Transcription factor networks in dendritic cell development

Seminars in Immunology

Volumn 23, Issue 5, 2011, Pages 388-397

  Satpathy, Ansuman T ^a   Murphy, Kenneth M ^a   Wumesh, K C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Common dendritic progenitor; Dendritic cell; Flt3 ligand; Lineage commitment; Transcription factor

Indexed keywords

BETA CATENIN; COLONY STIMULATING FACTOR 1; FLT3 LIGAND; GLYCOPROTEIN P 15095; I KAPPA B; IKAROS TRANSCRIPTION FACTOR; INTERFERON REGULATORY FACTOR 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAMMALIAN TARGET OF RAPAMYCIN; NOTCH1 RECEPTOR; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL SPECIFICITY; CELL STRUCTURE; CELL SURVIVAL; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE LOCUS; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MYELOID PROGENITOR CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELLS; HUMANS; MODELS, BIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 82555166971     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2011.08.009     Document Type: Review

References (117)

1. Steinman R.M., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973, 137:1142-1162.
2. Steinman R.M., Witmer M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A 1978, 75:5132-5136.
3. Ohnmacht C., Pullner A., King S.B., Drexler I., Meier S., Brocker T., et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009, 206:549-559.
4. Birnberg T., Bar-On L., Sapoznikov A., Caton M.L., Cervantes-Barragan L., Makia D., et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 2008, 29:986-997.
5. Vremec D., Zorbas M., Scollay R., Saunders D.J., Ardavin C.F., Wu L., et al. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med 1992, 176:47-58.
6. Wu L., Li C.L., Shortman K. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J Exp Med 1996, 184:903-911.
7. Naik S.H. Demystifying the development of dendritic cell subtypes, a little. Immunol Cell Biol 2008, 86:439-452.
8. Vremec D., Pooley J., Hochrein H., Wu L., Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol 2000, 164:2978-2986.
9. Edwards A.D., Chaussabel D., Tomlinson S., Schulz O., Sher A., Sousa C.R.E. Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol 2003, 171:47-60.
10. Blasius A.L., Giurisato E., Cella M., Schreiber R.D., Shaw A.S., Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 2006, 177:3260-3265.
11. Zhang J., Raper A., Sugita N., Hingorani R., Salio M., Palmowski M.J., et al. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood 2006, 107:3600-3608.
12. Grouard G., Rissoan M.C., Filgueira L., Durand I., Banchereau J., Liu Y.J. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997, 185:1101-1111.
13. Crozat K., Guiton R., Contreras V., Feuillet V., Dutertre C.A., Ventre E., et al. The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells. J Exp Med 2010, 207:1283-1292.
14. Poulin L.F., Salio M., Griessinger E., Anjos-Afonso F., Craciun L., Chen J.L., et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med 2010, 207:1261-1271.
15. Bachem A., Guettler S., Hartung E., Ebstein F., Schaefer M., Tannert A., et al. Superior antigen cross-presentation and XCR1 expression define human CD11c+ CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med 2010, 207:1273-1281.
16. Randolph G.J., Inaba K., Robbiani D.F., Steinman R.M., Muller W.A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 1999, 11:753-761.
17. Randolph G.J., Beaulieu S., Lebecque S., Steinman R.M., Muller W.A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 1998, 282:480-483.
18. Swiecki M., Gilfillan S., Vermi W., Wang Y., Colonna M. Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity 2010, 33:955-966.
19. Swiecki M., Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev 2010, 234:142-162.
20. Sapoznikov A., Pewzner-Jung Y., Kalchenko V., Krauthgamer R., Shachar I., Jung S. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 2008, 9:388-395.
21. McCartney S., Vermi W., Lonardi S., Rossini C., Otero K., Calderon B., et al. Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med 2009, 206:2967-2976.
22. Miyake T., Kumagai Y., Kato H., Guo Z., Matsushita K., Satoh T., et al. Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. J Immunol 2009, 183:2522-2528.
23. den Haan J.M., Lehar S.M., Bevan M.J. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 2000, 192:1685-1696.
24. Bevan M.J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med 1976, 143:1283-1288.
25. Sigal L.J., Crotty S., Andino R., Rock K.L. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 1999, 398:77-80.
