disord. 27, Suppl. 3, 35-40
22. Sartipy, P., and Loskutoff, D. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 7265-7270
23. Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., and Ferrante, A. W. (2006) J. Clin. Investig. 116, 115-124
24. Graves, R. A., Tontonoz, P., Platt, K. A., Ross, S. R., and Spiegelman, B. M. (1992) J. Cell. Biochem. 49, 219-224
25. Suzuki, R., Tobe, K., Terauchi, Y., Komeda, K., Kubota, N., Eto, K., Yamauchi, T., Azuma, K., Kaneto, H., Taguchi, T., Koga, T., German, M. S., Watada, H., Kawamori, R., Wright, C. V., Kajimoto, Y., Kimura, S., Nagai, R., and Kadowaki, T. (2003) J. Biol. Chem. 278, 43691-43698
26. Takahashi, M., Kamei, Y., and Ezaki, O. (2005) Am. J. Physiol. Endocrinol. Metab. 288, 117-124
27. Yamauchi, T., Tobe, K., Tamemoto, H., Ueki, K., Kaburagi, Y., Yamamoto-Honda, R., Takahashi, Y., Yoshizawa, F., Aizawa, S., Akanuma, Y., Sonenberg, N., Yazaki, Y., and Kadowaki, T. (1996) Mol. Cell. Biol. 16, 3074-3084
28. Murakami, K., Tsunoda, M., Ide, T., Ohashi, M., and Mochizuki, T. (1999) Metabolism 48, 1450-1454
29. Suzuki, R., Tobe, K., Aoyama, M., Inoue, A., Sakamoto, K., Yamauchi, T., Kamon, J., Kubota, N., Terauchi, Y., Yoshimatsu, H., Matsuhisa, M., Nagasaka, S., Ogata, H., Tokuyama, K., Nagai, R., and Kadowaki, T. (2004) J. Biol. Chem. 279, 25039-25049
30. Barlow, C., Schroeder, M., Lekstrom-Himes, J., Kylefjord, H., Deng, C. X., Wynshaw-Boris, A., Spiegelman, B. M., and Xanthopoulos, K. G. (1997) Nucleic Acids Res. 25, 2543-2545
31. Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P., and Bahouth, S. W. (2004) Endocrinology 145, 2273-2282
32. Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., Hawkins, M., Barzilai, N., Rhodes, C. J., Fantus, I. G., Brownlee, M., and Scherer, P. E. (2005) J. Biol. Chem. 280, 4617-4626
33. Suganami, T., Nishida, J., and Ogawa, Y. (2005) Arterioscler. Thromb. Vasc. Biol. 25, 2062-2068
34. Boden, G. (1997) Diabetes 46, 3-10
35. McGarry, J. D. (2002) Diabetes 51, 7-18
36. Kamei, N., Yamane, K., Nakanishi, S., Ishida, K., Ohtaki, M., Okubo, M., and Kohno, N. (2005) Metabolism 54, 713-718
37. Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., Sekihara, H., Yoshioka, S., Horikoshi, H., Furuta, Y., Ikawa, Y., Kasuga, M., Yazaki, Y., and Aizawa, S. (1994) Nature 372, 182-186
38. Tobe, K., Tamemoto, H., Yamauchi, T., Aizawa, S., Yazaki, Y., and Kadowaki, T. (1995) J. Biol. Chem. 270, 5698-5701
39. Withers, D. J., Gutierrez, J. S., Towery, H., Burks, D. J., Ren, J. M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., Bonner-Weir, S., and White, M. F. (1998) Nature 391, 900-904
40. Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Suzuki, R., Tsubamoto, Y., Komeda, K., Nakano, R., Miki, H., Satoh, S., Sekihara, H., Sciacchitano, S., Lesniak, M., Aizawa, S., Nagai, R., Kimura, S., Akanuma, Y., Taylor, S. I., and Kadowaki, T. (2000) Diabetes 49, 1880-1889
41. Tobe, K., Suzuki, R., Aoyama, M., Yamauchi, T., Kamon, J., Kubota, N., Terauchi, Y., Matsui, J., Akanuma, Y., Kimura, S., Tanaka, J., Abe, M., Ohsumi, J., Nagai, R., and Kadowaki, T. (2001) J. Biol. Chem. 276, 38337-38340
42. Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K., and Kasuga, M. (2006) J. Clin. Investig. 116, 1494-1505