26. Ochsenbein A.F., Sierro S., Odermatt B., Pericin M., Karrer U., Hermans J., et al. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 2001, 411:1058-1064.
27. Idoyaga J., Suda N., Suda K., Park C.G., Steinman R.M. Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen. Proc Natl Acad Sci U S A 2009, 106:1524-1529.
28. Qiu C.H., Miyake Y., Kaise H., Kitamura H., Ohara O., Tanaka M. Novel subset of CD8 alpha(+) dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol 2009, 182:4127-4136.
29. Reis e Sousa C., Hieny S., Scharton-Kersten T., Jankovic D., Charest H., Germain R.N., et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas [see comments]. J Exp Med 1997, 186:1819-1829.
30. Hochrein H., Shortman K., Vremec D., Scott B., Hertzog P., O'Keeffe M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol 2001, 166:5448-5455.
31. Dudziak D., Kamphorst A.O., Heidkamp G.F., Buchholz V.R., Trumpfheller C., Yamazaki S., et al. Differential antigen processing by dendritic cell subsets in vivo. Science 2007, 315:107-111.
32. Kamphorst A.O., Guermonprez P., Dudziak D., Nussenzweig M.C. Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol 2010, 185:3426-3435.
33. Cheong C., Matos I., Choi J.H., Dandamudi D.B., Shrestha E., Longhi M.P., et al. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell 2010, 143:416-429.
34. Nakano H., Lin K.L., Yanagita M., Charbonneau C., Cook D.N., Kakiuchi T., et al. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol 2009, 10:394-402.
35. Hume D.A. Macrophages as APC and the dendritic cell myth. J Immunol 2008, 181:5829-5835.
36. Yoshimoto T., Yasuda K., Tanaka H., Nakahira M., Imai Y., Fujimori Y., et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 2009, 10:706-712.
37. Sokol C.L., Chu N.Q., Yu S., Nish S.A., Laufer T.M., Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009, 10:713-720.
38. Hammad H., Plantinga M., Deswarte K., Pouliot P., Willart M.A., Kool M., et al. Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 2010, 207:2097-2111.
39. Manicassamy S., Reizis B., Ravindran R., Nakaya H., Salazar-Gonzalez R.M., Wany Y.C., et al. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 2010, 329:849-853.
40. Geissmann F., Gordon S., Hume D.A., Mowat A.M., Randolph G.J. Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol 2010, 10:453-460.
41. Liu K., Waskow C., Liu X., Yao K., Hoh J., Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol 2007, 8:578-583.
42. Kamath A.T., Pooley J., O'Keeffe M.A., Vremec D., Zhan Y., Lew A.M., et al. The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J Immunol 2000, 165:6762-6770.
43. Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997, 91:661-672.
44. Akashi K., Traver D., Miyamoto T., Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000, 404:193-197.
45. Manz M.G., Traver D., Miyamoto T., Weissman I.L., Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001, 97:3333-3341.
46. Manz M.G., Traver D., Akashi K., Merad M., Miyamoto T., Engleman E.G., et al. Dendritic cell development from common myeloid progenitors. Ann N Y Acad Sci 2001, 938:167-173.
47. Traver D., Akashi K., Manz M., Merad M., Miyamoto T., Engleman E.G., et al. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 2000, 290:2152-2154.
48. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992, 176:1693-1702.
49. Schlenner S.M., Madan V., Busch K., Tietz A., Laufle C., Costa C., et al. Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity 2010, 32:426-436.
50. Fogg D.K., Sibon C., Miled C., Jung S., Aucouturier P., Littman D.R., et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006, 311:83-87.
51. Onai N., Obata-Onai A., Schmid M.A., Ohteki T., Jarrossay D., Manz M.G. Identification of clonogenic common Flt3(+) M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 2007, 8:1207-1216.
52. Naik S.H., Sathe P., Park H.Y., Metcalf D., Proietto A.I., Dakic A., et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 2007, 8:1217-1226.
53. Liu K., Victora G.D., Schwickert T.A., Guermonprez P., Meredith M.M., Yao K., et al. In vivo analysis of dendritic cell development and homeostasis. Science 2009, 324:392-397.
54. Cisse B., Caton M.L., Lehner M., Maeda T., Scheu S., Locksley R., et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 2008, 135:37-48.
55. Naik S.H., Metcalf D., van Nieuwenhuijze A., Wicks I., Wu L., O'Keeffe M., et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 2006, 7:663-671.
56. Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994, 179:1109-1118.
57. Kingston D., Schmid M.A., Onai N., Obata-Onai A., Baumjohann D., Manz M.G. The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood 2009, 114:835-843.
58. Vremec D., Lieschke G.J., Dunn A.R., Robb L., Metcalf D., Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 1997, 27:40-44.
59. Serbina N.V., Salazar-Mather T.P., Biron C.A., Kuziel W.A., Pamer E.G. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 2003, 19:59-70.
60. Xu Y.K., Zhan Y.F., Lew A.M., Naik S.H., Kershaw M.H. Differential development of murine dendritic cells by GM-CSF versus flt3 ligand has implications for inflammation and trafficking. J Immunol 2007, 179:7577-7584.
61. Maraskovsky E., Pulendran B., Brasel K., Teepe M., Roux E.R., Shortman K., et al. Dramatic numerical increase of functionally mature dendritic cells in FLT3 ligand-treated mice. Adv Exp Med Biol 1997, 417:33-40.
62. Brasel K., De Smedt T., Smith J.L., Maliszewski C.R. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 2000, 96:3029-3039.
63. Onai N., Obata-Onai A., Tussiwand R., Lanzavecchia A., Manz M.G. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J Exp Med 2006, 203:227-238.
64. McKenna H.J., Stocking K.L., Miller R.E., Brasel K., De Smedt T., Maraskovsky E., et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000, 95:3489-3497.
65. Waskow C., Liu K., Darrasse-Jeze G., Guermonprez P., Ginhoux F., Merad M., et al. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 2008, 9:676-683.
66. Laouar Y., Welte T., Fu X.Y., Flavell R.A. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 2003, 19:903-912.
67. Sathaliyawala T., O'Gorman W.E., Greter M., Bogunovic M., Konjufca V., Hou Z.E., et al. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 2010, 33:597-606.
68. Tokoyoda K., Egawa T., Sugiyama T., Choi B.I., Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 2004, 20:707-718.
69. Schmid M.A., Kingston D., Boddupalli S., Manz M.G. Instructive cytokine signals in dendritic cell lineage commitment. Immunol Rev 2010, 234:32-44.
70. Esashi E., Wang Y.H., Perng O., Qin X.F., Liu Y.J., Watowich S.S. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 2008, 28:509-520.
71. Wu L., Nichogiannopoulou A., Shortman K., Georgopoulos K. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 1997, 7:483-492.
72. Allman D., Dalod M., Asselin-Paturel C., Delale T., Robbins S.H., Trinchieri G., et al. Ikaros is required for plasmacytoid dendritic cell differentiation. Blood 2006, 108:4025-4034.
73. Ng S.Y., Yoshida T., Zhang J., Georgopoulos K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 2009, 30:493-507.
74. Yoshida T., Ng S.Y., Georgopoulos K. Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr Opin Immunol 2010, 22:154-160.
75. Guerriero A., Langmuir P.B., Spain L.M., Scott E.W. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 2000, 95:879-885.
76. Anderson K.L., Perkin H., Surh C.D., Venturini S., Maki R.A., Torbett B.E. Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J Immunol 2000, 164:1855-1861.
77. Carotta S., Dakic A., D'Amico A., Pang S.H., Greig K.T., Nutt S.L., et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 2010, 32:628-641.
78. Zhang D.E., Hetherington C.J., Chen H.M., Tenen D.G. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol 1994, 14:373-381.
79. Hohaus S., Petrovick M.S., Voso M.T., Sun Z., Zhang D.E., Tenen D.G. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol 1995, 15:5830-5845.
80. Rathinam C., Geffers R., Yucel R., Buer J., Welte K., Moroy T., et al. The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. Immunity 2005, 22:717-728.
81. Rodel B., Tavassoli K., Karsunky H., Schmidt T., Bachmann M., Schaper F., et al. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J 2000, 19:5845-5855.
82. Duan Z., Horwitz M. Targets of the transcriptional repressor oncoprotein Gfi-1. Proc Natl Acad Sci U S A 2003, 100:5932-5937.
83. Kobayashi T., Walsh P.T., Walsh M.C., Speirs K.M., Chiffoleau E., King C.G., et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 2003, 19:353-363.
84. Spooner C.J., Cheng J.X., Pujadas E., Laslo P., Singh H. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 2009, 31:576-586.
85. Edelson B.T., KC W., Juang R., Kohyama M., Benoit L.A., Klekotka P.A., et al. Peripheral CD103(+) dendritic cells form a unified subset developmentally related to CD8 alpha(+) conventional dendritic cells. J Exp Med 2010, 207:823-836.
86. Ginhoux F., Liu K., Helft J., Bogunovic M., Greter M., Hashimoto D., et al. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 2009, 206:3115-3130.
87. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009, 27:693-733.
88. Wu L., D'Amico A., Winkel K.D., Suter M., Lo D., Shortman K. RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 1998, 9:839-847.
89. Burkly L., Hession C., Ogata L., Reilly C., Marconi L.A., Olson D., et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 1995, 373:531-536.
90. Suzuki S., Honma K., Matsuyama T., Suzuki K., Toriyama K., Akitoyo I., et al. Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha-dendritic cell development. Proc Natl Acad Sci U S A 2004, 101:8981-8986.
91. Eisenbeis C.F., Singh H., Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 1995, 9:1377-1387.
92. Brass A.L., Kehrli E., Eisenbeis C.F., Storb U., Singh H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev 1996, 10:2335-2347.
93. Biswas P.S., Bhagat G., Pernis A.B. IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?. Immunol Rev 2010, 233:79-96.
94. Tamura T., Tailor P., Yamaoka K., Kong H.J., Tsujimura H., O'Shea J.J., et al. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 2005, 174:2573-2581.
95. Schiavoni G., Mattei F., Sestili P., Borghi P., Venditti M., Morse H.C., et al. ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med 2002, 196:1415-1425.
96. Hildner K., Edelson B.T., Purtha W.E., Diamond M., Matsushita H., Kohyama M., et al. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008, 322:1097-1100.
97. Iacobelli M., Wachsman W., McGuire K.L. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J Immunol 2000, 165:860-868.
98. Bower K.E., Fritz J.M., McGuire K.L. Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. Oncogene 2004, 23:8805-8814.
99. Schraml B.U., Hildner K., Ise W., Lee W.L., Smith W.A., Solomon B., et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 2009, 460:405-409.
100. Betz B.C., Jordan-Williams K.L., Wang C., Kang S.G., Liao J., Logan M.R., et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med 2010, 207:933-942.
101. Caton M.L., Smith-Raska M.R., Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J Exp Med 2007, 204:1653-1664.
102. Ohtsuka H., Sakamoto A., Pan J., Inage S., Horigome S., Ichii H., et al. Bcl6 is required for the development of mouse CD4+ and CD8alpha+ dendritic cells. J Immunol 2011, 186:255-263.
103. Johnston R.J., Poholek A.C., DiToro D., Yusuf I., Eto D., Barnett B., et al. Bcl6 and blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009, 325:1006-1010.
104. Niu H., Cattoretti G., Dalla-Favera R. BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J Exp Med 2003, 198:211-221.
105. Nurieva R.I., Chung Y., Martinez G.J., Yang X.O., Tanaka S., Matskevitch T.D., et al. Bcl6 mediates the development of T follicular helper cells. Science 2009, 325:1001-1005.
106. Kee B.L. E and ID proteins branch out. Nat Rev Immunol 2009, 9:175-184.
107. Spits H., Couwenberg F., Bakker A.Q., Weijer K., Uittenbogaart C.H. Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J Exp Med 2000, 192:1775-1784.
108. Hacker C., Kirsch R.D., Ju X.-S., Hieronymus T., Gust T.C., Kuhl C., et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 2003, 4:380-386.
109. Robbins S.H., Walzer T., Dembélé D., Thibault C., Defays A., Bessou G., et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol 2008, 9:R17.
110. Ghosh H.S., Cisse B., Bunin A., Lewis K.L., Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 2010, 33:905-916.
111. Bar-On L., Birnberg T., Lewis K.L., Edelson B.T., Bruder D., Hildner K., et al. CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 2010, 107:14745-14750.
112. Pui J.C., Allman D., Xu L., DeRocco S., Karnell F.G., Bakkour S., et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999, 11:299-308.
113. Li L., Leid M., Rothenberg E.V. An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b. Science 2010, 329:89-93.
114. Li P., Burke S., Wang J., Chen X., Ortiz M., Lee S.-C., et al. Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 2010, 329:85-89.
115. Ikawa T., Hirose S., Masuda K., Kakugawa K., Satoh R., Shibano-Satoh A., et al. An essential developmental checkpoint for production of the T cell lineage. Science 2010, 329:93-96.
116. Felker P., Seré K., Lin Q., Becker C., Hristov M., Hieronymus T., et al. TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells. J Immunol 2010, 185:5326-5335.
117. Ouyang W., Löhning M., Gao Z., Assenmacher M., Ranganath S., Radbruch A., et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000, 12:27-37.